S L Cole

Summary

Affiliation: Northwestern University
Country: USA

Publications

  1. pmc The Alzheimer's disease beta-secretase enzyme, BACE1
    Sarah L Cole
    Department of Cell and Molecular Biology, The Feinberg School of Medicine, Northwestern University, Chicago Avenue, Chicago, IL, USA
    Mol Neurodegener 2:22. 2007
  2. pmc Linking vascular disorders and Alzheimer's disease: potential involvement of BACE1
    Sarah L Cole
    Northwestern University, The Feinberg School of Medicine, Department of Cell and Molecular Biology, 303 E Chicago Avenue, Chicago, IL 60611, USA
    Neurobiol Aging 30:1535-44. 2009
  3. ncbi request reprint Statins cause intracellular accumulation of amyloid precursor protein, beta-secretase-cleaved fragments, and amyloid beta-peptide via an isoprenoid-dependent mechanism
    Sarah L Cole
    Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University Medical School, Chicago, Illinois 60611, USA
    J Biol Chem 280:18755-70. 2005
  4. ncbi request reprint Isoprenoids and Alzheimer's disease: a complex relationship
    S L Cole
    Department of Cell and Molecular Biology, Northwestern University Medical School, Chicago, IL 60611, USA
    Neurobiol Dis 22:209-22. 2006
  5. pmc Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis
    Tracy O'Connor
    Department of Cell and Molecular Biology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Neuron 60:988-1009. 2008
  6. pmc BACE1 gene deletion prevents neuron loss and memory deficits in 5XFAD APP/PS1 transgenic mice
    Masuo Ohno
    Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611 3008, USA
    Neurobiol Dis 26:134-45. 2007
  7. ncbi request reprint Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation
    Holly Oakley
    Department of Cell and Molecular Biology, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Neurosci 26:10129-40. 2006
  8. pmc The role of amyloid precursor protein processing by BACE1, the beta-secretase, in Alzheimer disease pathophysiology
    Sarah L Cole
    Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Biol Chem 283:29621-5. 2008
  9. ncbi request reprint BACE1 structure and function in health and Alzheimer's disease
    Sarah L Cole
    Department of Cell and Molecular Biology, The Feinberg School of Medicine, Northwestern University, Chicago Avenue, Chicago, IL, USA
    Curr Alzheimer Res 5:100-20. 2008
  10. pmc Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1
    Qiang Liu
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
    Neuron 56:66-78. 2007

Collaborators

Detail Information

Publications10

  1. pmc The Alzheimer's disease beta-secretase enzyme, BACE1
    Sarah L Cole
    Department of Cell and Molecular Biology, The Feinberg School of Medicine, Northwestern University, Chicago Avenue, Chicago, IL, USA
    Mol Neurodegener 2:22. 2007
    ....
  2. pmc Linking vascular disorders and Alzheimer's disease: potential involvement of BACE1
    Sarah L Cole
    Northwestern University, The Feinberg School of Medicine, Department of Cell and Molecular Biology, 303 E Chicago Avenue, Chicago, IL 60611, USA
    Neurobiol Aging 30:1535-44. 2009
    ..However, given that vascular diseases can be addressed by lifestyle and pharmacologic interventions, the potential benefits of these therapies in delaying the clinical appearance and progression of AD may warrant investigation...
  3. ncbi request reprint Statins cause intracellular accumulation of amyloid precursor protein, beta-secretase-cleaved fragments, and amyloid beta-peptide via an isoprenoid-dependent mechanism
    Sarah L Cole
    Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University Medical School, Chicago, Illinois 60611, USA
    J Biol Chem 280:18755-70. 2005
    ....
  4. ncbi request reprint Isoprenoids and Alzheimer's disease: a complex relationship
    S L Cole
    Department of Cell and Molecular Biology, Northwestern University Medical School, Chicago, IL 60611, USA
    Neurobiol Dis 22:209-22. 2006
    ..Protein isoprenylation regulates multiple cellular and molecular events and here we review the complex roles of isoprenoids in AD-relevant processes and carefully evaluate isoprenoid pathways as potential AD therapeutic targets...
  5. pmc Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis
    Tracy O'Connor
    Department of Cell and Molecular Biology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Neuron 60:988-1009. 2008
    ..These results strongly suggest that eIF2alpha phosphorylation increases BACE1 levels and causes Abeta overproduction, which could be an early, initiating molecular mechanism in sporadic AD...
  6. pmc BACE1 gene deletion prevents neuron loss and memory deficits in 5XFAD APP/PS1 transgenic mice
    Masuo Ohno
    Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611 3008, USA
    Neurobiol Dis 26:134-45. 2007
    ..Our findings provide strong evidence that Abeta ultimately is responsible for neuron death in AD and validate the therapeutic potential of BACE1-inhibiting approaches for the treatment of AD...
  7. ncbi request reprint Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation
    Holly Oakley
    Department of Cell and Molecular Biology, The Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Neurosci 26:10129-40. 2006
    ..Thus, 5XFAD mice rapidly recapitulate major features of AD amyloid pathology and may be useful models of intraneuronal Abeta42-induced neurodegeneration and amyloid plaque formation...
  8. pmc The role of amyloid precursor protein processing by BACE1, the beta-secretase, in Alzheimer disease pathophysiology
    Sarah L Cole
    Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Biol Chem 283:29621-5. 2008
    ..We address pertinent questions such as putative causes of BACE1 elevation in AD and discuss why, nine years since the identification of BACE1, treatments that address the underlying pathological mechanisms of AD are still lacking...
  9. ncbi request reprint BACE1 structure and function in health and Alzheimer's disease
    Sarah L Cole
    Department of Cell and Molecular Biology, The Feinberg School of Medicine, Northwestern University, Chicago Avenue, Chicago, IL, USA
    Curr Alzheimer Res 5:100-20. 2008
    ....
  10. pmc Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1
    Qiang Liu
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
    Neuron 56:66-78. 2007
    ....