William J Catalona

Summary

Affiliation: Northwestern University
Country: USA

Publications

  1. ncbi request reprint Viewpoint: expanding prostate cancer screening
    William J Catalona
    Northwestern Feinberg School of Medicine, Department of Urology, Chicago, Illinois 60611, USA
    Ann Intern Med 144:441-3. 2006
  2. ncbi request reprint Under diagnosis and over diagnosis of prostate cancer
    Theresa Graif
    Department of Urology, Northwestern Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Urol 178:88-92. 2007
  3. pmc National Cancer Institute Prostate Cancer Genetics Workshop
    William J Catalona
    Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Cancer Res 71:3442-6. 2011
  4. pmc Prostate cancer screening and determining the appropriate prostate-specific antigen cutoff values
    William J Catalona
    Robert H Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Natl Compr Canc Netw 8:265-70. 2010
  5. pmc A multicenter study of [-2]pro-prostate specific antigen combined with prostate specific antigen and free prostate specific antigen for prostate cancer detection in the 2.0 to 10.0 ng/ml prostate specific antigen range
    William J Catalona
    Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Urol 185:1650-5. 2011
  6. ncbi request reprint Prostate specific antigen velocity in men with total prostate specific antigen less than 4 ng/ml
    Stacy Loeb
    Department of Urology, The James Buchanan Brady Urological Institute, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Urol 178:2348-52; discussion 2352-3. 2007
  7. ncbi request reprint Lymphovascular invasion in radical prostatectomy specimens: prediction of adverse pathologic features and biochemical progression
    Stacy Loeb
    Department of Urology, Georgetown University School of Medicine, Washington, DC, USA
    Urology 68:99-103. 2006
  8. doi request reprint Outcomes in patients with Gleason score 8-10 prostate cancer: relation to preoperative PSA level
    Barry B McGuire
    Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    BJU Int 109:1764-9. 2012
  9. doi request reprint Outcomes of radical prostatectomy for patients with clinical stage T1a and T1b disease
    Brian T Helfand
    Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    BJU Int 104:304-9. 2009
  10. pmc Is statin use associated with prostate cancer aggressiveness?
    Stacy Loeb
    Department of Urology, Johns Hopkins School of Medicine, Baltimore, MD, USA
    BJU Int 105:1222-5. 2010

Detail Information

Publications104 found, 100 shown here

  1. ncbi request reprint Viewpoint: expanding prostate cancer screening
    William J Catalona
    Northwestern Feinberg School of Medicine, Department of Urology, Chicago, Illinois 60611, USA
    Ann Intern Med 144:441-3. 2006
    ..They recommend screening for risk assessment for average-risk men beginning at age 40 years, screening selected healthy men older than age 70 years, and lowering the PSA threshold for considering biopsy to 2.5 ng/mL for all men...
  2. ncbi request reprint Under diagnosis and over diagnosis of prostate cancer
    Theresa Graif
    Department of Urology, Northwestern Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Urol 178:88-92. 2007
    ..We quantified the rates of over and under diagnosis of prostate cancer in 2 large patient cohorts during the last 15 years...
  3. pmc National Cancer Institute Prostate Cancer Genetics Workshop
    William J Catalona
    Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Cancer Res 71:3442-6. 2011
    ..The workshop, therefore, included state-of-the-art presentations by experts on new genotyping technologies, including sequencing and associated bioinformatics issues, which are just beginning to be applied to cancer genetics...
  4. pmc Prostate cancer screening and determining the appropriate prostate-specific antigen cutoff values
    William J Catalona
    Robert H Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Natl Compr Canc Netw 8:265-70. 2010
    ..e., treatment or surveillance) are still available in most cases...
  5. pmc A multicenter study of [-2]pro-prostate specific antigen combined with prostate specific antigen and free prostate specific antigen for prostate cancer detection in the 2.0 to 10.0 ng/ml prostate specific antigen range
    William J Catalona
    Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Urol 185:1650-5. 2011
    ....
  6. ncbi request reprint Prostate specific antigen velocity in men with total prostate specific antigen less than 4 ng/ml
    Stacy Loeb
    Department of Urology, The James Buchanan Brady Urological Institute, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Urol 178:2348-52; discussion 2352-3. 2007
    ..However, both of these frequently cited thresholds were determined largely in groups of men with a prostate specific antigen greater than 4 ng/ml...
  7. ncbi request reprint Lymphovascular invasion in radical prostatectomy specimens: prediction of adverse pathologic features and biochemical progression
    Stacy Loeb
    Department of Urology, Georgetown University School of Medicine, Washington, DC, USA
    Urology 68:99-103. 2006
    ..However, limited data are available concerning the relationship between LVI and preoperative screening characteristics, pathologic tumor features, and patient prognosis...
  8. doi request reprint Outcomes in patients with Gleason score 8-10 prostate cancer: relation to preoperative PSA level
    Barry B McGuire
    Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    BJU Int 109:1764-9. 2012
    ..A proportion of these tumours produce little PSA. This study demonstrates that among Gleason 8-10 prostate cancers, some of the worst survival outcomes are associated with the lowest PSA levels...
  9. doi request reprint Outcomes of radical prostatectomy for patients with clinical stage T1a and T1b disease
    Brian T Helfand
    Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    BJU Int 104:304-9. 2009
    ....
  10. pmc Is statin use associated with prostate cancer aggressiveness?
    Stacy Loeb
    Department of Urology, Johns Hopkins School of Medicine, Baltimore, MD, USA
    BJU Int 105:1222-5. 2010
    ....
  11. ncbi request reprint Risk of prostate cancer for young men with a prostate specific antigen less than their age specific median
    Stacy Loeb
    Department of Urology, Georgetown University School of Medicine, Washington, DC, USA
    J Urol 177:1745-8. 2007
    ..Although this suggests the need for close followup of men in their 40s with a prostate specific antigen level greater than 0.7 ng/ml, the appropriate screening strategy for men with a level less than the age specific median is unclear...
  12. ncbi request reprint Contemporary survival results and the role of radiation therapy in patients with node negative seminal vesicle invasion following radical prostatectomy
    Scott E Eggener
    Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    J Urol 173:1150-5. 2005
    ..Seminal vesicle invasion (SVI) in a radical prostatectomy (RRP) specimen is associated with a guarded prognosis. We evaluated patients with SVI treated in the pre-prostate specific antigen (PSA) (1983 to 1991) and PSA (1992 to 2003) eras...
  13. ncbi request reprint Comparison of methods for calculating prostate specific antigen velocity
    XiaoYing Yu
    Department of Urology, Northwestern University, Feinberg School of Medicine, Northwestern Medical Faculty Foundation, 675 N Saint Clair Street, Chicago, IL 60611, USA
    J Urol 176:2427-31; discussion 2431. 2006
    ....
  14. doi request reprint Nuclear factor-kappaB-mediated transforming growth factor-beta-induced expression of vimentin is an independent predictor of biochemical recurrence after radical prostatectomy
    Qiang Zhang
    Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Clin Cancer Res 15:3557-67. 2009
    ..In this study, we elucidated TGF-beta-mediated EMT as a predictor of disease recurrence after therapy for prostate cancer, which has not been reported before...
  15. pmc Correlation between serum prostate-specific antigen and cancer volume in prostate glands of different sizes
    Gustavo F Carvalhal
    Department of Urology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Urology 76:1072-6. 2010
    ..Although early studies showed a strong correlation between PSA and tumor volume, it has been suggested that PSA is no longer a valid marker for prostate cancer and only correlates with prostate size...
  16. ncbi request reprint Characteristics of prostate cancer detected by digital rectal examination only
    Onisuru T Okotie
    Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Urology 70:1117-20. 2007
    ..To examine clinical and pathologic features and postoperative survival outcomes of men with prostate cancer detected by digital rectal examination (DRE) alone, elevated prostate-specific antigen (PSA) level alone, or abnormalities in both...
  17. ncbi request reprint Improved stage and grade-specific progression-free survival rates after radical prostatectomy in the PSA era
    Naresh V Desireddi
    Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    Urology 70:950-5. 2007
    ..Our objective was to examine differences in PFS after radical prostatectomy between the pre-PSA era (before 1992) and the PSA era, controlling for tumor stage and grade...
  18. doi request reprint Prospective multicenter evaluation of the Beckman Coulter Prostate Health Index using WHO calibration
    Stacy Loeb
    Department of Urology, New York University Langone Medical Center, New York, New York, USA
    J Urol 189:1702-6. 2013
    ..The Beckman Coulter® Prostate Health Index and [-2]proPSA are newly approved serum markers associated with prostate cancer risk and aggressiveness. We studied the influence of assay standardization on these markers...
  19. pmc TGF-╬▓ regulates DNA methyltransferase expression in prostate cancer, correlates with aggressive capabilities, and predicts disease recurrence
    Qiang Zhang
    Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America
    PLoS ONE 6:e25168. 2011
    ..The specific mechanisms of DNMT's role in CaP remain undetermined. In this study, we describe the mechanism of TGF-╬▓-mediated DNMT in CaP and its association with clinical outcomes following radical prostatectomy...
  20. doi request reprint PSA velocity is associated with gleason score in radical prostatectomy specimen: marker for prostate cancer aggressiveness
    Stacy Loeb
    Department of Urology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    Urology 72:1116-20; discussion 1120. 2008
    ..To our knowledge, the relationship between preoperative PSAV and Gleason score in the radical prostatectomy specimen has not been formally demonstrated...
  21. ncbi request reprint Intermediate-term potency, continence, and survival outcomes of radical prostatectomy for clinically high-risk or locally advanced prostate cancer
    Stacy Loeb
    Department of Urology, Georgetown University School of Medicine, Washington, DC, USA
    Urology 69:1170-5. 2007
    ..We examined the intermediate-term cancer control and quality-of-life outcomes after radical retropubic prostatectomy (RRP) in selected patients...
  22. ncbi request reprint Use of 2.6 ng/ml prostate specific antigen prompt for biopsy in men older than 60 years
    Robert B Nadler
    Department of Urology, Feinberg School of Medicine, Northwestern University Medical Faculty Foundation, 675 North Saint Clair Street, Chicago, IL 60611, USA
    J Urol 174:2154-7, discussion 2157. 2005
    ..There has been recent investigation into lowering the PSA prompt for biopsy, especially in men younger than 60 years. We determined how a lower cutoff would perform in men older than 60 years...
  23. ncbi request reprint Use of prostate-specific antigen velocity to follow up patients with isolated high-grade prostatic intraepithelial neoplasia on prostate biopsy
    Stacy Loeb
    Department of Urology, Georgetown University School of Medicine, Washington, DC, USA
    Urology 69:108-12. 2007
    ..Thus, our objective was to identify the clinical factors that could help predict which men with isolated HG-PIN were at the greatest risk of subsequent CaP detection...
  24. ncbi request reprint Prostate specific antigen velocity threshold for predicting prostate cancer in young men
    Stacy Loeb
    Department of Urology, Georgetown University School of Medicine, Washington, DC, USA
    J Urol 177:899-902. 2007
    ..Prostate specific antigen velocity 0.75 ng/ml yearly has been proposed to distinguish prostate cancer from benign prostate conditions. However, this threshold might be too high in young men with lower total prostate specific antigen...
  25. doi request reprint Relationship of prostate-specific antigen velocity to histologic findings in a prostate cancer screening program
    Scott E Eggener
    Department of Urology, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Urology 71:1016-9. 2008
    ..We evaluated the relationship of PSAV to histologic findings on biopsy and assessed whether PSAV provides independent predictive information...
  26. ncbi request reprint Does body mass index affect preoperative prostate specific antigen velocity or pathological outcomes after radical prostatectomy?
    Stacy Loeb
    Department of Urology, Georgetown University School of Medicine, Washington, DC, USA
    J Urol 177:102-6; discussion 106. 2007
    ..We examined the associations among obesity, prostate specific antigen velocity and adverse tumor features in men treated with radical prostatectomy...
  27. pmc Preoperative prostate specific antigen doubling time is not a useful predictor of biochemical progression after radical prostatectomy
    Stacy Loeb
    Department of Urology, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Urol 183:1816-21. 2010
    ..Less is known about the usefulness of preoperative prostate specific antigen doubling time for the initial prediction of prostatectomy outcomes...
  28. pmc Genetic prostate cancer risk assessment: common variants in 9 genomic regions are associated with cumulative risk
    Brian T Helfand
    Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    J Urol 184:501-5. 2010
    ..We performed cumulative risk assessment incorporating all 9 genetic variants and determined the relationship of the new variants to clinicopathological tumor features...
  29. ncbi request reprint Delays in cancer detection using 2 and 4-year screening intervals for prostate cancer screening with initial prostate specific antigen less than 2 ng/ml
    Shilajit D Kundu
    Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    J Urol 173:1116-20. 2005
    ....
  30. pmc MEK4 function, genistein treatment, and invasion of human prostate cancer cells
    Li Xu
    Department of Medicine, Robert H Lurie Cancer Center and Center for Drug Discovery and Chemical Biology of Northwestern University, Chicago, IL60610, USA
    J Natl Cancer Inst 101:1141-55. 2009
    ..We investigated the target for genistein in prostate cancer cells...
  31. pmc Prostate cancer risk alleles and their associations with other malignancies
    Phillip R Cooper
    Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
    Urology 78:970.e15-20. 2011
    ..CaP has been associated with other common malignancies. Recently, numerous single nucleotide polymorphisms (SNPs) have been associated with CaP susceptibility...
  32. doi request reprint Combined prostate-specific antigen density and biopsy features to predict "clinically insignificant" prostate cancer
    Stacy Loeb
    Department of Urology, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Urology 72:143-7. 2008
    ..In this study, we examined the ability of PSAD and biopsy features to predict pathologic outcomes in a contemporary RRP population...
  33. pmc Number of prostate cancer risk alleles may identify possibly 'insignificant' disease
    Brian T Helfand
    Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
    BJU Int 106:1602-6. 2010
    ..To determine whether the cumulative effects of five prostate cancer risk alleles (three single-nucleotide polymorphisms [SNPs] on chromosome 8Q24 and two SNPs on chromosome 17a) could help to identify possibly 'insignificant' disease...
  34. pmc Characteristics of prostate cancers detected at prostate specific antigen levels less than 2.5 ng/ml
    Joshua J Meeks
    Department of Urology, Northwestern Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Urol 181:2515-8; discussion 2518-9. 2009
    ..However, limited published data describe the tumor features of prostate cancer detected at low prostate specific antigen levels (less than 2.5 ng/ml)...
  35. ncbi request reprint Baseline prostate-specific antigen compared with median prostate-specific antigen for age group as predictor of prostate cancer risk in men younger than 60 years old
    Stacy Loeb
    Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Urology 67:316-20. 2006
    ..Limited data are available concerning the extent to which the initial prostate-specific antigen (PSA) measurement in men younger than age 60 predicts for the risk of prostate cancer (CaP) and how this compares to other known risk factors...
  36. ncbi request reprint More favorable tumor features and progression-free survival rates in a longitudinal prostate cancer screening study: PSA era and threshold-specific effects
    Thomas L Jang
    Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Urology 67:343-8. 2006
    ....
  37. ncbi request reprint Pathological features after radical prostatectomy in potential candidates for active monitoring
    Christopher R Griffin
    Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Urol 178:860-3; discussion 863. 2007
    ..When counseling patients with low grade prostate cancer about treatment options, it is useful to know the results of surgical treatment in this population...
  38. doi request reprint Long-term rates of undetectable PSA with initial observation and delayed salvage radiotherapy after radical prostatectomy
    Stacy Loeb
    Department of Urology, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    Eur Urol 54:88-94. 2008
    ..Less is known about the relative advantages and disadvantages of initial observation with delayed salvage radiation therapy (SRT)...
  39. doi request reprint Association of prostate cancer risk alleles with unfavourable pathological characteristics in potential candidates for active surveillance
    Barry B McGuire
    Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
    BJU Int 110:338-43. 2012
    ....
  40. doi request reprint Delay of surgery in men with low risk prostate cancer
    Daniel O'Brien
    Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    J Urol 185:2143-7. 2011
    ..We determined the impact of surgical delay on radical prostatectomy outcomes specifically in low risk patients...
  41. doi request reprint Comparison of prostate specific antigen velocity in screened versus referred patients with prostate cancer
    Joshua J Meeks
    Department of Urology, Northwestern Feinberg School of Medicine, Chicago, Illinois, USA
    J Urol 179:1340-3. 2008
    ..We compared the prostate specific antigen velocity profile between patients with prostate cancer in whom the tumor was detected in a formal screening study and those who were referred for treatment...
  42. ncbi request reprint Prostate specific antigen density correlates with features of prostate cancer aggressiveness
    Shilajit D Kundu
    Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Urol 177:505-9. 2007
    ..We tested the association of prostate specific antigen density with features of tumor aggressiveness in a screened and in a nonscreened cohort of patients with clinically localized prostate cancer treated with radical prostatectomy...
  43. ncbi request reprint Prediagnosis prostate specific antigen velocity is associated with risk of prostate cancer progression following brachytherapy and external beam radiation therapy
    Scott E Eggener
    Department of Urology, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    J Urol 176:1399-403. 2006
    ..We evaluated the relationship between prediagnosis prostate specific antigen velocity and cancer progression following primary radiation therapy...
  44. doi request reprint Is the utility of prostate-specific antigen velocity for prostate cancer detection affected by age?
    Stacy Loeb
    Department of Urology, Johns Hopkins School of Medicine, Baltimore, MD, USA
    BJU Int 101:817-21. 2008
    ..To determine whether prostate-specific antigen velocity (PSAV) is useful for prostate cancer detection in men from different age groups, and whether the same PSAV thresholds can reasonably be applied to all men aged >or=40 years...
  45. doi request reprint Tumor characteristics of carriers and noncarriers of the deCODE 8q24 prostate cancer susceptibility alleles
    Brian T Helfand
    Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    J Urol 179:2197-201; discussion 2202. 2008
    ..In this study we examine the differences in clinical and pathological tumor features between carriers and noncarriers of these 8q24 alleles in patients with prostate cancer...
  46. ncbi request reprint The association between total prostate specific antigen concentration and prostate specific antigen velocity
    XiaoYing Yu
    Department of Urology, Northwestern Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Urol 177:1298-302; discussion 1301-2. 2007
    ..Because prostate specific antigen and prostate specific antigen velocity contain much of the same predictive information, our objective was to further examine the relationship between them...
  47. pmc Treatment outcomes of radical prostatectomy in potential candidates for 3 published active surveillance protocols
    C Shad Thaxton
    Department of Urology, Northwestern Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Urology 75:414-8. 2010
    ..AS protocols are designed to spare the potential morbidity of treatment to patients with low-risk prostate cancer (PCa)...
  48. pmc Can prostate specific antigen velocity thresholds decrease insignificant prostate cancer detection?
    Stacy Loeb
    Department of Urology, The Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    J Urol 183:112-6. 2010
    ..Because PSA kinetics were previously linked to prostate cancer specific mortality, we determined whether prostate specific antigen velocity is associated with clinically significant prostate cancer...
  49. ncbi request reprint Pathological characteristics of prostate cancer detected through prostate specific antigen based screening
    Stacy Loeb
    Department of Urology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA
    J Urol 175:902-6. 2006
    ..However, it is uncertain to what extent clinically insignificant tumors are being diagnosed and treated. In a large, community based population we determined the pathological characteristics of screening detected cancers...
  50. pmc Pathological outcomes associated with the 17q prostate cancer risk variants
    Brian T Helfand
    Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Urol 181:2502-7. 2009
    ..Less is known about tumor pathological features in carriers of these variants...
  51. doi request reprint Bacteriuria and antibiotic resistance in catheter urine specimens following radical prostatectomy
    Jessica A Banks
    Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Urol Oncol 31:1049-53. 2013
    ..To determine infectious complications at catheter removal following radical prostatectomy (RP), another setting in daily urological practice where fluoroquinolone prophylaxis is frequently used...
  52. doi request reprint Baseline prostate-specific antigen testing at a young age
    Stacy Loeb
    Department of Urology, New York University School of Medicine, New York, NY, USA
    Eur Urol 61:1-7. 2012
    ..Prostate cancer screening is highly controversial, including the age to begin prostate-specific antigen (PSA) testing. Several studies have evaluated the usefulness of baseline PSA measurements at a young age...
  53. pmc Prostate-specific antigen velocity (PSAV) risk count improves the specificity of screening for clinically significant prostate cancer
    Stacy Loeb
    Department of Urology, New York University School of Medicine, New York, NY, USA
    BJU Int 109:508-13; discussion 513-4. 2012
    ..e. the number of times PSAV exceeds a specific threshold) could increase the specificity of screening for prostate cancer and potentially life-threatening tumours...
  54. pmc [-2]Proenzyme prostate specific antigen is more accurate than total and free prostate specific antigen in differentiating prostate cancer from benign disease in a prospective prostate cancer screening study
    Brian V Le
    Department of Urology, Northwestern University, Chicago, Illinois 60611, USA
    J Urol 183:1355-9. 2010
    ..We examined the usefulness of this isoform in a prospective prostate cancer screening study...
  55. doi request reprint Prostate specific antigen assay standardization bias could affect clinical decision making
    Stacy Loeb
    Department of Urology, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    J Urol 180:1959-62; discussion 1962-3. 2008
    ..Most commercial prostate specific antigen assays are standardized to the WHO 90:10 standard or aligned with the original Hybritech assay with potentially disparate results...
  56. pmc Reducing blood loss in open radical retropubic prostatectomy with prophylactic periprostatic sutures
    Gustavo F Carvalhal
    Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
    BJU Int 105:1650-3. 2010
    ..To determine whether the placement of small-calibre, rapidly absorbed prophylactic periprostatic sutures before the mobilization of the prostate could reduce blood loss during open retropubic radical prostatectomy (RRP)...
  57. pmc Bladder neck contracture after retropubic radical prostatectomy: incidence and risk factors from a large single-surgeon experience
    Bradley A Erickson
    Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    BJU Int 104:1615-9. 2009
    ..To examine a large, single-surgeon series of patients with prostate cancer who underwent retropubic radical prostatectomy (RRP) for men with postoperative bladder neck contractures (BNCs)...
  58. ncbi request reprint Salvage radiation therapy for prostate specific antigen progression following radical prostatectomy: 10-year outcome estimates
    Joseph F Pazona
    Department of Urology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA
    J Urol 174:1282-6. 2005
    ..We evaluated men treated with salvage radiation therapy for increasing serum prostate specific antigen (PSA) following radical retropubic prostatectomy (RRP)...
  59. ncbi request reprint Predictors of subsequent prostate cancer in men with a prostate specific antigen of 2.6 to 4.0 ng/ml and an initially negative biopsy
    Scott E Eggener
    Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Urol 174:500-4. 2005
    ..Deciding whether and when to repeat the biopsy is challenging. We determined if patient specific variables might identify men at increased risk for the subsequent detection of prostate cancer...
  60. pmc Does diabetes mellitus modify the association between 17q12 risk variant and prostate cancer aggressiveness?
    Stacy Loeb
    Department of Urology, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    BJU Int 104:1200-3. 2009
    ..Specifically, we sought to evaluate for effect modification between DM, a newly discovered prostate cancer susceptibility locus on chromosome 17q12 (single nucleotide polymorphism rs4430796) and prostate cancer features...
  61. doi request reprint Prostate cancer diagnosis is associated with an increased risk of erectile dysfunction after prostate biopsy
    Brian T Helfand
    Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
    BJU Int 111:38-43. 2013
    ..To evaluate prospectively the characteristics, erectile function and lower urinary tract symptoms (LUTS) of men undergoing prostate needle biopsy (PNBx)...
  62. ncbi request reprint Should an isolated humeral lesion detected during prostate cancer metastatic survey be biopsied?
    Shilajit D Kundu
    Department of Urology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA
    J Urol 172:1825-6. 2004
  63. ncbi request reprint Prostate-specific antigen and screening for prostate cancer
    Misop Han
    Department of Urology, Feinberg School of Medicine, Northwestern University, 675 North St Clair Street, Suite 20 150, Chicago, IL 60611, USA
    Med Clin North Am 88:245-65, ix. 2004
    ..Topics explored include the history of PSA testing, the biology of PSA, clinical uses of PSA testing, improving the accuracy of PSA testing, and controversies in prostate cancer screening...
  64. doi request reprint Complications of open radical retropubic prostatectomy in potential candidates for active monitoring
    Stacy Loeb
    Department of Urology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    Urology 72:887-91. 2008
    ..To address this issue, we examined the potency, continence and overall complication rates associated with radical prostatectomy (RP), specifically in potential candidates for active monitoring...
  65. ncbi request reprint Accuracy of prostate weight estimation by digital rectal examination versus transrectal ultrasonography
    Stacy Loeb
    Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    J Urol 173:63-5. 2005
    ..We evaluated the relative accuracy of these weight estimates by comparing them to prostate weight following radical retropubic prostatectomy (RRP)...
  66. ncbi request reprint Potency, continence and complications in 3,477 consecutive radical retropubic prostatectomies
    Shilajit D Kundu
    Department of Urology, Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Urol 172:2227-31. 2004
    ..We report results in a series of 3,477 consecutive patients treated with anatomical nerve sparing radical retropubic prostatectomy (RRP) in terms of recovery of erectile function, urinary continence and postoperative complications...
  67. pmc What is the true number needed to screen and treat to save a life with prostate-specific antigen testing?
    Stacy Loeb
    Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, MD, USA
    J Clin Oncol 29:464-7. 2011
    ..Our objective was to re-examine the effect of varying follow-up times on NNS and NNT using data extrapolated from the ERSPC report...
  68. doi request reprint What to do with an abnormal PSA test
    Stacy Loeb
    Department of Urology, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Oncologist 13:299-305. 2008
    ..This review describes the evolution of prostate cancer screening and provides clinical insights into the informed use of PSA and its adjunctive measurements...
  69. pmc Fine-mapping of prostate cancer aggressiveness loci on chromosome 7q22-35
    Xin Liu
    Mary Ann and J Milburn Smith Child Health Research Program, Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    Prostate 71:682-9. 2011
    ..To further clarify this finding and focus on the potentially causative gene, we undertook a fine-mapping study across the 7q22-35 region...
  70. pmc Risk factors for prostate cancer detection after a negative biopsy: a novel multivariable longitudinal approach
    Peter H Gann
    Department of Pathology, University of Illinois at Chicago, Chicago, IL 60612, USA
    J Clin Oncol 28:1714-20. 2010
    ..To introduce a novel approach for the time-dependent quantification of risk factors for prostate cancer (PCa) detection after an initial negative biopsy...
  71. ncbi request reprint Association of hemospermia with prostate cancer
    Misop Han
    Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Urol 172:2189-92. 2004
    ..We studied the incidence of hemospermia and the association between prostate cancer and hemospermia in a large prostate cancer screening population...
  72. ncbi request reprint Prostate cancer screening
    William J Catalona
    Clinical Prostate Cancer Program, Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    BJU Int 94:964-6. 2004
  73. ncbi request reprint Preoperative PSA level significantly associated with interval to biochemical progression after radical retropubic prostatectomy
    Chris M Gonzalez
    Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Urology 64:723-8. 2004
    ..To evaluate the association between the preoperative prostate-specific antigen (PSA) level and the interval to biochemical progression after radical retropubic prostatectomy (RRP) for prostate cancer...
  74. ncbi request reprint Making prostate-specific antigen testing more effective
    William J Catalona
    Department of Urology, Northwestern Feinberg School of Medicine, Chicago, IL, USA
    Urol Oncol 24:177-9. 2006
  75. ncbi request reprint Strategies combining total and percent free prostate specific antigen for detecting prostate cancer: a prospective evaluation
    Peter H Gann
    Department of Preventive Medicine, Robert H Lurie Comprehensive Cancer Center, Northwestern University Medical School, Chicago, Illinois, USA
    J Urol 167:2427-34. 2002
    ....
  76. ncbi request reprint Open radical retropubic prostatectomy
    Stacy Loeb
    Department of Urology, Georgetown University School of Medicine, Washington, D C 20037, USA
    Urol Oncol 25:494-8. 2007
    ..Additional experience with these methods and long-term follow-up data are necessary to determine whether the cancer control and functional outcomes meet the standards of open radical prostatectomy...
  77. ncbi request reprint Counterpoint: the case for immediate active treatment
    Stacy Loeb
    Department of Urology, Georgetown University School of Medicine, Washington, DC, USA
    J Natl Compr Canc Netw 5:699-702. 2007
    ..This article describes the available evidence regarding treatment outcomes in men with low-risk prostate cancer and presents the case for immediate active treatment...
  78. ncbi request reprint Results of compliance with prostate cancer screening guidelines
    Robert L Grubb
    Division of Urology, Washington University School of Medicine, St Louis, Missouri, USA
    J Urol 174:668-72; discussion 672. 2005
    ..We report early outcome data on men who entered a prostate cancer screening study, complied with the screening guidelines and were subsequently diagnosed with prostate cancer...
  79. ncbi request reprint Preoperative PSA velocity and the risk of death from prostate cancer after radical prostatectomy
    Anthony V D'Amico
    Brigham and Women s Hospital and Dana Farber Cancer Institute, Boston, USA
    N Engl J Med 351:125-35. 2004
    ..We evaluated whether men at risk for death from prostate cancer after radical prostatectomy can be identified using information available at diagnosis...
  80. ncbi request reprint Informed consent for prostate-specific antigen screening
    William J Catalona
    Urology 61:17-9. 2003
  81. ncbi request reprint Screening for prostate cancer in high risk populations
    William J Catalona
    Division of Urologic Surgery, Department of Surgery, Washington University School of Medicine, St Louis, Missouri, USA
    J Urol 168:1980-3; discussion 1983-4. 2002
    ..Consequently, screening at a younger age has been recommended for high risk men, however, there are limited data on actual screening results in young, high risk populations...
  82. ncbi request reprint Effect of verification bias on screening for prostate cancer by measurement of prostate-specific antigen
    Rinaa S Punglia
    Joint Center for Radiation Therapy, Harvard Medical School, Boston, USA
    N Engl J Med 349:335-42. 2003
    ..We assessed the screening characteristics of the prostate-specific antigen (PSA) measurement after correction for verification bias...
  83. ncbi request reprint Prostate-specific antigen cutoff of 2.6 ng/mL for prostate cancer screening is associated with favorable pathologic tumor features
    Jason S Krumholtz
    Division of Urologic Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Urology 60:469-73; discussion 473-4. 2002
    ..6 to 4.0-ng/mL PSA range and compare them with Stage T1c cancers concurrently detected in the 4.1 to 10.0-ng/mL PSA range. All cancers were detected in a prostate cancer screening study...
  84. ncbi request reprint Assay standardization bias: different prostate cancer detection rates and clinical outcomes resulting from different assays for free and total prostate-specific antigen
    Rene J Sotelo
    Instituto Medico La Floresta, Cauro Foundation, Caracas, Venezuela
    Urology 69:1143-6. 2007
    ..These assays can be referenced to different laboratory standards, and interassay variability occurs. Patients and physicians might be affected by the variability between PSA assays that results from the use of different PSA standards...
  85. ncbi request reprint Survival results in patients with screen-detected prostate cancer versus physician-referred patients treated with radical prostatectomy: early results
    Kimberly A Roehl
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63105, USA
    Urol Oncol 24:465-71. 2006
    ....
  86. ncbi request reprint Identifying men diagnosed with clinically localized prostate cancer who are at high risk for death from prostate cancer
    Anthony V D'Amico
    Department of Radiation Oncology, Brigham and Women s Hospital and Dana Farber Cancer Institute, 75 Francis Street, Boston, MA 02215, USA
    J Urol 176:S11-5. 2006
    ..We identified factors at diagnosis that are significantly associated with time to prostate cancer specific mortality following radical prostatectomy or external beam radiation therapy...
  87. ncbi request reprint Impact of age, benign prostatic hyperplasia, and cancer on prostate-specific antigen level
    Rinaa S Punglia
    Department of Radiation Oncology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Cancer 106:1507-13. 2006
    ..Correcting for verification bias, the means and variances of PSA values were estimated in specific clinical scenarios...
  88. ncbi request reprint Operating characteristics of prostate-specific antigen and verification bias
    Rinaa S Punglia
    JAMA 294:2698; author reply 2698-9. 2005
  89. ncbi request reprint Intermediate term biochemical progression rates after radical prostatectomy and radiotherapy in patients with screen detected prostate cancer
    Julie M Krygiel
    Waterman Research Solutions, St Louis, Missouri, USA
    J Urol 174:126-30. 2005
    ....
  90. ncbi request reprint Biopsy of men with PSA level of 2.6 to 4.0 ng/mL associated with favorable pathologic features and PSA progression rate: a preliminary analysis
    Hui Zhu
    Division of Urologic Surgery, Washington University School of Medicine, St Louis, Missouri, USA
    Urology 66:547-51. 2005
    ..6 and 4.0 ng/mL than with a PSA level greater than 4 ng/mL. However, it is uncertain whether this will affect clinical outcomes...
  91. ncbi request reprint Proenzyme forms of prostate-specific antigen in serum improve the detection of prostate cancer
    Stephen D Mikolajczyk
    Beckman Coulter, Inc, San Diego, CA, USA
    Clin Chem 50:1017-25. 2004
    ..Immunoassays were developed to measure specific proPSA forms containing propeptides of 2, 4, and 7 amino acids [(-2)proPSA, (-4)proPSA, and (-7)proPSA, respectively]...
  92. ncbi request reprint High-grade prostatic intraepithelial neoplasia in needle biopsy as risk factor for detection of adenocarcinoma: current level of risk in screening population
    Neriman Gokden
    Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    Urology 65:538-42. 2005
    ....
  93. ncbi request reprint Serial biopsy results in prostate cancer screening study
    Kimberly A Roehl
    Division of Urologic Surgery, Department of Surgery, Washington University School of Medicine, St Louis, Missouri, USA
    J Urol 167:2435-9. 2002
    ..We evaluated prostate biopsy results in men with elevated prostate specific antigen (PSA) levels and/or suspicious digital rectal examination whose initial biopsies did not reveal cancer...
  94. ncbi request reprint Robustness of free prostate specific antigen measurements to reduce unnecessary biopsies in the 2.6 to 4.0 ng./ml. range
    Kimberly A Roehl
    Division of Urologic Surgery, Department of Surgery, Washington University School of Medicine, St Louis, Missouri, USA
    J Urol 168:922-5. 2002
    ..ml. to eliminate unnecessary biopsies. There are limited data on the robustness of free PSA measurements in the 2.6 to 4.0 ng./ml. total PSA range...
  95. ncbi request reprint Prostate-specific antigen in clinical practice
    Stacy Loeb
    Department of Urology, Georgetown University School of Medicine, Washington, DC, United States
    Cancer Lett 249:30-9. 2007
    ..5% reduction in the age-adjusted prostate cancer mortality rate through 2003. The history and evidence underlying each of these parameters are reviewed in the following article...
  96. ncbi request reprint Early versus delayed intervention for prostate cancer: the case for early intervention
    Stacy Loeb
    Georgetown University School of Medicine, Washington DC, USA
    Nat Clin Pract Urol 4:348-9. 2007
  97. ncbi request reprint RNASEL Arg462Gln variant is implicated in up to 13% of prostate cancer cases
    Graham Casey
    Department of Cancer Biology, ND50, Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA
    Nat Genet 32:581-3. 2002
    ..Men that are heterozygous with respect to the mutated allele have 50% greater risk of prostate cancer than non-carriers, and homozygotes have more than double the risk...
  98. ncbi request reprint Characteristics of patients with familial versus sporadic prostate cancer
    Kimberly A Roehl
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri, USA
    J Urol 176:2438-42; discussion 2442. 2006
    ....
  99. ncbi request reprint Association between genetic polymorphisms in the prostate-specific antigen gene promoter and serum prostate-specific antigen levels
    Scott D Cramer
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Natl Cancer Inst 95:1044-53. 2003
    ..However, polymorphisms associated with variations in PSA levels have not been identified...
  100. ncbi request reprint Serum pro-prostate specific antigen preferentially detects aggressive prostate cancers in men with 2 to 4 ng/ml prostate specific antigen
    William J Catalona
    Washington University, St Louis, Missouri, USA
    J Urol 171:2239-44. 2004
    ..Pro forms of prostate specific antigen (PSA) have been reported to be more cancer specific markers of prostate cancer than total PSA and they also may preferentially detect the more aggressive forms of the disease...
  101. ncbi request reprint Serum pro prostate specific antigen improves cancer detection compared to free and complexed prostate specific antigen in men with prostate specific antigen 2 to 4 ng/ml
    William J Catalona
    Washington University, St Louis, Missouri, USA
    J Urol 170:2181-5. 2003
    ..Serum pPSA was measured in the clinically relevant early detection PSA range of 2 to 10 ng/ml...