Anis Contractor

Summary

Affiliation: Northwestern University
Country: USA

Publications

  1. pmc Altered activity-rest patterns in mice with a human autosomal-dominant nocturnal frontal lobe epilepsy mutation in the β2 nicotinic receptor
    J Xu
    Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Mol Psychiatry 16:1048-61. 2011
  2. pmc Broadening roles for FMRP: big news for big potassium (BK) channels
    Anis Contractor
    Department of Physiology and Department of Neurobiology, Northwestern University, 303 E Chicago Avenue, Chicago, IL 60613, USA
    Neuron 77:601-3. 2013
  3. ncbi request reprint AMPA receptor cycling in the synapse
    Anis Contractor
    Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Sci STKE 2004:tr7. 2004
  4. pmc Kainate receptors coming of age: milestones of two decades of research
    Anis Contractor
    Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Trends Neurosci 34:154-63. 2011
  5. pmc High-affinity kainate receptor subunits are necessary for ionotropic but not metabotropic signaling
    Herman B Fernandes
    Department of Physiology, Northwestern University School of Medicine, 303 E Chicago Avenue, Chicago, IL 60611, USA
    Neuron 63:818-29. 2009
  6. pmc Genetic ablation of the GluK4 kainate receptor subunit causes anxiolytic and antidepressant-like behavior in mice
    Justin S Catches
    Department of Physiology, Northwestern University, Feinberg School of Medicine, 303 E Chicago Avenue, Chicago, IL 60611, USA
    Behav Brain Res 228:406-14. 2012
  7. pmc Critical period plasticity is disrupted in the barrel cortex of FMR1 knockout mice
    Emily G Harlow
    Department of Physiology, Northwestern University Feinberg School of Medicine, 303 E Chicago Avenue, Chicago, IL 60611, USA
    Neuron 65:385-98. 2010
  8. ncbi request reprint Loss of kainate receptor-mediated heterosynaptic facilitation of mossy-fiber synapses in KA2-/- mice
    Anis Contractor
    Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Neurosci 23:422-9. 2003
  9. pmc Ephrin-B3 regulates glutamate receptor signaling at hippocampal synapses
    Marcia D Antion
    Department of Physiology, Northwestern University Feinberg School of Medicine, 303 E Chicago Ave, Chicago, IL 60611, USA
    Mol Cell Neurosci 45:378-88. 2010
  10. pmc AMPA receptor desensitization mutation results in severe developmental phenotypes and early postnatal lethality
    Louisa A Christie
    Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Proc Natl Acad Sci U S A 107:9412-7. 2010

Research Grants

  1. Mechanisms of plasticity at the Mossy Fiber Synapse
    Anis Contractor; Fiscal Year: 2004
  2. Kainate receptor signaling at excitatory synapses
    Anis Contractor; Fiscal Year: 2009
  3. Kainate receptor signaling at excitatory synapses
    Anis Contractor; Fiscal Year: 2010
  4. Kainate receptor signaling at excitatory synapses
    Anis Contractor; Fiscal Year: 2009
  5. Mechanisms of plasticity at the Mossy Fiber Synapse
    Anis Contractor; Fiscal Year: 2007
  6. Mechanisms of plasticity at the Mossy Fiber Synapse
    Anis Contractor; Fiscal Year: 2006
  7. Mechanisms of plasticity at the Mossy Fiber Synapse
    Anis Contractor; Fiscal Year: 2005
  8. Retrograde Signaling at Hippocampal Mossy Fiber Synapses
    Anis Contractor; Fiscal Year: 2003
  9. Kainate receptor signaling at excitatory synapses
    Anis Contractor; Fiscal Year: 2010

Collaborators

Detail Information

Publications19

  1. pmc Altered activity-rest patterns in mice with a human autosomal-dominant nocturnal frontal lobe epilepsy mutation in the β2 nicotinic receptor
    J Xu
    Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Mol Psychiatry 16:1048-61. 2011
    ..Together, these findings emphasize several important roles of β2* nicotinic receptors in complex biological processes including the activity-rest cycle, natural reward and anxiety...
  2. pmc Broadening roles for FMRP: big news for big potassium (BK) channels
    Anis Contractor
    Department of Physiology and Department of Neurobiology, Northwestern University, 303 E Chicago Avenue, Chicago, IL 60613, USA
    Neuron 77:601-3. 2013
    ..In this issue of Neuron, Deng et al. (2013) demonstrate a novel translation-independent function for FMRP as a regulator of presynaptic BK channels that modulate the dynamics of neurotransmitter release...
  3. ncbi request reprint AMPA receptor cycling in the synapse
    Anis Contractor
    Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Sci STKE 2004:tr7. 2004
    ..The animation provides an interactive illustration of how activity-dependent changes in the glutamate receptor composition and numbers at the synapse may contribute to synaptic plasticity...
  4. pmc Kainate receptors coming of age: milestones of two decades of research
    Anis Contractor
    Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Trends Neurosci 34:154-63. 2011
    ....
  5. pmc High-affinity kainate receptor subunits are necessary for ionotropic but not metabotropic signaling
    Herman B Fernandes
    Department of Physiology, Northwestern University School of Medicine, 303 E Chicago Avenue, Chicago, IL 60611, USA
    Neuron 63:818-29. 2009
    ....
  6. pmc Genetic ablation of the GluK4 kainate receptor subunit causes anxiolytic and antidepressant-like behavior in mice
    Justin S Catches
    Department of Physiology, Northwestern University, Feinberg School of Medicine, 303 E Chicago Avenue, Chicago, IL 60611, USA
    Behav Brain Res 228:406-14. 2012
    ....
  7. pmc Critical period plasticity is disrupted in the barrel cortex of FMR1 knockout mice
    Emily G Harlow
    Department of Physiology, Northwestern University Feinberg School of Medicine, 303 E Chicago Avenue, Chicago, IL 60611, USA
    Neuron 65:385-98. 2010
    ..Our results indicate that FMRP is required for the normal developmental progression of synaptic maturation, and loss of this important RNA binding protein impacts the timing of the critical period for layer IV synaptic plasticity...
  8. ncbi request reprint Loss of kainate receptor-mediated heterosynaptic facilitation of mossy-fiber synapses in KA2-/- mice
    Anis Contractor
    Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Neurosci 23:422-9. 2003
    ..These results identify the KA2 subunit as a determinant of kainate receptor function at presynaptic and postsynaptic mossy-fiber kainate receptors...
  9. pmc Ephrin-B3 regulates glutamate receptor signaling at hippocampal synapses
    Marcia D Antion
    Department of Physiology, Northwestern University Feinberg School of Medicine, 303 E Chicago Ave, Chicago, IL 60611, USA
    Mol Cell Neurosci 45:378-88. 2010
    ..Our data suggests that ephrin-B3 limits EphB RTK-mediated phosphorylation of the NR2B subunit through an inhibitory cis- interaction which is required for the correct function of glutamatergic CA1 synapses...
  10. pmc AMPA receptor desensitization mutation results in severe developmental phenotypes and early postnatal lethality
    Louisa A Christie
    Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Proc Natl Acad Sci U S A 107:9412-7. 2010
    ..The dramatic phenotype observed in this study by the introduction of a single amino acid change demonstrates an essential role in vivo for AMPA receptor desensitization...
  11. ncbi request reprint B-ephrin reverse signaling is required for NMDA-independent long-term potentiation of mossy fibers in the hippocampus
    John N Armstrong
    Molecular Neurobiology Laboratory, The Salk Institute, La Jolla, California 93037, USA
    J Neurosci 26:3474-81. 2006
    ..These results indicate that B-ephrin reverse signaling into the presynaptic mossy fiber bouton is required for the induction of NMDA receptor-independent LTP at this synapse...
  12. doi request reprint The developmental switch in GABA polarity is delayed in fragile X mice
    Qionger He
    Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, Department of Pediatrics and Department of Physiology, School of Medicine, Keio University, Shinjuku ku, Tokyo 160 8582, and Department of Neurobiology, Weinberg College of Arts and Sciences, Northwestern University, Evanston, Illinois 60208
    J Neurosci 34:446-50. 2014
    ..Disruption of the trophic effects of GABA during cortical development could contribute to the altered trajectory of synaptic maturation in fragile X syndrome. ..
  13. ncbi request reprint Glutamate receptor trafficking in synaptic plasticity
    Anis Contractor
    Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Sci STKE 2002:re14. 2002
    ..Here, we review recent evidence that some forms of synaptic strengthening rely on the modification of the glutamate receptor complement at synapses in response to activity-dependent processes...
  14. pmc Potentiating mGluR5 function with a positive allosteric modulator enhances adaptive learning
    Jian Xu
    Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Learn Mem 20:438-45. 2013
    ..Together these results demonstrate a role for mGluR5 signaling in adaptive learning, and suggest that mGluR5 PAMs represent a viable strategy for treatment of maladaptive learning and for improving behavioral flexibility. ..
  15. pmc mGluR5 has a critical role in inhibitory learning
    Jian Xu
    The Salk Institute for Biological Studies, Molecular Neurobiology Laboratory, La Jolla, California 92037, USA
    J Neurosci 29:3676-84. 2009
    ....
  16. ncbi request reprint Trans-synaptic Eph receptor-ephrin signaling in hippocampal mossy fiber LTP
    Anis Contractor
    Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 296:1864-9. 2002
    ..These findings suggest that PDZ interactions in the postsynaptic neuron and trans-synaptic interactions between postsynaptic EphB receptors and presynaptic B-ephrins are necessary for the induction of mossy fiber LTP...
  17. ncbi request reprint Distinct roles for the kainate receptor subunits GluR5 and GluR6 in kainate-induced hippocampal gamma oscillations
    André Fisahn
    Laboratory of Cellular and Synaptic Neurophysiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 24:9658-68. 2004
    ....
  18. ncbi request reprint Attenuated plasticity of postsynaptic kainate receptors in hippocampal CA3 pyramidal neurons
    Koichi Ito
    Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555 1031, USA
    J Neurosci 24:6228-36. 2004
    ..These synaptic features may be a mechanism for limiting activation of kainate receptors at mossy fiber synapses, which has been shown to be involved in seizurogenic firing of the CA3 network...
  19. ncbi request reprint Differential activation of individual subunits in heteromeric kainate receptors
    Geoffrey T Swanson
    Department of Pharmacology and Toxicology, University of Texas Medical Branch, 301 University Boulevard, Galveston 77555, USA
    Neuron 34:589-98. 2002
    ....

Research Grants10

  1. Mechanisms of plasticity at the Mossy Fiber Synapse
    Anis Contractor; Fiscal Year: 2004
    ..In addition, we will explore the exact pre- and postsynaptic mechanisms by which these molecules exert their action. These studies will provide new insight relevant to synaptic transmission and memory processes in the mammalian brain. ..
  2. Kainate receptor signaling at excitatory synapses
    Anis Contractor; Fiscal Year: 2009
    ....
  3. Kainate receptor signaling at excitatory synapses
    Anis Contractor; Fiscal Year: 2010
    ....
  4. Kainate receptor signaling at excitatory synapses
    Anis Contractor; Fiscal Year: 2009
    ....
  5. Mechanisms of plasticity at the Mossy Fiber Synapse
    Anis Contractor; Fiscal Year: 2007
    ..In addition, we will explore the exact pre- and postsynaptic mechanisms by which these molecules exert their action. These studies will provide new insight relevant to synaptic transmission and memory processes in the mammalian brain. ..
  6. Mechanisms of plasticity at the Mossy Fiber Synapse
    Anis Contractor; Fiscal Year: 2006
    ..In addition, we will explore the exact pre- and postsynaptic mechanisms by which these molecules exert their action. These studies will provide new insight relevant to synaptic transmission and memory processes in the mammalian brain. ..
  7. Mechanisms of plasticity at the Mossy Fiber Synapse
    Anis Contractor; Fiscal Year: 2005
    ..In addition, we will explore the exact pre- and postsynaptic mechanisms by which these molecules exert their action. These studies will provide new insight relevant to synaptic transmission and memory processes in the mammalian brain. ..
  8. Retrograde Signaling at Hippocampal Mossy Fiber Synapses
    Anis Contractor; Fiscal Year: 2003
    ..A complete understanding of the cellular and molecular mechanisms of hippocampal LTP will provide insight into approaches to treat memory related symptoms of neurological disorders. ..
  9. Kainate receptor signaling at excitatory synapses
    Anis Contractor; Fiscal Year: 2010
    ....