Erwin Goldberg

Summary

Affiliation: Northwestern University
Country: USA

Publications

  1. pmc LDHC: the ultimate testis-specific gene
    Erwin Goldberg
    Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, IL 60208, USA
    J Androl 31:86-94. 2010
  2. pmc Regulation of murine lactate dehydrogenase C (Ldhc) gene expression
    HuangHui Tang
    Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, 2205 Tech Drive, Evanston, IL 60208, USA
    Biol Reprod 78:455-61. 2008
  3. doi request reprint Human lactate dehydrogenase A (LDHA) rescues mouse Ldhc-null sperm function
    HuangHui Tang
    Department of Molecular Biosciences, Northwestern University, Evanston, IL 60208, USA
    Biol Reprod 88:96. 2013
  4. ncbi request reprint A transgenic analysis of mouse lactate dehydrogenase C promoter activity in the testis
    Tim L Kroft
    Department of Biochemistry, Northwestern University, Chicago, Illinois, USA
    J Androl 24:843-52. 2003
  5. doi request reprint Testis specific lactate dehydrogenase as target for immunoliposomes
    Ranjna C Dutta
    Department of Biochemistry, Molecular Biology and Cell Biology Northwestern University, Evanston, IL 60208, USA
    Am J Reprod Immunol 60:26-32. 2008
  6. pmc A-MYB (MYBL1) stimulates murine testis-specific Ldhc expression via the cAMP-responsive element (CRE) site
    HuangHui Tang
    Department of Molecular Biosciences, Northwestern University, Evanston, Illinois 60208, USA
    Biol Reprod 86:30. 2012
  7. doi request reprint Homo sapiens lactate dehydrogenase c (Ldhc) gene expression in cancer cells is regulated by transcription factor Sp1, CREB, and CpG island methylation
    HuangHui Tang
    Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, IL 60208, USA
    J Androl 30:157-67. 2009
  8. pmc Smad4 overexpression causes germ cell ablation and leydig cell hyperplasia in transgenic mice
    Anita Narula
    Department of Biochemistry, Northwestern University, Evanston, Illinois 60208, USA
    Am J Pathol 161:1723-34. 2002

Research Grants

Collaborators

Detail Information

Publications8

  1. pmc LDHC: the ultimate testis-specific gene
    Erwin Goldberg
    Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, IL 60208, USA
    J Androl 31:86-94. 2010
    ..Here, we will review the history of LDHC and the work that demonstrates clearly that it is required for sperm to accomplish their ultimate goal, fertilization...
  2. pmc Regulation of murine lactate dehydrogenase C (Ldhc) gene expression
    HuangHui Tang
    Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, 2205 Tech Drive, Evanston, IL 60208, USA
    Biol Reprod 78:455-61. 2008
    ..Therefore, we conclude that simultaneous occupancy of the GC box and CRE sites in the core promoter is necessary for full expression of Ldhc in the testis...
  3. doi request reprint Human lactate dehydrogenase A (LDHA) rescues mouse Ldhc-null sperm function
    HuangHui Tang
    Department of Molecular Biosciences, Northwestern University, Evanston, IL 60208, USA
    Biol Reprod 88:96. 2013
    ..We suggest that it is the localization of the transgene to the sperm cytosol that is mainly responsible for restoration of sperm function and fertility...
  4. ncbi request reprint A transgenic analysis of mouse lactate dehydrogenase C promoter activity in the testis
    Tim L Kroft
    Department of Biochemistry, Northwestern University, Chicago, Illinois, USA
    J Androl 24:843-52. 2003
    ..Our results suggest that the high level of LDH-C(4) in postmeiotic cells results from mRNA and protein stability...
  5. doi request reprint Testis specific lactate dehydrogenase as target for immunoliposomes
    Ranjna C Dutta
    Department of Biochemistry, Molecular Biology and Cell Biology Northwestern University, Evanston, IL 60208, USA
    Am J Reprod Immunol 60:26-32. 2008
    ..Is it possible to deliver therapeutic agents to testis through specific targeting?..
  6. pmc A-MYB (MYBL1) stimulates murine testis-specific Ldhc expression via the cAMP-responsive element (CRE) site
    HuangHui Tang
    Department of Molecular Biosciences, Northwestern University, Evanston, Illinois 60208, USA
    Biol Reprod 86:30. 2012
    ....
  7. doi request reprint Homo sapiens lactate dehydrogenase c (Ldhc) gene expression in cancer cells is regulated by transcription factor Sp1, CREB, and CpG island methylation
    HuangHui Tang
    Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, IL 60208, USA
    J Androl 30:157-67. 2009
    ..In addition, these findings suggest the possibility of developing a biomarker for cancer diagnosis/prognosis based on DNA methylation of the Ldhc gene...
  8. pmc Smad4 overexpression causes germ cell ablation and leydig cell hyperplasia in transgenic mice
    Anita Narula
    Department of Biochemistry, Northwestern University, Evanston, Illinois 60208, USA
    Am J Pathol 161:1723-34. 2002
    ..In the absence of normal levels of Smad4 testicular function is compromised...

Research Grants26

  1. REPRODUCTIVE BIOCHEMISTRY OF TESTIS-SPECIFIC LDH-X
    Erwin Goldberg; Fiscal Year: 2002
    ..Ultimately, these data will permit us to fully realize the potential of gene therapy in alleviating male infertility and for fertility control. ..
  2. Reproductive Biochemistry of Testis Specific LDH-X
    Erwin Goldberg; Fiscal Year: 2005
    ..This work will provide a foundation for understanding disorders of reproductive health as well as resolving questions of male infertility and fertility regulation. ..
  3. Reproductive Biochemistry of Testis Specific LDH-X
    Erwin Goldberg; Fiscal Year: 2007
    ..Completion of these specific aims will further our understanding of LDH-C4 function, of testis specific gene regulation and of macromolecular interactions necessary for normal spermatogenesis and sperm function. ..
  4. REPRODUCTIVE BIOCHEMISTRY OF TESTES-SPECIFIC LDH-X
    Erwin Goldberg; Fiscal Year: 1992
    ....
  5. REPRODUCTIVE BIOCHEMISTRY OF TESTES SPECIFIC LDH-X
    Erwin Goldberg; Fiscal Year: 1980
    ..Antibody binding peptides will be conjugated to appropriate carriers to determne if they can provoke antibody specific to determinants in LDH-C4. ..