Robert D Goldman

Summary

Affiliation: Northwestern University
Country: USA

Publications

  1. pmc Withaferin a alters intermediate filament organization, cell shape and behavior
    Boris Grin
    Department of Cell and Molecular Biology, Feinberg School of Medicine at Northwestern University, Chicago, Illinois, United States of America
    PLoS ONE 7:e39065. 2012
  2. pmc Inroads into the structure and function of intermediate filament networks
    Robert D Goldman
    Department of Cell and Molecular Biology, Northwestern University s Feinberg School of Medicine, 303 E Chicago Avenue, Chicago, IL 60611, USA
    J Struct Biol 177:14-23. 2012
  3. pmc Insights into the dynamic properties of keratin intermediate filaments in living epithelial cells
    K H Yoon
    Department of Cell and Molecular Biology, Northwestern University Medical School, Chicago, Illinois 60611
    J Cell Biol 153:503-16. 2001
  4. pmc Intermediate filaments: versatile building blocks of cell structure
    Robert D Goldman
    Department of Cell and Molecular Biology, Northwestern University s Feinberg School of Medicine, Chicago, IL 60611, USA
    Curr Opin Cell Biol 20:28-34. 2008
  5. pmc Accumulation of mutant lamin A causes progressive changes in nuclear architecture in Hutchinson-Gilford progeria syndrome
    Robert D Goldman
    Department of Cell and Molecular Biology, Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, Chicago, IL 60611, USA
    Proc Natl Acad Sci U S A 101:8963-8. 2004
  6. pmc Vimentin organization modulates the formation of lamellipodia
    Brian T Helfand
    Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Mol Biol Cell 22:1274-89. 2011
  7. pmc A progeria mutation reveals functions for lamin A in nuclear assembly, architecture, and chromosome organization
    Pekka Taimen
    Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Proc Natl Acad Sci U S A 106:20788-93. 2009
  8. pmc The highly conserved nuclear lamin Ig-fold binds to PCNA: its role in DNA replication
    Dale K Shumaker
    Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    J Cell Biol 181:269-80. 2008
  9. pmc The role of nuclear lamin B1 in cell proliferation and senescence
    Takeshi Shimi
    Department of Cell and Molecular Biology, Division of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Genes Dev 25:2579-93. 2011
  10. pmc Shear stress induced reorganization of the keratin intermediate filament network requires phosphorylation by protein kinase C zeta
    Sivaraj Sivaramakrishnan
    Department of Biomedical Engineering, Northwestern University, Chicago, IL 60611, USA
    Mol Biol Cell 20:2755-65. 2009

Research Grants

Collaborators

Detail Information

Publications58

  1. pmc Withaferin a alters intermediate filament organization, cell shape and behavior
    Boris Grin
    Department of Cell and Molecular Biology, Feinberg School of Medicine at Northwestern University, Chicago, Illinois, United States of America
    PLoS ONE 7:e39065. 2012
    ..In light of our findings that WFA affects multiple IF systems, which are expressed in many tissues of the body, caution is warranted in its use as an anti-cancer agent, since it may have debilitating organism-wide effects...
  2. pmc Inroads into the structure and function of intermediate filament networks
    Robert D Goldman
    Department of Cell and Molecular Biology, Northwestern University s Feinberg School of Medicine, 303 E Chicago Avenue, Chicago, IL 60611, USA
    J Struct Biol 177:14-23. 2012
    ..Many of our advances in understanding IF are based on conversations with Ueli which have taken place during adventurous and sometimes dangerous hiking and biking trips throughout the world...
  3. pmc Insights into the dynamic properties of keratin intermediate filaments in living epithelial cells
    K H Yoon
    Department of Cell and Molecular Biology, Northwestern University Medical School, Chicago, Illinois 60611
    J Cell Biol 153:503-16. 2001
    ..This suggests that there are different factors regulating the dynamic properties of different types of IFs within the same cytoplasmic regions...
  4. pmc Intermediate filaments: versatile building blocks of cell structure
    Robert D Goldman
    Department of Cell and Molecular Biology, Northwestern University s Feinberg School of Medicine, Chicago, IL 60611, USA
    Curr Opin Cell Biol 20:28-34. 2008
    ..IF also play a role in the organization of organelles by modulating their motility and providing anchorage sites within the cytoplasm...
  5. pmc Accumulation of mutant lamin A causes progressive changes in nuclear architecture in Hutchinson-Gilford progeria syndrome
    Robert D Goldman
    Department of Cell and Molecular Biology, Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, Chicago, IL 60611, USA
    Proc Natl Acad Sci U S A 101:8963-8. 2004
    ....
  6. pmc Vimentin organization modulates the formation of lamellipodia
    Brian T Helfand
    Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Mol Biol Cell 22:1274-89. 2011
    ..These findings demonstrate an antagonistic relationship between VIF and the formation of lamellipodia...
  7. pmc A progeria mutation reveals functions for lamin A in nuclear assembly, architecture, and chromosome organization
    Pekka Taimen
    Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Proc Natl Acad Sci U S A 106:20788-93. 2009
    ..The study also emphasizes the importance of lamins in nuclear assembly and chromatin organization...
  8. pmc The highly conserved nuclear lamin Ig-fold binds to PCNA: its role in DNA replication
    Dale K Shumaker
    Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    J Cell Biol 181:269-80. 2008
    ..These findings also provide insights into the mechanisms underlying the numerous disease-causing mutations located within the lamin Ig-fold...
  9. pmc The role of nuclear lamin B1 in cell proliferation and senescence
    Takeshi Shimi
    Department of Cell and Molecular Biology, Division of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Genes Dev 25:2579-93. 2011
    ..This overexpression eventually leads to cell cycle arrest at the G1/S boundary. These results demonstrate the importance of LB1 in regulating the proliferation and senescence of human diploid cells through a ROS signaling pathway...
  10. pmc Shear stress induced reorganization of the keratin intermediate filament network requires phosphorylation by protein kinase C zeta
    Sivaraj Sivaramakrishnan
    Department of Biomedical Engineering, Northwestern University, Chicago, IL 60611, USA
    Mol Biol Cell 20:2755-65. 2009
    ....
  11. pmc Alterations in mitosis and cell cycle progression caused by a mutant lamin A known to accelerate human aging
    Thomas Dechat
    Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, 303 East Chicago Avenue, Chicago, IL 60611, USA
    Proc Natl Acad Sci U S A 104:4955-60. 2007
    ..These results provide insights into the mechanisms responsible for premature aging and also shed light on the role of lamins in the normal process of human aging...
  12. pmc Recruitment of vimentin to the cell surface by beta3 integrin and plectin mediates adhesion strength
    Ramona Bhattacharya
    Department of Cell and Molecular Biology, Northwestern University Medical School, Chicago, IL 60611, USA
    J Cell Sci 122:1390-400. 2009
    ..These differences require an intact vimentin network. Therefore, vimentin IF recruitment to the cell surface is tightly regulated and modulates the strength of adhesion of cells to their substrate...
  13. ncbi The motility and dynamic properties of intermediate filaments and their constituent proteins
    Ying Hao Chou
    Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, 303 East Chicago Avenue, Chicago, IL 60611, USA
    Exp Cell Res 313:2236-43. 2007
    ..The recent findings that IF and their precursors are frequently associated with signaling molecules have revealed new functions for IF beyond their more traditional roles as mechanical integrators of cells and tissues...
  14. pmc Insights into the mechanical properties of epithelial cells: the effects of shear stress on the assembly and remodeling of keratin intermediate filaments
    Eric W Flitney
    Department of Cell and Molecular Biology, Feinberg School of Medicine of Northwestern University, 303 E Chicago Avenue, Chicago, IL 60611, USA
    FASEB J 23:2110-9. 2009
    ..We suggest that keratin particles constitute a reservoir of protein that can be recruited into KIFs under flow, creating a more robust cytoskeleton able to withstand shear forces more effectively...
  15. ncbi Intermediate filaments are dynamic and motile elements of cellular architecture
    Brian T Helfand
    Feinberg School of Medicine, Northwestern University, Department of Cell and Molecular Biology, 303 E Chicago Avenue, Chicago, IL 60611, USA
    J Cell Sci 117:133-41. 2004
    ..These differences in motility may be related to their interactions with different types of molecular motor and/or other factors, such as IF-associated proteins...
  16. pmc Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging
    Dale K Shumaker
    Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, 303 East Chicago Avenue, Chicago, IL 60611, USA
    Proc Natl Acad Sci U S A 103:8703-8. 2006
    ..The epigenetic changes described most likely represent molecular mechanisms responsible for the rapid progression of premature aging in HGPS patients...
  17. pmc The A- and B-type nuclear lamin networks: microdomains involved in chromatin organization and transcription
    Takeshi Shimi
    Department of Cell and Molecular Biology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Genes Dev 22:3409-21. 2008
    ..Our evidence suggests that the organization and regulation of chromatin are influenced by interconnections between these lamin microdomains...
  18. ncbi Intermediate filament proteins participate in signal transduction
    Brian T Helfand
    Department of Cell and Molecular Biology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
    Trends Cell Biol 15:568-70. 2005
    ....
  19. pmc Giant axonal neuropathy-associated gigaxonin mutations impair intermediate filament protein degradation
    Saleemulla Mahammad
    Department of Cell and Molecular Biology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Clin Invest 123:1964-75. 2013
    ..Together, these findings identify gigaxonin as a major factor in the degradation of cytoskeletal IFs and provide an explanation for IF aggregate accumulation, the subcellular hallmark of this devastating human disease...
  20. pmc Nuclear lamins
    Thomas Dechat
    Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Cold Spring Harb Perspect Biol 2:a000547. 2010
    ..They may also regulate chromatin functions by interacting with factors that epigenetically modify the chromatin or directly regulate replication or transcription...
  21. pmc Nuclear lamins: major factors in the structural organization and function of the nucleus and chromatin
    Thomas Dechat
    Department of Cell and Molecular Biology, Northwestern University Medical School, Chicago, Illinois 60611, USA
    Genes Dev 22:832-53. 2008
    ..In addition, we discuss recent evidence supporting the importance of lamins in viral infections...
  22. ncbi Keratin 8 phosphorylation by protein kinase C delta regulates shear stress-mediated disassembly of keratin intermediate filaments in alveolar epithelial cells
    Karen M Ridge
    Division of Pulmonary and Critical Care Medicine, Northwestern University Medical School, Chicago, Illinois 60611, USA
    J Biol Chem 280:30400-5. 2005
    ..Importantly, these data provided clues regarding a molecular link between mechanically induced signal transduction and alterations in cytoskeletal IF...
  23. pmc Nestin promotes the phosphorylation-dependent disassembly of vimentin intermediate filaments during mitosis
    Ying Hao Chou
    Department of Cell and Molecular Biology, Northwestern University, 303 East Chicago Avenue, Chicago, IL 60611, USA
    Mol Biol Cell 14:1468-78. 2003
    ..On the basis of these observations, we speculate that nestin may play a role in the trafficking and distribution of IF proteins and potentially other cellular factors to daughter cells during progenitor cell division...
  24. pmc Ubiquitin-proteasome-mediated degradation of keratin intermediate filaments in mechanically stimulated A549 cells
    Ariel Jaitovich
    Division of Pulmonary and Critical Care Medicine, Northwestern University Medical School, 240 East Huron, Chicago, IL 60611, USA
    J Biol Chem 283:25348-55. 2008
    ..These data suggest that shear stress promotes the disassembly and degradation of the keratin IF network via phosphorylation and the ubiquitin-proteasome pathway...
  25. pmc Assembling an intermediate filament network by dynamic cotranslation
    Lynne Chang
    Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    J Cell Biol 172:747-58. 2006
    ..The results show that the motility and targeting of peripherin mRNPs, their translational control, and the assembly of an IF cytoskeletal system are linked together in a process we have termed dynamic cotranslation...
  26. ncbi Fluorescence-based methods for studying intermediate filaments
    Eric W Flitney
    Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Methods Cell Biol 78:297-319. 2004
  27. pmc Vimentin induces changes in cell shape, motility, and adhesion during the epithelial to mesenchymal transition
    Melissa G Mendez
    Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    FASEB J 24:1838-51. 2010
    ..Our results demonstrate that VIFs play a predominant role in the changes in shape, adhesion, and motility that occur during the EMT...
  28. pmc Structural changes in intermediate filament networks alter the activity of insulin-degrading enzyme
    Ying Hao Chou
    Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, 303 East Chicago Ave, Chicago, IL 60611, USA
    FASEB J 23:3734-42. 2009
    ..Taken together, our data demonstrate that the nestin-mediated disassembly of vimentin IFs generates a structure capable of sequestering and modulating the activity of IDE...
  29. ncbi Nuclear lamins: building blocks of nuclear architecture
    Robert D Goldman
    Northwestern University Medical School, Department of Cell and Molecular Biology, Chicago, Illinois 60611, USA
    Genes Dev 16:533-47. 2002
  30. pmc The functions of the nuclear envelope in mediating the molecular crosstalk between the nucleus and the cytoplasm
    Takeshi Shimi
    Department of Cell and Molecular Biology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
    Curr Opin Cell Biol 24:71-8. 2012
    ..These mutations are also providing important new insights into nuclear-cytoplasmic interactions...
  31. ncbi The dynamic and motile properties of intermediate filaments
    Brian T Helfand
    Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Annu Rev Cell Dev Biol 19:445-67. 2003
    ..This review considers the functional implications of the motile properties of IFs and discusses the potential relationships between malfunctions in these motile activities and human diseases...
  32. ncbi Rapid transport of neural intermediate filament protein
    Brian T Helfand
    Department of Cell and Molecular Biology, Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, Ward 11 145, Chicago, IL 60611, USA
    J Cell Sci 116:2345-59. 2003
    ..Our data demonstrate that peripherin particles and squiggles can move as components of a rapid transport system capable of delivering cytoskeletal subunits to the most distal regions of neurites over relatively short time periods...
  33. pmc Desmoplakin assembly dynamics in four dimensions: multiple phases differentially regulated by intermediate filaments and actin
    Lisa M Godsel
    Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    J Cell Biol 171:1045-59. 2005
    ....
  34. pmc Functions and dysfunctions of the nuclear lamin Ig-fold domain in nuclear assembly, growth, and Emery-Dreifuss muscular dystrophy
    Dale K Shumaker
    Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, 303 East Chicago Avenue, Chicago, IL 60611, USA
    Proc Natl Acad Sci U S A 102:15494-9. 2005
    ....
  35. pmc A role for intermediate filaments in determining and maintaining the shape of nerve cells
    Brian T Helfand
    Department of Cell and Molecular Biology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Mol Biol Cell 14:5069-81. 2003
    ..Furthermore, the results of these experiments demonstrate that peripherin IF are critical determinants of the overall shape and architecture of neurons...
  36. pmc Nuclear lamin functions and disease
    Veronika Butin-Israeli
    Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, 303 East Chicago Avenue, Chicago, IL 60611, USA
    Trends Genet 28:464-71. 2012
    ..We summarize these recent findings, focusing on data from mice and humans, and highlight the expanding knowledge of these proteins in both healthy and diseased cells...
  37. ncbi The nucleoskeleton: lamins and actin are major players in essential nuclear functions
    Dale K Shumaker
    Northwestern University, Feinberg School of Medicine, Department of Cell and Molecular Biology, 303 East Chicago Avenue, Chicago, IL 60611, USA
    Curr Opin Cell Biol 15:358-66. 2003
    ..This range of activities might help to explain why genetic defects in some of the nucleoskeletal proteins contribute to an ever-expanding list of human diseases...
  38. pmc Regulation of nuclear lamin polymerization by importin alpha
    Stephen A Adam
    Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    J Biol Chem 283:8462-8. 2008
    ..These results suggest a role for importin alpha in regulating lamin assembly and possibly modulating the interactions of lamins with lamin-binding proteins...
  39. ncbi Intermediate filaments mediate cytoskeletal crosstalk
    Lynne Chang
    Feinberg School of Medicine, Northwestern University, Department of Cell and Molecular Biology, 303 East Chicago Avenue, Chicago, Illinois 60611, USA
    Nat Rev Mol Cell Biol 5:601-13. 2004
    ..Recent studies have revealed that intermediate filaments and their associated proteins are important components in mediating this crosstalk...
  40. ncbi Nuclear lamins: building blocks of nuclear structure and function
    Robert D Goldman
    Department of Cell and Molecular Biology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611 3008, USA
    Novartis Found Symp 264:3-16; discussion 16-21, 227-30. 2005
    ....
  41. pmc Disruption of lamin B1 and lamin B2 processing and localization by farnesyltransferase inhibitors
    Stephen A Adam
    Department of Cell and Molecular Biology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
    Nucleus 4:142-50. 2013
    ..Farnesyltransferase inhibitors also cause a rapid cell cycle arrest leading to cellular senescence. This study suggests that the long-term inhibition of protein farnesylation could have unforeseen consequences on nuclear functions...
  42. pmc Ubiquitin is a novel substrate for human insulin-degrading enzyme
    Luis A Ralat
    Ben May Department for Cancer Research, The University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA
    J Mol Biol 406:454-66. 2011
    ..Together, our studies link the control of Ub clearance with IDE...
  43. pmc Simian virus 40 induces lamin A/C fluctuations and nuclear envelope deformation during cell entry
    Veronika Butin-Israeli
    Department of Hematology, Hebrew University Hadassah Medical School, Jerusalem, Israel
    Nucleus 2:320-30. 2011
    ..As SV40 serves as a paradigm for the pathogenic human BK, JC and Merkel cell polyomavirus, this study suggests nuclear entry as a novel drug target for these infections...
  44. ncbi Loss of adhesion-regulated proteinase production is correlated with invasive activity in oral squamous cell carcinoma
    Supurna Ghosh
    Department of Cell and Molecular Biology, Northwestern University Medical School, Chicago, Illinois 60611, USA
    Cancer 95:2524-33. 2002
    ..Invasion of OSCC requires multiple cellular events including dissolution of cell-cell junctions, basement membrane attachment, extracellular matrix proteolysis, and migration...
  45. pmc A requirement for cytoplasmic dynein and dynactin in intermediate filament network assembly and organization
    Brian T Helfand
    Northwestern University School of Medicine, Department of Cell and Molecular Biology, Chicago, IL 60611, USA
    J Cell Biol 157:795-806. 2002
    ..Furthermore, these motors are to a large extent responsible for the long recognized relationships between vimentin IFs and MTs...
  46. pmc Regulation of nucleotide excision repair by nuclear lamin b1
    Veronika Butin-Israeli
    The Department of Cell and Molecular Biology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America
    PLoS ONE 8:e69169. 2013
    ..Our findings are relevant to understanding the relationship between the loss of LB1 expression, DNA damage signaling, and replicative senescence. ..
  47. ncbi Microfilament-dependent movement of the beta3 integrin subunit within focal contacts of endothelial cells
    Daisuke Tsuruta
    Department of Cell and Molecular Biology, Northwestern University Medical School, Chicago, Illinois 60611, USA
    FASEB J 16:866-8. 2002
    ..We propose that integrins are mobile within the confines of focal contacts and that this mobility is supported by an actin-associated molecular motor...
  48. pmc Alteration of nuclear lamin organization inhibits RNA polymerase II-dependent transcription
    Timothy P Spann
    Department of Cell and Molecular Biology, Northwestern University Medical School, Chicago, IL 60611, USA
    J Cell Biol 156:603-8. 2002
    ..Furthermore, immunofluorescence observations indicate that this selective inhibition of polymerase II-dependent transcription involves the TATA binding protein, a component of the basal transcription factor TFIID...
  49. pmc Tracking melanosomes inside a cell to study molecular motors and their interaction
    Comert Kural
    Center for Biophysics and Computational Biology and Department of Physics, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Proc Natl Acad Sci U S A 104:5378-82. 2007
    ..We observed 35-nm myosin V steps in melanophores containing no IFs. We find that myosin V steps occur faster in the absence of IFs, indicating that the IF network physically hinders organelle transport...
  50. pmc A nestin scaffold links Cdk5/p35 signaling to oxidant-induced cell death
    Cecilia M Sahlgren
    Turku Centre for Biotechnology, University of Turku and Abo Akademi University, Turku, Finlandand
    EMBO J 25:4808-19. 2006
    ..Our data imply that nestin is a survival determinant whose action is based upon a novel mode of Cdk5 regulation, affecting the targeting, activity, and turnover of the Cdk5/p35 signaling complex...
  51. ncbi Nuclear lamins, diseases and aging
    Anna Mattout
    Department of Genetics, The Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
    Curr Opin Cell Biol 18:335-41. 2006
    ..These diseases, collectively termed laminopathies, affect muscle, adipose, bone, nerve and skin cells and range from muscular dystrophies to accelerated aging...
  52. ncbi A mitotic lamin B matrix induced by RanGTP required for spindle assembly
    Ming Ying Tsai
    Department of Embryology, Carnegie Institution of Washington and Howard Hughes Medical Institute, Baltimore, MD 21218, USA
    Science 311:1887-93. 2006
    ..We propose that lamin B is a structural component of the long-sought-after spindle matrix that promotes microtubule assembly and organization in mitosis...
  53. ncbi Specific in vivo phosphorylation sites determine the assembly dynamics of vimentin intermediate filaments
    John E Eriksson
    Department of Biology, Laboratory of Animal Physiology, University of Turku, Science Building 1, FIN 20014 Turku, Finland
    J Cell Sci 117:919-32. 2004
    ..Taken together, our results suggest that elevated phosphorylation regulates IF assembly in vivo by changing the equilibrium constant of subunit exchange towards a higher off-rate...
  54. ncbi Cdk5 regulates axonal transport and phosphorylation of neurofilaments in cultured neurons
    Thomas B Shea
    Center for Cellular Neurobiology and Neurodegeneration Research, Department of Biological Sciences, University of Massachusetts, Lowell, One University Avenue, Lowell, MA 01854, USA
    J Cell Sci 117:933-41. 2004
    ..These findings suggest that Cdk5-p35 activity regulates normal NF distribution and that overexpression of Cdk5-p35 induces perikaryal accumulation of phosphorylated-NFs similar to those observed under pathological conditions...
  55. ncbi Tropomyosins are present in lamellipodia of motile cells
    Louise Hillberg
    Department of Cell Biology, The Wenner Gren Institute, Stockholm University, SE 10691 Stockholm, Sweden
    Eur J Cell Biol 85:399-409. 2006
    ....
  56. ncbi The nuclear lamina comes of age
    Yosef Gruenbaum
    Department of Genetics, The Institute of Life Sciences, The Hebrew University of Jerusalem, Givat Ram, Jerusalem, 91904 Israel
    Nat Rev Mol Cell Biol 6:21-31. 2005
    ....
  57. pmc Micromechanical properties of keratin intermediate filament networks
    Sivaraj Sivaramakrishnan
    Department of Biomedical Engineering, Northwestern University, 2145 North Sheridan Road, Evanston, IL 60208, USA
    Proc Natl Acad Sci U S A 105:889-94. 2008
    ..The high storage modulus of the KIF network, coupled with its solid-like rheological behavior, supports the role of KIF as an intracellular structural scaffold that helps epithelial cells to withstand external mechanical forces...
  58. ncbi The nuclear lamina and its functions in the nucleus
    Yosef Gruenbaum
    Department of Genetics, The Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
    Int Rev Cytol 226:1-62. 2003
    ....

Research Grants41

  1. LAMIN A PROGERIA MUTATIONS AND NUCLEAR FUNCTION
    Robert D Goldman; Fiscal Year: 2010
    ..These collective studies will provide important insights into how hLA mutations cause the defects seen in progeria. ..
  2. INTERACTIONS BETWEEN INTERMEDIATE FILAMENTS AND NUCLEUS
    Robert Goldman; Fiscal Year: 2007
    ..In addition, attempts will be made to identify the specific binding partners, which link the A and B-type lamins to the RNA polymerase II machinery and to the DNA replication elongation complex. ..
  3. INTERACTIONS BETWEEN INTERMEDIATE FILAMENTS AND NUCLEUS
    Robert Goldman; Fiscal Year: 2003
    ....
  4. INTERMEDIATE FILAMENT CELL SURFACE INTERACTIONS
    Robert Goldman; Fiscal Year: 2007
    ..The latter include the formation of Mallory bodies in alcoholic liver disease and Lewy bodies in Parkinson's disease. ..
  5. INTERMEDIATE FILAMENT CELL SURFACE INTERACTIONS
    Robert D Goldman; Fiscal Year: 2010
    ....
  6. INTERACTIONS BETWEEN INTERMEDIATE FILAMENTS AND NUCLEUS
    Robert D Goldman; Fiscal Year: 2010
    ..Progress in this area is particularly important since mutations in nuclear lamins cause a variety of diseases including muscular dystrophies, lipodystrophies, cardiomyopathies, and premature aging syndromes. ..
  7. INTERACTIONS BETWEEN INTERMEDIATE FILAMENTS AND NUCLEUS
    Robert Goldman; Fiscal Year: 2009
    ..Progress in this area is particularly important since mutations in nuclear lamins cause a variety of diseases including muscular dystrophies, lipodystrophies, cardiomyopathies, and premature aging syndromes. ..
  8. INTERMEDIATE FILAMENT--CELL SURFACE INTERACTIONS
    Robert Goldman; Fiscal Year: 1991
    ....
  9. INTERACTIONS BETWEEN INTERMEDIATE FILAMENTS AND NUCLEUS
    Robert Goldman; Fiscal Year: 1992
    ..With regard to disease processes, this system is frequently found in an altered state in many diseases including cancer, Alzheimers disease, liver diseases and several other neurological disorders...