T C Gamblin

Summary

Affiliation: Northwestern University
Country: USA

Publications

  1. ncbi request reprint Oxidative regulation of fatty acid-induced tau polymerization
    T C Gamblin
    Department of Cell and Molecular Biology and The Cognitive Neurology and Alzheimer s Disease Center, Northwestern University Medical School, Chicago, Illinois 60611 3008, USA
    Biochemistry 39:14203-10. 2000
  2. ncbi request reprint C-terminal inhibition of tau assembly in vitro and in Alzheimer's disease
    A Abraha
    Department of Cell and Molecular Biology, Northwestern University Medical School, Chicago, IL 60611, USA
    J Cell Sci 113:3737-45. 2000
  3. ncbi request reprint In vitro polymerization of tau protein monitored by laser light scattering: method and application to the study of FTDP-17 mutants
    T C Gamblin
    Department of Cell and Molecular Biology and Cognitive Neurology and Alzheimer s Disease Center, Northwestern University Medical School, 303 E Chicago Avenue, Chicago, Illinois 60611 3008, USA
    Biochemistry 39:6136-44. 2000
  4. ncbi request reprint Differential assembly of human tau isoforms in the presence of arachidonic acid
    M E King
    Department of Cell and Molecular Biology and Cognitive Neurology and Alzheimer s Disease Center, Northwestern University Medical School, Chicago, Illinois 60611, USA
    J Neurochem 74:1749-57. 2000
  5. ncbi request reprint Inhibition of tau polymerization by its carboxy-terminal caspase cleavage fragment
    R W Berry
    Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, 303 East Chicago Avenue, Chicago, Illinois 60611, USA
    Biochemistry 42:8325-31. 2003
  6. ncbi request reprint The L266V tau mutation is associated with frontotemporal dementia and Pick-like 3R and 4R tauopathy
    Marion Hogg
    Neurogenetics Laboratory, Mayo Clinic Jacksonville, Jacksonville, Florida, USA
    Acta Neuropathol 106:323-36. 2003

Collaborators

Detail Information

Publications6

  1. ncbi request reprint Oxidative regulation of fatty acid-induced tau polymerization
    T C Gamblin
    Department of Cell and Molecular Biology and The Cognitive Neurology and Alzheimer s Disease Center, Northwestern University Medical School, Chicago, Illinois 60611 3008, USA
    Biochemistry 39:14203-10. 2000
    ..Therefore, we postulate that specific fatty acid oxidative products could provide a direct link between oxidative stress mechanisms and the formation of neurofibrillary tangles in AD...
  2. ncbi request reprint C-terminal inhibition of tau assembly in vitro and in Alzheimer's disease
    A Abraha
    Department of Cell and Molecular Biology, Northwestern University Medical School, Chicago, IL 60611, USA
    J Cell Sci 113:3737-45. 2000
    ....
  3. ncbi request reprint In vitro polymerization of tau protein monitored by laser light scattering: method and application to the study of FTDP-17 mutants
    T C Gamblin
    Department of Cell and Molecular Biology and Cognitive Neurology and Alzheimer s Disease Center, Northwestern University Medical School, 303 E Chicago Avenue, Chicago, Illinois 60611 3008, USA
    Biochemistry 39:6136-44. 2000
    ..Several of these mutant proteins display enhanced polymerization in the presence of arachidonic acid, suggesting a direct role for these mutations in tau the filament formation that characterizes FTDP-17...
  4. ncbi request reprint Differential assembly of human tau isoforms in the presence of arachidonic acid
    M E King
    Department of Cell and Molecular Biology and Cognitive Neurology and Alzheimer s Disease Center, Northwestern University Medical School, Chicago, Illinois 60611, USA
    J Neurochem 74:1749-57. 2000
    ..Moreover, tau isoforms containing three versus four microtubule binding repeats display different assembly properties depending on the solvent conditions employed...
  5. ncbi request reprint Inhibition of tau polymerization by its carboxy-terminal caspase cleavage fragment
    R W Berry
    Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, 303 East Chicago Avenue, Chicago, Illinois 60611, USA
    Biochemistry 42:8325-31. 2003
    ..These findings indicate that formation of the fibrillar pathologies during the course of Alzheimer's disease may be driven or sustained by apoptotic events leading to caspase activation...
  6. ncbi request reprint The L266V tau mutation is associated with frontotemporal dementia and Pick-like 3R and 4R tauopathy
    Marion Hogg
    Neurogenetics Laboratory, Mayo Clinic Jacksonville, Jacksonville, Florida, USA
    Acta Neuropathol 106:323-36. 2003
    ..In addition, the results of the RD3 and ET3 immunostains clearly explain for the first time the presence of both 3R and 4R tau isoforms in preparations of insoluble tau from some Pick's disease cases...