David F Cella

Summary

Affiliation: Northwestern University
Country: USA

Publications

  1. ncbi request reprint What is a clinically meaningful change on the Functional Assessment of Cancer Therapy-Lung (FACT-L) Questionnaire? Results from Eastern Cooperative Oncology Group (ECOG) Study 5592
    David Cella
    Evanston Northwestern Healthcare and Northwestern University, 1001 University Place, Suite 100, Evanston, IL 60201, USA
    J Clin Epidemiol 55:285-95. 2002
  2. doi request reprint Validity of the FACT Hepatobiliary (FACT-Hep) questionnaire for assessing disease-related symptoms and health-related quality of life in patients with metastatic pancreatic cancer
    David Cella
    Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, 720 N Lake Shore Drive, 7th Floor, Chicago, IL 60611, USA
    Qual Life Res 22:1105-12. 2013
  3. pmc Patient-reported outcomes for axitinib vs sorafenib in metastatic renal cell carcinoma: phase III (AXIS) trial
    D Cella
    Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, 633 N St, Clair 19th Floor Chicago, IL 60611, USA
    Br J Cancer 108:1571-8. 2013
  4. doi request reprint The FACIT-AI, a new tool for assessing symptoms associated with malignant ascites
    David Cella
    Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Gynecol Oncol 128:187-90. 2013
  5. doi request reprint Measuring health-related quality of life in leukemia: the Functional Assessment of Cancer Therapy--Leukemia (FACT-Leu) questionnaire
    David Cella
    Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Value Health 15:1051-8. 2012
  6. pmc Neuro-QOL: brief measures of health-related quality of life for clinical research in neurology
    D Cella
    Northwestern University Feinberg School of Medicine, Chicago, IL, USA
    Neurology 78:1860-7. 2012
  7. pmc Baseline quality of life as a prognostic survival tool in patients receiving sunitinib for metastatic renal cell carcinoma
    D Cella
    Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
    Br J Cancer 106:646-50. 2012
  8. doi request reprint Health-related quality of life in patients with advanced renal cell carcinoma receiving pazopanib or placebo in a randomised phase III trial
    D Cella
    Northwestern University Feinberg School of Medicine, Evanston, IL 60611, USA
    Eur J Cancer 48:311-23. 2012
  9. pmc Responsiveness and minimal important differences for patient reported outcomes
    Dennis A Revicki
    Center for Health Outcomes Research, United BioSource Corporation, 7101 Wisconsin Ave, Suite 600, Bethesda, MD 20814, USA
    Health Qual Life Outcomes 4:70. 2006
  10. pmc The Functional Assessment of Chronic Illness Therapy (FACIT) Measurement System: properties, applications, and interpretation
    Kimberly Webster
    Center on Outcomes, Research and Education, Evanston Northwestern Healthcare and Northwestern University Feinberg School of Medicine, Evanston, Illinois, United States
    Health Qual Life Outcomes 1:79. 2003

Research Grants

Detail Information

Publications110 found, 100 shown here

  1. ncbi request reprint What is a clinically meaningful change on the Functional Assessment of Cancer Therapy-Lung (FACT-L) Questionnaire? Results from Eastern Cooperative Oncology Group (ECOG) Study 5592
    David Cella
    Evanston Northwestern Healthcare and Northwestern University, 1001 University Place, Suite 100, Evanston, IL 60201, USA
    J Clin Epidemiol 55:285-95. 2002
    ....
  2. doi request reprint Validity of the FACT Hepatobiliary (FACT-Hep) questionnaire for assessing disease-related symptoms and health-related quality of life in patients with metastatic pancreatic cancer
    David Cella
    Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, 720 N Lake Shore Drive, 7th Floor, Chicago, IL 60611, USA
    Qual Life Res 22:1105-12. 2013
    ..Evaluate reliability and validity of the Functional Assessment of Cancer Therapy-Hepatobiliary (FACT-Hep) questionnaire and its derivative FACT Hepatobiliary Symptom Indexes (FHSI-18 and FHSI-8) in people with metastatic pancreatic cancer...
  3. pmc Patient-reported outcomes for axitinib vs sorafenib in metastatic renal cell carcinoma: phase III (AXIS) trial
    D Cella
    Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, 633 N St, Clair 19th Floor Chicago, IL 60611, USA
    Br J Cancer 108:1571-8. 2013
    ....
  4. doi request reprint The FACIT-AI, a new tool for assessing symptoms associated with malignant ascites
    David Cella
    Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Gynecol Oncol 128:187-90. 2013
    ....
  5. doi request reprint Measuring health-related quality of life in leukemia: the Functional Assessment of Cancer Therapy--Leukemia (FACT-Leu) questionnaire
    David Cella
    Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Value Health 15:1051-8. 2012
    ..Develop and validate a health-related quality-of-life (measure for patients with acute and chronic leukemia...
  6. pmc Neuro-QOL: brief measures of health-related quality of life for clinical research in neurology
    D Cella
    Northwestern University Feinberg School of Medicine, Chicago, IL, USA
    Neurology 78:1860-7. 2012
    ..To address the need for brief, reliable, valid, and standardized quality of life (QOL) assessment applicable across neurologic conditions...
  7. pmc Baseline quality of life as a prognostic survival tool in patients receiving sunitinib for metastatic renal cell carcinoma
    D Cella
    Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
    Br J Cancer 106:646-50. 2012
    ..Using this dataset, we have developed a novel prognostic tool that establishes a relationship between baseline QoL scores and median survival time...
  8. doi request reprint Health-related quality of life in patients with advanced renal cell carcinoma receiving pazopanib or placebo in a randomised phase III trial
    D Cella
    Northwestern University Feinberg School of Medicine, Evanston, IL 60611, USA
    Eur J Cancer 48:311-23. 2012
    ..62, p-value<0.0001), without important differences in health-related quality of life (HRQoL). This post-hoc analysis evaluated time to HRQoL deterioration and whether tumour response/stabilisation was associated with HRQoL improvement...
  9. pmc Responsiveness and minimal important differences for patient reported outcomes
    Dennis A Revicki
    Center for Health Outcomes Research, United BioSource Corporation, 7101 Wisconsin Ave, Suite 600, Bethesda, MD 20814, USA
    Health Qual Life Outcomes 4:70. 2006
    ..Responsiveness and MID must be demonstrated and documented for the particular study population, and these measurement characteristics are needed for PRO labeling and promotional claims...
  10. pmc The Functional Assessment of Chronic Illness Therapy (FACIT) Measurement System: properties, applications, and interpretation
    Kimberly Webster
    Center on Outcomes, Research and Education, Evanston Northwestern Healthcare and Northwestern University Feinberg School of Medicine, Evanston, Illinois, United States
    Health Qual Life Outcomes 1:79. 2003
    ..Available scoring, normative data and information on meaningful change now allow one to interpret results in the context of a growing literature base...
  11. pmc Psychometric evaluation of the Osteoporosis Patient Treatment Satisfaction Questionnaire (OPSAT-Q), a novel measure to assess satisfaction with bisphosphonate treatment in postmenopausal women
    Emuella M Flood
    Oxford Outcomes Inc, Bethesda, MD, USA
    Health Qual Life Outcomes 4:42. 2006
    ..The objective of this study was to evaluate the psychometric characteristics of the OPSAT-Q...
  12. pmc A brief symptom index for advanced renal cell carcinoma
    David T Eton
    Center on Outcomes, Research and Education, Evanston Northwestern Healthcare, 1001 University Place, Suite 100, Evanston IL 60201, USA
    Health Qual Life Outcomes 4:68. 2006
    ..Our objective was to test a brief, symptom index for advanced renal cell carcinoma, a disease affecting over 38,000 Americans each year and often diagnosed in late stages...
  13. pmc Impact of chronic Immune Thrombocytopenic Purpura (ITP) on health-related quality of life: a conceptual model starting with the patient perspective
    Susan D Mathias
    Health Outcomes Solutions, P, O, Box 2343 Winter Park, Florida 32790, USA
    Health Qual Life Outcomes 6:13. 2008
    ..The aim of this research is to develop a conceptual model to describe the impact of ITP and its treatment on patients' health-related quality of life (HRQoL)...
  14. pmc Brief assessment of priority symptoms in hormone refractory prostate cancer: the FACT Advanced Prostate Symptom Index (FAPSI)
    Susan Yount
    Center on Outcomes, Research and Education, Evanston Northwestern Healthcare and Northwestern University, 1001 University Place, Suite 100, Evanston, IL 60201 USA
    Health Qual Life Outcomes 1:69. 2003
    ..The objective of this study was to construct and validate a brief, clinically-relevant symptom index for advanced prostate cancer...
  15. pmc Estimation of minimally important differences in EQ-5D utility and VAS scores in cancer
    A Simon Pickard
    Center for Pharmacoeconomic Research, Department of Pharmacy Practice, College of Pharmacy, University of Illinois at Chicago, Chicago, USA
    Health Qual Life Outcomes 5:70. 2007
    ..The aim of this study was to provide a range of estimates of minimally important differences (MIDs) in EQ-5D scores in cancer and to determine if estimates are comparable in lung cancer...
  16. pmc Deep vein thrombosis: validation of a patient-reported leg symptom index
    Stacie A Hudgens
    Center on Outcomes, Research and Education, Evanston Northwestern Healthcare, 1001 University Place, Suite 100, Evanston, Illinois 60201, USA
    Health Qual Life Outcomes 1:76. 2003
    ..As a result, a clinical tool in addition to US to detect symptom emergence or exacerbation in patients after DVT would be of value...
  17. pmc Symptom burden among patients with renal cell carcinoma (RCC): content for a symptom index
    Gale Harding
    UBC Center for Health Outcomes Research, Bethesda MD, USA
    Health Qual Life Outcomes 5:34. 2007
    ..Renal cell carcinoma (RCC) has multiple symptoms stemming from disease and treatments. There are few validated scales for evaluating RCC symptoms...
  18. ncbi request reprint The future of outcomes measurement: item banking, tailored short-forms, and computerized adaptive assessment
    David Cella
    Psychiatry and Behavioral Sciences, Institute for Healthcare Studies, Feinberg School of Medicine, Northwestern University, Evanston, IL 60201, USA
    Qual Life Res 16:133-41. 2007
    ..Some barriers to success include limitations in the methods themselves, controversies and disagreements across approaches, and end-user reluctance to move away from the familiar...
  19. pmc The Patient-Reported Outcomes Measurement Information System (PROMIS): progress of an NIH Roadmap cooperative group during its first two years
    David Cella
    Evanston Northwestern Healthcare, Evanston, Illinois 60201, USA
    Med Care 45:S3-S11. 2007
    ..In this article, we will summarize the organization and scientific activity of the PROMIS network during its first 2 years...
  20. ncbi request reprint Quality of life and clinical decisions in chemotherapy-induced anemia
    David Cella
    Center on Outcomes, Research, and Education, Evanston Northwestern Healthcare, Evanston, Illinois, USA
    Oncology (Williston Park) 20:25-8. 2006
    ..Studies of erythropoiesis-stimulating proteins to treat chemotherapy-induced anemia have shown increases in patients' hemoglobin levels, improvement in their FACT-F and FACT-General scores, and improvements in their quality of life...
  21. ncbi request reprint Symptom measurement in the Breast Cancer Prevention Trial (BCPT) (P-1): psychometric properties of a new measure of symptoms for midlife women
    David Cella
    National Surgical Adjuvant Breast and Bowel Project NSABP, Pittsburgh, PA, USA
    Breast Cancer Res Treat 109:515-26. 2008
    ..To evaluate scalability of a symptom scale administered to women enrolled in the Breast Cancer Prevention Trial (BCPT) (P-1) conducted by the National Surgical Adjuvant Breast and Bowel Project (NSABP)...
  22. doi request reprint Health-related quality of life outcomes associated with four cisplatin-based doublet chemotherapy regimens for stage IVB recurrent or persistent cervical cancer: a Gynecologic Oncology Group study
    David Cella
    Northwestern University Feinberg School of Medicine, Robert H Lurie Comprehensive Cancer Center, Chicago, IL, USA
    Gynecol Oncol 119:531-7. 2010
    ..To assess the differences in health-related quality of life (HRQL) of 4 cisplatin containing doublet chemotherapy combinations in women with advanced/recurrent cervical carcinoma...
  23. ncbi request reprint Measuring the concerns of cancer patients with low platelet counts: the Functional Assessment of Cancer Therapy--thrombocytopenia (FACT-Th) questionnaire
    David Cella
    Center on Outcomes, Research and Education, Evanston Northwestern Healthcare, Feinberg School of Medicine, Northwestern University, 1001 University Place, Suite 100, Evanston, IL 60201, USA
    Support Care Cancer 14:1220-31. 2006
    ..We report on the development and validation of questions specifically targeted to patients with thrombocytopenia that can be added to the more general concerns in the Functional Assessment of Cancer Therapy-General...
  24. ncbi request reprint Development and validation of the Functional Assessment of Cancer Therapy-Kidney Symptom Index (FKSI)
    David Cella
    Center on Outcomes, Research and Education, Evanston Northwestern Healthcare, Evanston, Illinois 60201, USA
    J Support Oncol 4:191-9. 2006
    ..Thus, the FKSI-15 and FKSI-10 are reliable and valid symptom indices for evaluating kidney cancer patients...
  25. ncbi request reprint Quality of life of postmenopausal women in the ATAC ("Arimidex", tamoxifen, alone or in combination) trial after completion of 5 years' adjuvant treatment for early breast cancer
    David Cella
    Feinberg School of Medicine, Evanston Northwestern Healthcare and Northwestern University, 1001 University Place, Suite 100, Evanston, IL 60201, USA
    Breast Cancer Res Treat 100:273-84. 2006
    ....
  26. ncbi request reprint Recognition and management of treatment-related side effects for breast cancer patients receiving adjuvant endocrine therapy
    David Cella
    Center on Outcomes, Research and Education, Northwestern University Feinberg School of Medicine, Evanston, IL 60201, USA
    Breast Cancer Res Treat 107:167-80. 2008
    ..Also highlighted are specific management strategies that may improve patient QoL and thereby optimize adherence to therapy, which in turn might improve patient outcomes...
  27. doi request reprint Quality of life in patients with metastatic renal cell carcinoma treated with sunitinib or interferon alfa: results from a phase III randomized trial
    David Cella
    Center on Outcomes, Research and Education, Evanston Northwestern Healthcare and Northwestern University Feinberg School of Medicine, 1001 University Place, Evanston, IL 60201, USA
    J Clin Oncol 26:3763-9. 2008
    ..001; objective response rate, 31% v 6%, respectively; P < .001). We report health-related quality-of-life (QOL) results from this trial...
  28. pmc The neurology quality-of-life measurement initiative
    David Cella
    Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Arch Phys Med Rehabil 92:S28-36. 2011
    ....
  29. ncbi request reprint Development and validation of 11 symptom indexes to evaluate response to chemotherapy for advanced cancer
    David Cella
    Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    J Natl Compr Canc Netw 9:268-78. 2011
    ..Beyond the clinical value of such indexes, they may also contribute significantly to satisfying regulatory requirements for a standardized tool to evaluate drug efficacy with respect to symptomatology...
  30. doi request reprint Beyond traditional outcomes: improving quality of life in patients with renal cell carcinoma
    David Cella
    Robert H Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois 60611, USA
    Oncologist 16:23-31. 2011
    ..The HRQOL effects of bevacizumab plus IFN-α have not been reported. As new agents enter clinical investigation, HRQOL data can help determine their overall role in treatment...
  31. doi request reprint Patient-reported peripheral neuropathy of doxorubicin and cisplatin with and without paclitaxel in the treatment of advanced endometrial cancer: Results from GOG 184
    David Cella
    Robert H Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
    Gynecol Oncol 119:538-42. 2010
    ..We now compare patient-reported neuropathy between treatment arms and patient reports to the clinician reports of neuropathy...
  32. doi request reprint Self-reported fatigue: one dimension or more? Lessons from the Functional Assessment of Chronic Illness Therapy--Fatigue (FACIT-F) questionnaire
    David Cella
    Northwestern University Feinberg School of Medicine, Chicago, IL, USA
    Support Care Cancer 19:1441-50. 2011
    ..Fatigue as an outcome or trial endpoint can be expressed as a single number, and the experience of the symptom is more likely to be endorsed at mild levels of fatigue, presumably before the symptom exerts an adverse impact upon function...
  33. pmc The Patient-Reported Outcomes Measurement Information System (PROMIS) developed and tested its first wave of adult self-reported health outcome item banks: 2005-2008
    David Cella
    Medical Social Sciences, Northwestern University, 710 North Lakeshore Drive, Chicago, IL 60611, USA
    J Clin Epidemiol 63:1179-94. 2010
    ..We report results from the first large-scale testing of PROMIS items...
  34. pmc Health-related quality of life in patients with metastatic renal cell carcinoma treated with sunitinib vs interferon-alpha in a phase III trial: final results and geographical analysis
    D Cella
    Robert H Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL 60611, USA
    Br J Cancer 102:658-64. 2010
    ..We report the final health-related quality of life (HRQoL) results...
  35. doi request reprint Quality of life in patients with metastatic renal cell carcinoma: the importance of patient-reported outcomes
    David Cella
    Department of Medical Social Sciences and The Robert H Lurie Comprehensive Cancer Center of Northwestern University, Evanston, IL, USA
    Cancer Treat Rev 35:733-7. 2009
    ....
  36. doi request reprint Improving health-related quality of life in non-small-cell lung cancer with current treatment options
    David F Cella
    Evanston Northwestern Healthcare, Evanston, IL, USA
    Clin Lung Cancer 9:206-12. 2008
    ..This article discusses current approaches to measuring health-related QOL. This discussion is followed by a brief review of some of the current treatment options for patients with NSCLC and their effect on health-related QOL...
  37. pmc Development of a fatigue and functional impact scale in anemic cancer patients receiving chemotherapy
    David Cella
    Center on Outcomes Research and Education, Evanston Northwestern Healthcare and Northwestern University, Evanston, Illinois 60201, USA
    Cancer 113:1480-8. 2008
    ..This study was conducted to develop a brief measure of fatigue and functional impact in cancer patients with anemia...
  38. doi request reprint Relationship between symptom change, objective tumor measurements, and performance status during chemotherapy for advanced lung cancer
    David Cella
    Center on Outcomes, Research, and Education, Evanston Northwestern Healthcare, Illinois, Institute for Healthcare Studies, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60201, USA
    Clin Lung Cancer 9:51-8. 2008
    ..Our objective was to identify which symptoms of advanced lung cancer are most likely to change with objective tumor measurements (progressions and responses) or changes in performance status (PS)...
  39. ncbi request reprint Role of quality of life in men with metastatic hormone-refractory prostate cancer: how does atrasentan influence quality of life?
    David Cella
    Northwestern University, Chicago, Illinois 60201, USA
    Eur Urol 49:781-9. 2006
    ..This review summarizes the known QOL literature and estimates the potential effect of atrasentan, a novel, selective endothelin A receptor antagonist (SERA), on the QOL of HRPC patients...
  40. ncbi request reprint Fatigue in cancer patients compared with fatigue in the general United States population
    David Cella
    Center on Outcomes Research and Education CORE, Evanston Northwestern Healthcare and Northwestern University, Illinois 60201, USA
    Cancer 94:528-38. 2002
    ..Because the etiology of fatigue is multifactorial, it also has been difficult to appreciate fully the relative contribution of anemia to cancer-related fatigue...
  41. ncbi request reprint The longitudinal relationship of hemoglobin, fatigue and quality of life in anemic cancer patients: results from five randomized clinical trials
    D Cella
    Northwestern University and Evanston Northwestern Healthcare, Evanston, IL 60201, USA
    Ann Oncol 15:979-86. 2004
    ..Anemia is common in cancer and has been associated with fatigue and reduced health-related quality of life (HRQOL). We report the association between hemoglobin and fatigue and the impact of reducing fatigue on several domains of HRQOL...
  42. ncbi request reprint What are the most important symptom targets when treating advanced cancer? A survey of providers in the National Comprehensive Cancer Network (NCCN)
    David Cella
    Center on Outcomes, Research and Education, Evanston Northwestern Healthcare, Northwestern University, Evanston, Illinois, USA
    Cancer Invest 21:526-35. 2003
    ..These results await validation in patient populations and examination of the extent to which changes in symptomatology translate into meaningful improvement to the patient...
  43. ncbi request reprint Measuring the side effects of taxane therapy in oncology: the functional assesment of cancer therapy-taxane (FACT-taxane)
    David Cella
    Center on Outcomes, Research and Education CORE, Evanston Northwestern Healthcare, and Northwestern University, Evanston, Illinois 60201, USA
    Cancer 98:822-31. 2003
    ..Cancer chemotherapy with some of the taxane class of agents can be associated with significant neurotoxicity, arthralgias, myalgias, and skin changes that may offset the therapeutic benefits of taxane use...
  44. ncbi request reprint Evaluation of pain associated with oral mucositis during the acute period after administration of high-dose chemotherapy
    David Cella
    Institute for Health Services Research and Policy Studies, Evanston Northwestern Healthcare and Northwestern University, Evanston, Illinois 60201, USA
    Cancer 98:406-12. 2003
    ..The findings of the current study may provide a clinical context for understanding the relation between objective indicators and patients' perceptions of OM...
  45. ncbi request reprint Quality of life considerations in patients with advanced lung cancer
    David Cella
    Center on Outcomes, Research, and Education CORE, Evanston Northwestern Healthcare, 1001 University Place, Ste 100, Evanston, IL 60201, USA
    Semin Oncol 31:16-20. 2004
    ..Finally, it discusses the need for a better understanding of the QOL and treatment preferences of patients with poor performance status...
  46. ncbi request reprint Control of cancer-related anemia with erythropoietic agents: a review of evidence for improved quality of life and clinical outcomes
    D Cella
    Institute for Health Services Research and Policy Studies, Northwestern University, Evanston, IL, USA
    Ann Oncol 14:511-9. 2003
    ..Recent preclinical and preliminary clinical data have also suggested that anemia may be associated with poorer outcomes following chemotherapy or surgery...
  47. ncbi request reprint Epoetin alfa treatment results in clinically significant improvements in quality of life in anemic cancer patients when referenced to the general population
    David Cella
    Center on Outcomes, Research and Education, Evanston Northwestern Healthcare and Institute for Health Sciences Research and Policy Studies, Northwestern University, IL 60201, USA
    J Clin Oncol 21:366-73. 2003
    ..This is, in part, because scales and measures of QOL are still relatively unfamiliar to most clinicians and because population-based reference ranges are lacking, thus making clinical trial results difficult to interpret...
  48. ncbi request reprint A brief assessment of concerns associated with genetic testing for cancer: the Multidimensional Impact of Cancer Risk Assessment (MICRA) questionnaire
    David Cella
    Center on Outcomes Research and Education, Evanston Northwestern Healthcare, Illinois 60201, USA
    Health Psychol 21:564-72. 2002
    ..77), and Positive Experiences (4 items, alpha = .75). All 3 MICRA subscales differentiated participants who were BRCA1/2 positive from the other 3 groups. MICRA thus helps identify subgroups of vulnerable genetic testing participants...
  49. ncbi request reprint The effects of anemia and anemia treatment on the quality of life of people with cancer
    David Cella
    Center on Outcomes Research and Education, Evanston Northwestern Healthcare, Illinois, USA
    Oncology (Williston Park) 16:125-32. 2002
    ..The data collected over the years to address these questions have helped define and clarify the relationship between anemia and health-related quality of life in people with cancer. That relationship is summarized in this article...
  50. ncbi request reprint Clinically meaningful improvement in symptoms and quality of life for patients with non-small-cell lung cancer receiving gefitinib in a randomized controlled trial
    David Cella
    Evanston Northwestern Healthcare and Northwestern University, 1001 University Place, Ste 100, Evanston, IL 60201, USA
    J Clin Oncol 23:2946-54. 2005
    ..Among these NSCLC patients treated with gefitinib, symptom improvement was complementary to and, for most patients, preceded evidence of radiographic regression...
  51. ncbi request reprint Measuring quality of life in chronic illness: the functional assessment of chronic illness therapy measurement system
    David Cella
    Northwestern University, Evanston, IL, USA
    Arch Phys Med Rehabil 83:S10-7. 2002
    ..Future directions in HRQOL assessment include test equating, item banking, and computerized adaptive testing...
  52. ncbi request reprint Defining higher order dimensions of self-reported health: further evidence for a two-dimensional structure
    David Cella
    Evanston Northwestern Healthcare and Northwestern University, Evanston, IL 60201, USA
    Eval Health Prof 28:122-41. 2005
    ..These results agree with other research and provide direction for further studies defining these dimensions within an item response theory (IRT) tradition...
  53. ncbi request reprint Validation of the Functional Assessment of Chronic Illness Therapy Fatigue Scale relative to other instrumentation in patients with rheumatoid arthritis
    David Cella
    Center on Outcomes, Research and Education, Evanston Northwestern Healthcare and Northwestern University, Evanston, Illinois 60201, USA
    J Rheumatol 32:811-9. 2005
    ..This study validated a brief measure of fatigue in rheumatoid arthritis (RA), the Functional Assessment of Chronic Illness Therapy (FACIT) Fatigue Scale...
  54. ncbi request reprint Using multiple anchor- and distribution-based estimates to evaluate clinically meaningful change on the Functional Assessment of Cancer Therapy-Biologic Response Modifiers (FACT-BRM) instrument
    Kathleen J Yost
    Center on Outcomes, Research and Education CORE, Evanston, IL 60201, USA
    Value Health 8:117-27. 2005
    ....
  55. doi request reprint Factors affecting enrollment in literacy studies for English- and Spanish-speaking cancer patients
    Hongyan Du
    Center on Outcomes, Research and Education, Evanston Northwestern Healthcare, Evanston, IL 60201, USA
    Stat Med 27:4119-31. 2008
    ..Study participation bias can affect inferences regarding outcomes...
  56. ncbi request reprint Combining anchor and distribution-based methods to derive minimal clinically important differences on the Functional Assessment of Cancer Therapy (FACT) anemia and fatigue scales
    David Cella
    Evanston Northwestern Healthcare and Northwestern University, IL, USA
    J Pain Symptom Manage 24:547-61. 2002
    ..They can also be used in conjunction with more traditional clinical markers to assist investigators in determining treatment efficacy...
  57. doi request reprint A patient-based utility measure of health for clinical trials of cancer therapy based on the European Organization for the Research and Treatment of Cancer Quality of Life Questionnaire
    A Simon Pickard
    Center for Pharmacoeconomic Research, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612 7230, USA
    Value Health 12:977-88. 2009
    ..The aims of this study were to: 1) map QLQ-C30 responses onto patient time trade-off utility scores; and 2) compare a multiattribute approach to a global evaluation approach to modeling utility scores...
  58. ncbi request reprint Impact of ZD1839 on non-small cell lung cancer-related symptoms as measured by the functional assessment of cancer therapy-lung scale
    David Cella
    Institute for Health Services Research and Policy Studies, Northwestern University, Chicago, IL, USA
    Semin Oncol 30:39-48. 2003
    ..The FACT-L questionnaire has also been included in phase III trials of ZD1839 treatment in combination with chemotherapy regimens...
  59. ncbi request reprint Meaningful change in cancer-specific quality of life scores: differences between improvement and worsening
    David Cella
    Evanston Northwestern Healthcare and Northwestern University, Evanston, Illinois 60201, USA
    Qual Life Res 11:207-21. 2002
    ..It has been assumed that improvements and declines of comparable magnitude have the same meaning or value...
  60. ncbi request reprint Validation of the Functional Assessment of Cancer Therapy-Breast Symptom Index (FBSI)
    Kathleen J Yost
    Center on Outcomes, Research and Education CORE, Evanston Northwestern Healthcare Research Institute, 1001 University Place, Suite 100, Evanston, IL 60201, USA
    Breast Cancer Res Treat 90:295-8. 2005
    ..The FBSI is a brief, clinically relevant, and psychometrically sound instrument that can be used to measure symptoms in patients with breast cancer...
  61. ncbi request reprint Standardizing patient-reported outcomes assessment in cancer clinical trials: a patient-reported outcomes measurement information system initiative
    Sofia F Garcia
    Center on Outcomes, Research and Education, Evanston Northwestern Healthcare, Institute for Healthcare Studies, and Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60201, USA
    J Clin Oncol 25:5106-12. 2007
    ..We also present our work in the fatigue domain, including a short-form measure, as a sample of PROMIS methodology and work to date. Plans for future validation and application of PROMIS measures are discussed...
  62. ncbi request reprint Psychometric comparison of the standard EQ-5D to a 5 level version in cancer patients
    A Simon Pickard
    Center for Pharmacoeconomic Research and Department of Pharmacy Practice, College of Pharmacy, University of Illinois at Chicago 60612, and Midwest Center for Health Services and Policy Research, Hines VA Hospital, Hines, Illinois, USA
    Med Care 45:259-63. 2007
    ....
  63. ncbi request reprint A comprehensive method for the translation and cross-cultural validation of health status questionnaires
    Sonya L Eremenco
    Center on Outcomes, Research and Education CORE, Evanston Northwestern Healthcare, Northwestern University, USA
    Eval Health Prof 28:212-32. 2005
    ..The FACIT translation methodology aims to establish equivalence of meaning and measurement between different country versions through the use of the decentered model of translation and advanced statistical methods...
  64. ncbi request reprint An item response theory-based pain item bank can enhance measurement precision
    Jin Shei Lai
    Center on Outcomes Research and Education, Evanston Northwestern Healthcare and Northwestern University, Evanston, Illinois 60201, USA
    J Pain Symptom Manage 30:278-88. 2005
    ..We conclude that this bank demonstrates good psychometric properties, is sensitive to pain reported by patients, and can be used as the foundation for a CAT pain-testing platform for use in clinical practice...
  65. doi request reprint Quality of life assessment in renal transplant: review and future directions
    Zeeshan Butt
    Center on Outcomes, Research and Education CORE, Evanston Northwestern Healthcare, Evanston, IL 60201, USA
    Clin Transplant 22:292-303. 2008
    ..In the present article, we review the most commonly used instruments, their use in renal transplant, and suggest future directions to improve QOL assessment in this population...
  66. ncbi request reprint Developing a self-report outcome measure for complementary and alternative medicine
    David T Eton
    Evanston Northwestern Healthcare, Evanston, IL, USA
    Explore (NY) 1:177-85. 2005
    ..Current options for assessing subjective outcomes in CAM are either too burdensome or fail to represent diverse outcomes. A single measure specifying common, patient-reported outcomes of CAM would be of value...
  67. doi request reprint Validation of the functional assessment of chronic illness therapy-fatigue scale in patients with moderately to severely active systemic lupus erythematosus, participating in a clinical trial
    Jin Shei Lai
    Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    J Rheumatol 38:672-9. 2011
    ..Fatigue is a common symptom of systemic lupus erythematosus (SLE). Our objective was to validate the 13-item Functional Assessment of Chronic Illness Therapy (FACIT)-Fatigue scale in patients with SLE...
  68. ncbi request reprint Longitudinal evaluation of the oral mucositis weekly questionnaire-head and neck cancer, a patient-reported outcomes questionnaire
    Joel B Epstein
    Department of Oral Medicine and Diagnostic Sciences, College of Dentistry and Chicago Cancer Center, University of Illinois, Chicago, Illinois 60612, USA
    Cancer 109:1914-22. 2007
    ..The OMWQ-HN is a patient-reported outcome questionnaire that measures the symptoms of mucositis, including mouth and throat soreness (MTS), and their impact on patient well-being and function...
  69. pmc Evaluating the dimensionality of perceived cognitive function
    Jin Shei Lai
    Department of Medical Social Sciences, Feinberg School of Medicine, Northwestern University, Rubloff Bldg, 9th Floor, 750N Lake Shore Dr, Chicago, IL 60611, USA
    J Pain Symptom Manage 37:982-95. 2009
    ..Scoring of PCF based on these two factors should lead to improved assessment of PCF for people with cancer...
  70. ncbi request reprint Issues in the development of an item bank
    Rita K Bode
    Rehabilitation Institute of Chicago, Institute of Health Services Research and Policy Studies, Northwestern University, Chicago, IL 60611, USA
    Arch Phys Med Rehabil 84:S52-60. 2003
    ..To describe and illustrate 2 issues involved in the development of an item bank that can be used to improve measurement across settings and over time...
  71. ncbi request reprint Factor analysis techniques for assessing sufficient unidimensionality of cancer related fatigue
    Jin Shei Lai
    Center on Outcomes, Research and Education, Evanston Northwestern Healthcare and Northwestern University, 1001 University Place, Suite 100, 60201 Evanston, IL, USA corrected
    Qual Life Res 15:1179-90. 2006
    ..We evaluated this question using factor analysis techniques including the theory-driven bi-factor model...
  72. ncbi request reprint Patient-reported outcomes in phase II cancer clinical trials: lessons learned and future directions
    Lynne I Wagner
    Center on Outcomes, Research and Education, Evanston Northwestern Healthcare and the Robert H Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL 60611, USA
    J Clin Oncol 25:5058-62. 2007
    ..These contributions significantly enhance the design of phase III trials, ultimately leading to the efficient utilization of clinical trial resources...
  73. ncbi request reprint Assessment is not enough: a randomized controlled trial of the effects of HRQL assessment on quality of life and satisfaction in oncology clinical practice
    Sarah K Rosenbloom
    Center on Outcomes, Research and Education, Evanston Northwestern Healthcare, Evanston, IL 60201, USA
    Psychooncology 16:1069-79. 2007
    ..It is suggested that positive effects may require supplementing assessment results with specific suggestions for clinical management changes...
  74. doi request reprint Literacy-fair measurement of health-related quality of life will facilitate comparative effectiveness research in Spanish-speaking cancer outpatients
    Elizabeth A Hahn
    Department of Medical Social Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Med Care 48:S75-82. 2010
    ..Appropriately translated and user-friendly HRQL measures are essential to ensure inclusion of low-literate and non-English-speaking patients in comparative effectiveness research...
  75. ncbi request reprint Validation of the functional assessment of cancer therapy--lung symptom index-12 (FLSI-12)
    David T Eton
    Center on Outcomes, Research and Education, Evanston Northwestern Healthcare Research Institute, 1001 University Place, Suite 100, Evanston, IL 60201, USA
    Lung Cancer 57:339-47. 2007
    ..The results show that the FLSI-12 is a psychometrically sound measure and support its use as an endpoint in clinical trials of advanced-stage lung cancer...
  76. ncbi request reprint The health related quality of life outcomes of English and Spanish speaking persons living with HIV/AIDS from the continental United States and Puerto Rico
    Deepa Rao
    Institute for Healthcare Studies, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    AIDS Patient Care STDS 21:339-46. 2007
    ..Women appear to be particularly vulnerable to adverse quality of life impacts in the physical domains, and ethnic minorities appear vulnerable to adverse impacts in the psychosocial domains...
  77. ncbi request reprint Health outcomes assessment in vulnerable populations: measurement challenges and recommendations
    Elizabeth A Hahn
    Evanston Northwestern Healthcare and Institute for Health Services Research and Policy Studies, Northwestern University, Evanston, IL, USA
    Arch Phys Med Rehabil 84:S35-42. 2003
    ..Recommendations for clinical practice and research are offered specifically to address medically underserved and vulnerable populations...
  78. ncbi request reprint Measuring fatigue for children with cancer: development and validation of the pediatric Functional Assessment of Chronic Illness Therapy-Fatigue (pedsFACIT-F)
    Jin Shei Lai
    Center on Outcomes, Research and Education CORE, Evanston Northwestern Healthcare, Evanston, IL 60201, USA
    J Pediatr Hematol Oncol 29:471-9. 2007
    ..The pedsFACIT-F was significantly correlated to the PedsQL Multidimensional Fatigue Scale. In conclusion, the pedsFACIT-F demonstrates satisfactory reliability and validity and can be a useful tool in clinical trials and other research...
  79. ncbi request reprint Methods and progress in assessing the quality of life effects of supportive care with erythropoietin therapy
    Susan Yount
    Center on Outcomes, Research and Education, Evanston Northwestern Healthcare and Northwestern University, Evanston, Illinois 60201, USA
    Curr Opin Hematol 9:234-40. 2002
    ....
  80. ncbi request reprint Measuring spiritual well-being in people with cancer: the functional assessment of chronic illness therapy--Spiritual Well-being Scale (FACIT-Sp)
    Amy H Peterman
    Northwestern University, Center on Outcomes, Research and Education, Center on Outcomes, Research and Education, Evanston, IL 60201, USA
    Ann Behav Med 24:49-58. 2002
    ..Results of the two studies demonstrate that the FACIT-Sp is a psychometrically sound measure of spiritual well-being for people with cancer and other chronic illnesses...
  81. ncbi request reprint Developing a health-related quality of life instrument for childhood brain tumor survivors
    Jin Shei Lai
    Center on Outcomes, Research and Education, Evanston Northwestern Healthcare, 1001 University Place, Suite 100, Evanston, IL 60201, USA
    Childs Nerv Syst 23:47-57. 2007
    ..This paper documents the development of the Pediatric Functional Assessment of Cancer Therapy-Childhood Brain Tumor Survivor (PedsFACT-BrS) for use with survivors for at least 1 year posttreatment...
  82. ncbi request reprint Advances in quality of life measurements in oncology patients
    David Cella
    Center on Outcomes Research and Education, Northwestern University, Evanston Northwestern Healthcare, Evanston, IL 60201, USA
    Semin Oncol 29:60-8. 2002
    ..While the instruments currently available provide reliable and valid measurement, further improvements in precision and application are anticipated...
  83. ncbi request reprint Expansion of a physical function item bank and development of an abbreviated form for clinical research
    Rita K Bode
    Center for Rehabilitation Outcomes Research, Rehabilitation Institute of Chicago Northwestern University, IL 60611, USA
    J Appl Meas 7:1-15. 2006
    ..Future research on this bank will include the development of a CAT version, the PF-CAT...
  84. ncbi request reprint Use of a single-item screening tool to detect clinically significant fatigue, pain, distress, and anorexia in ambulatory cancer practice
    Zeeshan Butt
    Center on Outcomes, Research and Education, Evanston Northwestern Healthcare, Evanston, Illinois, USA
    J Pain Symptom Manage 35:20-30. 2008
    ..In turn, such assessments may improve identification of those at risk of morbidity and decreased quality of life due to excess symptom burden...
  85. doi request reprint Development of a conceptual framework and calibrated item banks to measure patient-reported dyspnea severity and related functional limitations
    Seung W Choi
    Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Value Health 14:291-306. 2011
    ..We developed an item bank for dyspnea severity and related functional limitations on the basis of a PRO conceptual framework derived from patient input...
  86. ncbi request reprint Longitudinal screening and management of fatigue, pain, and emotional distress associated with cancer therapy
    Zeeshan Butt
    Center on Outcomes, Research and Education CORE, Evanston Northwestern Healthcare, Evanston, IL 60201, USA
    Support Care Cancer 16:151-9. 2008
    ..Fatigue, pain, and emotional distress are common symptoms among patients with cancer. We sought to learn about patient perceptions of these symptoms and their treatment...
  87. doi request reprint Comparability of interview- and self-administration of the Functional Assessment of Cancer Therapy-General (FACT-G) in English- and Spanish-speaking ambulatory cancer patients
    Elizabeth A Hahn
    Center on Outcomes, Research and Education CORE, Evanston Northwestern Healthcare, Evanston, Illinois 60201, USA
    Med Care 46:423-31. 2008
    ..Flexibility is important in choosing methods and modes of questionnaire administration, to accommodate the needs of patients with diverse linguistic, cultural, educational, and functional skills...
  88. ncbi request reprint The talking touchscreen: a new approach to outcomes assessment in low literacy
    Elizabeth A Hahn
    Center on Outcomes, Research and Education, Evanston Northwestern Healthcare, Evanston, IL 60201, USA
    Psychooncology 13:86-95. 2004
    ..Outcomes measurement in low literacy patients may provide new insight into problems previously undetected due to the challenges of completing paper-and-pencil forms...
  89. ncbi request reprint Anorexia/cachexia-related quality of life for children with cancer
    Jin Shei Lai
    Center on Outcomes, Research and Education CORE, Evanston Northwestern Healthcare, Evanston, Illinois 60201, USA
    Cancer 104:1531-9. 2005
    ..The purpose of the current article was to test the psychometric properties of a newly developed pediatric Functional Assessment of Anorexia and Cachexia Therapy (peds-FAACT) for children with cancer...
  90. pmc Relative to the general US population, chronic diseases are associated with poorer health-related quality of life as measured by the Patient-Reported Outcomes Measurement Information System (PROMIS)
    Nan E Rothrock
    Department of Medical Social Sciences, Northwestern University, 625N Michigan Ave, Chicago, IL 60611, USA
    J Clin Epidemiol 63:1195-204. 2010
    ..We report on the HRQL impact of individual and comorbid conditions as well as conditions that are described as limiting activity...
  91. ncbi request reprint A combination of distribution- and anchor-based approaches determined minimally important differences (MIDs) for four endpoints in a breast cancer scale
    David T Eton
    Evanston Northwestern Healthcare and Northwestern University, Feinberg School of Medicine, 1001 University Place, Suite 100, Evanston, IL 60201, USA
    J Clin Epidemiol 57:898-910. 2004
    ....
  92. ncbi request reprint Giving meaning to measure: linking self-reported fatigue and function to performance of everyday activities
    Trudy Mallinson
    Rehabilitation Institute of Chicago and Northwestern University, Chicago, Illinois 60611, USA
    J Pain Symptom Manage 31:229-41. 2006
    ..These relationships enable one to begin linking fatigue scores directly to a person's ability to perform everyday activities...
  93. pmc Age-associated differences in fatigue among patients with cancer
    Zeeshan Butt
    Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Pain Symptom Manage 40:217-23. 2010
    ..There has been some suggestion that the fatigue experienced by older cancer patients is more severe than that of younger cohorts; however, there is little empirical evidence to support this claim...
  94. ncbi request reprint Cost-effectiveness analysis of anastrozole versus tamoxifen as primary adjuvant therapy for postmenopausal women with early breast cancer: a US healthcare system perspective. The 5-year completed treatment analysis of the ATAC ('Arimidex', Tamoxifen Alone
    Gershon Y Locker
    Evanston Northwestern Healthcare, 2650 Ridge Room 5134, Evanston, IL 60201, USA
    Breast Cancer Res Treat 106:229-38. 2007
    ..This study evaluated the cost-effectiveness of anastrozole versus generic tamoxifen for primary adjuvant treatment of postmenopausal women with hormone receptor-positive (HR+) early breast cancer (EBC), from a US healthcare perspective...
  95. ncbi request reprint An item bank was created to improve the measurement of cancer-related fatigue
    Jin Shei Lai
    Evanston Northwestern Healthcare, 1001 University Place, 100, Evanston, IL 60201, USA
    J Clin Epidemiol 58:190-7. 2005
    ..A working item bank is essential for development of a CAT platform. The present report describes the building of an operational item bank for use in clinical settings with the ultimate goal of improving CRF identification and treatment...
  96. ncbi request reprint Measuring health-related quality of life and neutropenia-specific concerns among older adults undergoing chemotherapy: validation of the Functional Assessment of Cancer Therapy-Neutropenia (FACT-N)
    Lynne I Wagner
    Center on Outcomes, Research and Education, Evanston Northwestern Healthcare and Northwestern University Feinberg Medical School, 1001 University Place, Evanston, IL 60201, USA
    Support Care Cancer 16:47-56. 2008
    ....
  97. ncbi request reprint A randomized validation study comparing embedded versus extracted FACT Head and Neck Symptom Index scores
    Susan Yount
    Center on Outcomes, Research and Education CORE, Evanston Northwestern Healthcare, Evanston, IL 60201, USA
    Qual Life Res 16:1615-26. 2007
    ..To evaluate the impact of administration context (embedded versus stand-alone) on the reliability and validity of the FACT Head and Neck Symptom Index (FHNSI)...
  98. ncbi request reprint Fatigue is the most important symptom for advanced cancer patients who have had chemotherapy
    Zeeshan Butt
    Center on Outcomes, Research, and Education, Evanston Northwestern Healthcare, Evanston, Illinois 60201, USA
    J Natl Compr Canc Netw 6:448-55. 2008
    ....
  99. pmc Racial/Ethnic differences in the health-related quality of life of cancer patients
    Deepa Rao
    Institute for Healthcare Studies, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Pain Symptom Manage 36:488-96. 2008
    ..Some items appear to be responded to differently by AAs and EAs, suggesting it is important to consider race/ethnicity when evaluating responses to questions about health-related quality of life...
  100. ncbi request reprint Data pooling and analysis to build a preliminary item bank: an example using bowel function in prostate cancer
    David T Eton
    Northwestern University School of Medicine, Evanston, IL 60201, USA
    Eval Health Prof 28:142-59. 2005
    ..A fifth item assessing hemorrhoids was poorly correlated with other items. Our analyses supported four related components of BF: diarrhea, rectal urgency, pain, and bother/distress...
  101. ncbi request reprint General population and cancer patient norms for the Functional Assessment of Cancer Therapy-General (FACT-G)
    Penny S Brucker
    Feinberg School of Medicine at Northwestern University, Evanston, IL 60201, USA
    Eval Health Prof 28:192-211. 2005
    ..S. adult population and (b) a large, heterogeneous sample of adult patients with cancer. In addition, we demonstrate various uses of the normative data...

Research Grants17

  1. NIH PROMIS Statistical Coordinating Center(RMI)
    David Cella; Fiscal Year: 2007
    ..This collaborative effort will ensure the success of the PROMIS initiative. ..
  2. ITEM BANKING AND CAT FOR QUALITY OF LIFE OUTCOMES
    David Cella; Fiscal Year: 2007
    ..We will also monitor treatment/management changes, and evaluate acceptability of computer assessments and the perceived benefits of the recommendations. ..
  3. ITEM BANKING AND CAT FOR QUALITY OF LIFE OUTCOMES
    David Cella; Fiscal Year: 2004
    ..abstract_text> ..