CARA GOTTARDI

Summary

Affiliation: Northwestern University
Country: USA

Publications

  1. pmc Phospho-regulation of Beta-catenin adhesion and signaling functions
    Rebecca Leadem Daugherty
    The Integrated Graduate Program in the Life Sciences, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    Physiology (Bethesda) 22:303-9. 2007
  2. pmc Terminating Wnt signals: a novel nuclear export mechanism targets activated (beta)-catenin
    Meghan E Thorne
    Department of Medicine, Northwestern University, Chicago, IL 60637, USA
    J Cell Biol 171:761-3. 2005
  3. pmc Beta-catenin phosphorylated at serine 45 is spatially uncoupled from beta-catenin phosphorylated in the GSK3 domain: implications for signaling
    Meghan T Maher
    Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America
    PLoS ONE 5:e10184. 2010
  4. pmc Activity of the beta-catenin phosphodestruction complex at cell-cell contacts is enhanced by cadherin-based adhesion
    Meghan T Maher
    Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    J Cell Biol 186:219-28. 2009
  5. pmc Issues associated with assessing nuclear localization of N-terminally unphosphorylated beta-catenin with monoclonal antibody 8E7
    Meghan T Maher
    Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Biol Direct 4:5. 2009
  6. pmc Distinct molecular forms of beta-catenin are targeted to adhesive or transcriptional complexes
    Cara J Gottardi
    Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    J Cell Biol 167:339-49. 2004
  7. pmc Polycystin-1 C-terminal tail associates with beta-catenin and inhibits canonical Wnt signaling
    Mark Lal
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06510, USA
    Hum Mol Genet 17:3105-17. 2008
  8. doi request reprint VE-cadherin and beta-catenin binding dynamics during histamine-induced endothelial hyperpermeability
    Mingzhang Guo
    Department of Surgery, University of California Davis School of Medicine, Sacramento, CA 95817, USA
    Am J Physiol Cell Physiol 294:C977-84. 2008
  9. ncbi request reprint When domestiques rebel: kinesins, cadherins and neuronal proliferation
    Cara J Gottardi
    Nat Cell Biol 7:445-7. 2005
  10. ncbi request reprint Role for ICAT in beta-catenin-dependent nuclear signaling and cadherin functions
    Cara J Gottardi
    Department of Cell Biology, School of Medicine, University of Virginia, Charlottesville, VA 22908 0732, USA
    Am J Physiol Cell Physiol 286:C747-56. 2004

Collaborators

Detail Information

Publications12

  1. pmc Phospho-regulation of Beta-catenin adhesion and signaling functions
    Rebecca Leadem Daugherty
    The Integrated Graduate Program in the Life Sciences, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    Physiology (Bethesda) 22:303-9. 2007
    ..Inputs from various cell-signaling events can therefore impact beta-catenin function, which may be necessary for the finely tuned adhesive and signaling responses required for tissue morphogenesis...
  2. pmc Terminating Wnt signals: a novel nuclear export mechanism targets activated (beta)-catenin
    Meghan E Thorne
    Department of Medicine, Northwestern University, Chicago, IL 60637, USA
    J Cell Biol 171:761-3. 2005
    ..We speculate that cells may use multiple export mechanisms to inhibit beta-catenin signaling in different ways...
  3. pmc Beta-catenin phosphorylated at serine 45 is spatially uncoupled from beta-catenin phosphorylated in the GSK3 domain: implications for signaling
    Meghan T Maher
    Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America
    PLoS ONE 5:e10184. 2010
    ....
  4. pmc Activity of the beta-catenin phosphodestruction complex at cell-cell contacts is enhanced by cadherin-based adhesion
    Meghan T Maher
    Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    J Cell Biol 186:219-28. 2009
    ....
  5. pmc Issues associated with assessing nuclear localization of N-terminally unphosphorylated beta-catenin with monoclonal antibody 8E7
    Meghan T Maher
    Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Biol Direct 4:5. 2009
    ....
  6. pmc Distinct molecular forms of beta-catenin are targeted to adhesive or transcriptional complexes
    Cara J Gottardi
    Department of Cell Biology, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    J Cell Biol 167:339-49. 2004
    ..This model explains how cells can control whether beta-catenin is used independently in cell adhesion and nuclear signaling, or competitively so that the two processes are coordinated and interrelated...
  7. pmc Polycystin-1 C-terminal tail associates with beta-catenin and inhibits canonical Wnt signaling
    Mark Lal
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06510, USA
    Hum Mol Genet 17:3105-17. 2008
    ..Our results suggest a novel mechanism through which PC1 cleavage may impact upon Wnt-dependent signaling and thereby modulate both developmental processes and cystogenesis...
  8. doi request reprint VE-cadherin and beta-catenin binding dynamics during histamine-induced endothelial hyperpermeability
    Mingzhang Guo
    Department of Surgery, University of California Davis School of Medicine, Sacramento, CA 95817, USA
    Am J Physiol Cell Physiol 294:C977-84. 2008
    ..Taken together, these data suggest that inflammatory agents like histamine cause a transient and reversible disruption of binding between beta-catenin and VE-cadherin, during which endothelial permeability is elevated...
  9. ncbi request reprint When domestiques rebel: kinesins, cadherins and neuronal proliferation
    Cara J Gottardi
    Nat Cell Biol 7:445-7. 2005
  10. ncbi request reprint Role for ICAT in beta-catenin-dependent nuclear signaling and cadherin functions
    Cara J Gottardi
    Department of Cell Biology, School of Medicine, University of Virginia, Charlottesville, VA 22908 0732, USA
    Am J Physiol Cell Physiol 286:C747-56. 2004
    ....
  11. pmc Terminal regions of beta-catenin come into view
    Cara J Gottardi
    Structure 16:336-8. 2008
  12. pmc Molecular components of the adherens junction
    Carien M Niessen
    Center for Molecular Medicine, University of Cologne, LFI, 05, Room 59, Joseph Stelzmannstrasse 9, D 50931 Cologne, Germany
    Biochim Biophys Acta 1778:562-71. 2008
    ..The molecular machineries that organize these adhesion receptor complexes into higher order junction structures, and the functional consequences of this junctional organization will be discussed...

Research Grants7

  1. Mechanism of b-catenin targeting to adhesive or transcriptional complexes
    CARA GOTTARDI; Fiscal Year: 2006
    ....
  2. Mechanism of b-catenin targeting to adhesive or transcriptional complexes
    CARA GOTTARDI; Fiscal Year: 2007
    ....
  3. Mechanism of b-catenin targeting to adhesive or transcriptional complexes
    CARA GOTTARDI; Fiscal Year: 2009
    ..abstract_text> ..
  4. Mechanism of b-catenin targeting to adhesive or transcriptional complexes
    Cara J Gottardi; Fiscal Year: 2010
    ..abstract_text> ..
  5. Mechanism of b-catenin targeting to adhesive or transcriptional complexes
    CARA GOTTARDI YAJNIK; Fiscal Year: 2009
    ..abstract_text> ..
  6. Role for Wnt/beta-catenin signaling in alveolar repair and fibrosis
    Cara J Gottardi; Fiscal Year: 2011
    ..Thus, new insights into the mechanisms of pulmonary fibrosis are needed to generate novel therapeutic treatments. ..