Research Topics
| PETER J DALLOSSummaryAffiliation: Northwestern University Country: USA Publications
Research Grants
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Detail Information
Publications
Organ of Corti kinematicsPeter Dallos
Auditory Physiology Laboratory, The Hugh Knowles Center and Neuroscience Institute, Department of Neurobiology, Northwestern University, Evanston, IL 60208, USA
J Assoc Res Otolaryngol 4:416-21. 2003..The model also simulates cilia deflection when the mechanical stimulus is the length change of outer hair cells...- Identifying components of the hair-cell interactome involved in cochlear amplificationJing Zheng
Department of Communication Sciences and Disorders, The Hugh Knowles Center, Northwestern University, Evanston, IL 60208, USA
BMC Genomics 10:127. 2009..Prestin is a basolateral membrane protein responsible for OHC somatic electromotility... - Two models of outer hair cell stiffness and motilityP Dallos
The Hugh Knowles Center, Department of Neurobiology, Northwestern University, Evanston, IL 60208, USA
J Assoc Res Otolaryngol 1:283-91. 2000..Finally, the behavior of the model is compared with available data when the voltage stimulus comprises a brief sinusoid upon a DC pedestal... - Cochlear amplification, outer hair cells and prestinPeter Dallos
Northwestern University, Departments of Neurobiology and Physiology and Communication Sciences and Disorders, The Hugh Knowles Center, 2240 Campus Drive, Evanston, IL 60208, USA
Curr Opin Neurobiol 18:370-6. 2008..One of the central outstanding problems in mammalian cochlear neurobiology is the relation between the two amplification processes... - Prestin-based outer hair cell motility is necessary for mammalian cochlear amplificationPeter Dallos
Department of Neurobiology and Physiology, Northwestern University, Evanston, IL 60208, USA
Neuron 58:333-9. 2008..These animals have knockout-like behavior, demonstrating that prestin-based electromotility is required for cochlear amplification... - Prestin and the cochlear amplifierPeter Dallos
Department of Neurobiology and Physiology, Northwestern University, 2240 Campus Drive, Evanston, IL 60208, USA
J Physiol 576:37-42. 2006..Here we consider new work pertaining to this protein and its potential role as the mammalian cochlear amplifier... 
Prestin, a new type of motor proteinPeter Dallos
Auditory Physiology Laboratory, The Hugh Knowles Center, Department of Neurobiology, The Institute for Neuroscience, Northwestern University, Evanston, Illinois 60208, USA
Nat Rev Mol Cell Biol 3:104-11. 2002..As prestin mediates changes in outer hair cell length in response to membrane potential variations, it might be responsible for sound amplification in the mammalian hearing organ...- N-linked glycosylation sites of the motor protein prestin: effects on membrane targeting and electrophysiological functionKeiji Matsuda
Auditory Physiology Laboratory, Department of Communication Sciences and Disorders, Northwestern University, Evanston, Illinois 60208, USA
J Neurochem 89:928-38. 2004..These data suggest that glycosylation of prestin may quantitatively affect OHC electromotility... - EHD4 and CDH23 are interacting partners in cochlear hair cellsSoma Sengupta
Department of Communication Sciences and Disorders, Hugh Knowles Center, Northwestern University, Evanston, Illinois 60208, USA
J Biol Chem 284:20121-9. 2009..Taken together, these data indicate that EHD4 is a novel CDH23-interacting protein that could regulate CDH23 trafficking/localization in a calcium-sensitive manner... - Stiffness of the gerbil basilar membrane: radial and longitudinal variationsGulam Emadi
Department of Biomedical Engineering, Northwestern University, Evanston 60208, USA
J Neurophysiol 91:474-88. 2004..The bulk of our data was obtained in the hemicochlea preparation, and we include a comparison of this set of data to data obtained in vivo... - Using the cochlear microphonic as a tool to evaluate cochlear function in mouse models of hearingMary Ann Cheatham
Department of Communication Sciences and Disorders, The Hugh Knowles Center, Northwestern University, 2240 Campus Drive, Evanston, IL 60208 3550, USA
J Assoc Res Otolaryngol 12:113-25. 2011..Based on this current evaluation, CM measurements are consistent with early descriptions where this AC cochlear potential is dominated by basal OHCs, when recorded at the round window... - A chimera analysis of prestin knock-out miceMary Ann Cheatham
Departments of Communication Sciences and Disorders, The Hugh Knowles Center, Northwestern University, Evanston, Illinois 60208, USA
J Neurosci 29:12000-8. 2009..Accordingly, we demonstrate a proportional reduction in sensitivity and in the tip length of CAP tuning curves as the number of OHCs derived from the KO genome increases; i.e., genotype ratio and phenotype are closely related... - Prestin, the motor protein of outer hair cellsJing Zheng
Department of Communication Sciences and Disorders, Auditory Physiology Laboratory, The Hugh Knowles Center, Northwestern University, Evanston, Ill 60208, USA
Audiol Neurootol 7:9-12. 2002..Prestin shares overall structure similarity with this anion transporter family. Recently, intracellular anions (chloride or bicarbonate) were found to be essential for OHC electromotility and prestin's function... - Identification of differentially expressed cDNA clones from gerbil cochlear outer hair cellsJing Zheng
Auditory Physiology Laboratory Hugh Knowles Center, Department of Communication Sciences and Disorders, Northwestern University, Evanston, IL 60802, USA
Audiol Neurootol 7:277-88. 2002.... - Tectorial membrane stiffness gradientsClaus Peter Richter
Auditory Physiology Laboratory The Hugh Knowles Center, Department of Communication Sciences and Disorders, Northwestern University, 303 E Chicago Avenue, Chicago, IL 60611, USA
Biophys J 93:2265-76. 2007..Young's modulus, which was obtained from measurements performed in the transversal direction, decreased by -2.6 dB/mm from base to apex... - Analysis of the oligomeric structure of the motor protein prestinJing Zheng
Department of Communication Sciences and Disorders, Northwestern University, Evanston, Illinois 60208, USA
J Biol Chem 281:19916-24. 2006..This stable dimer may act as the building block for producing the higher order oligomers that form the approximately 11-nM particles in the outer hair cell's basolateral membrane... - The C-terminus of prestin influences nonlinear capacitance and plasma membrane targetingJing Zheng
Auditory Physiology Laboratory, Department of Communication Sciences and Disorders, Northwestern University, Evanston, IL 60208 USA
J Cell Sci 118:2987-96. 2005..Together, these data suggest that certain specific sequences and individual amino acids in the C-terminus are necessary for correct cellular distribution and function... - Evidence that prestin has at least two voltage-dependent stepsKazuaki Homma
Department of Communication Sciences and Disorders, The Hugh Knowles Center, Northwestern University, Evanston, Illinois 60208, USA
J Biol Chem 286:2297-307. 2011..Here, we suggest a molecular mechanism of prestin with at least two voltage-dependent conformational transition steps having distinct electromechanical coupling efficiencies... - Interaction between the motor protein prestin and the transporter protein VAPASoma Sengupta
Department of Otolaryngology, Feinberg School of Medicine, Northwestern University, 303 East Chicago Avenue, Chicago, IL 60611, USA
Biochim Biophys Acta 1803:796-804. 2010..These data suggest that VAPA could be involved in prestin's transportation inside OHCs and may facilitate the targeting of this abundant OHC protein to the plasma membrane... - Effects of cyclic nucleotides on the function of prestinLevente Deak
Auditory Physiology Laboratory, Department of Communication Sciences and Disorders, The Neuroscience Institute, Northwestern University, Evanston, IL 60208, USA
J Physiol 563:483-96. 2005..One of these sites may influence the membrane targeting process of prestin. Finally, a new topology map of prestin is proposed... - Interaction between CFTR and prestin (SLC26A5)Kazuaki Homma
Department of Communication Sciences and Disorders, The Hugh Knowles Center, Northwestern University, Evanston, IL 60208, USA
Biochim Biophys Acta 1798:1029-40. 2010..Electrophysiological experiments demonstrated that cAMP-activated CFTR is capable of enhancing voltage-dependent charge displacement, a signature of OHC motility, whereas prestin does not affect the chloride conductance of CFTR...
Research Grants
- STUDIES IN COCHLEAR HAIR CELL TRANSDUCTIONPeter Dallos; Fiscal Year: 2005....
- STUDIES IN COCHLEAR HAIR CELL TRANSDUCTIONPeter Dallos; Fiscal Year: 2007..A very significant fraction of these deficits involve deterioration or death of hair cells, especially OHCs. Our entire effort is focused on unraveling the properties of OHCs and their unique function in the hearing process. ..
- COCHLEAR HAIR CELL TRANSDUCTIONPeter Dallos; Fiscal Year: 2000..A subset of these studies is aimed at finally resolving the long-standing discrepancy in the production of intracellular tonic receptor potentials, generated by outer hair cells in the high versus low frequency regions of the cochlea. ..
- STUDIES IN COCHLEAR HAIR CELL TRANSDUCTIONPeter Dallos; Fiscal Year: 1993..An understanding of the neurobiology of hair cells is a key to prevention and eventual remediation of hearing loss. Our work has been and is designed to provide such fundamental understanding...
- STUDIES IN COCHLEAR HAIR CELL TRANSDUCTIONPeter Dallos; Fiscal Year: 1990..These goals are pursued by a combined application of physiological (gross potential recording, single hair cell recording, and single nerve fiber recording), behavioral and histological measurements...
- STUDIES IN COCHLEAR HAIR CELL TRANSDUCTIONPETER J DALLOS; Fiscal Year: 2010..Our entire effort is focused on unreveling the properties of OHCs and their unique function in the hearing process. ..