Research Topics
Species | Richard CarthewSummaryAffiliation: Northwestern University Country: USA Publications
Research Grants
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Publications
Gene regulation by microRNAsRichard W Carthew
Department of Biochemistry, Molecular Biology and Cell Biology, 2205 Tech Drive, Northwestern University, Evanston, IL 60208, USA
Curr Opin Genet Dev 16:203-8. 2006..This mechanism is an efficient means to regulate production of a diverse range of proteins...
Origins and Mechanisms of miRNAs and siRNAsRichard W Carthew
Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, 2205 Tech Drive, Evanston, IL 60208 3500, USA
Cell 136:642-55. 2009..Our understanding of siRNA- and miRNA-based regulation has direct implications for fundamental biology as well as disease etiology and treatment...- RNA interference: the fragile X syndrome connectionRichard W Carthew
Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, Illinois 60208, USA
Curr Biol 12:R852-4. 2002..Now FMRP has been found to associate with the RNP complex that mediates post-transcriptional silencing by RNAi... - Pattern formation in the Drosophila eyeRichard W Carthew
Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, 2205 Tech Drive, Evanston, IL 60208, United States
Curr Opin Genet Dev 17:309-13. 2007..This sorting and culling process results in a sculpted pattern with a precise number and position of cells that is repeated hundreds of times in each compound eye... - Molecular biology. A new RNA dimension to genome controlRichard W Carthew
Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, Evanston, IL 60208, USA
Science 313:305-6. 2006 - Adhesion proteins and the control of cell shapeRichard W Carthew
Department of Biochemistry, Molecular Biology and Cell Biology, 2205 Tech Drive, Northwestern University, Evanston, IL 60208, USA
Curr Opin Genet Dev 15:358-63. 2005..Recent insights into adherens junction remodeling have revealed the importance of polarized localization of myosin and Par3 at the adherens junction... - Distinct roles for Drosophila Dicer-1 and Dicer-2 in the siRNA/miRNA silencing pathwaysYoung Sik Lee
Department of Biochemistry, Northwestern University, 2205 Tech Drive, Evanston, IL 60208, USA
Cell 117:69-81. 2004..However, Dicer-1 but not Dicer-2 is essential for miRISC-directed translation repression. Thus, siRISCs and miRISCs are different with respect to Dicers in Drosophila... - RNAi is activated during Drosophila oocyte maturation in a manner dependent on aubergine and spindle-EJason R Kennerdell
Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, Illinois 60208, USA
Genes Dev 16:1884-9. 2002.... - Loqs and R2D2 act sequentially in the siRNA pathway in DrosophilaJoao Trindade Marques
Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, Illinois, USA
Nat Struct Mol Biol 17:24-30. 2010..Loqs is primarily required for dsRNA processing, whereas R2D2 is essential for the subsequent loading of siRNAs into effector Ago-RISC complexes... - A Dicer-2-dependent 80s complex cleaves targeted mRNAs during RNAi in DrosophilaJohn W Pham
Department of Biochemistry, Northwestern University, 2205 Tech Drive, Evanston, IL 60208, USA
Cell 117:83-94. 2004..Dcr-2 does not simply transfer siRNAs to a distinct effector complex, but rather assembles into RISC along with the siRNAs, indicating that its role extends beyond the initiation phase of RNAi... - Silencing by small RNAs is linked to endosomal traffickingYoung Sik Lee
Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, IL 60201, USA
Nat Cell Biol 11:1150-6. 2009..We suggest that the recycling of RISCs is promoted by MVBs, resulting in RISCs more effectively engaging with small RNA effectors and possibly target RNAs. It may provide a means to enhance the dynamics of RNA silencing in the cytoplasm... - A microRNA mediates EGF receptor signaling and promotes photoreceptor differentiation in the Drosophila eyeXin Li
Department of Biochemistry, Molecular Biology and Cell Biology, 2205 Tech Drive, Northwestern University, Evanston, Illinois 60208, USA
Cell 123:1267-77. 2005..Expression is switched when EGFR signaling transiently triggers Yan degradation. This two-tiered mechanism explains how signal transduction activity can robustly generate a stable change in gene-expression patterns... - Physical modeling of cell geometric order in an epithelial tissueSascha Hilgenfeldt
Engineering Sciences and Applied Mathematics, Department of Mechanical Engineering, Northwestern University, Evanston, IL 60208, USA
Proc Natl Acad Sci U S A 105:907-11. 2008.... - Conversion of pre-RISC to holo-RISC by Ago2 during assembly of RNAi complexesKevin Kim
Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, Illinois 60208, USA
RNA 13:22-9. 2007..We have also identified a new intermediate complex in the RISC assembly pathway, pre-RISC, in which Ago2 is stably bound to double-stranded siRNA... - Par-1 kinase establishes cell polarity and functions in Notch signaling in the Drosophila embryoJennifer Bayraktar
Department of Biochemistry, Molecular Biology and Cell Biology, 2205 Tech Drive, Northwestern University, Evanston, IL 60208, USA
J Cell Sci 119:711-21. 2006..Epistasis analysis indicates that Par-1 functions upstream of Notch and is critical for proper localization of the Notch ligand Delta... - Targets of microRNA regulation in the Drosophila oocyte proteomeKenji Nakahara
Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, Evanston, IL 60208, USA
Proc Natl Acad Sci U S A 102:12023-8. 2005..The preponderance of genes that control global protein abundance suggests this process is under tight control by miRNAs at the onset of fertilization... - Silence from within: endogenous siRNAs and miRNAsErik J Sontheimer
Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, 2205 Tech Drive, Evanston, Illinois 60208, USA
Cell 122:9-12. 2005..Bioinformatic analyses indicate that target genes in vertebrate species may number in the thousands... - Surface mechanics mediate pattern formation in the developing retinaTakashi Hayashi
Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, Illinois 60208, USA
Nature 431:647-52. 2004..Thus, simple patterned expression of N-cadherin results in a complex spatial pattern of cells owing to cellular surface mechanics... - Molecular biology. Argonaute journeys into the heart of RISCErik J Sontheimer
Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, Evanston, IL 60208, USA
Science 305:1409-10. 2004 - Phyllopod acts as an adaptor protein to link the sina ubiquitin ligase to the substrate protein tramtrackSonghui Li
Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, Evanston, Illinois 60208, USA
Mol Cell Biol 22:6854-65. 2002..These results illustrate how Ras signaling can modulate an E3 ligase activity not by the phosphorylation of substrate proteins but by regulating the expression of specific E3 adaptors... - Cell-type-specific transcription of prospero is controlled by combinatorial signaling in the Drosophila eyeTakashi Hayashi
Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, 2205 Tech Drive, Evanston, IL 60208, USA
Development 135:2787-96. 2008..The activity level, therefore, is dictated by the proper combination of highly cooperative selector and pre-pattern factors present in the cell... - Lola regulates cell fate by antagonizing Notch induction in the Drosophila eyeLimin Zheng
Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, IL 60208, USA
Mech Dev 125:18-29. 2008..The predicted consequence of this mechanism is to sharpen a cell's responsiveness to Notch signaling by creating a threshold... - Expanding roles for miRNAs and siRNAs in cell regulationKenji Nakahara
Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, Illinois 60208, USA
Curr Opin Cell Biol 16:127-33. 2004..As new microRNAs and their mRNA targets rapidly emerge, it is becoming apparent that RNA-based regulation of mRNAs may rival ubiquitination as a mechanism to control protein levels... - A call to arms: coevolution of animal viruses and host innate immune responsesJoao T Marques
Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, IL 60208, USA
Trends Genet 23:359-64. 2007..We review how RNAi is used as an antiviral strategy and the mechanisms that viruses have evolved to suppress the RNAi response... - A microRNA imparts robustness against environmental fluctuation during developmentXin Li
Department of Biochemistry, Molecular Biology and Cell Biology, 2205 Tech Drive, Northwestern University, Evanston, Illinois 60208, USA
Cell 137:273-82. 2009..We suggest that some conserved microRNAs like miR-7 may enter into novel genetic relationships to buffer developmental programs against variation and impart robustness to diverse regulatory networks... - Making a better RNAi vector for Drosophila: use of intron spacersYoung Sik Lee
Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, 2153 North Campus Drive, Evanston, Illinois 60208, USA
Methods 30:322-9. 2003..Moreover, the presence of the intron spacer greatly enhances the stability of inverted-repeat sequences in bacteria, facilitating the cloning procedure... - BMP signaling goes posttranscriptional in a microRNA sort of wayCatherine A Reinke
Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, Evanston, IL 60208, USA
Dev Cell 15:174-5. 2008..expands our understanding of miRNA biogenesis and maturation, elucidating a mechanism by which extracellular signaling directs cell differentiation via posttranscriptional regulation of miRNA expression... - Cell adhesion and cortex contractility determine cell patterning in the Drosophila retinaJos Käfer
Laboratoire de Spectrometrie Physique, Unite Mixte de Recherche 5588, Université Joseph Fourier Grenoble I and Centre National de la Recherche Scientifique, 140 Avenue de la Physique, 38402 Saint Martin d Heres, France
Proc Natl Acad Sci U S A 104:18549-54. 2007..Furthermore, by changing only the corresponding parameters, this model can describe the mutants with different numbers of cells or changes in cadherin expression... - Functional analysis of dicer-2 missense mutations in the siRNA pathway of DrosophilaDo Hwan Lim
Division of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Anam Dong, Seongbuk gu, Seoul 136 713, South Korea
Biochem Biophys Res Commun 371:525-30. 2008..We also found that the carboxyl-terminal region of R2D2 is essential for Dicer-2 binding. These results provide further insight into the structure-function relationship of Dicer, which plays a critical role in the siRNA pathway... - Chibby, a nuclear beta-catenin-associated antagonist of the Wnt/Wingless pathwayKen Ichi Takemaru
Howard Hughes Medical Institute, Room K536C Health Sciences Building, Campus Box 357750, Department of Pharmacology, and Center for Developmental Biology, University of Washington School of Medicine, Seattle, Washington 98195, USA
Nature 422:905-9. 2003..In addition, epistasis experiments indicate that chibby acts downstream of wingless and upstream of armadillo... 
The birth and death of microRNA genes in DrosophilaJian Lu
Department of Ecology and Evolution, University of Chicago, 1101 East 57th Street, Chicago, Illinois 60637, USA
Nat Genet 40:351-5. 2008..The estimated net gain of long-lived miRNA genes, which is not strongly affected by either the depth or the breadth (number of tissues) of sequencing, is 0.3 genes per Myr in Drosophila...- Making and breaking with nucleases and small RNAsRichard W Carthew
Nat Struct Biol 10:776-7. 2003
Research Grants
- Molecular Mechanisms of Gene Silencing by RNAiRichard Carthew; Fiscal Year: 2006..Moreover, RNAi has been used experimentally to probe gene function and holds promise as a therapeutic model, making its basic understanding an important biomedical research goal. ..
- MicroRNA regulation of biological mechanismsRichard Carthew; Fiscal Year: 2007..The combined effects of microRNAs may affect the expression of many human genes, and misregulation of microRNAs may well underlie complex disease phenomena such as cancer susceptibility and progression. ..
- Molecular Mechanisms of Gene Silencing by RNAiRichard Carthew; Fiscal Year: 2007..Moreover, RNAi has been used experimentally to probe gene function and holds great promise as a therapeutic model, making its basic understanding an important biomedical research goal. ..
- Molecular Mechanisms of Gene Silencing by RNAiRichard Carthew; Fiscal Year: 2007..Moreover, RNAi has been used experimentally to probe gene function and holds great promise as a therapeutic model, making its basic understanding an important biomedical research goal. ..
- MicroRNA regulation of biological mechanismsRichard Carthew; Fiscal Year: 2009..The combined effects of microRNAs may affect the expression of many human genes, and misregulation of microRNAs may well underlie complex disease phenomena such as cancer susceptibility and progression. ..
- Molecular Mechanisms of Gene Silencing by RNAiRichard W Carthew; Fiscal Year: 2010..Moreover, RNAi has been used experimentally to probe gene function and holds great promise as a therapeutic model, making its basic understanding an important biomedical research goal. ..
- PHOTORECEPTOR CELL DEVELOPMENT AND SIGNAL TRANSDUCTIONRichard Carthew; Fiscal Year: 2005..abstract_text> ..
- PHOTORECEPTOR CELL DEVELOPMENT AND SIGNAL TRANSDUCTIONRichard Carthew; Fiscal Year: 1993....
- PHOTORECEPTOR CELL DEVELOPMENT AND SIGNAL TRANSDUCTIONRichard Carthew; Fiscal Year: 2001....
- MicroRNA regulation of biological mechanismsRichard W Carthew; Fiscal Year: 2010..Additionally, microRNAs play important functions during infection by numerous viruses. This project is to understand how microRNAs control gene expression and their natural functions within the body. ..