Elizabeth Eklund

Summary

Affiliation: Northwestern University
Country: USA

Publications

  1. pmc Constitutively active SHP2 cooperates with HoxA10 overexpression to induce acute myeloid leukemia
    Hao Wang
    The Feinberg School of Medicine and the Robert H Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois 60611, USA
    J Biol Chem 284:2549-67. 2009
  2. pmc The role of Hox proteins in leukemogenesis: insights into key regulatory events in hematopoiesis
    Elizabeth Eklund
    The Feinberg School at Northwestern University and Jesse Brown VA Medical Center, 303 E Superior St, Lurie 5 105, Chicago, IL 60611, USA
    Crit Rev Oncog 16:65-76. 2011
  3. pmc Genomic analysis of acute myeloid leukemia: potential for new prognostic indicators
    Elizabeth A Eklund
    The Feinberg School of Medicine, Northwestern University, Jesse Brown VA Medical Center, Chicago, Illinois, USA
    Curr Opin Hematol 17:75-8. 2010
  4. ncbi request reprint SHP1 protein-tyrosine phosphatase regulates HoxA10 DNA binding and transcriptional repression activity in undifferentiated myeloid cells
    Elizabeth A Eklund
    Department of Medicine, Northwestern University Medical School, Chicago, Illinois 60611, USA
    J Biol Chem 277:36878-88. 2002
  5. ncbi request reprint The role of HOX genes in malignant myeloid disease
    Elizabeth A Eklund
    The Feinberg School at Northwestern University and Jesse Brown VHA Medical Center, Chicago, Illinois 60611, USA
    Curr Opin Hematol 14:85-9. 2007
  6. ncbi request reprint The role of HOX genes in myeloid leukemogenesis
    Elizabeth A Eklund
    The Feinberg School of Medicine, Northwestern University and Jesse Brown VHA Medical Center, 710 N Fairbanks Court, Chicago, IL 60611, USA
    Curr Opin Hematol 13:67-73. 2006
  7. ncbi request reprint HOXA9 activates transcription of the gene encoding gp91Phox during myeloid differentiation
    Ling Bei
    Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    J Biol Chem 280:12359-70. 2005
  8. ncbi request reprint HoxA10 represses gene transcription in undifferentiated myeloid cells by interaction with histone deacetylase 2
    YuFeng Lu
    Fineberg School of Medicine and Robert H Lurie Comprehensive Cancer Center, Northwestern University, and Chicago Lakeside Veterans Affairs Hospital, Illinois 60611, USA
    J Biol Chem 278:47792-802. 2003
  9. ncbi request reprint The interferon consensus sequence-binding protein activates transcription of the gene encoding neurofibromin 1
    Chunliu Zhu
    Feinberg School of Medicine and the Robert H Lurie Comprehensive Cancer Center, Northwestern University and Chicago Lakeside Veterans Affairs Hospital, Chicago, Illinois 60611, USA
    J Biol Chem 279:50874-85. 2004
  10. pmc Constitutive activation of SHP2 protein tyrosine phosphatase inhibits ICSBP-induced transcription of the gene encoding gp91PHOX during myeloid differentiation
    Chunliu Zhu
    Feinberg School of Medicine, Northwestern University, 710 N Fairbanks Court, Chicago, IL 60611, USA
    J Leukoc Biol 83:680-91. 2008

Research Grants

  1. HoxA10 Function During Myeloid Differentiation
    Elizabeth Eklund; Fiscal Year: 2007
  2. HoxA10 Function During Myeloid Differentiation
    Elizabeth Eklund; Fiscal Year: 2009
  3. ICSBP Function During Myeloid Differentiation
    ELIZABETH ANN EKLUND; Fiscal Year: 2010
  4. ICSBP Function During Myeloid Differentiation
    Elizabeth Eklund; Fiscal Year: 2009
  5. ICSBP Function During Myeloid Differentiation
    Elizabeth Eklund; Fiscal Year: 2006
  6. HoxA10 Function During Myeloid Differentiation
    Elizabeth Eklund; Fiscal Year: 2006
  7. HoxA10 Function During Myeloid Differentiation
    ELIZABETH ANN EKLUND; Fiscal Year: 2010

Collaborators

  • Wei Zhou
  • Hao Wang
  • M S Tallman
  • Shahab Uddin
  • Leonidas C Platanias
  • Weiqi Huang
  • Elizabeth Horvath
  • Chunliu Zhu
  • Ling Bei
  • Stephan Lindsey
  • Gurveen Saberwal
  • YuFeng Lu
  • Iwona Konieczna
  • Surinder Kaur
  • Efstratios Katsoulidis
  • Antonella Sassano
  • Eleanor N Fish
  • Renu Kakar
  • Simrit Parmar
  • Chirag Shah
  • Elizabeth Hjort
  • Liping Hu
  • Beata Majchrzak-Kita
  • Ajith M Joseph
  • Amit Verma
  • Saskia M Brachmann
  • Iwonna Konieczna
  • Susan L Bellis
  • Jessica Smith
  • Suman Kambhampati
  • Beata Majchrzak
  • Yu Feng Lu
  • Bryan Kautz
  • Inna Goldenberg
  • Jelena Andrejic

Detail Information

Publications24

  1. pmc Constitutively active SHP2 cooperates with HoxA10 overexpression to induce acute myeloid leukemia
    Hao Wang
    The Feinberg School of Medicine and the Robert H Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois 60611, USA
    J Biol Chem 284:2549-67. 2009
    ..Because both HoxA10 overexpression and constitutive SHP2 activation are found in poor prognosis human AML, these studies contribute to understanding biochemical aspects of disease progression in myeloid malignancy...
  2. pmc The role of Hox proteins in leukemogenesis: insights into key regulatory events in hematopoiesis
    Elizabeth Eklund
    The Feinberg School at Northwestern University and Jesse Brown VA Medical Center, 303 E Superior St, Lurie 5 105, Chicago, IL 60611, USA
    Crit Rev Oncog 16:65-76. 2011
    ..Studies are beginning to identify Hox target genes which may be rational targets for therapeutic approaches to this poor prognosis leukemia subset...
  3. pmc Genomic analysis of acute myeloid leukemia: potential for new prognostic indicators
    Elizabeth A Eklund
    The Feinberg School of Medicine, Northwestern University, Jesse Brown VA Medical Center, Chicago, Illinois, USA
    Curr Opin Hematol 17:75-8. 2010
    ..These findings advanced the ability to predict outcome and to tailor treatments in AML. These studies also suggested that a more detailed analysis of somatic genomic mutations might extend these advances...
  4. ncbi request reprint SHP1 protein-tyrosine phosphatase regulates HoxA10 DNA binding and transcriptional repression activity in undifferentiated myeloid cells
    Elizabeth A Eklund
    Department of Medicine, Northwestern University Medical School, Chicago, Illinois 60611, USA
    J Biol Chem 277:36878-88. 2002
    ..Therefore, increased HoxA10 repression of myeloid gene transcription is a molecular mechanism for SHP1 inhibition of myeloid differentiation...
  5. ncbi request reprint The role of HOX genes in malignant myeloid disease
    Elizabeth A Eklund
    The Feinberg School at Northwestern University and Jesse Brown VHA Medical Center, Chicago, Illinois 60611, USA
    Curr Opin Hematol 14:85-9. 2007
    ..The purpose of this review is to outline recent progress in understanding the role that dysregulation of HOX-gene expression plays in the pathogenesis of myeloid leukemogenesis...
  6. ncbi request reprint The role of HOX genes in myeloid leukemogenesis
    Elizabeth A Eklund
    The Feinberg School of Medicine, Northwestern University and Jesse Brown VHA Medical Center, 710 N Fairbanks Court, Chicago, IL 60611, USA
    Curr Opin Hematol 13:67-73. 2006
    ..The purpose of this review is to outline recent progress in understanding molecular mechanisms involved in Hox regulation of myelopoiesis and myeloid leukemogenesis...
  7. ncbi request reprint HOXA9 activates transcription of the gene encoding gp91Phox during myeloid differentiation
    Ling Bei
    Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    J Biol Chem 280:12359-70. 2005
    ..These studies also suggest overexpression of Meis1 or Nup98-hoxA9 represses myeloid-specific gene transcription, thereby contributing to differentiation block in leukemogenesis...
  8. ncbi request reprint HoxA10 represses gene transcription in undifferentiated myeloid cells by interaction with histone deacetylase 2
    YuFeng Lu
    Fineberg School of Medicine and Robert H Lurie Comprehensive Cancer Center, Northwestern University, and Chicago Lakeside Veterans Affairs Hospital, Illinois 60611, USA
    J Biol Chem 278:47792-802. 2003
    ..Our results suggest that insight into this problem can be obtained from biochemical characterization of the various molecular mechanisms of Hox protein function...
  9. ncbi request reprint The interferon consensus sequence-binding protein activates transcription of the gene encoding neurofibromin 1
    Chunliu Zhu
    Feinberg School of Medicine and the Robert H Lurie Comprehensive Cancer Center, Northwestern University and Chicago Lakeside Veterans Affairs Hospital, Chicago, Illinois 60611, USA
    J Biol Chem 279:50874-85. 2004
    ..This novel ICSBP function provides insight into regulation of myelopoiesis under normal conditions and in myeloproliferative disorders...
  10. pmc Constitutive activation of SHP2 protein tyrosine phosphatase inhibits ICSBP-induced transcription of the gene encoding gp91PHOX during myeloid differentiation
    Chunliu Zhu
    Feinberg School of Medicine, Northwestern University, 710 N Fairbanks Court, Chicago, IL 60611, USA
    J Leukoc Biol 83:680-91. 2008
    ..As these two abnormalities may coexist, our results identified a potential molecular mechanism for impaired phagocyte function in this malignant myeloid disease...
  11. ncbi request reprint JAK2 is necessary and sufficient for interferon-gamma-induced transcription of the gene encoding gp91PHOX
    Renu Kakar
    The Feinberg School of Medicine and the Robert H Lurie Comprehensive Cancer Center, Northwestern University, and Jesse Brown VA Medical Center, Chicago, IL 60611, USA
    J Leukoc Biol 77:120-7. 2005
    ..Therefore, these findings provide direct demonstration of JAK2 dependence of IFN-gamma-induced CYBB transcription. In addition, these results identify a mechanism mediating this effect...
  12. ncbi request reprint HoxA10 represses transcription of the gene encoding p67phox in phagocytic cells
    Stephan Lindsey
    Feinberg School of Medicine and the Robert H Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA
    J Immunol 175:5269-79. 2005
    ..Because p67(phox) and gp91(phox) are rate-limiting components for respiratory burst activity, our studies may identify rational therapeutic targets to modulate free radical generation in pathological conditions...
  13. pmc Leukemia-associated, constitutively active mutants of SHP2 protein tyrosine phosphatase inhibit NF1 transcriptional activation by the interferon consensus sequence binding protein
    Weiqi Huang
    Feinberg School of Medicine, 710 North Fairbanks Court, Olson Pavilion Room 8524, Chicago, IL 60611, USA
    Mol Cell Biol 26:6311-32. 2006
    ..Therefore, these studies suggest that leukemia-associated ICSBP deficiency cooperates with leukemia-associated activating mutants of SHP2-PTP to contribute to the proliferative phenotype in myeloid malignancies...
  14. pmc The interferon consensus sequence binding protein (ICSBP/IRF8) activates transcription of the FANCF gene during myeloid differentiation
    Gurveen Saberwal
    The Feinberg School of Medicine and Robert H Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois 60611, USA
    J Biol Chem 284:33242-54. 2009
    ..Our studies suggest that ICSBP deficiency may be functionally important for accumulation of chromosomal abnormalities during disease progression in these myeloid malignancies...
  15. pmc Constitutive activation of SHP2 in mice cooperates with ICSBP deficiency to accelerate progression to acute myeloid leukemia
    Iwona Konieczna
    Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Clin Invest 118:853-67. 2008
    ..Since SHP2 activation and ICSBP deficiency may coexist in human myeloid malignancies, our studies have identified a molecular mechanism potentially involved in disease progression in such diseases...
  16. ncbi request reprint HoxA10 activates transcription of the gene encoding mitogen-activated protein kinase phosphatase 2 (Mkp2) in myeloid cells
    Hao Wang
    Fineberg School of Medicine and the Robert H Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois 60611, USA
    J Biol Chem 282:16164-76. 2007
    ..Consistent with this, HoxA10 overexpression decreases apoptosis in differentiating myeloid cells. Therefore, our studies identify a mechanism by which overexpressed HoxA10 contributes to inappropriate cell survival during myelopoiesis...
  17. ncbi request reprint Activation of SHP2 protein-tyrosine phosphatase increases HoxA10-induced repression of the genes encoding gp91(PHOX) and p67(PHOX)
    Stephan Lindsey
    Feinberg School of Medicine and the Robert H Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois 60611, USA
    J Biol Chem 282:2237-49. 2007
    ..Therefore, our results suggest that these mutations could cooperate, leading to decreased myeloid-specific gene transcription and functional differentiation block in myeloid cells with both defects...
  18. ncbi request reprint Identification of a HoxA10 activation domain necessary for transcription of the gene encoding beta3 integrin during myeloid differentiation
    Ling Bei
    Fineberg School of Medicine and the Robert H Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois 60611, USA
    J Biol Chem 282:16846-59. 2007
    ..Our studies also suggested that HoxA10 is a bifunctional protein that is involved in dynamic regulation of multiple aspects of phagocyte phenotype and function...
  19. pmc Interferon consensus sequence binding protein (ICSBP) decreases beta-catenin activity in myeloid cells by repressing GAS2 transcription
    Weiqi Huang
    Feinberg School of Medicine and Robert H Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois, USA
    Mol Cell Biol 30:4575-94. 2010
    ..Therefore, these studies have identified a Gas2/calpain-dependent mechanism by which ICSBP influences beta-catenin activity in myeloid leukemia...
  20. pmc HoxA10 activates CDX4 transcription and Cdx4 activates HOXA10 transcription in myeloid cells
    Ling Bei
    Feinberg School of Medicine and Robert H Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois 60611, USA
    J Biol Chem 286:19047-64. 2011
    ..Therefore, these studies identified a positive feedback relationship between HoxA10 and Cdx4, which potentially amplified the contribution of either transcription factor to the pathogenesis of AML...
  21. pmc Dual regulatory roles of phosphatidylinositol 3-kinase in IFN signaling
    Surinder Kaur
    Robert H Lurie Comprehensive Cancer Center and Division of Hematology Oncology, Northwestern University Medical School, Chicago, IL 60611, USA
    J Immunol 181:7316-23. 2008
    ..Thus, integration of signals via PI3K is a critical event during engagement of the IFN receptors that complements both the transcriptional activity of Jak-STAT pathways and controls initiation of mRNA translation...
  22. doi request reprint The interferon consensus sequence-binding protein (ICSBP/IRF8) represses PTPN13 gene transcription in differentiating myeloid cells
    Weiqi Huang
    The Feinberg School of Medicine and the Robert H Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois 60611, USA
    J Biol Chem 283:7921-35. 2008
    ..Therefore, these studies identified a mechanism for increased survival of mature myeloid cells in the ICSBP-deficient murine model and in human myeloid malignancies with decreased ICSBP expression...
  23. ncbi request reprint PU.1, interferon regulatory factor (IRF) 2, and the interferon consensus sequence-binding protein (ICSBP/IRF8) cooperate to activate NF1 transcription in differentiating myeloid cells
    Weiqi Huang
    The Feinberg School of Medicine and the Robert H Lurie Comprehensive Cancer Center, Northwestern University, Chicago, Illinois 60611, USA
    J Biol Chem 282:6629-43. 2007
    ..Therefore, these studies identify a target gene for the previously observed tumor-suppressor effect of PU.1. Additionally, these studies identify a tumor-suppressor function for the "oncogenic" transcription factor, IRF2...
  24. pmc Differential regulation of the p70 S6 kinase pathway by interferon alpha (IFNalpha) and imatinib mesylate (STI571) in chronic myelogenous leukemia cells
    Simrit Parmar
    Robert H Lurie Comprehensive Cancer Center and Division of Hematology Oncology, Northwestern University Medical School, Lakeside Veterans Administration Medical Center, Section of Hematology Oncology, University of Chicago, IL, USA
    Blood 106:2436-43. 2005
    ..They also support the concept that combined use of imatinib mesylate with mTOR inhibitors may be an appropriate future therapeutic strategy for the treatment of CML...

Research Grants16

  1. HoxA10 Function During Myeloid Differentiation
    Elizabeth Eklund; Fiscal Year: 2007
    ..Therefore, the goal of these studies is to identify novel targets for the treatment of myeloid malignancy. ..
  2. HoxA10 Function During Myeloid Differentiation
    Elizabeth Eklund; Fiscal Year: 2009
    ..Therefore, the goal of these studies is to identify novel targets for the treatment of myeloid malignancy. ..
  3. ICSBP Function During Myeloid Differentiation
    ELIZABETH ANN EKLUND; Fiscal Year: 2010
    ..Functional characterization of such a pathway has implications for identifying early markers of disease progression in human myeloid malignancy and rational targets for molecular therapeutic approaches to diseases such as CML and MDS. ..
  4. ICSBP Function During Myeloid Differentiation
    Elizabeth Eklund; Fiscal Year: 2009
    ..Functional characterization of such a pathway has implications for identifying early markers of disease progression in human myeloid malignancy and rational targets for molecular therapeutic approaches to diseases such as CML and MDS. ..
  5. ICSBP Function During Myeloid Differentiation
    Elizabeth Eklund; Fiscal Year: 2006
    ..These studies will determine if ICSBP tyrosine phosphorylation is necessary for myeloid differentiation and leukemia suppression, providing a unique model to dissect early events in the evolution of myeloid malignancy. ..
  6. HoxA10 Function During Myeloid Differentiation
    Elizabeth Eklund; Fiscal Year: 2006
    ..These investigations will identify the molecular mechanisms of target gene regulation by HoxA10, which may suggest a role for HoxA10 in differentiation block in myeloid leukemia. ..
  7. HoxA10 Function During Myeloid Differentiation
    ELIZABETH ANN EKLUND; Fiscal Year: 2010
    ..Therefore, the goal of these studies is to identify novel targets for the treatment of myeloid malignancy. ..