R K Burt

Summary

Affiliation: Northwestern University
Country: USA

Publications

  1. ncbi request reprint Prevalence and reversibility of pulmonary dysfunction in refractory systemic lupus: improvement correlates with disease remission following hematopoietic stem cell transplantation
    Ann E Traynor
    Division of Hematology Oncology and Bone Marrow Transplantation, University of Massachusetts Memorial Medical Center and Medical School, Worcester, MA, USA
    Chest 127:1680-9. 2005
  2. ncbi request reprint Induction of tolerance in autoimmune diseases by hematopoietic stem cell transplantation: getting closer to a cure?
    Richard K Burt
    Division of Immune Therapy and Autoimmune Disease, Northwestern University Medical Center, 320 E Superior, Searle Bldg Rm 3 489, Chicago, IL 60611, USA
    Blood 99:768-84. 2002
  3. ncbi request reprint Autologous hematopoietic stem cell transplantation in patients with refractory Crohn's disease
    Yu Oyama
    Division of Immunotherapy, Department of Medicine, Northwestern University Medical Center, Chicago, Illinois 60611, USA
    Gastroenterology 128:552-63. 2005
  4. doi request reprint Cardiac involvement and treatment-related mortality after non-myeloablative haemopoietic stem-cell transplantation with unselected autologous peripheral blood for patients with systemic sclerosis: a retrospective analysis
    Richard K Burt
    Division of Immunotherapy, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Lancet 381:1116-24. 2013
  5. doi request reprint Mitotically inactivated embryonic stem cells can be used as an in vivo feeder layer to nurse damaged myocardium after acute myocardial infarction: a preclinical study
    Richard K Burt
    Division of Immunotherapy, Northwestern University, Feinberg School of Medicine, 750 North Lake Shore Dr, Suite 647, Chicago, IL 60611
    Circ Res 111:1286-96. 2012
  6. ncbi request reprint Hematopoietic stem cell transplantation for multiple sclerosis
    Richard K Burt
    Division of Immunotherapy, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Ill 60611, USA
    Arch Neurol 62:860-4. 2005
  7. ncbi request reprint Randomized controlled trials of autologous hematopoietic stem cell transplantation for autoimmune diseases: the evolution from myeloablative to lymphoablative transplant regimens
    Richard K Burt
    Northwestern University Feinberg School of Medicine, Chicago, Illinois 60011, USA
    Arthritis Rheum 54:3750-60. 2006
  8. doi request reprint Clinical applications of blood-derived and marrow-derived stem cells for nonmalignant diseases
    Richard K Burt
    Division of Immunotherapy, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    JAMA 299:925-36. 2008
  9. doi request reprint Autologous non-myeloablative haemopoietic stem cell transplantation in relapsing-remitting multiple sclerosis: a phase I/II study
    Richard K Burt
    Division of Immunotherapy, Department of Medicine, Northwestern University, Chicago, IL 60611, USA
    Lancet Neurol 8:244-53. 2009
  10. ncbi request reprint Hematopoietic stem cell transplantation for progressive multiple sclerosis: failure of a total body irradiation-based conditioning regimen to prevent disease progression in patients with high disability scores
    Richard K Burt
    Department of Neurology, Northwestern University Medical School, Chicago, IL, USA
    Blood 102:2373-8. 2003

Detail Information

Publications59

  1. ncbi request reprint Prevalence and reversibility of pulmonary dysfunction in refractory systemic lupus: improvement correlates with disease remission following hematopoietic stem cell transplantation
    Ann E Traynor
    Division of Hematology Oncology and Bone Marrow Transplantation, University of Massachusetts Memorial Medical Center and Medical School, Worcester, MA, USA
    Chest 127:1680-9. 2005
    ..To report the prevalence and reversibility of pulmonary function test (PFT) abnormalities among systemic lupus erythematosus (SLE) patients, refractory to therapy, undergoing hematopoietic stem cell transplantation (HSCT)...
  2. ncbi request reprint Induction of tolerance in autoimmune diseases by hematopoietic stem cell transplantation: getting closer to a cure?
    Richard K Burt
    Division of Immune Therapy and Autoimmune Disease, Northwestern University Medical Center, 320 E Superior, Searle Bldg Rm 3 489, Chicago, IL 60611, USA
    Blood 99:768-84. 2002
    ..HSCT-induced remission of an autoimmune disease allows for a prospective analysis of events involved in immune tolerance not available in cross-sectional studies...
  3. ncbi request reprint Autologous hematopoietic stem cell transplantation in patients with refractory Crohn's disease
    Yu Oyama
    Division of Immunotherapy, Department of Medicine, Northwestern University Medical Center, Chicago, Illinois 60611, USA
    Gastroenterology 128:552-63. 2005
    ..Due to a high morbidity and/or an increase in mortality in refractory cases, a new treatment approach is needed. In theory, maximum immune ablation by autologous hematopoietic stem cell transplantation (HSCT) can induce a remission...
  4. doi request reprint Cardiac involvement and treatment-related mortality after non-myeloablative haemopoietic stem-cell transplantation with unselected autologous peripheral blood for patients with systemic sclerosis: a retrospective analysis
    Richard K Burt
    Division of Immunotherapy, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Lancet 381:1116-24. 2013
    ..We aimed to assess efficacy of HSCT and use of rigorous cardiac screening in this group...
  5. doi request reprint Mitotically inactivated embryonic stem cells can be used as an in vivo feeder layer to nurse damaged myocardium after acute myocardial infarction: a preclinical study
    Richard K Burt
    Division of Immunotherapy, Northwestern University, Feinberg School of Medicine, 750 North Lake Shore Dr, Suite 647, Chicago, IL 60611
    Circ Res 111:1286-96. 2012
    ..The mechanism(s) of action of iESCs seems to be related to cell-cell exchange, paracrine factors, and a scaffolding effect between iESCs and neighboring host cardiomyocytes...
  6. ncbi request reprint Hematopoietic stem cell transplantation for multiple sclerosis
    Richard K Burt
    Division of Immunotherapy, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Ill 60611, USA
    Arch Neurol 62:860-4. 2005
  7. ncbi request reprint Randomized controlled trials of autologous hematopoietic stem cell transplantation for autoimmune diseases: the evolution from myeloablative to lymphoablative transplant regimens
    Richard K Burt
    Northwestern University Feinberg School of Medicine, Chicago, Illinois 60011, USA
    Arthritis Rheum 54:3750-60. 2006
  8. doi request reprint Clinical applications of blood-derived and marrow-derived stem cells for nonmalignant diseases
    Richard K Burt
    Division of Immunotherapy, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    JAMA 299:925-36. 2008
    ..In contrast, clinical indications for blood-derived (from peripheral or umbilical cord blood) and bone marrow-derived stem cells, which can be easily and safely harvested, are rapidly increasing...
  9. doi request reprint Autologous non-myeloablative haemopoietic stem cell transplantation in relapsing-remitting multiple sclerosis: a phase I/II study
    Richard K Burt
    Division of Immunotherapy, Department of Medicine, Northwestern University, Chicago, IL 60611, USA
    Lancet Neurol 8:244-53. 2009
    ..We evaluated the safety and clinical outcome of autologous non-myeloablative haemopoietic stem cell transplantation in patients with relapsing-remitting multiple sclerosis (MS) who had not responded to treatment with interferon beta...
  10. ncbi request reprint Hematopoietic stem cell transplantation for progressive multiple sclerosis: failure of a total body irradiation-based conditioning regimen to prevent disease progression in patients with high disability scores
    Richard K Burt
    Department of Neurology, Northwestern University Medical School, Chicago, IL, USA
    Blood 102:2373-8. 2003
    ..Specifically, more patients and longer follow-up would be required in patients with an EDSS of 6.0 or less before drawing conclusions on this subgroup...
  11. doi request reprint Autologous peripheral blood CD133+ cell implantation for limb salvage in patients with critical limb ischemia
    R K Burt
    Division of Immunotherapy, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Bone Marrow Transplant 45:111-6. 2010
    ..08). There was a trend towards the improvement in pain-free treadmill walking time (P=0.13) and exercise capacity (P=0.16) at 1 year. Lower extremity limb salvage was achieved for seven of the nine treated patients...
  12. doi request reprint Autologous nonmyeloablative hematopoietic stem cell transplantation in patients with severe anti-TNF refractory Crohn disease: long-term follow-up
    Richard K Burt
    Division of Immunotherapy, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Blood 116:6123-32. 2010
    ..This trial was registered at www.clinicaltrials.gov as NCT0027853...
  13. doi request reprint Autologous non-myeloablative haemopoietic stem-cell transplantation compared with pulse cyclophosphamide once per month for systemic sclerosis (ASSIST): an open-label, randomised phase 2 trial
    Richard K Burt
    Division of Immunotherapy, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Lancet 378:498-506. 2011
    ..We aimed to assess safety and efficacy of autologous non-myeloablative HSCT in a phase 2 trial compared with the standard of care, cyclophosphamide...
  14. doi request reprint Hematopoietic stem cell transplantation for autoimmune diseases: what have we learned?
    Richard K Burt
    Division of Immunotherapy, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    J Autoimmun 30:116-20. 2008
    ..An emphasis will be placed on both the scientific basis for the development of autologous hematopoietic stem cell transplantation and a summary of the data in a variety of human diseases...
  15. doi request reprint Hematopoietic stem cell transplantation for systemic sclerosis: history and current status
    Richard K Burt
    Division of Immunotherapy, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    Curr Opin Rheumatol 23:519-29. 2011
    ..Mortality in severe diffuse disease with internal organ involvement is elevated. Autologous hematopoietic transplantation (HSCT) has emerged in the last decade as a promising disease-modifying treatment...
  16. ncbi request reprint Induction of remission of severe and refractory rheumatoid arthritis by allogeneic mixed chimerism
    Richard K Burt
    Division of Immunotherapy, Northwestern University School of Medicine, Chicago, Illinois 60611, USA
    Arthritis Rheum 50:2466-70. 2004
    ..This is the first published report of allogeneic HSCT performed for the indication of RA. Mixed chimerism has resulted in marked amelioration of RA, without GVHD...
  17. ncbi request reprint Nonmyeloablative hematopoietic stem cell transplantation for systemic lupus erythematosus
    Richard K Burt
    Division of Immunotherapy, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Ill 60611, USA
    JAMA 295:527-35. 2006
    ..Nevertheless, there remains a subset of SLE patients for whom current strategies are insufficient to control disease...
  18. ncbi request reprint Non-myeloablative stem cell transplantation for autoimmune diseases
    Richard K Burt
    Division of Immunotherapy, Northwestern University Feinberg School of Medicine, 320 East Superior, Searle 3 489, Chicago, IL 60611, USA
    Springer Semin Immunopathol 26:57-69. 2004
    ..In addition, for allogeneic hematopoietic stem cell transplantation engraftment of disease resistant donor stem cells will alter the genetic predisposition towards autoimmune disease susceptibility...
  19. ncbi request reprint Autologous hematopoietic stem cell transplantation in systemic lupus erythematosus patients with cardiac dysfunction: feasibility and reversibility of ventricular and valvular dysfunction with transplant-induced remission
    Y Loh
    Division of Immunotherapy, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Bone Marrow Transplant 40:47-53. 2007
    ..Elevated pulmonary pressures paralleled activity of underlying lupus. These data suggest that auto-HSCT is feasible in selected patients with lupus-related cardiac dysfunction, and with control of disease activity, may improve...
  20. ncbi request reprint Allogeneic stem cell transplantation for Evans syndrome
    Y Oyama
    Division of Immune Therapy and Autoimmune Diseases, Northwestern University Medical Center, Chicago, IL, USA
    Bone Marrow Transplant 28:903-5. 2001
    ..Allogeneic HSCT may be the only current curative therapy for Evans syndrome but may also be complicated by significant toxicities...
  21. ncbi request reprint Autologous non-myeloablative haematopoietic stem cell transplantation for refractory systemic vasculitis
    L Statkute
    Division of Immunotherapy, Department of Medicine, Northwestern University Feinberg School of Medicine, 750 N Lake Shore Drive, Suite 649, Chicago, Illinois 60611, USA
    Ann Rheum Dis 67:991-7. 2008
    ..We herein report our single-centre experience in treating four patients with refractory SV employing non-myeloablative autologous haematopoietic stem cell transplantation (HSCT)...
  22. ncbi request reprint Hematopoietic stem cell transplantation for systemic sclerosis with rapid improvement in skin scores: is neoangiogenesis occurring?
    R K Burt
    Department of Medicine, Division of Immunotherapy, Northwestern University Medical Center, 320 East Superior, Searle 3 489, Chicago, IL 60611, USA
    Bone Marrow Transplant 32:S65-7. 2003
    ..Engraftment occurred rapidly (day 8) with minimal unexpected toxicity, no infections, and unexpectedly rapid improvement in the modified Rodnan Skin Score...
  23. ncbi request reprint Allogeneic stem cell transplantation for autoimmune diseases: nonmyeloablative conditioning regimens
    Y Oyama
    Division of Immunotherapy, Northwestern University Medical School, 320 E Superior, 3 489, Chicago, IL 60611, USA
    Bone Marrow Transplant 32:S81-3. 2003
    ....
  24. ncbi request reprint Autologous non-myeloablative hematopoietic stem cell transplantation in patients with systemic sclerosis
    Y Oyama
    Division of Immunotherapy, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
    Bone Marrow Transplant 40:549-55. 2007
    ..Autologous HSCT utilizing a non-myeloablative conditioning regimen appears to result in improved skin flexibility similar to a myeloablative TBI containing regimen, but without the toxicity and risks associated with TBI...
  25. ncbi request reprint High-dose immune suppression and autologous hematopoietic stem cell transplantation in refractory Crohn disease
    Richard K Burt
    Division of Immunotherapy, Northwestern University Medical School, Chicago, IL 60611, USA
    Blood 101:2064-6. 2003
    ..Patients have remained in remission (CDAI < 100) for 1 year since HSCT. We conclude that further HSCT studies for severe Crohn disease appear warranted...
  26. ncbi request reprint Nonmyeloablative autologous hematopoietic stem celltransplantation for refractory CIDP
    Y Oyama
    Department of Medicine, Division of Immunotherapy, Feinberg School of Medicine, Northwestern University, 750 N Lakeshore Dr 649, Chicago, IL 60611, USA
    Neurology 69:1802-3. 2007
  27. ncbi request reprint Mobilization, harvesting and selection of peripheral blood stem cells in patients with autoimmune diseases undergoing autologous hematopoietic stem cell transplantation
    L Statkute
    Division of Immunotherapy, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Bone Marrow Transplant 39:317-29. 2007
    ..When adjusted for CD34(+) cell/kg dose, patients treated with a myeloablative regimen had significantly slower WBC and platelet recovery compared to non-myeloablative regimens...
  28. ncbi request reprint Collection of hematopoietic stem cells from patients with autoimmune diseases
    R K Burt
    Northwestern University Medical Center, Department of Medicine, Chicago, IL 60611-2950, USA
    Bone Marrow Transplant 28:1-12. 2001
    ..Optimization with regard to cell yields and safety are likely to be disease-specific and prospective disease-specific studies of mobilization procedures appear warranted...
  29. ncbi request reprint Hematopoietic stem cell transplantation for severe Crohn's disease
    R M Craig
    Division of Immunotherapy, Northwestern University Medical Center, Chicago, IL 60611, USA
    Bone Marrow Transplant 32:S57-9. 2003
    ..It is suggested that HSCT should be considered a reasonable option for patients who have failed standard CD therapy, although long-term follow-up will be necessary to confirm the duration of the induced clinical remission...
  30. ncbi request reprint Future strategies in hematopoietic stem cell transplantation for rheumatoid arthritis
    R K Burt
    Division of Immunotherapy and Autoimmune Disease, Northwestern University, Chicago, Illinois, USA
    J Rheumatol Suppl 64:42-8. 2001
    ..We propose a new, well tolerated, nonmyeloablative allogeneic stem cell transplant regimen as treatment for RA...
  31. ncbi request reprint Development of a phase III trial of hematopoietic stem cell transplantation for systemic lupus erythematosus
    R K Burt
    Northwestern University Medical Center, Chicago, IL 60611, USA
    Bone Marrow Transplant 32:S49-51. 2003
    ..A phase III HSCT trial is being developed to confirm efficacy of HSCT vs continuing the currently accepted standard of care, intravenous pulse cyclophosphamide...
  32. ncbi request reprint Stem cell transplantation for autoimmune diseases
    Richard K Burt
    Division of Immunotherapy, Northwestern University Feinberg Medical Center, Chicago, IL 60611, USA
    Clin Adv Hematol Oncol 2:313-9. 2004
    ....
  33. ncbi request reprint Engraftment syndrome: a common cause for rash and fever following autologous hematopoietic stem cell transplantation for multiple sclerosis
    Y Oyama
    Division of Immune Therapy and Autoimmune Disease, Northwestern University School of Medicine, Chicago, IL 60611, USA
    Bone Marrow Transplant 29:81-5. 2002
    ..This syndrome occurred in 26% of our series of patients (5/19) undergoing HSCT for multiple sclerosis. The engraftment syndrome is usually self-limited but may require intervention with systemic corticosteroids...
  34. ncbi request reprint Treatment of severe systemic lupus erythematosus with high-dose chemotherapy and haemopoietic stem-cell transplantation: a phase I study
    A E Traynor
    Robert H Lurie Cancer Center, Division of Immunotherapy for Autoimmune Diseases, Northwestern University, Chicago, IL, USA
    Lancet 356:701-7. 2000
    ..We investigated the safety and efficacy of immune suppression and autologous haemopoietic stem-cell infusion to treat such patients...
  35. ncbi request reprint Stem cell therapy for autoimmune disease: overview of concepts from the Snowbird 2002 tolerance and tissue regeneration meeting
    R K Burt
    Northwestern University Medical Center, 320 East Superior, Searle, Room 3 489 Chicago, IL 60611, USA
    Bone Marrow Transplant 32:S3-5. 2003
    ..What follows are general concepts from chairpersons of this meeting...
  36. ncbi request reprint Effect of hematopoietic growth factors on severity of experimental autoimmune encephalomyelitis
    L Verda
    Division of Immunotherapy, Feinberg School of Medicine, Northwestern University Medical Center, Chicago, IL 60611, USA
    Bone Marrow Transplant 38:453-60. 2006
    ..The mechanism of their effects remains unknown: it may be related to both T helper (Th) 1/Th2 skewing and/or homing of inflammatory cells to the disease-affected organ...
  37. ncbi request reprint High-dose therapy and bone marrow transplantation in cutaneous T-cell lymphoma
    Yu Oyama
    Division of Immunotherapy, Department of Medicine, The Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University 320 East Superior, Searle 3 489, Chicago, IL 60611, USA
    Hematol Oncol Clin North Am 17:1475-83, xi. 2003
    ..Allogeneic HSCT, in contrast, provides durable long-term remissions and is currently the only potentially curative therapy...
  38. ncbi request reprint Hematopoietic stem cell transplantation for multiple sclerosis: finding equipoise
    R K Burt
    Northwestern University Medical Center, 320 East Superior, Searle 3 489 Chicago, IL 60611, USA
    Bone Marrow Transplant 32:S45-8. 2003
    ....
  39. ncbi request reprint Herpes simplex thymidine kinase gene-transduced donor lymphocyte infusions
    Richard K Burt
    Northwestern University School of Medicine, Division of Immunotherapy, Chicago, Illinois 60611, USA
    Exp Hematol 31:903-10. 2003
    ..To this end, we also report on a study of whether HSVtk-DLI induces GVHD/GVL and if infusion of GCV allows abrogation of GVHD by selective killing of donor lymphocytes...
  40. pmc Embryonic stem cells as an alternate marrow donor source: engraftment without graft-versus-host disease
    Richard K Burt
    Division of Immunotherapy, Department of Medicine, Feinberg School of Medicine, Northwestern University, 320 East Superior Street, Searle, Room 3 489, Chicago, IL 60611, USA
    J Exp Med 199:895-904. 2004
    ..ESCs might be used as a renewable alternate marrow donor source that reconstitutes hematopoiesis with intact immune responsiveness without GVHD despite crossing MHC barriers...
  41. ncbi request reprint Hematopoietic stem cell transplantation for severe and refractory lupus. Analysis after five years and fifteen patients
    Ann E Traynor
    Northwestern Memorial Hospital and Northwestern University School of Medicine, Chicago, Illinois, USA
    Arthritis Rheum 46:2917-23. 2002
    ..To determine the safety and long-term efficacy of immune ablation and autologous hematopoietic stem cell transplantation (HSCT) in severe systemic lupus erythematosus (SLE)...
  42. ncbi request reprint The promise of hematopoietic stem cell transplantation for autoimmune diseases
    R K Burt
    Northwestern University Department of Medicine, Chicago, IL, USA
    Bone Marrow Transplant 31:521-4. 2003
    ....
  43. ncbi request reprint Development of a secondary autoimmune disorder after hematopoietic stem cell transplantation for autoimmune diseases: role of conditioning regimen used
    Yvonne Loh
    Division of Immunotherapy, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Blood 109:2643-548. 2007
    ..011). In contrast, sex, type of ATG used, and CD34-selection of peripheral blood stem cells were not found to be significantly associated with development of a secondary autoimmune disorder...
  44. pmc Regulatory T cell (Treg) subsets return in patients with refractory lupus following stem cell transplantation, and TGF-beta-producing CD8+ Treg cells are associated with immunological remission of lupus
    Li Zhang
    Division of Rheumatology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    J Immunol 183:6346-58. 2009
    ....
  45. doi request reprint A case of autoimmune-related retinopathy and optic neuropathy syndrome treated by autologous nonmyeloablative hematopoietic stem cell transplantation
    Yu Oyama
    Department of Medicine, Division of Immunotherapy, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    J Neuroophthalmol 29:43-9. 2009
    ..Clinical manifestations appeared to stabilize. This report suggests that autologous HSCT may have a therapeutic role in ARRON syndrome...
  46. ncbi request reprint Hematopoietic stem cell therapy for type 1 diabetes: induction of tolerance and islet cell neogenesis
    Richard K Burt
    Department of Medicine, Northwestern University Medical Center, Chicago, IL 60611, USA
    Autoimmun Rev 1:133-8. 2002
    ..It is possible that HSC may also be able to switch lineage and, therefore, be a convenient source of stem cells for both inducing tolerance and islet cell regeneration...
  47. doi request reprint Autologous hematopoietic stem cell transplantation for childhood autoimmune disease
    Francesca Milanetti
    Division of Immunotherapy, Department of Medicine, Northwestern University Feinberg School of Medicine, 750 North Lake Shore Drive, Chicago, IL 60611, USA
    Pediatr Clin North Am 57:239-71. 2010
    ..This article reviews the experience of using autologous HSCT in treating the most common childhood autoimmune and rheumatic diseases, primarily juvenile idiopathic arthritis, systemic lupus erythematosus, and diabetes mellitus...
  48. ncbi request reprint Ruminating on rheumatoid arthritis and transplantation
    Richard K Burt
    Northwestern University, Feinberg School of Medicine, Chicago, IL 60208, USA
    Clin Immunol 115:129-30. 2005
  49. ncbi request reprint Antiphospholipid syndrome in patients with systemic lupus erythematosus treated by autologous hematopoietic stem cell transplantation
    Laisvyde Statkute
    Division of Immunotherapy, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Blood 106:2700-9. 2005
    ..There was no treatment-related mortality. Autologous HSCT may be performed safely in patients with APS and appears to be effective therapy for eliminating ALPAs and preventing thrombotic complications in patients with SLE...
  50. ncbi request reprint Induction of tolerance in autoimmune diseases by hematopoietic stem cell transplantation: getting closer to a cure?
    Richard K Burt
    Northwestern University Medical Center, Division of Immune Therapy and Autoimmune Disease, Chicago, IL, USA
    Int J Hematol 76:226-47. 2002
    ..HSCT-induced remission of an autoimmune disease allows for a prospective analysis of events involved in immune tolerance not available in cross-sectional studies...
  51. ncbi request reprint Hematopoietic mixed chimerism derived from allogeneic embryonic stem cells prevents autoimmune diabetes mellitus in NOD mice
    Larissa Verda
    Division of Immunotherapy, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    Stem Cells 26:381-6. 2008
    ..ESC-derived HSC can induce an islet cell tolerizing GVA effect without GVHD. This study represents the first instance, to our knowledge, of ESC-derived HSC cells treating disease in an animal model...
  52. pmc SLE - hematopoietic stem cell transplantation for systemic lupus erythematosus
    Richard K Burt
    Division of Immunotherapy, Northwestern University School of Medicine, Chicago, Illinois, USA
    Arthritis Res Ther 5:207-9. 2003
    ..Encouraging responses are raising new hope about the role of adult hematopoietic stem cells in systemic lupus erythematosus...
  53. ncbi request reprint Autologous hematopoietic stem cell transplantation for systemic sclerosis
    Francesca Milanetti
    Division of Immunotherapy, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Curr Stem Cell Res Ther 6:16-28. 2011
    ..The results from these trials should clarify the role of autologous HSCT in the currently limited therapeutic arsenal of severe systemic sclerosis...
  54. pmc The human "Treg MLR": immune monitoring for FOXP3+ T regulatory cell generation
    Josh Levitsky
    Division of Hepatology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Transplantation 88:1303-11. 2009
    ..Controversy exists about the conditions effecting the development of forkhead/winghead helix transcription factor P3 (FOXP3) expressing T cells and their relevance in transplant recipients...
  55. ncbi request reprint Autologous nonmyeloablative hematopoietic stem cell transplantation in newly diagnosed type 1 diabetes mellitus
    Julio C Voltarelli
    Department of Clinical Medicine, School of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Brazil
    JAMA 297:1568-76. 2007
    ..Previous animal and clinical studies suggest that moderate immunosuppression in newly diagnosed type 1 DM can prevent further loss of insulin production and can reduce insulin needs...
  56. pmc Thymic output generates a new and diverse TCR repertoire after autologous stem cell transplantation in multiple sclerosis patients
    Paolo A Muraro
    Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 201:805-16. 2005
    ....
  57. ncbi request reprint Plasticity of hematopoietic stem cells: enough to induce tolerance and repair tissue?
    Richard K Burt
    Arthritis Rheum 46:855-8. 2002
  58. ncbi request reprint Autologous hemopoietic stem cell transplantation in severe rheumatoid arthritis: a report from the EBMT and ABMTR
    John A Snowden
    Department of Rheumatology, Felix Platter Spital, University of Basel, Basel, Switzerland
    J Rheumatol 31:482-8. 2004
    ..To date, published reports have been individual cases or series containing small numbers. This study combined the worldwide experience in a single analysis...
  59. doi request reprint Reversal of new-onset type 1 diabetes in mice by syngeneic bone marrow transplantation
    Yanting Wen
    Department of Hematology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, 321, Zhongshan Road, Nanjing 210008, China
    Biochem Biophys Res Commun 374:282-7. 2008
    ..We conclude that autologous HSCT remission of diabetes is more than transient immune suppression, and is capable of prolonged remission-induction via regeneration of CD4+CD25+FoxP3+ Tregs...