Research Topics
| Serdar BulunSummaryAffiliation: Northwestern University Country: USA Publications
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Publications
The use of aromatase inhibitors for ovulation induction and superovulationMary Ellen Pavone
MD, John J SciarraChair, Department of Obstetrics and Gynecology, Feinberg School of Medicine at Northwestern University, 250 East Superior Street, Chicago, Illinois 60611
J Clin Endocrinol Metab 98:1838-44. 2013..Conclusions: Aromatase inhibitors may be an effective alternative treatment to clomiphene citrate for both ovulation induction and superovulation...
Progesterone action in endometrial cancer, endometriosis, uterine fibroids, and breast cancerJ Julie Kim
Division of Reproductive Biology Research, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
Endocr Rev 34:130-62. 2013..This review provides a unifying perspective for the diverse effects of progesterone across human tissues and diseases...- Role of estrogen receptor-β in endometriosisSerdar E Bulun
Division of Reproductive Biology Research, Department Obstetrics and Gynecology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
Semin Reprod Med 30:39-45. 2012..ERβ-selective estradiol antagonists may serve as novel therapeutics of endometriosis in the future... - A novel promoter controls Cyp19a1 gene expression in mouse adipose tissueHong Zhao
Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
Reprod Biol Endocrinol 7:37. 2009..It remains unknown whether aromatase is expressed in other mouse tissues via novel and tissue-specific promoters... 
Regulation of aromatase expression in estrogen-responsive breast and uterine disease: from bench to treatmentSerdar E Bulun
Division of Reproductive Biology Research, Department of Obstetric and Gynecology, Northwestern University, Chicago, IL 60611, USA
Pharmacol Rev 57:359-83. 2005....- Progesterone resistance in endometriosis: link to failure to metabolize estradiolSerdar E Bulun
Division of Reproductive Biology Research, Department of Obstetrics and Gynecology, Feinberg School of Medicine at Northwestern University, 303 East Superior Street, Chicago, IL 60611, USA
Mol Cell Endocrinol 248:94-103. 2006..The cellular and molecular mechanisms underlying progesterone resistance and failure to metabolize E2 in endometriosis are reviewed... - 17Beta-hydroxysteroid dehydrogenase-2 deficiency and progesterone resistance in endometriosisSerdar E Bulun
Division of Reproductive Biology Research, Department Obstetrics and Gynecology Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
Semin Reprod Med 28:44-50. 2010..The molecular details of this physiological paracrine interaction between the stroma and epithelium in normal endometrium and its lack thereof in endometriosis are discussed... - Estrogen receptor-beta, estrogen receptor-alpha, and progesterone resistance in endometriosisSerdar E Bulun
Division of Reproductive Biology Research, Department Obstetrics and Gynecology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
Semin Reprod Med 28:36-43. 2010..In this review, we propose a molecular model that may be responsible for changes in ERbeta and ERalpha leading to PR loss and progesterone resistance in endometriosis... - Progesterone and mifepristone regulate L-type amino acid transporter 2 and 4F2 heavy chain expression in uterine leiomyoma cellsXia Luo
Division of Reproductive Biology Research, Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
J Clin Endocrinol Metab 94:4533-9. 2009..Until now, little is known about the roles of LAT2/4F2hc in the regulation of the growth of human uterine leiomyoma... - Aromatase in endometriosis and uterine leiomyomataSerdar E Bulun
Department of Obstetric and Gynecology, Northwestern University, 303 E Superior Street, Suite 4 123, Chicago, IL 60611, USA
J Steroid Biochem Mol Biol 95:57-62. 2005..Successful treatment of endometriosis and uterine leiomyomata using aromatase inhibitors by recent pilot trials underscores the clinical significance of these molecular studies... - Regulation of aromatase expression in breast cancer tissueS E Bulun
Division of Reproductive Biology Research, Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
Ann N Y Acad Sci 1155:121-31. 2009..The signaling pathways that mediate the regulation of the promoter I.3/II region in undifferentiated fibroblasts in malignant breast tumors are reviewed... - Aromatase excess in cancers of breast, endometrium and ovarySerdar E Bulun
Robert H Lurie Comprehensive Cancer Center and Division of Reproductive Biology Research, Department of Obstetrics and Gynecology, Northwestern University, Chicago, IL 60611, USA
J Steroid Biochem Mol Biol 106:81-96. 2007..Thus, inflammatory substances such as PGE(2) may play important roles in inducing local production of estrogen that promotes tumor growth... - Steroidogenic factor-1 and endometriosisSerdar E Bulun
Division of Reproductive Biology Research, Department of Obstetrics and Gynecology, Northwestern University Feinberg School of Medicine, 333 E Superior Street, Suite 484, Chicago, IL 60611, United States
Mol Cell Endocrinol 300:104-8. 2009..Aromatase inhibitors diminish endometriotic implants and associated pain refractory to existing treatments in affected women... - Endometriosis: the ultimate hormonal diseaseBilgin Gurates
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Illinois at Chicago, 820 S. Wood Street, M/C 808, Chicago, IL 60612, USA
Semin Reprod Med 21:125-34. 2003..We found a number of abnormalities in the expression of aromatase, 17beta-HSD type 2, and the PR-B/PR-A ratio in endometriosis tissue. These abnormalities and their functional consequences are discussed in this review article... - BRCA1 negatively regulates the cancer-associated aromatase promoters I.3 and II in breast adipose fibroblasts and malignant epithelial cellsMeiling Lu
Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
J Clin Endocrinol Metab 91:4514-9. 2006..Heterozygous mutations of the breast cancer susceptibility gene 1 (BRCA1) gene that lead to haploinsufficiency increase the risk of breast cancer. The underlying mechanism is unknown... - WT1 and DAX-1 inhibit aromatase P450 expression in human endometrial and endometriotic stromal cellsBilgin Gurates
Department of Obstetrics and Gynecology, University of Illinois at Chicago, Chicago, Illinois 60612, USA
J Clin Endocrinol Metab 87:4369-77. 2002..In vivo down-regulation of WT1 in endometriotic stromal cells (vs. normal endometrial stromal cells) may in part be responsible for aberrantly increased P450arom expression and estrogen formation in this pathological tissue... - Altered retinoid uptake and action contributes to cell survival in endometriosisMary Ellen Pavone
Division of Reproductive Biology Research, Department of Obstetrics and Gynecology, Feinberg School of Medicine at Northwestern University, Chicago, Illinois 60611, USA
J Clin Endocrinol Metab 95:E300-9. 2010..The roles of these mechanisms in endometrium or endometriosis remain unknown... - Regulation of aromatase P450 expression in endometriotic and endometrial stromal cells by CCAAT/enhancer binding proteins (C/EBPs): decreased C/EBPbeta in endometriosis is associated with overexpression of aromataseSijun Yang
Department of Obstetrics, University of Illinois at Chicago, Chicago, Illinois 60612, USA
J Clin Endocrinol Metab 87:2336-45. 2002..In vivo down-regulation of C/EBPbeta in endometriotic stromal cells and its up-regulation in endometrial stromal cells may in part account for the induction of P450arom expression in endometriosis and its inhibition in endometrium... - A novel role of sodium butyrate in the regulation of cancer-associated aromatase promoters I.3 and II by disrupting a transcriptional complex in breast adipose fibroblastsSantanu Deb
Division of Reproductive Biology Research, Northwestern University, Chicago, Illinois 60611, USA
J Biol Chem 281:2585-97. 2006..Together, these findings represent a novel mechanism of sodium butyrate action and provide evidence that aromatase activity can be ablated in a signaling pathway- and cell-specific fashion... - Promoter methylation regulates estrogen receptor 2 in human endometrium and endometriosisQing Xue
Division of Reproductive Biology Research, Department of Obsterics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
Biol Reprod 77:681-7. 2007..These findings may be applied to a number of areas ranging from diagnosis to the treatment of endometriosis... - Estrogen excess associated with novel gain-of-function mutations affecting the aromatase geneMakio Shozu
Department of Obstetrics and Gynecology, University of Illinois at Chicago, Chicago, USA
N Engl J Med 348:1855-65. 2003.... - Stromal cells of endometriosis fail to produce paracrine factors that induce epithelial 17beta-hydroxysteroid dehydrogenase type 2 gene and its transcriptional regulator Sp1: a mechanism for defective estradiol metabolismYou Hong Cheng
Division of Reproductive Biology Research, Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611 3095, USA
Am J Obstet Gynecol 196:391.e1-7; discussion 391.e7-8. 2007..The objective of this study is to define the cellular defect responsible for the disruption of this stromal-epithelial interaction in endometriosis... - High aromatase expression in uterine leiomyoma tissues of African-American womenHiroshi Ishikawa
Division of Reproductive Biology Research, Robert H Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL 60611, USA
J Clin Endocrinol Metab 94:1752-6. 2009..African-American women develop uterine leiomyomas at an earlier age and with higher frequency compared with Caucasian-American women or other races; however, the underlying mechanism for this discrepancy is unknown... - Paracrine-stimulated gene expression profile favors estradiol production in breast tumorsSanober A Amin
Department of Obstetrics and Gynecology, Northwestern University, Chicago, IL 60611, USA
Mol Cell Endocrinol 253:44-55. 2006.... - Progesterone receptor regulates Bcl-2 gene expression through direct binding to its promoter region in uterine leiomyoma cellsPing Yin
Division of Reproductive Biology Research, Department of Obstetrics and Gynecology, Feinberg School of Medicine at Northwestern University, Chicago, Illinois 60611, USA
J Clin Endocrinol Metab 92:4459-66. 2007..Progesterone stimulates their growth, whereas treatment with progesterone receptor (PR) antagonists or selective progesterone receptor modulators shrinks these tumors. Molecular mechanisms underlying these observations are unknown... - CCAAT/enhancer binding protein beta regulates aromatase expression via multiple and novel cis-regulatory sequences in uterine leiomyomaHiroshi Ishikawa
Division of Reproductive Biology Research, Feinberg School of Medicine at Northwestern University, 303 Superior Street, Suite 4 123, Chicago, Illinois 60611, USA
J Clin Endocrinol Metab 93:981-91. 2008..The mechanisms that regulate aromatase expression in leiomyoma are unknown... - Mechanisms of excessive estrogen formation in endometriosisSerdar E Bulun
Department of Obstetrics and Gynecology, University of Illinois at Chicago, 820 S Wood St M C 808, Chicago, IL 60612, USA
J Reprod Immunol 55:21-33. 2002..The clinical relevance of these findings was exemplified by the successful treatment of an unusually aggressive case of postmenopausal endometriosis using an aromatase inhibitor... - Genetic or enzymatic disruption of aromatase inhibits the growth of ectopic uterine tissueZongjuan Fang
Department of Obstetrics and Gynecology, University of Illinois, 820 South Wood Street, M C 808, Chicago, IL 60612, USA
J Clin Endocrinol Metab 87:3460-6. 2002..We conclude that both an intact P450arom gene and the presence of aromatase enzyme activity are essential for the growth of ectopic uterine tissue in a mouse model of endometriosis... - Steroid receptor and aromatase expression in baboon endometriotic lesionsAsgerally T Fazleabas
Department of Obstetrics and Gynecology, University of Illinois, Chicago, Illinois 60612, USA
Fertil Steril 80:820-7. 2003..To evaluate steroid receptor and aromatase gene expression in endometriotic lesions, and determine the effects of endometriosis on uterine receptivity in a baboon model for endometriosis... - Transcriptional activation of steroidogenic factor-1 by hypomethylation of the 5' CpG island in endometriosisQing Xue
Division of Reproductive Biology Research, Department of Obstetrics and Gynecology, Northwestern University, Chicago, Illinois 60611, USA
J Clin Endocrinol Metab 92:3261-7. 2007.... - Estrogen receptor (ER) beta regulates ERalpha expression in stromal cells derived from ovarian endometriosisElena Trukhacheva
Division of Reproductive Biology Research, Department of Obstetrics and Gynecology, Feinberg School of Medicine at Northwestern University, 303 East Superior Street, 4 123, Chicago, Illinois 60611, USA
J Clin Endocrinol Metab 94:615-22. 2009..endometrial tissue and stromal cells, whereas ERalpha levels are lower in endometriosis. Estradiol regulates ERalpha gene expression via its alternatively used promoters A, B, and C... - Prostaglandin E2 via steroidogenic factor-1 coordinately regulates transcription of steroidogenic genes necessary for estrogen synthesis in endometriosisErkut Attar
Division of Reproductive Biology Research, Department of Obstetrics and Gynecology, Feinberg School of Medicine at Northwestern University, 303 East Superior Street, 4 123, Chicago, Illinois 60611, USA
J Clin Endocrinol Metab 94:623-31. 2009.... - Transcription factor KLF11 integrates progesterone receptor signaling and proliferation in uterine leiomyoma cellsPing Yin
Division of Reproductive Biology Research, Department of Obstetrics and Gynecology, Feinberg School of Medicine at Northwestern University, Chicago, IL 60611, USA
Cancer Res 70:1722-30. 2010..Taken together, using a ChIP-cloning approach, we uncovered KLF11 as an integrator of PR signaling and proliferation in uterine leiomyoma cells... - Upstream stimulatory factor-2 regulates steroidogenic factor-1 expression in endometriosisHiroki Utsunomiya
Division of Reproductive Biology Research, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
Mol Endocrinol 22:904-14. 2008..Taken together, the elevated levels of USF2 in endometriosis account for, in part, the aberrant expression of SF-1 and its target gene StAR and aromatase... - Cloning and characterization of a novel endothelial promoter of the human CYP19 (aromatase P450) gene that is up-regulated in breast cancer tissueSiby Sebastian
Department of Obstetrics and Gynecology, University of Illinois at Chicago, Chicago, Illinois 60612, USA
Mol Endocrinol 16:2243-54. 2002..The activity of this promoter may also be important for intracrine and paracrine effects of estrogen on blood vessels... - Progesterone is essential for maintenance and growth of uterine leiomyomaHiroshi Ishikawa
Division of Reproductive Biology Research, Northwestern University Feinberg School of Medicine, Department of Obstetrics and Gynecology, 4th Floor, Suite 4 127, 303 East Superior Street, Chicago, Illinois 60611, USA
Endocrinology 151:2433-42. 2010..Taken together, our findings define that volume maintenance and growth of human UL are progesterone dependent... - Aromatase and endometriosisSerdar E Bulun
Department of Obstetrics and Gynecology, Northwestern University, Chicago, Illinois 60611, USA
Semin Reprod Med 22:45-50. 2004..We were able to target this positive feedback cycle in endometriosis using aromatase inhibitors. In fact, pilot trials showed that aromatase inhibitors could decrease pelvic pain associated with endometriosis... - Estrogen production and metabolism in endometriosisSerdar E Bulun
Department of Obstetrics and Gynecology, University of Illinois at Chicago, 60612, USA
Ann N Y Acad Sci 955:75-85; discussion 86-8, 396-406. 2002..The clinical relevance of these findings was exemplified by the successful treatment of an unusually aggressive case of postmenopausal endometriosis using an aromatase inhibitor... - Progestins activate the AKT pathway in leiomyoma cells and promote survivalAnna V Hoekstra
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Northwestern University, Chicago, Illinois 60611, USA
J Clin Endocrinol Metab 94:1768-74. 2009..Progesterone has been associated with promoting growth of uterine leiomyomas. The mechanisms involved remain unclear... - Up-regulation of cyclooxygenase-2 expression and prostaglandin synthesis in endometrial stromal cells by malignant endometrial epithelial cells. A paracrine effect mediated by prostaglandin E2 and nuclear factor-kappa BMitsutoshi Tamura
Department of Obstetrics and Gynecology and Molecular Genetics, The University of Illinois, Chicago, Illinois 60612, USA
J Biol Chem 277:26208-16. 2002..In conclusion, malignant endometrial epithelial cells secrete PGE(2) that induces COX-2 expression in normal endometrial stromal cells in a paracrine fashion through activation of transcription and stabilization of COX-2 mRNA... - Regulation of 17-beta hydroxysteroid dehydrogenase type 2 in human placental endothelial cellsEmily J Su
Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Northwestern University, Chicago, Illinois 60611, USA
Biol Reprod 77:517-25. 2007..Together, these data indicate that regulation of HSD17B2 mRNA levels and enzymatic activity by RA in the placenta is mediated by RARA and RXRA... - WT1 and DAX-1 regulate SF-1-mediated human P450arom gene expression in gonadal cellsBilgin Gurates
Departments of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, University of Illinois at Chicago, 820 S Wood Street, M C 808, Chicago, IL 60612, USA
Mol Cell Endocrinol 208:61-75. 2003..Given the characterized roles of these transcription factors in gonadal development and function, modulation of SF-1 action by WT1 and DAX-1 may represent an important key mechanism in steroidogenesis... - Aromatase promoter I.f is regulated by estrogen receptor alpha (ESR1) in mouse hypothalamic neuronal cell linesM Bertan Yilmaz
Division of Reproductive Biology Research, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
Biol Reprod 81:956-65. 2009..f by enhanced binding of an ESR1/JUN complex to distinct AP-1 motifs in hypothalamic cells. We speculate that this mechanism may, in part, regulate gonadotropin secretion and sexual activity... - Novel estrogen receptor-alpha binding sites and estradiol target genes identified by chromatin immunoprecipitation cloning in breast cancerZhihong Lin
Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
Cancer Res 67:5017-24. 2007..Our findings suggest that at least a subset of these genes, including Wnt11, may play important in vivo and in vitro biological roles in breast cancer... - CpG dinucleotide methylation of the CYP19 I.3/II promoter modulates cAMP-stimulated aromatase activityMasashi Demura
Division of Reproductive Biology Research, Department of Obstetrics and Gynecology, Northwestern University Feinberg School of Medicine, 303 E Superior Street, Suite 4 123, Chicago, IL 60611 3095, USA
Mol Cell Endocrinol 283:127-32. 2008..3/II regulates aromatase expression and may be one source of inter-individual variability. Furthermore, abnormal methylation of the aromatase promoter may contribute to aromatase overexpression in breast cancer... - SP1 and SP3 mediate progesterone-dependent induction of the 17beta hydroxysteroid dehydrogenase type 2 gene in human endometriumYou Hong Cheng
Division of Reproductive Biology Research, Department of Obstetrics and Gynecology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611 3095, USA
Biol Reprod 75:605-14. 2006.... - Estrogen up-regulates cyclooxygenase-2 via estrogen receptor in human uterine microvascular endothelial cellsMitsutoshi Tamura
Departments of Obstetrics and Gynecology and Molecular Genetics, University of Illinois at Chicago, Chicago, Illinois 60611, USA
Fertil Steril 81:1351-6. 2004..CONCLUSION(S): We conclude that various levels of E(2) can significantly increase COX-2 expression and PGE(2) synthesis in HUMEC via the estrogen receptor... - Prostaglandin E(2) induces breast cancer related aromatase promoters via activation of p38 and c-Jun NH(2)-terminal kinase in adipose fibroblastsDong Chen
Division of Reproductive Biology Research, Department of Obstetrics and Gynecology, Northwestern University, Chicago, Illinois 60611, USA
Cancer Res 67:8914-22. 2007..Taken together, PGE(2) activation of p38 and JNK1 via PKA and PKC is necessary for aromatase induction in BAFs, and p38 and JNK1 are potential new drug targets for tissue-specific ablation of aromatase expression in breast cancer... - The human CYP19 (aromatase P450) gene: update on physiologic roles and genomic organization of promotersSerdar E Bulun
Department of Obstetrics and Gynecology and Molecular Genetics, University of Illinois at Chicago, 820 S Wood St M C 808, Chicago, IL 60612, USA
J Steroid Biochem Mol Biol 86:219-24. 2003..3, I.7 and I.4) for aromatase expression. The sum of P450arom mRNA species arising from these four promoters markedly increase total P450arom mRNA levels in breast cancer compared with the normal breast... - Estrogen regulates expression of tumor necrosis factor receptors in breast adipose fibroblastsSantanu Deb
Department of Obstetrics and Gynecology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, USA
J Clin Endocrinol Metab 89:4018-24. 2004..We conclude that high levels of estrogen found in breast tumors promote the antiadipogenic action of TNF on breast adipose fibroblasts by selectively up-regulating TNFR1, which may be a critical mechanism for desmoplastic reaction... - LAT1 regulates growth of uterine leiomyoma smooth muscle cells- Xia Luo
Division of Reproductive Biology Research, Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
Reprod Sci 17:791-7. 2010..Taken together, LAT1 may have a critical and complex role in regulating human leiomyoma cell growth... - Aromatase expression in women's cancersSerdar E Bulun
Department of Obstetric and Gynecology, Northwestern University, Chicago, IL 60611, USA
Adv Exp Med Biol 630:112-32. 2008..Thus, inflammatory substances such as PGE2 may play important roles in inducing local production of estrogen that promotes tumor growth... - Regulation of breast cancer-associated aromatase promotersDong Chen
Division of Reproductive Biology Research, Department of Obstetrics and Gynecology, Northwestern University, 303 E Superior Street, Chicago, IL 60611, USA
Cancer Lett 273:15-27. 2009..Clinical side effects of these agents require development of new drugs with better specificity and efficacy, and epigenetic therapies with breast cancer tissue-selective aromatase siRNA-conjugated nanoparticles... - Retinoic acid (RA) regulates 17beta-hydroxysteroid dehydrogenase type 2 expression in endometrium: interaction of RA receptors with specificity protein (SP) 1/SP3 for estradiol metabolismYou Hong Cheng
Division of Reproductive Biology Research, Department of Obstetrics and Gynecology, Northwestern University, 303 E Superior Street, Chicago, IL 60611, USA
J Clin Endocrinol Metab 93:1915-23. 2008..Retinoic acid (RA) induces HSD17B2 expression, but the underlying mechanism is not known... - Aromatase expression in uterine leiomyomata is regulated primarily by proximal promoters I.3/IIAyse Gonca Imir
Department of Obstetrics and Gynecology, Northwestern University, 303 East Superior Street, Suite 4 123, Chicago, IL 60611, USA
J Clin Endocrinol Metab 92:1979-82. 2007..Uterine leiomyoma tissue, but not normal myometrium, overexpresses aromatase leading to estrogen-stimulated cell proliferation. Aromatase inhibitor treatment shrank uterine leiomyomata in a few women... - JunD and JunB integrate prostaglandin E2 activation of breast cancer-associated proximal aromatase promotersDong Chen
Division of Reproductive Biology Research, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
Mol Endocrinol 25:767-75. 2011..3/II via CRE(-211/-199). JunB also activates aromatase promoters I.3/II by maintaining JunD expression. Targeting JunD may abolish aromatase expression selectively in breast cancer tissue... - Retinoic acid inhibits endometrial cancer cell growth via multiple genomic mechanismsYou Hong Cheng
Department of Obstetrics and Gynecology, Northwestern University Feinberg School of Medicine, 303 East Superior Street, Suite 4 131, Chicago, Illinois 60611 3095, USA
J Mol Endocrinol 46:139-53. 2011..These pathways could, therefore, mediate the carcinogenesis of human endometrial cancer... - Interleukin-1beta elevates cyclooxygenase-2 protein level and enzyme activity via increasing its mRNA stability in human endometrial stromal cells: an effect mediated by extracellularly regulated kinases 1 and 2Mitsutoshi Tamura
Department of Obstetrics and Gynecology, University of Illinois at Chicago, 820 South Wood Street, Chicago, IL 60612, USA
J Clin Endocrinol Metab 87:3263-73. 2002..Moreover, posttranscriptional mRNA stability is an important mechanism for IL-1beta-induced elevation of COX-2 expression in ESC... - The selective progesterone receptor modulator CDB4124 inhibits proliferation and induces apoptosis in uterine leiomyoma cellsXia Luo
Division of Reproductive Biology Research, Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
Fertil Steril 93:2668-73. 2010..To evaluate the effects of selective P receptor (PR) modulator CDB4124 on cell proliferation and apoptosis in cultured human uterine leiomyoma smooth muscle (LSM) cells and control myometrial smooth muscle (MSM) cells in matched uteri... - Organization of the human aromatase p450 (CYP19) geneSerdar E Bulun
Department of Obstetrics and Gynecology, Northwestern University, Chicago, Illinois 60611, USA
Semin Reprod Med 22:5-9. 2004..4. Because each mRNA species contains the identical coding region regardless of the variable untranslated first exon, the encoded protein functions as the aromatase enzyme in each case... - Expression Profiling of Nuclear Receptors Identifies Key Roles of NR4A Subfamily in Uterine FibroidsHanwei Yin
Feinberg School of Medicine, Northwestern University, 303 E Superior Street, Lurie 4 119, Chicago, Illinois 60611
Mol Endocrinol 27:726-40. 2013..Together, our results implicate several NRs including the NR4A subfamily in leiomyoma etiology and identify NR4As as potential therapeutic targets for treating fibrotic diseases... - Endometriosis and ovarian cancer: a review of clinical, pathologic, and molecular aspectsJian Jun Wei
Department of Pathology, Division of Reproductive Biology Research, Northwestern University Feinberg School of Medicine, 251 E Huron St, Chicago, IL, 60611, USA
Int J Gynecol Pathol 30:553-68. 2011..This study is a review of the natural history of endometriosis and the role of microenvironments that favor the accumulation of genetic alterations and endometriosis-associated ovarian cancer progression... - Treatment of endometriosis and chronic pelvic pain with letrozole and norethindrone acetate: a pilot studyRadhika K Ailawadi
Department of Obstetrics and Gynecology, University of Illinois at Chicago, Chicago, Illinois, USA
Fertil Steril 81:290-6. 2004..On this basis, letrozole should be a candidate for the medical management of endometriosis... - Differential expression of microRNA species in human uterine leiomyoma versus normal myometriumErica E Marsh
Division of Reproductive Biology Research, Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
Fertil Steril 89:1771-6. 2008..To determine whether microRNAs (miRNAs) are differentially expressed in human leiomyoma versus matched myometrial tissue... - Intact progesterone receptors are essential to counteract the proliferative effect of estradiol in a genetically engineered mouse model of endometriosisZongjuan Fang
Department of Obstetrics and Gynecology, Northwestern University, 333 East Superior Street, Chicago, IL 60611, USA
Fertil Steril 82:673-8. 2004..To determine the role of P and its nuclear receptor PR in the growth of ectopic uterine tissue of mice with or without a disrupted PR gene... - Regional rearrangements in chromosome 15q21 cause formation of cryptic promoters for the CYP19 (aromatase) geneMasashi Demura
Division of Reproductive Biology Research, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
Hum Mol Genet 16:2529-41. 2007..Taken together, small rearrangements may create cryptic promoters that direct inappropriate transcription of CYP19 or other critical genes... - A modified baboon model for endometriosisAsgerally T Fazleabas
Department of Obstetrics and Gynecology, University of Illinois at Chicago, 60612 7313, USA
Ann N Y Acad Sci 955:308-17; discussion 340-2, 396-406. 2002.... - Ovulation induction in women with infertility: a new indication for aromatase inhibitorsSerdar E Bulun
Department of Obstetrics and Gynecology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, USA
Fertil Steril 80:1338; discussion 1339. 2003 - Aromatase inhibitors: the next generation of therapeutics for endometriosis?Erkut Attar
Division of Reproductive Biology Research, Department of Obstetrics and Gynecology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
Fertil Steril 85:1307-18. 2006..The side-effect profile of AIs administered in combination with an oral contraceptive or a progestin is remarkably benign. We review herein the published clinical evidence for the use of AIs in the treatment of endometriosis... - Steroid hormones and leiomyomasErica E Marsh
Division of Reproductive Biology Research, Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Robert H. Lurie Medical Research Center, 303 East Superior Street, 4-123, Chicago, IL 60611, USA
Obstet Gynecol Clin North Am 33:59-67. 2006.... - Vascular endothelial growth factor up-regulates cyclooxygenase-2 expression in human endothelial cellsMitsutoshi Tamura
Department of Ostetrics and Gynecology, The University of Illinois at Chicago, 820 South Wood Street, Chicago, IL 60612, USA
J Clin Endocrinol Metab 87:3504-7. 2002..These observations are of particular importance given the recent demonstrations of critical requirement of COX-2 isoenzyme for tumor growth and angiogenesis... - Estrogen receptor-beta mediates cyclooxygenase-2 expression and vascular prostanoid levels in human placental villous endothelial cellsEmily J Su
Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
Am J Obstet Gynecol 200:427.e1-8. 2009..Previously, we demonstrated that villous endothelial cells express estrogen receptor-beta (ESR2), and we sought to determine its role in the mediation of fetoplacental vascular function... - Anastrazole and oral contraceptives: a novel treatment for endometriosisLisa L Amsterdam
Indiana University School of Medicine, Indianapolis, Indiana, USA
Fertil Steril 84:300-4. 2005..1 mg levonorgestrel with minimal side effects. This treatment for endometriosis is a promising new modality that warrants further investigation...
Research Grants
- Breast Cancer-Proximal Stroma Interaction & AromataseSerdar Bulun; Fiscal Year: 2007..noncarrier controls. Proposed studies may lead to new pilot trials of treatment and prevention using p38/JNK inhibitors in BRCA1 mutation carriers. ..
- MECHANISMS OF ESTROGEN BIOSYNTHESIS IN ENDOMETRIOSISSerdar Bulun; Fiscal Year: 2007..Investigation of local feedback mechanisms responsible for interactions between estrogen biosynthesis, tissue growth, and inflammation will lead to the rational design of novel drug treatments. ..
- ESTROGEN BIOSYNTHESIS AND UTERINE LEIOMYOMATASerdar Bulun; Fiscal Year: 2007..We predict that these studies will establish the critical role of P450arom in uterine leiomyomata and lead to identification of novel therapeutic targets. ..
- Breast Cancer-Proximal Stroma Interaction and AromataseSerdar Bulun; Fiscal Year: 2006....
- MECHANISMS OF ESTROGEN BIOSYNTHESIS IN ENDOMETRIOSISSerdar Bulun; Fiscal Year: 2002..The role of aromatase inhibitors in the treatment of endometriosis (in comparison with conventional treatments) will also be characterized in this model. ..
- Breast Cancer-Proximal Stroma Interaction & AromataseSerdar E Bulun; Fiscal Year: 2010..noncarrier controls. Proposed studies may lead to new pilot trials of treatment and prevention using p38/JNK inhibitors in BRCA1 mutation carriers. ..