Affiliation: Northwestern University
Eklund E. The role of HOX genes in malignant myeloid disease. Curr Opin Hematol. 2007;14:85-9 pubmed
..Such results suggest that dysregulation of the 'Hox code' is important in the pathogenesis of myeloid malignancy. ..
Shah C, Broglie L, Hu L, Bei L, Huang W, Dressler D, et al
. Stat3 and CCAAT enhancer-binding protein β (C/ebpβ) activate Fanconi C gene transcription during emergency granulopoiesis. J Biol Chem. 2018;293:3937-3948 pubmed publisher
..Our work reveals that Stat3- and C/ebpβ-mediated FancC expression is a critical component for initiating and sustaining key innate immune responses. ..
Wang H, Bei L, Shah C, Huang W, Platanias L, Eklund E. The E3 ubiquitin ligase Triad1 influences development of Mll-Ell-induced acute myeloid leukemia. Oncogene. 2018;37:2532-2544 pubmed publisher
..Our studies identify Triad1 as a leukemia suppressor in 11q23-AML. This suggests defining relevant Triad1 substrates may indicate novel therapeutic targets in this disease. ..
Hu L, Huang W, Hjort E, Bei L, Platanias L, Eklund E. The Interferon Consensus Sequence Binding Protein (Icsbp/Irf8) Is Required for Termination of Emergency Granulopoiesis. J Biol Chem. 2016;291:4107-20 pubmed publisher
..Our results suggest that impaired Icsbp expression enhances leukemogenesis by deregulating processes that normally limit granulocyte expansion during the innate immune response. ..
Hu L, Huang W, Bei L, Broglie L, Eklund E. TP53 Haploinsufficiency Rescues Emergency Granulopoiesis in FANCC-/- Mice. J Immunol. 2018;200:2129-2139 pubmed publisher
..Therefore, activation of Atr-with consequent Fanconi-mediated DNA repair or p53-dependent apoptosis-is an essential component of emergency granulopoiesis and it protects the bone marrow from genotoxic stress during this process. ..
Eklund E, Goldenberg I, Lu Y, Andrejic J, Kakar R. SHP1 protein-tyrosine phosphatase regulates HoxA10 DNA binding and transcriptional repression activity in undifferentiated myeloid cells. J Biol Chem. 2002;277:36878-88 pubmed
..Therefore, increased HoxA10 repression of myeloid gene transcription is a molecular mechanism for SHP1 inhibition of myeloid differentiation. ..
Eklund E. The role of Hox proteins in leukemogenesis: insights into key regulatory events in hematopoiesis. Crit Rev Oncog. 2011;16:65-76 pubmed
..Studies are beginning to identify Hox target genes which may be rational targets for therapeutic approaches to this poor prognosis leukemia subset. ..
Wang H, Bei L, Shah C, Hu L, Eklund E. HoxA10 Terminates Emergency Granulopoiesis by Increasing Expression of Triad1. J Immunol. 2015;194:5375-87 pubmed publisher
..Our studies demonstrate a previously undescribed role for HoxA10 in terminating emergency granulopoiesis, suggesting an important contribution by Hox proteins to the innate immune response. ..