R Burt

Summary

Affiliation: Northwestern University
Country: USA

Publications

  1. ncbi request reprint Autologous hematopoietic stem cell transplantation in patients with refractory Crohn's disease
    Yu Oyama
    Division of Immunotherapy, Department of Medicine, Northwestern University Medical Center, Chicago, Illinois 60611, USA
    Gastroenterology 128:552-63. 2005
  2. ncbi request reprint Hematopoietic stem cell transplantation for cardiac and peripheral vascular disease
    R Burt
    Division of Immunotherapy, Department of Medicine, Northwestern University Medical School, Chicago, IL 60611, USA
    Bone Marrow Transplant 32:S29-31. 2003
  3. pmc Thymic output generates a new and diverse TCR repertoire after autologous stem cell transplantation in multiple sclerosis patients
    Paolo A Muraro
    Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 201:805-16. 2005
  4. ncbi request reprint Hematopoietic stem cell transplantation for multiple sclerosis: finding equipoise
    R K Burt
    Northwestern University Medical Center, 320 East Superior, Searle 3 489 Chicago, IL 60611, USA
    Bone Marrow Transplant 32:S45-8. 2003
  5. pmc SLE - hematopoietic stem cell transplantation for systemic lupus erythematosus
    Richard K Burt
    Division of Immunotherapy, Northwestern University School of Medicine, Chicago, Illinois, USA
    Arthritis Res Ther 5:207-9. 2003
  6. ncbi request reprint Herpes simplex thymidine kinase gene-transduced donor lymphocyte infusions
    Richard K Burt
    Northwestern University School of Medicine, Division of Immunotherapy, Chicago, Illinois 60611, USA
    Exp Hematol 31:903-10. 2003
  7. pmc Embryonic stem cells as an alternate marrow donor source: engraftment without graft-versus-host disease
    Richard K Burt
    Division of Immunotherapy, Department of Medicine, Feinberg School of Medicine, Northwestern University, 320 East Superior Street, Searle, Room 3 489, Chicago, IL 60611, USA
    J Exp Med 199:895-904. 2004
  8. ncbi request reprint High-dose immune suppression and autologous hematopoietic stem cell transplantation in refractory Crohn disease
    Richard K Burt
    Division of Immunotherapy, Northwestern University Medical School, Chicago, IL 60611, USA
    Blood 101:2064-6. 2003
  9. ncbi request reprint Stem cell transplantation for autoimmune diseases
    Richard K Burt
    Division of Immunotherapy, Northwestern University Feinberg Medical Center, Chicago, IL 60611, USA
    Clin Adv Hematol Oncol 2:313-9. 2004
  10. ncbi request reprint Induction of tolerance in autoimmune diseases by hematopoietic stem cell transplantation: getting closer to a cure?
    Richard K Burt
    Division of Immune Therapy and Autoimmune Disease, Northwestern University Medical Center, 320 E Superior, Searle Bldg Rm 3 489, Chicago, IL 60611, USA
    Blood 99:768-84. 2002

Collaborators

Detail Information

Publications34

  1. ncbi request reprint Autologous hematopoietic stem cell transplantation in patients with refractory Crohn's disease
    Yu Oyama
    Division of Immunotherapy, Department of Medicine, Northwestern University Medical Center, Chicago, Illinois 60611, USA
    Gastroenterology 128:552-63. 2005
    ..Due to a high morbidity and/or an increase in mortality in refractory cases, a new treatment approach is needed. In theory, maximum immune ablation by autologous hematopoietic stem cell transplantation (HSCT) can induce a remission...
  2. ncbi request reprint Hematopoietic stem cell transplantation for cardiac and peripheral vascular disease
    R Burt
    Division of Immunotherapy, Department of Medicine, Northwestern University Medical School, Chicago, IL 60611, USA
    Bone Marrow Transplant 32:S29-31. 2003
    ....
  3. pmc Thymic output generates a new and diverse TCR repertoire after autologous stem cell transplantation in multiple sclerosis patients
    Paolo A Muraro
    Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 201:805-16. 2005
    ....
  4. ncbi request reprint Hematopoietic stem cell transplantation for multiple sclerosis: finding equipoise
    R K Burt
    Northwestern University Medical Center, 320 East Superior, Searle 3 489 Chicago, IL 60611, USA
    Bone Marrow Transplant 32:S45-8. 2003
    ....
  5. pmc SLE - hematopoietic stem cell transplantation for systemic lupus erythematosus
    Richard K Burt
    Division of Immunotherapy, Northwestern University School of Medicine, Chicago, Illinois, USA
    Arthritis Res Ther 5:207-9. 2003
    ..Encouraging responses are raising new hope about the role of adult hematopoietic stem cells in systemic lupus erythematosus...
  6. ncbi request reprint Herpes simplex thymidine kinase gene-transduced donor lymphocyte infusions
    Richard K Burt
    Northwestern University School of Medicine, Division of Immunotherapy, Chicago, Illinois 60611, USA
    Exp Hematol 31:903-10. 2003
    ..To this end, we also report on a study of whether HSVtk-DLI induces GVHD/GVL and if infusion of GCV allows abrogation of GVHD by selective killing of donor lymphocytes...
  7. pmc Embryonic stem cells as an alternate marrow donor source: engraftment without graft-versus-host disease
    Richard K Burt
    Division of Immunotherapy, Department of Medicine, Feinberg School of Medicine, Northwestern University, 320 East Superior Street, Searle, Room 3 489, Chicago, IL 60611, USA
    J Exp Med 199:895-904. 2004
    ..ESCs might be used as a renewable alternate marrow donor source that reconstitutes hematopoiesis with intact immune responsiveness without GVHD despite crossing MHC barriers...
  8. ncbi request reprint High-dose immune suppression and autologous hematopoietic stem cell transplantation in refractory Crohn disease
    Richard K Burt
    Division of Immunotherapy, Northwestern University Medical School, Chicago, IL 60611, USA
    Blood 101:2064-6. 2003
    ..Patients have remained in remission (CDAI < 100) for 1 year since HSCT. We conclude that further HSCT studies for severe Crohn disease appear warranted...
  9. ncbi request reprint Stem cell transplantation for autoimmune diseases
    Richard K Burt
    Division of Immunotherapy, Northwestern University Feinberg Medical Center, Chicago, IL 60611, USA
    Clin Adv Hematol Oncol 2:313-9. 2004
    ....
  10. ncbi request reprint Induction of tolerance in autoimmune diseases by hematopoietic stem cell transplantation: getting closer to a cure?
    Richard K Burt
    Division of Immune Therapy and Autoimmune Disease, Northwestern University Medical Center, 320 E Superior, Searle Bldg Rm 3 489, Chicago, IL 60611, USA
    Blood 99:768-84. 2002
    ..HSCT-induced remission of an autoimmune disease allows for a prospective analysis of events involved in immune tolerance not available in cross-sectional studies...
  11. ncbi request reprint Future strategies in hematopoietic stem cell transplantation for rheumatoid arthritis
    R K Burt
    Division of Immunotherapy and Autoimmune Disease, Northwestern University, Chicago, Illinois, USA
    J Rheumatol Suppl 64:42-8. 2001
    ..We propose a new, well tolerated, nonmyeloablative allogeneic stem cell transplant regimen as treatment for RA...
  12. ncbi request reprint Stem cell therapy for autoimmune disease: overview of concepts from the Snowbird 2002 tolerance and tissue regeneration meeting
    R K Burt
    Northwestern University Medical Center, 320 East Superior, Searle, Room 3 489 Chicago, IL 60611, USA
    Bone Marrow Transplant 32:S3-5. 2003
    ..What follows are general concepts from chairpersons of this meeting...
  13. ncbi request reprint CD34(+) cell collection efficiency does not correlate with the pre-leukapheresis hematocrit
    J Mehta
    The Hematopoietic Stem Cell Transplant Program, Division of Hematology/Oncology, Department of Internal Medicine, Northwestern University Medical School and The Robert H Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL 60611, USA
    Bone Marrow Transplant 28:597-601. 2001
    ..60; P < 10(-6)). We conclude that the minimum acceptable Hct or hemoglobin level for leukapheresis should be dictated by clinical circumstances because it does not affect stem cell collection...
  14. ncbi request reprint Randomized controlled trials of autologous hematopoietic stem cell transplantation for autoimmune diseases: the evolution from myeloablative to lymphoablative transplant regimens
    Richard K Burt
    Northwestern University Feinberg School of Medicine, Chicago, Illinois 60011, USA
    Arthritis Rheum 54:3750-60. 2006
  15. ncbi request reprint Autologous nonmyeloablative hematopoietic stem cell transplantation in newly diagnosed type 1 diabetes mellitus
    Julio C Voltarelli
    Department of Clinical Medicine, School of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Brazil
    JAMA 297:1568-76. 2007
    ..Previous animal and clinical studies suggest that moderate immunosuppression in newly diagnosed type 1 DM can prevent further loss of insulin production and can reduce insulin needs...
  16. ncbi request reprint Hematopoietic mixed chimerism derived from allogeneic embryonic stem cells prevents autoimmune diabetes mellitus in NOD mice
    Larissa Verda
    Division of Immunotherapy, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    Stem Cells 26:381-6. 2008
    ..ESC-derived HSC can induce an islet cell tolerizing GVA effect without GVHD. This study represents the first instance, to our knowledge, of ESC-derived HSC cells treating disease in an animal model...
  17. ncbi request reprint Development of a secondary autoimmune disorder after hematopoietic stem cell transplantation for autoimmune diseases: role of conditioning regimen used
    Yvonne Loh
    Division of Immunotherapy, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Blood 109:2643-548. 2007
    ..011). In contrast, sex, type of ATG used, and CD34-selection of peripheral blood stem cells were not found to be significantly associated with development of a secondary autoimmune disorder...
  18. ncbi request reprint Nonmyeloablative hematopoietic stem cell transplantation for systemic lupus erythematosus
    Richard K Burt
    Division of Immunotherapy, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Ill 60611, USA
    JAMA 295:527-35. 2006
    ..Nevertheless, there remains a subset of SLE patients for whom current strategies are insufficient to control disease...
  19. doi request reprint Hematopoietic stem cell transplantation for autoimmune diseases: what have we learned?
    Richard K Burt
    Division of Immunotherapy, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    J Autoimmun 30:116-20. 2008
    ..An emphasis will be placed on both the scientific basis for the development of autologous hematopoietic stem cell transplantation and a summary of the data in a variety of human diseases...
  20. ncbi request reprint Clinical applications of blood-derived and marrow-derived stem cells for nonmalignant diseases
    Richard K Burt
    Division of Immunotherapy, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    JAMA 299:925-36. 2008
    ..In contrast, clinical indications for blood-derived (from peripheral or umbilical cord blood) and bone marrow-derived stem cells, which can be easily and safely harvested, are rapidly increasing...
  21. ncbi request reprint Prevalence and reversibility of pulmonary dysfunction in refractory systemic lupus: improvement correlates with disease remission following hematopoietic stem cell transplantation
    Ann E Traynor
    Division of Hematology Oncology and Bone Marrow Transplantation, University of Massachusetts Memorial Medical Center and Medical School, Worcester, MA, USA
    Chest 127:1680-9. 2005
    ..To report the prevalence and reversibility of pulmonary function test (PFT) abnormalities among systemic lupus erythematosus (SLE) patients, refractory to therapy, undergoing hematopoietic stem cell transplantation (HSCT)...
  22. ncbi request reprint Plasticity of hematopoietic stem cells: enough to induce tolerance and repair tissue?
    Richard K Burt
    Arthritis Rheum 46:855-8. 2002
  23. ncbi request reprint Hematopoietic stem cell transplantation for severe and refractory lupus. Analysis after five years and fifteen patients
    Ann E Traynor
    Northwestern Memorial Hospital and Northwestern University School of Medicine, Chicago, Illinois, USA
    Arthritis Rheum 46:2917-23. 2002
    ..To determine the safety and long-term efficacy of immune ablation and autologous hematopoietic stem cell transplantation (HSCT) in severe systemic lupus erythematosus (SLE)...
  24. ncbi request reprint Induction of tolerance in autoimmune diseases by hematopoietic stem cell transplantation: getting closer to a cure?
    Richard K Burt
    Northwestern University Medical Center, Division of Immune Therapy and Autoimmune Disease, Chicago, IL, USA
    Int J Hematol 76:226-47. 2002
    ..HSCT-induced remission of an autoimmune disease allows for a prospective analysis of events involved in immune tolerance not available in cross-sectional studies...
  25. ncbi request reprint Hematopoietic stem cell transplantation for progressive multiple sclerosis: failure of a total body irradiation-based conditioning regimen to prevent disease progression in patients with high disability scores
    Richard K Burt
    Department of Neurology, Northwestern University Medical School, Chicago, IL, USA
    Blood 102:2373-8. 2003
    ..Specifically, more patients and longer follow-up would be required in patients with an EDSS of 6.0 or less before drawing conclusions on this subgroup...
  26. ncbi request reprint Hematopoietic stem cell therapy for type 1 diabetes: induction of tolerance and islet cell neogenesis
    Richard K Burt
    Department of Medicine, Northwestern University Medical Center, Chicago, IL 60611, USA
    Autoimmun Rev 1:133-8. 2002
    ..It is possible that HSC may also be able to switch lineage and, therefore, be a convenient source of stem cells for both inducing tolerance and islet cell regeneration...
  27. ncbi request reprint High-dose therapy and bone marrow transplantation in cutaneous T-cell lymphoma
    Yu Oyama
    Division of Immunotherapy, Department of Medicine, The Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University 320 East Superior, Searle 3 489, Chicago, IL 60611, USA
    Hematol Oncol Clin North Am 17:1475-83, xi. 2003
    ..Allogeneic HSCT, in contrast, provides durable long-term remissions and is currently the only potentially curative therapy...
  28. ncbi request reprint Autologous hemopoietic stem cell transplantation in severe rheumatoid arthritis: a report from the EBMT and ABMTR
    John A Snowden
    Department of Rheumatology, Felix Platter Spital, University of Basel, Basel, Switzerland
    J Rheumatol 31:482-8. 2004
    ..To date, published reports have been individual cases or series containing small numbers. This study combined the worldwide experience in a single analysis...
  29. ncbi request reprint Induction of remission of severe and refractory rheumatoid arthritis by allogeneic mixed chimerism
    Richard K Burt
    Division of Immunotherapy, Northwestern University School of Medicine, Chicago, Illinois 60611, USA
    Arthritis Rheum 50:2466-70. 2004
    ..This is the first published report of allogeneic HSCT performed for the indication of RA. Mixed chimerism has resulted in marked amelioration of RA, without GVHD...
  30. ncbi request reprint Non-myeloablative stem cell transplantation for autoimmune diseases
    Richard K Burt
    Division of Immunotherapy, Northwestern University Feinberg School of Medicine, 320 East Superior, Searle 3 489, Chicago, IL 60611, USA
    Springer Semin Immunopathol 26:57-69. 2004
    ..In addition, for allogeneic hematopoietic stem cell transplantation engraftment of disease resistant donor stem cells will alter the genetic predisposition towards autoimmune disease susceptibility...
  31. ncbi request reprint Hematopoietic stem cell transplantation for multiple sclerosis
    Richard K Burt
    Division of Immunotherapy, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Ill 60611, USA
    Arch Neurol 62:860-4. 2005
  32. ncbi request reprint Ruminating on rheumatoid arthritis and transplantation
    Richard K Burt
    Northwestern University, Feinberg School of Medicine, Chicago, IL 60208, USA
    Clin Immunol 115:129-30. 2005
  33. ncbi request reprint Antiphospholipid syndrome in patients with systemic lupus erythematosus treated by autologous hematopoietic stem cell transplantation
    Laisvyde Statkute
    Division of Immunotherapy, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Blood 106:2700-9. 2005
    ..There was no treatment-related mortality. Autologous HSCT may be performed safely in patients with APS and appears to be effective therapy for eliminating ALPAs and preventing thrombotic complications in patients with SLE...
  34. ncbi request reprint Reversal of new-onset type 1 diabetes in mice by syngeneic bone marrow transplantation
    Yanting Wen
    Department of Hematology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, 321, Zhongshan Road, Nanjing 210008, China
    Biochem Biophys Res Commun 374:282-7. 2008
    ..We conclude that autologous HSCT remission of diabetes is more than transient immune suppression, and is capable of prolonged remission-induction via regeneration of CD4+CD25+FoxP3+ Tregs...