Research Topics
| R BurtSummaryAffiliation: Northwestern University Country: USA Publications
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Detail Information
Publications
Thymic output generates a new and diverse TCR repertoire after autologous stem cell transplantation in multiple sclerosis patientsPaolo A Muraro
Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
J Exp Med 201:805-16. 2005....
Autologous hematopoietic stem cell transplantation in patients with refractory Crohn's diseaseYu Oyama
Division of Immunotherapy, Department of Medicine, Northwestern University Medical Center, Chicago, Illinois 60611, USA
Gastroenterology 128:552-63. 2005..Due to a high morbidity and/or an increase in mortality in refractory cases, a new treatment approach is needed. In theory, maximum immune ablation by autologous hematopoietic stem cell transplantation (HSCT) can induce a remission...- Hematopoietic stem cell transplantation for cardiac and peripheral vascular diseaseR Burt
Division of Immunotherapy, Department of Medicine, Northwestern University Medical School, Chicago, IL 60611, USA
Bone Marrow Transplant 32:S29-31. 2003.... - Hematopoietic stem cell transplantation for multiple sclerosis: finding equipoiseR K Burt
Northwestern University Medical Center, 320 East Superior, Searle 3 489 Chicago, IL 60611, USA
Bone Marrow Transplant 32:S45-8. 2003.... - SLE - hematopoietic stem cell transplantation for systemic lupus erythematosusRichard K Burt
Division of Immunotherapy, Northwestern University School of Medicine, Chicago, Illinois, USA
Arthritis Res Ther 5:207-9. 2003..Encouraging responses are raising new hope about the role of adult hematopoietic stem cells in systemic lupus erythematosus... - Herpes simplex thymidine kinase gene-transduced donor lymphocyte infusionsRichard K Burt
Northwestern University School of Medicine, Division of Immunotherapy, Chicago, Illinois 60611, USA
Exp Hematol 31:903-10. 2003..To this end, we also report on a study of whether HSVtk-DLI induces GVHD/GVL and if infusion of GCV allows abrogation of GVHD by selective killing of donor lymphocytes... - Embryonic stem cells as an alternate marrow donor source: engraftment without graft-versus-host diseaseRichard K Burt
Division of Immunotherapy, Department of Medicine, Feinberg School of Medicine, Northwestern University, 320 East Superior Street, Searle, Room 3 489, Chicago, IL 60611, USA
J Exp Med 199:895-904. 2004..ESCs might be used as a renewable alternate marrow donor source that reconstitutes hematopoiesis with intact immune responsiveness without GVHD despite crossing MHC barriers... - High-dose immune suppression and autologous hematopoietic stem cell transplantation in refractory Crohn diseaseRichard K Burt
Division of Immunotherapy, Northwestern University Medical School, Chicago, IL 60611, USA
Blood 101:2064-6. 2003..Patients have remained in remission (CDAI < 100) for 1 year since HSCT. We conclude that further HSCT studies for severe Crohn disease appear warranted... - Stem cell transplantation for autoimmune diseasesRichard K Burt
Division of Immunotherapy, Northwestern University Feinberg Medical Center, Chicago, IL 60611, USA
Clin Adv Hematol Oncol 2:313-9. 2004.... - Induction of tolerance in autoimmune diseases by hematopoietic stem cell transplantation: getting closer to a cure?Richard K Burt
Division of Immune Therapy and Autoimmune Disease, Northwestern University Medical Center, 320 E Superior, Searle Bldg Rm 3 489, Chicago, IL 60611, USA
Blood 99:768-84. 2002..HSCT-induced remission of an autoimmune disease allows for a prospective analysis of events involved in immune tolerance not available in cross-sectional studies... - Future strategies in hematopoietic stem cell transplantation for rheumatoid arthritisR K Burt
Division of Immunotherapy and Autoimmune Disease, Northwestern University, Chicago, Illinois, USA
J Rheumatol Suppl 64:42-8. 2001..We propose a new, well tolerated, nonmyeloablative allogeneic stem cell transplant regimen as treatment for RA... - Stem cell therapy for autoimmune disease: overview of concepts from the Snowbird 2002 tolerance and tissue regeneration meetingR K Burt
Northwestern University Medical Center, 320 East Superior, Searle, Room 3 489 Chicago, IL 60611, USA
Bone Marrow Transplant 32:S3-5. 2003..What follows are general concepts from chairpersons of this meeting... - CD34(+) cell collection efficiency does not correlate with the pre-leukapheresis hematocritJ Mehta
The Hematopoietic Stem Cell Transplant Program, Division of Hematology/Oncology, Department of Internal Medicine, Northwestern University Medical School and The Robert H Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL 60611, USA
Bone Marrow Transplant 28:597-601. 2001..60; P < 10(-6)). We conclude that the minimum acceptable Hct or hemoglobin level for leukapheresis should be dictated by clinical circumstances because it does not affect stem cell collection... - Randomized controlled trials of autologous hematopoietic stem cell transplantation for autoimmune diseases: the evolution from myeloablative to lymphoablative transplant regimensRichard K Burt
Northwestern University Feinberg School of Medicine, Chicago, Illinois 60011, USA
Arthritis Rheum 54:3750-60. 2006 - Autologous nonmyeloablative hematopoietic stem cell transplantation in newly diagnosed type 1 diabetes mellitusJulio C Voltarelli
Department of Clinical Medicine, School of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Brazil
JAMA 297:1568-76. 2007..Previous animal and clinical studies suggest that moderate immunosuppression in newly diagnosed type 1 DM can prevent further loss of insulin production and can reduce insulin needs... - Hematopoietic mixed chimerism derived from allogeneic embryonic stem cells prevents autoimmune diabetes mellitus in NOD miceLarissa Verda
Division of Immunotherapy, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
Stem Cells 26:381-6. 2008..ESC-derived HSC can induce an islet cell tolerizing GVA effect without GVHD. This study represents the first instance, to our knowledge, of ESC-derived HSC cells treating disease in an animal model... - Development of a secondary autoimmune disorder after hematopoietic stem cell transplantation for autoimmune diseases: role of conditioning regimen usedYvonne Loh
Division of Immunotherapy, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
Blood 109:2643-548. 2007..011). In contrast, sex, type of ATG used, and CD34-selection of peripheral blood stem cells were not found to be significantly associated with development of a secondary autoimmune disorder... - Nonmyeloablative hematopoietic stem cell transplantation for systemic lupus erythematosusRichard K Burt
Division of Immunotherapy, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Ill 60611, USA
JAMA 295:527-35. 2006..Nevertheless, there remains a subset of SLE patients for whom current strategies are insufficient to control disease... 
Hematopoietic stem cell transplantation for autoimmune diseases: what have we learned?Richard K Burt
Division of Immunotherapy, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
J Autoimmun 30:116-20. 2008..An emphasis will be placed on both the scientific basis for the development of autologous hematopoietic stem cell transplantation and a summary of the data in a variety of human diseases...- Clinical applications of blood-derived and marrow-derived stem cells for nonmalignant diseasesRichard K Burt
Division of Immunotherapy, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
JAMA 299:925-36. 2008..In contrast, clinical indications for blood-derived (from peripheral or umbilical cord blood) and bone marrow-derived stem cells, which can be easily and safely harvested, are rapidly increasing... - Prevalence and reversibility of pulmonary dysfunction in refractory systemic lupus: improvement correlates with disease remission following hematopoietic stem cell transplantationAnn E Traynor
Division of Hematology Oncology and Bone Marrow Transplantation, University of Massachusetts Memorial Medical Center and Medical School, Worcester, MA, USA
Chest 127:1680-9. 2005..To report the prevalence and reversibility of pulmonary function test (PFT) abnormalities among systemic lupus erythematosus (SLE) patients, refractory to therapy, undergoing hematopoietic stem cell transplantation (HSCT)... - Plasticity of hematopoietic stem cells: enough to induce tolerance and repair tissue?Richard K Burt
Arthritis Rheum 46:855-8. 2002 - Hematopoietic stem cell transplantation for severe and refractory lupus. Analysis after five years and fifteen patientsAnn E Traynor
Northwestern Memorial Hospital and Northwestern University School of Medicine, Chicago, Illinois, USA
Arthritis Rheum 46:2917-23. 2002..A phase III randomized trial is warranted to determine the relative efficacy and durability of remission of HSCT compared with standard therapies... - Induction of tolerance in autoimmune diseases by hematopoietic stem cell transplantation: getting closer to a cure?Richard K Burt
Northwestern University Medical Center, Division of Immune Therapy and Autoimmune Disease, Chicago, IL, USA
Int J Hematol 76:226-47. 2002..HSCT-induced remission of an autoimmune disease allows for a prospective analysis of events involved in immune tolerance not available in cross-sectional studies... - Hematopoietic stem cell transplantation for progressive multiple sclerosis: failure of a total body irradiation-based conditioning regimen to prevent disease progression in patients with high disability scoresRichard K Burt
Department of Neurology, Northwestern University Medical School, Chicago, IL, USA
Blood 102:2373-8. 2003..Specifically, more patients and longer follow-up would be required in patients with an EDSS of 6.0 or less before drawing conclusions on this subgroup... - Hematopoietic stem cell therapy for type 1 diabetes: induction of tolerance and islet cell neogenesisRichard K Burt
Department of Medicine, Northwestern University Medical Center, Chicago, IL 60611, USA
Autoimmun Rev 1:133-8. 2002..It is possible that HSC may also be able to switch lineage and, therefore, be a convenient source of stem cells for both inducing tolerance and islet cell regeneration... - High-dose therapy and bone marrow transplantation in cutaneous T-cell lymphomaYu Oyama
Division of Immunotherapy, Department of Medicine, The Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University 320 East Superior, Searle 3 489, Chicago, IL 60611, USA
Hematol Oncol Clin North Am 17:1475-83, xi. 2003..Allogeneic HSCT, in contrast, provides durable long-term remissions and is currently the only potentially curative therapy... - Autologous hemopoietic stem cell transplantation in severe rheumatoid arthritis: a report from the EBMT and ABMTRJohn A Snowden
Department of Rheumatology, Felix-Platter-Spital, University of Basel, Basel, Switzerland
J Rheumatol 31:482-8. 2004..Clinical trials are necessary to develop this approach in patients with aggressive disease who have failed conventional treatment including anti-tumor necrosis factor agents... - Induction of remission of severe and refractory rheumatoid arthritis by allogeneic mixed chimerismRichard K Burt
Division of Immunotherapy, Northwestern University School of Medicine, Chicago, Illinois 60611, USA
Arthritis Rheum 50:2466-70. 2004..This is the first published report of allogeneic HSCT performed for the indication of RA. Mixed chimerism has resulted in marked amelioration of RA, without GVHD... - Non-myeloablative stem cell transplantation for autoimmune diseasesRichard K Burt
Division of Immunotherapy, Northwestern University Feinberg School of Medicine, 320 East Superior, Searle 3 489, Chicago, IL 60611, USA
Springer Semin Immunopathol 26:57-69. 2004..In addition, for allogeneic hematopoietic stem cell transplantation engraftment of disease resistant donor stem cells will alter the genetic predisposition towards autoimmune disease susceptibility... - Hematopoietic stem cell transplantation for multiple sclerosisRichard K Burt
Division of Immunotherapy, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Ill 60611, USA
Arch Neurol 62:860-4. 2005 - Ruminating on rheumatoid arthritis and transplantationRichard K Burt
Northwestern University, Feinberg School of Medicine, Chicago, IL 60208, USA
Clin Immunol 115:129-30. 2005 - Antiphospholipid syndrome in patients with systemic lupus erythematosus treated by autologous hematopoietic stem cell transplantationLaisvyde Statkute
Division of Immunotherapy, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
Blood 106:2700-9. 2005..There was no treatment-related mortality. Autologous HSCT may be performed safely in patients with APS and appears to be effective therapy for eliminating ALPAs and preventing thrombotic complications in patients with SLE... - Reversal of new-onset type 1 diabetes in mice by syngeneic bone marrow transplantationYanting Wen
Department of Hematology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, 321, Zhongshan Road, Nanjing 210008, China
Biochem Biophys Res Commun 374:282-7. 2008..We conclude that autologous HSCT remission of diabetes is more than transient immune suppression, and is capable of prolonged remission-induction via regeneration of CD4+CD25+FoxP3+ Tregs...