Margarita L Dubocovich

Summary

Affiliation: Northwestern University
Country: USA

Publications

  1. ncbi Melatonin differentially modulates the expression and function of the hMT1 and hMT2 melatonin receptors upon prolonged withdrawal
    Monica I Masana
    Department of Molecular Pharmacology and Biological Chemistry S215, Northwestern University Medical School, 303 East Chicago Ave, IL 60611, USA
    Biochem Pharmacol 65:731-9. 2003
  2. ncbi Functional MT1 and MT2 melatonin receptors in mammals
    Margarita L Dubocovich
    Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Feinberg School of Medicine Center for Drug Discovery and Chemical Biology, Chicago, IL 60611, USA
    Endocrine 27:101-10. 2005
  3. ncbi Effect of MT1 melatonin receptor deletion on melatonin-mediated phase shift of circadian rhythms in the C57BL/6 mouse
    M L Dubocovich
    Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    J Pineal Res 39:113-20. 2005
  4. ncbi Molecular pharmacology, regulation and function of mammalian melatonin receptors
    Margarita L Dubocovich
    Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Feinberg School of Medicine, Chicago, IL 60611 3008, USA
    Front Biosci 8:d1093-108. 2003
  5. ncbi Melatonin receptors: role on sleep and circadian rhythm regulation
    Margarita L Dubocovich
    Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Sleep Med 8:34-42. 2007
  6. ncbi Immortalized cells from the rat suprachiasmatic nucleus express functional melatonin receptors
    Moises A Rivera-Bermudez
    Department of Molecular Pharmacology and Biological Chemistry, The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Brain Res 1002:21-7. 2004
  7. ncbi MT(2) melatonin receptors are present and functional in rat caudal artery
    Monica I Masana
    Department of Molecular Pharmacology and Biological Chemistry, The Feinberg School of Medicine, Northwestern University, 303 E Chicago Avenue, Chicago, IL 60611, USA
    J Pharmacol Exp Ther 302:1295-302. 2002
  8. ncbi Functional melatonin receptors in rat ovaries at various stages of the estrous cycle
    Jose M Soares
    Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611 3008, USA
    J Pharmacol Exp Ther 306:694-702. 2003
  9. ncbi Melatonin desensitizes endogenous MT2 melatonin receptors in the rat suprachiasmatic nucleus: relevance for defining the periods of sensitivity of the mammalian circadian clock to melatonin
    Matthew J Gerdin
    Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Feinberg School of Medicine, Chicago, IL 60611 3008, USA
    FASEB J 18:1646-56. 2004
  10. ncbi 17Beta-estradiol modulates hMT1 melatonin receptor function
    Monica I Masana
    Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611 3008, USA
    Neuroendocrinology 81:87-95. 2005

Research Grants

Collaborators

Detail Information

Publications23

  1. ncbi Melatonin differentially modulates the expression and function of the hMT1 and hMT2 melatonin receptors upon prolonged withdrawal
    Monica I Masana
    Department of Molecular Pharmacology and Biological Chemistry S215, Northwestern University Medical School, 303 East Chicago Ave, IL 60611, USA
    Biochem Pharmacol 65:731-9. 2003
    ..In conclusion, melatonin differentially regulates the expression of its own receptors, which may have important implications in the transduction of dark signals in vivo...
  2. ncbi Functional MT1 and MT2 melatonin receptors in mammals
    Margarita L Dubocovich
    Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Feinberg School of Medicine Center for Drug Discovery and Chemical Biology, Chicago, IL 60611, USA
    Endocrine 27:101-10. 2005
    ..Together, these studies underscore the importance of carefully linking each melatonin receptor type to specific functional responses in target tissues to facilitate the design and development of novel therapeutic agent...
  3. ncbi Effect of MT1 melatonin receptor deletion on melatonin-mediated phase shift of circadian rhythms in the C57BL/6 mouse
    M L Dubocovich
    Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    J Pineal Res 39:113-20. 2005
    ....
  4. ncbi Molecular pharmacology, regulation and function of mammalian melatonin receptors
    Margarita L Dubocovich
    Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Feinberg School of Medicine, Chicago, IL 60611 3008, USA
    Front Biosci 8:d1093-108. 2003
    ....
  5. ncbi Melatonin receptors: role on sleep and circadian rhythm regulation
    Margarita L Dubocovich
    Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Sleep Med 8:34-42. 2007
    ....
  6. ncbi Immortalized cells from the rat suprachiasmatic nucleus express functional melatonin receptors
    Moises A Rivera-Bermudez
    Department of Molecular Pharmacology and Biological Chemistry, The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Brain Res 1002:21-7. 2004
    ..We conclude that SCN2.2 cells express functional melatonin receptors, providing an in vitro model to unveil the melatonin signaling pathway(s) involved in the regulation of circadian rhythms...
  7. ncbi MT(2) melatonin receptors are present and functional in rat caudal artery
    Monica I Masana
    Department of Molecular Pharmacology and Biological Chemistry, The Feinberg School of Medicine, Northwestern University, 303 E Chicago Avenue, Chicago, IL 60611, USA
    J Pharmacol Exp Ther 302:1295-302. 2002
    ..1 nM-10 microM). We conclude that MT(2) melatonin receptors expressed in vascular smooth muscle mediate vasodilation in contrast to vascular MT(1) receptors mediating vasoconstriction...
  8. ncbi Functional melatonin receptors in rat ovaries at various stages of the estrous cycle
    Jose M Soares
    Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611 3008, USA
    J Pharmacol Exp Ther 306:694-702. 2003
    ..These results underscore the implications of the levels of ovarian estrogen when melatonin receptor ligands are used as therapeutic agents...
  9. ncbi Melatonin desensitizes endogenous MT2 melatonin receptors in the rat suprachiasmatic nucleus: relevance for defining the periods of sensitivity of the mammalian circadian clock to melatonin
    Matthew J Gerdin
    Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Feinberg School of Medicine, Chicago, IL 60611 3008, USA
    FASEB J 18:1646-56. 2004
    ....
  10. ncbi 17Beta-estradiol modulates hMT1 melatonin receptor function
    Monica I Masana
    Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611 3008, USA
    Neuroendocrinology 81:87-95. 2005
    ..We suggest that 17beta-estradiol differentially affects MT1 and MT2 melatonin receptor functions, attenuates melatonin responses through activation of MT1 receptors, and increases the MT2 receptors density...
  11. ncbi Behavioral characterization and modulation of circadian rhythms by light and melatonin in C3H/HeN mice homozygous for the RORbeta knockout
    Monica I Masana
    Department of Molecular Pharmacology and Biological Chemistry Northwestern University Feinberg School of Medicine, Chicago, IL 60611 3008, USA
    Am J Physiol Regul Integr Comp Physiol 292:R2357-67. 2007
    ....
  12. ncbi Melatonin-mediated regulation of human MT(1) melatonin receptors expressed in mammalian cells
    Matthew J Gerdin
    Department of Molecular Pharmacology and Biological Chemistry, The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Biochem Pharmacol 67:2023-30. 2004
    ....
  13. ncbi Regulation of basal rhythmicity in protein kinase C activity by melatonin in immortalized rat suprachiasmatic nucleus cells
    Moises A Rivera-Bermudez
    Department of Molecular Pharmacology and Biological Chemistry, The Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Neurosci Lett 346:37-40. 2003
    ..We conclude that melatonin regulates the basal rhythm in PKC activity generated in SCN2.2 cells at the same periods of sensitivity observed in the native SCN...
  14. ncbi Mutagenesis studies of the human MT2 melatonin receptor
    Matthew J Gerdin
    Department of Molecular Pharmacology and Biological Chemistry S215, The Feinberg School of Medicine, Northwestern University, 303 East Chicago Avenue, Chicago, IL 60611 3008, USA
    Biochem Pharmacol 66:315-20. 2003
    ....
  15. ncbi Phase-dependent treatment of delayed sleep phase syndrome with melatonin
    Kavita Mundey
    Department of Neurology, Northwestern University Feinberg School of Medicine, Evanston, IL, USA
    Sleep 28:1271-8. 2005
    ..However, little is known about the most effective dose or time of administration. In the present study, we tested the effectiveness of melatonin to advance the timing of sleep and circadian phase in individuals with DSPS...
  16. doi Circadian periods of sensitivity for ramelteon on the onset of running-wheel activity and the peak of suprachiasmatic nucleus neuronal firing rhythms in C3H/HeN mice
    Oliver Rawashdeh
    Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    Chronobiol Int 28:31-8. 2011
    ..In conclusion, melatonin and ramelteon showed identical periods of circadian sensitivity at CT10 (advance) and CT2 (delay) to shift the onset of circadian activity rhythms in vivo and the peak of SCN neuronal firing rhythms in vitro...
  17. ncbi Constitutively active melatonin MT(1) receptors in male rat caudal arteries
    Cagatay Ersahin
    Department of Molecular Pharmacology and Biological Chemistry S215, Northwestern University Medical School, 303 East Chicago Avenue, Chicago, IL 60611, USA
    Eur J Pharmacol 439:171-2. 2002
    ..Formation of constitutively active receptors during subjective day, when the levels of melatonin are low, may be a physiological mechanism by which the organism maintains vascular tone...
  18. ncbi Agomelatine targets a range of major depressive disorder symptoms
    Margarita L Dubocovich
    Department of Molecular Pharmacology and Biological Chemistry, The Feinberg School of Medicine, Center for Drug Discovery and Chemical Biology, Northwestern University, Chicago, IL 60611, USA
    Curr Opin Investig Drugs 7:670-80. 2006
    ..Phase III trials have been completed and a registration dossier has been submitted to the EMEA in Western Europe...
  19. ncbi Nimodipine potentiates light-induced phase shifts of circadian activity rhythms but not c-fos expression in the suprachiasmatic nucleus of mice
    Susan Benloucif
    Department of Molecular Pharmacology and Biological Chemistry, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
    Brain Res 966:157-61. 2003
    ..01), but not in the suprachiasmatic nuclei (SCN). These results suggest that nimodipine may affect phase shifts of circadian activity rhythms through a mechanism independent of c-fos expression in the SCN...
  20. doi Long-term effects of maternal separation on the responsiveness of the circadian system to melatonin in the diurnal nonhuman primate (Macaca mulatta)
    Oliver Rawashdeh
    Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
    J Pineal Res 56:254-63. 2014
    ..We conclude that the melatonergic system is targeted by early-life adversity of maternal separation and that melatonin supplementation ameliorates the negative impact of stress on the circadian system...
  21. ncbi Melatonin-depleted blood from premenopausal women exposed to light at night stimulates growth of human breast cancer xenografts in nude rats
    David E Blask
    Laboratory of Chrono Neuroendocrine Oncology, Bassett Research Institute, The Mary Imogene Bassett Hospital, Cooperstown, New York 13326, USA
    Cancer Res 65:11174-84. 2005
    ..These mechanistic studies are the first to provide a rational biological explanation for the increased breast cancer risk in female night shift workers...
  22. ncbi MT(1) melatonin receptor overexpression enhances the growth suppressive effect of melatonin in human breast cancer cells
    Lin Yuan
    Department of Structural and Cellular Biology, Tulane University Medical School, 1430 Tulane Avenue, New Orleans, LA 70112, USA
    Mol Cell Endocrinol 192:147-56. 2002
    ..These data suggest the involvement of the MT(1) melatonin receptor in mediation of melatonin effects on growth-suppression and gene-modulation in breast cancer cells...
  23. ncbi The impact of school daily schedule on adolescent sleep
    Martha Hansen
    Science Department, Evanston Township High School, Evanston, Illinois, USA
    Pediatrics 115:1555-61. 2005
    ....

Research Grants8

  1. Mentoring For Success: Developing Fundamental Skills For Biomedical Research
    Margarita Dubocovich; Fiscal Year: 2007
    ....
  2. Modulation of Methamphetamine Actions in the CNS
    Margarita Dubocovich; Fiscal Year: 2007
    ....
  3. Chicago State-Northwestern MS-PhD Bridge to the Future
    Margarita Dubocovich; Fiscal Year: 2007
    ..The BP will continue to benefit from periodic examination and assessment by experienced and highly accomplished external advisors and evaluators. ..