Serdar Bulun

Summary

Affiliation: Northwestern University
Country: USA

Publications

  1. pmc Expression of estrogen-related gene markers in breast cancer tissue predicts aromatase inhibitor responsiveness
    Irene Moy
    Northwestern University, Department of Obstetrics and Gynecology, Chicago, Illinois, United States of America
    PLoS ONE 8:e77543. 2013
  2. pmc Role of stem cells in human uterine leiomyoma growth
    Masanori Ono
    Division of Reproductive Biology Research, Department of Obstetrics and Gynecology, Feinberg School of Medicine at Northwestern University, Chicago, Illinois, USA
    PLoS ONE 7:e36935. 2012
  3. pmc Genome-wide DNA methylation indicates silencing of tumor suppressor genes in uterine leiomyoma
    Antonia Navarro
    Division of Reproductive Biology Research, Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America
    PLoS ONE 7:e33284. 2012
  4. pmc Adenosine A1 receptor, a target and regulator of estrogen receptoralpha action, mediates the proliferative effects of estradiol in breast cancer
    Z Lin
    Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Oncogene 29:1114-22. 2010
  5. pmc Genome-wide DNA methylation analysis predicts an epigenetic switch for GATA factor expression in endometriosis
    Matthew T Dyson
    Division of Reproductive Biology Research, Dept Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America
    PLoS Genet 10:e1004158. 2014
  6. pmc Aromatase and estrogen receptor α deficiency
    Serdar E Bulun
    Department of Obstetrics and Gynecology, Northwestern University, Chicago, Illinois Electronic address
    Fertil Steril 101:323-9. 2014
  7. pmc Clinical review: The use of aromatase inhibitors for ovulation induction and superovulation
    Mary Ellen Pavone
    Department of Obstetrics and Gynecology, Feinberg School of Medicine at Northwestern University, 250 East Superior Street, Chicago, Illinois 60611, USA
    J Clin Endocrinol Metab 98:1838-44. 2013
  8. pmc Progesterone action in endometrial cancer, endometriosis, uterine fibroids, and breast cancer
    J Julie Kim
    Division of Reproductive Biology Research, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
    Endocr Rev 34:130-62. 2013
  9. pmc Role of estrogen receptor-β in endometriosis
    Serdar E Bulun
    Division of Reproductive Biology Research, Department Obstetrics and Gynecology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Semin Reprod Med 30:39-45. 2012
  10. pmc A novel promoter controls Cyp19a1 gene expression in mouse adipose tissue
    Hong Zhao
    Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Reprod Biol Endocrinol 7:37. 2009

Collaborators

Detail Information

Publications79

  1. pmc Expression of estrogen-related gene markers in breast cancer tissue predicts aromatase inhibitor responsiveness
    Irene Moy
    Northwestern University, Department of Obstetrics and Gynecology, Chicago, Illinois, United States of America
    PLoS ONE 8:e77543. 2013
    ..In conclusion, expression levels of estrogen-related mRNAs are predictive for AI responsiveness in postmenopausal women with breast cancer, and mRNA expression analysis may improve patient selection. ..
  2. pmc Role of stem cells in human uterine leiomyoma growth
    Masanori Ono
    Division of Reproductive Biology Research, Department of Obstetrics and Gynecology, Feinberg School of Medicine at Northwestern University, Chicago, Illinois, USA
    PLoS ONE 7:e36935. 2012
    ..Thus, we tested the hypothesis that a distinct stem/reservoir cell-enriched population, designated as the leiomyoma-derived side population (LMSP), is responsible for cell proliferation and tumor growth...
  3. pmc Genome-wide DNA methylation indicates silencing of tumor suppressor genes in uterine leiomyoma
    Antonia Navarro
    Division of Reproductive Biology Research, Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America
    PLoS ONE 7:e33284. 2012
    ..Epigenetic dysregulation of individual genes has been demonstrated in leiomyoma cells; however, the in vivo genome-wide distribution of such epigenetic abnormalities remains unknown...
  4. pmc Adenosine A1 receptor, a target and regulator of estrogen receptoralpha action, mediates the proliferative effects of estradiol in breast cancer
    Z Lin
    Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Oncogene 29:1114-22. 2010
    ..These data suggest that Adora1 may represent an important target for therapeutic intervention in hormone-dependent breast cancer...
  5. pmc Genome-wide DNA methylation analysis predicts an epigenetic switch for GATA factor expression in endometriosis
    Matthew T Dyson
    Division of Reproductive Biology Research, Dept Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America
    PLoS Genet 10:e1004158. 2014
    ....
  6. pmc Aromatase and estrogen receptor α deficiency
    Serdar E Bulun
    Department of Obstetrics and Gynecology, Northwestern University, Chicago, Illinois Electronic address
    Fertil Steril 101:323-9. 2014
    ..Thus far, one man and an unrelated woman with estrogen resistance due to mutations in the estrogen receptor α (ESR1) gene have been described. Their clinical presentations are similar to that of aromatase-deficient men and women. ..
  7. pmc Clinical review: The use of aromatase inhibitors for ovulation induction and superovulation
    Mary Ellen Pavone
    Department of Obstetrics and Gynecology, Feinberg School of Medicine at Northwestern University, 250 East Superior Street, Chicago, Illinois 60611, USA
    J Clin Endocrinol Metab 98:1838-44. 2013
    ..Alternative agents, including aromatase inhibitors, have been used that have not been associated with these side effects...
  8. pmc Progesterone action in endometrial cancer, endometriosis, uterine fibroids, and breast cancer
    J Julie Kim
    Division of Reproductive Biology Research, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
    Endocr Rev 34:130-62. 2013
    ..This review provides a unifying perspective for the diverse effects of progesterone across human tissues and diseases...
  9. pmc Role of estrogen receptor-β in endometriosis
    Serdar E Bulun
    Division of Reproductive Biology Research, Department Obstetrics and Gynecology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Semin Reprod Med 30:39-45. 2012
    ..ERβ-selective estradiol antagonists may serve as novel therapeutics of endometriosis in the future...
  10. pmc A novel promoter controls Cyp19a1 gene expression in mouse adipose tissue
    Hong Zhao
    Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Reprod Biol Endocrinol 7:37. 2009
    ..It remains unknown whether aromatase is expressed in other mouse tissues via novel and tissue-specific promoters...
  11. ncbi request reprint Aromatase in endometriosis and uterine leiomyomata
    Serdar E Bulun
    Department of Obstetric and Gynecology, Northwestern University, 303 E Superior Street, Suite 4 123, Chicago, IL 60611, USA
    J Steroid Biochem Mol Biol 95:57-62. 2005
    ..Successful treatment of endometriosis and uterine leiomyomata using aromatase inhibitors by recent pilot trials underscores the clinical significance of these molecular studies...
  12. ncbi request reprint 17Beta-hydroxysteroid dehydrogenase-2 deficiency and progesterone resistance in endometriosis
    Serdar E Bulun
    Division of Reproductive Biology Research, Department Obstetrics and Gynecology Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Semin Reprod Med 28:44-50. 2010
    ..The molecular details of this physiological paracrine interaction between the stroma and epithelium in normal endometrium and its lack thereof in endometriosis are discussed...
  13. ncbi request reprint Regulation of aromatase expression in estrogen-responsive breast and uterine disease: from bench to treatment
    Serdar E Bulun
    Division of Reproductive Biology Research, Department of Obstetric and Gynecology, Northwestern University, Chicago, IL 60611, USA
    Pharmacol Rev 57:359-83. 2005
    ....
  14. pmc Progesterone and mifepristone regulate L-type amino acid transporter 2 and 4F2 heavy chain expression in uterine leiomyoma cells
    Xia Luo
    Division of Reproductive Biology Research, Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Clin Endocrinol Metab 94:4533-9. 2009
    ..Until now, little is known about the roles of LAT2/4F2hc in the regulation of the growth of human uterine leiomyoma...
  15. ncbi request reprint Progesterone resistance in endometriosis: link to failure to metabolize estradiol
    Serdar E Bulun
    Division of Reproductive Biology Research, Department of Obstetrics and Gynecology, Feinberg School of Medicine at Northwestern University, 303 East Superior Street, Chicago, IL 60611, USA
    Mol Cell Endocrinol 248:94-103. 2006
    ..The cellular and molecular mechanisms underlying progesterone resistance and failure to metabolize E2 in endometriosis are reviewed...
  16. pmc Estrogen receptor-beta, estrogen receptor-alpha, and progesterone resistance in endometriosis
    Serdar E Bulun
    Division of Reproductive Biology Research, Department Obstetrics and Gynecology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Semin Reprod Med 28:36-43. 2010
    ..In this review, we propose a molecular model that may be responsible for changes in ERbeta and ERalpha leading to PR loss and progesterone resistance in endometriosis...
  17. ncbi request reprint Regulation of aromatase expression in breast cancer tissue
    S E Bulun
    Division of Reproductive Biology Research, Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Ann N Y Acad Sci 1155:121-31. 2009
    ..The signaling pathways that mediate the regulation of the promoter I.3/II region in undifferentiated fibroblasts in malignant breast tumors are reviewed...
  18. doi request reprint Steroidogenic factor-1 and endometriosis
    Serdar E Bulun
    Division of Reproductive Biology Research, Department of Obstetrics and Gynecology, Northwestern University Feinberg School of Medicine, 333 E Superior Street, Suite 484, Chicago, IL 60611, United States
    Mol Cell Endocrinol 300:104-8. 2009
    ..Aromatase inhibitors diminish endometriotic implants and associated pain refractory to existing treatments in affected women...
  19. pmc Aromatase excess in cancers of breast, endometrium and ovary
    Serdar E Bulun
    Robert H Lurie Comprehensive Cancer Center and Division of Reproductive Biology Research, Department of Obstetrics and Gynecology, Northwestern University, Chicago, IL 60611, USA
    J Steroid Biochem Mol Biol 106:81-96. 2007
    ..Thus, inflammatory substances such as PGE(2) may play important roles in inducing local production of estrogen that promotes tumor growth...
  20. ncbi request reprint BRCA1 negatively regulates the cancer-associated aromatase promoters I.3 and II in breast adipose fibroblasts and malignant epithelial cells
    Meiling Lu
    Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Clin Endocrinol Metab 91:4514-9. 2006
    ..Heterozygous mutations of the breast cancer susceptibility gene 1 (BRCA1) gene that lead to haploinsufficiency increase the risk of breast cancer. The underlying mechanism is unknown...
  21. ncbi request reprint Endometriosis: the ultimate hormonal disease
    Bilgin Gurates
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Illinois at Chicago, 820 S Wood Street, M C 808, Chicago, IL 60612, USA
    Semin Reprod Med 21:125-34. 2003
    ..We found a number of abnormalities in the expression of aromatase, 17beta-HSD type 2, and the PR-B/PR-A ratio in endometriosis tissue. These abnormalities and their functional consequences are discussed in this review article...
  22. ncbi request reprint WT1 and DAX-1 inhibit aromatase P450 expression in human endometrial and endometriotic stromal cells
    Bilgin Gurates
    Department of Obstetrics and Gynecology, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    J Clin Endocrinol Metab 87:4369-77. 2002
    ..In vivo down-regulation of WT1 in endometriotic stromal cells (vs. normal endometrial stromal cells) may in part be responsible for aberrantly increased P450arom expression and estrogen formation in this pathological tissue...
  23. pmc Altered retinoid uptake and action contributes to cell survival in endometriosis
    Mary Ellen Pavone
    Division of Reproductive Biology Research, Department of Obstetrics and Gynecology, Feinberg School of Medicine at Northwestern University, Chicago, Illinois 60611, USA
    J Clin Endocrinol Metab 95:E300-9. 2010
    ..The roles of these mechanisms in endometrium or endometriosis remain unknown...
  24. ncbi request reprint Regulation of aromatase P450 expression in endometriotic and endometrial stromal cells by CCAAT/enhancer binding proteins (C/EBPs): decreased C/EBPbeta in endometriosis is associated with overexpression of aromatase
    Sijun Yang
    Department of Obstetrics, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    J Clin Endocrinol Metab 87:2336-45. 2002
    ..In vivo down-regulation of C/EBPbeta in endometriotic stromal cells and its up-regulation in endometrial stromal cells may in part account for the induction of P450arom expression in endometriosis and its inhibition in endometrium...
  25. pmc High aromatase expression in uterine leiomyoma tissues of African-American women
    Hiroshi Ishikawa
    Division of Reproductive Biology Research, Robert H Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL 60611, USA
    J Clin Endocrinol Metab 94:1752-6. 2009
    ..African-American women develop uterine leiomyomas at an earlier age and with higher frequency compared with Caucasian-American women or other races; however, the underlying mechanism for this discrepancy is unknown...
  26. ncbi request reprint Promoter methylation regulates estrogen receptor 2 in human endometrium and endometriosis
    Qing Xue
    Division of Reproductive Biology Research, Department of Obsterics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Biol Reprod 77:681-7. 2007
    ..These findings may be applied to a number of areas ranging from diagnosis to the treatment of endometriosis...
  27. ncbi request reprint Stromal cells of endometriosis fail to produce paracrine factors that induce epithelial 17beta-hydroxysteroid dehydrogenase type 2 gene and its transcriptional regulator Sp1: a mechanism for defective estradiol metabolism
    You Hong Cheng
    Division of Reproductive Biology Research, Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611 3095, USA
    Am J Obstet Gynecol 196:391.e1-7; discussion 391.e7-8. 2007
    ..The objective of this study is to define the cellular defect responsible for the disruption of this stromal-epithelial interaction in endometriosis...
  28. ncbi request reprint A novel role of sodium butyrate in the regulation of cancer-associated aromatase promoters I.3 and II by disrupting a transcriptional complex in breast adipose fibroblasts
    Santanu Deb
    Division of Reproductive Biology Research, Northwestern University, Chicago, Illinois 60611, USA
    J Biol Chem 281:2585-97. 2006
    ..Together, these findings represent a novel mechanism of sodium butyrate action and provide evidence that aromatase activity can be ablated in a signaling pathway- and cell-specific fashion...
  29. ncbi request reprint Estrogen excess associated with novel gain-of-function mutations affecting the aromatase gene
    Makio Shozu
    Department of Obstetrics and Gynecology, University of Illinois at Chicago, Chicago, USA
    N Engl J Med 348:1855-65. 2003
    ....
  30. pmc CCAAT/enhancer binding protein beta regulates aromatase expression via multiple and novel cis-regulatory sequences in uterine leiomyoma
    Hiroshi Ishikawa
    Division of Reproductive Biology Research, Feinberg School of Medicine at Northwestern University, 303 Superior Street, Suite 4 123, Chicago, Illinois 60611, USA
    J Clin Endocrinol Metab 93:981-91. 2008
    ..The mechanisms that regulate aromatase expression in leiomyoma are unknown...
  31. ncbi request reprint Progesterone receptor regulates Bcl-2 gene expression through direct binding to its promoter region in uterine leiomyoma cells
    Ping Yin
    Division of Reproductive Biology Research, Department of Obstetrics and Gynecology, Feinberg School of Medicine at Northwestern University, Chicago, Illinois 60611, USA
    J Clin Endocrinol Metab 92:4459-66. 2007
    ..Progesterone stimulates their growth, whereas treatment with progesterone receptor (PR) antagonists or selective progesterone receptor modulators shrinks these tumors. Molecular mechanisms underlying these observations are unknown...
  32. ncbi request reprint Mechanisms of excessive estrogen formation in endometriosis
    Serdar E Bulun
    Department of Obstetrics and Gynecology, University of Illinois at Chicago, 820 S Wood St M C 808, Chicago, IL 60612, USA
    J Reprod Immunol 55:21-33. 2002
    ..The clinical relevance of these findings was exemplified by the successful treatment of an unusually aggressive case of postmenopausal endometriosis using an aromatase inhibitor...
  33. ncbi request reprint Genetic or enzymatic disruption of aromatase inhibits the growth of ectopic uterine tissue
    Zongjuan Fang
    Department of Obstetrics and Gynecology, University of Illinois, 820 South Wood Street, M C 808, Chicago, IL 60612, USA
    J Clin Endocrinol Metab 87:3460-6. 2002
    ..We conclude that both an intact P450arom gene and the presence of aromatase enzyme activity are essential for the growth of ectopic uterine tissue in a mouse model of endometriosis...
  34. pmc Estrogen receptor (ER) beta regulates ERalpha expression in stromal cells derived from ovarian endometriosis
    Elena Trukhacheva
    Division of Reproductive Biology Research, Department of Obstetrics and Gynecology, Feinberg School of Medicine at Northwestern University, 303 East Superior Street, 4 123, Chicago, Illinois 60611, USA
    J Clin Endocrinol Metab 94:615-22. 2009
    ..endometrial tissue and stromal cells, whereas ERalpha levels are lower in endometriosis. Estradiol regulates ERalpha gene expression via its alternatively used promoters A, B, and C...
  35. ncbi request reprint Transcriptional activation of steroidogenic factor-1 by hypomethylation of the 5' CpG island in endometriosis
    Qing Xue
    Division of Reproductive Biology Research, Department of Obstetrics and Gynecology, Northwestern University, Chicago, Illinois 60611, USA
    J Clin Endocrinol Metab 92:3261-7. 2007
    ....
  36. ncbi request reprint Steroid receptor and aromatase expression in baboon endometriotic lesions
    Asgerally T Fazleabas
    Department of Obstetrics and Gynecology, University of Illinois, Chicago, Illinois 60612, USA
    Fertil Steril 80:820-7. 2003
    ..To evaluate steroid receptor and aromatase gene expression in endometriotic lesions, and determine the effects of endometriosis on uterine receptivity in a baboon model for endometriosis...
  37. ncbi request reprint Paracrine-stimulated gene expression profile favors estradiol production in breast tumors
    Sanober A Amin
    Department of Obstetrics and Gynecology, Northwestern University, Chicago, IL 60611, USA
    Mol Cell Endocrinol 253:44-55. 2006
    ....
  38. pmc Progestins activate the AKT pathway in leiomyoma cells and promote survival
    Anna V Hoekstra
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Northwestern University, Chicago, Illinois 60611, USA
    J Clin Endocrinol Metab 94:1768-74. 2009
    ..Progesterone has been associated with promoting growth of uterine leiomyomas. The mechanisms involved remain unclear...
  39. ncbi request reprint Cloning and characterization of a novel endothelial promoter of the human CYP19 (aromatase P450) gene that is up-regulated in breast cancer tissue
    Siby Sebastian
    Department of Obstetrics and Gynecology, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Mol Endocrinol 16:2243-54. 2002
    ..The activity of this promoter may also be important for intracrine and paracrine effects of estrogen on blood vessels...
  40. pmc Prostaglandin E2 via steroidogenic factor-1 coordinately regulates transcription of steroidogenic genes necessary for estrogen synthesis in endometriosis
    Erkut Attar
    Division of Reproductive Biology Research, Department of Obstetrics and Gynecology, Feinberg School of Medicine at Northwestern University, 303 East Superior Street, 4 123, Chicago, Illinois 60611, USA
    J Clin Endocrinol Metab 94:623-31. 2009
    ....
  41. pmc Upstream stimulatory factor-2 regulates steroidogenic factor-1 expression in endometriosis
    Hiroki Utsunomiya
    Division of Reproductive Biology Research, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Mol Endocrinol 22:904-14. 2008
    ..Taken together, the elevated levels of USF2 in endometriosis account for, in part, the aberrant expression of SF-1 and its target gene StAR and aromatase...
  42. ncbi request reprint Estrogen production and metabolism in endometriosis
    Serdar E Bulun
    Department of Obstetrics and Gynecology, University of Illinois at Chicago, 60612, USA
    Ann N Y Acad Sci 955:75-85; discussion 86-8, 396-406. 2002
    ..The clinical relevance of these findings was exemplified by the successful treatment of an unusually aggressive case of postmenopausal endometriosis using an aromatase inhibitor...
  43. pmc Transcription factor KLF11 integrates progesterone receptor signaling and proliferation in uterine leiomyoma cells
    Ping Yin
    Division of Reproductive Biology Research, Department of Obstetrics and Gynecology, Feinberg School of Medicine at Northwestern University, Chicago, IL 60611, USA
    Cancer Res 70:1722-30. 2010
    ..Taken together, using a ChIP-cloning approach, we uncovered KLF11 as an integrator of PR signaling and proliferation in uterine leiomyoma cells...
  44. pmc Progesterone is essential for maintenance and growth of uterine leiomyoma
    Hiroshi Ishikawa
    Division of Reproductive Biology Research, Northwestern University Feinberg School of Medicine, Department of Obstetrics and Gynecology, 4th Floor, Suite 4 127, 303 East Superior Street, Chicago, Illinois 60611, USA
    Endocrinology 151:2433-42. 2010
    ..Taken together, our findings define that volume maintenance and growth of human UL are progesterone dependent...
  45. ncbi request reprint Aromatase and endometriosis
    Serdar E Bulun
    Department of Obstetrics and Gynecology, Northwestern University, Chicago, Illinois 60611, USA
    Semin Reprod Med 22:45-50. 2004
    ..We were able to target this positive feedback cycle in endometriosis using aromatase inhibitors. In fact, pilot trials showed that aromatase inhibitors could decrease pelvic pain associated with endometriosis...
  46. pmc Expression profiling of nuclear receptors identifies key roles of NR4A subfamily in uterine fibroids
    Hanwei Yin
    Division of Reproductive Biology Research, Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Mol Endocrinol 27:726-40. 2013
    ..Together, our results implicate several NRs including the NR4A subfamily in leiomyoma etiology and identify NR4As as potential therapeutic targets for treating fibrotic diseases...
  47. ncbi request reprint Aromatase promoter I.f is regulated by estrogen receptor alpha (ESR1) in mouse hypothalamic neuronal cell lines
    M Bertan Yilmaz
    Division of Reproductive Biology Research, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Biol Reprod 81:956-65. 2009
    ..f by enhanced binding of an ESR1/JUN complex to distinct AP-1 motifs in hypothalamic cells. We speculate that this mechanism may, in part, regulate gonadotropin secretion and sexual activity...
  48. ncbi request reprint SP1 and SP3 mediate progesterone-dependent induction of the 17beta hydroxysteroid dehydrogenase type 2 gene in human endometrium
    You Hong Cheng
    Division of Reproductive Biology Research, Department of Obstetrics and Gynecology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611 3095, USA
    Biol Reprod 75:605-14. 2006
    ....
  49. ncbi request reprint Up-regulation of cyclooxygenase-2 expression and prostaglandin synthesis in endometrial stromal cells by malignant endometrial epithelial cells. A paracrine effect mediated by prostaglandin E2 and nuclear factor-kappa B
    Mitsutoshi Tamura
    Department of Obstetrics and Gynecology and Molecular Genetics, The University of Illinois, Chicago, Illinois 60612, USA
    J Biol Chem 277:26208-16. 2002
    ..In conclusion, malignant endometrial epithelial cells secrete PGE(2) that induces COX-2 expression in normal endometrial stromal cells in a paracrine fashion through activation of transcription and stabilization of COX-2 mRNA...
  50. ncbi request reprint WT1 and DAX-1 regulate SF-1-mediated human P450arom gene expression in gonadal cells
    Bilgin Gurates
    Departments of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, University of Illinois at Chicago, 820 S Wood Street, M C 808, Chicago, IL 60612, USA
    Mol Cell Endocrinol 208:61-75. 2003
    ..Given the characterized roles of these transcription factors in gonadal development and function, modulation of SF-1 action by WT1 and DAX-1 may represent an important key mechanism in steroidogenesis...
  51. doi request reprint CpG dinucleotide methylation of the CYP19 I.3/II promoter modulates cAMP-stimulated aromatase activity
    Masashi Demura
    Division of Reproductive Biology Research, Department of Obstetrics and Gynecology, Northwestern University Feinberg School of Medicine, 303 E Superior Street, Suite 4 123, Chicago, IL 60611 3095, USA
    Mol Cell Endocrinol 283:127-32. 2008
    ..3/II regulates aromatase expression and may be one source of inter-individual variability. Furthermore, abnormal methylation of the aromatase promoter may contribute to aromatase overexpression in breast cancer...
  52. ncbi request reprint Novel estrogen receptor-alpha binding sites and estradiol target genes identified by chromatin immunoprecipitation cloning in breast cancer
    Zhihong Lin
    Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Cancer Res 67:5017-24. 2007
    ..Our findings suggest that at least a subset of these genes, including Wnt11, may play important in vivo and in vitro biological roles in breast cancer...
  53. ncbi request reprint Regulation of 17-beta hydroxysteroid dehydrogenase type 2 in human placental endothelial cells
    Emily J Su
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Northwestern University, Chicago, Illinois 60611, USA
    Biol Reprod 77:517-25. 2007
    ..Together, these data indicate that regulation of HSD17B2 mRNA levels and enzymatic activity by RA in the placenta is mediated by RARA and RXRA...
  54. ncbi request reprint Estrogen up-regulates cyclooxygenase-2 via estrogen receptor in human uterine microvascular endothelial cells
    Mitsutoshi Tamura
    Departments of Obstetrics and Gynecology and Molecular Genetics, University of Illinois at Chicago, Chicago, Illinois 60611, USA
    Fertil Steril 81:1351-6. 2004
    ..To investigate the effects of 17beta-estradiol (E(2)) on cyclooxygenase-2 (COX-2) expression and prostaglandin E(2) (PGE(2)) synthesis in primary human uterine microvascular endothelial cells (HUMEC)...
  55. doi request reprint LAT1 regulates growth of uterine leiomyoma smooth muscle cells
    - Xia Luo
    Division of Reproductive Biology Research, Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Reprod Sci 17:791-7. 2010
    ..Taken together, LAT1 may have a critical and complex role in regulating human leiomyoma cell growth...
  56. doi request reprint Regulation of breast cancer-associated aromatase promoters
    Dong Chen
    Division of Reproductive Biology Research, Department of Obstetrics and Gynecology, Northwestern University, 303 E Superior Street, Chicago, IL 60611, USA
    Cancer Lett 273:15-27. 2009
    ..Clinical side effects of these agents require development of new drugs with better specificity and efficacy, and epigenetic therapies with breast cancer tissue-selective aromatase siRNA-conjugated nanoparticles...
  57. pmc JunD and JunB integrate prostaglandin E2 activation of breast cancer-associated proximal aromatase promoters
    Dong Chen
    Division of Reproductive Biology Research, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Mol Endocrinol 25:767-75. 2011
    ..3/II via CRE(-211/-199). JunB also activates aromatase promoters I.3/II by maintaining JunD expression. Targeting JunD may abolish aromatase expression selectively in breast cancer tissue...
  58. ncbi request reprint The human CYP19 (aromatase P450) gene: update on physiologic roles and genomic organization of promoters
    Serdar E Bulun
    Department of Obstetrics and Gynecology and Molecular Genetics, University of Illinois at Chicago, 820 S Wood St M C 808, Chicago, IL 60612, USA
    J Steroid Biochem Mol Biol 86:219-24. 2003
    ..3, I.7 and I.4) for aromatase expression. The sum of P450arom mRNA species arising from these four promoters markedly increase total P450arom mRNA levels in breast cancer compared with the normal breast...
  59. ncbi request reprint Estrogen regulates expression of tumor necrosis factor receptors in breast adipose fibroblasts
    Santanu Deb
    Department of Obstetrics and Gynecology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Clin Endocrinol Metab 89:4018-24. 2004
    ..We conclude that high levels of estrogen found in breast tumors promote the antiadipogenic action of TNF on breast adipose fibroblasts by selectively up-regulating TNFR1, which may be a critical mechanism for desmoplastic reaction...
  60. ncbi request reprint Aromatase expression in women's cancers
    Serdar E Bulun
    Department of Obstetric and Gynecology, Northwestern University, Chicago, IL 60611, USA
    Adv Exp Med Biol 630:112-32. 2008
    ..Thus, inflammatory substances such as PGE2 may play important roles in inducing local production of estrogen that promotes tumor growth...
  61. pmc Retinoic acid (RA) regulates 17beta-hydroxysteroid dehydrogenase type 2 expression in endometrium: interaction of RA receptors with specificity protein (SP) 1/SP3 for estradiol metabolism
    You Hong Cheng
    Division of Reproductive Biology Research, Department of Obstetrics and Gynecology, Northwestern University, 303 E Superior Street, Chicago, IL 60611, USA
    J Clin Endocrinol Metab 93:1915-23. 2008
    ..Retinoic acid (RA) induces HSD17B2 expression, but the underlying mechanism is not known...
  62. ncbi request reprint Aromatase expression in uterine leiomyomata is regulated primarily by proximal promoters I.3/II
    Ayse Gonca Imir
    Department of Obstetrics and Gynecology, Northwestern University, 303 East Superior Street, Suite 4 123, Chicago, IL 60611, USA
    J Clin Endocrinol Metab 92:1979-82. 2007
    ..Uterine leiomyoma tissue, but not normal myometrium, overexpresses aromatase leading to estrogen-stimulated cell proliferation. Aromatase inhibitor treatment shrank uterine leiomyomata in a few women...
  63. ncbi request reprint Prostaglandin E(2) induces breast cancer related aromatase promoters via activation of p38 and c-Jun NH(2)-terminal kinase in adipose fibroblasts
    Dong Chen
    Division of Reproductive Biology Research, Department of Obstetrics and Gynecology, Northwestern University, Chicago, Illinois 60611, USA
    Cancer Res 67:8914-22. 2007
    ..Taken together, PGE(2) activation of p38 and JNK1 via PKA and PKC is necessary for aromatase induction in BAFs, and p38 and JNK1 are potential new drug targets for tissue-specific ablation of aromatase expression in breast cancer...
  64. ncbi request reprint Retinoic acid inhibits endometrial cancer cell growth via multiple genomic mechanisms
    You Hong Cheng
    Department of Obstetrics and Gynecology, Northwestern University Feinberg School of Medicine, 303 East Superior Street, Suite 4 131, Chicago, Illinois 60611 3095, USA
    J Mol Endocrinol 46:139-53. 2011
    ..These pathways could, therefore, mediate the carcinogenesis of human endometrial cancer...
  65. pmc The selective progesterone receptor modulator CDB4124 inhibits proliferation and induces apoptosis in uterine leiomyoma cells
    Xia Luo
    Division of Reproductive Biology Research, Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Fertil Steril 93:2668-73. 2010
    ..To evaluate the effects of selective P receptor (PR) modulator CDB4124 on cell proliferation and apoptosis in cultured human uterine leiomyoma smooth muscle (LSM) cells and control myometrial smooth muscle (MSM) cells in matched uteri...
  66. ncbi request reprint Interleukin-1beta elevates cyclooxygenase-2 protein level and enzyme activity via increasing its mRNA stability in human endometrial stromal cells: an effect mediated by extracellularly regulated kinases 1 and 2
    Mitsutoshi Tamura
    Department of Obstetrics and Gynecology, University of Illinois at Chicago, 820 South Wood Street, Chicago, IL 60612, USA
    J Clin Endocrinol Metab 87:3263-73. 2002
    ..Moreover, posttranscriptional mRNA stability is an important mechanism for IL-1beta-induced elevation of COX-2 expression in ESC...
  67. ncbi request reprint Organization of the human aromatase p450 (CYP19) gene
    Serdar E Bulun
    Department of Obstetrics and Gynecology, Northwestern University, Chicago, Illinois 60611, USA
    Semin Reprod Med 22:5-9. 2004
    ..4. Because each mRNA species contains the identical coding region regardless of the variable untranslated first exon, the encoded protein functions as the aromatase enzyme in each case...
  68. pmc Endometriosis and ovarian cancer: a review of clinical, pathologic, and molecular aspects
    Jian Jun Wei
    Department of Pathology, Division of Reproductive Biology Research, Northwestern University Feinberg School of Medicine, 251 E Huron St, Chicago, IL, 60611, USA
    Int J Gynecol Pathol 30:553-68. 2011
    ..This study is a review of the natural history of endometriosis and the role of microenvironments that favor the accumulation of genetic alterations and endometriosis-associated ovarian cancer progression...
  69. pmc Differential expression of microRNA species in human uterine leiomyoma versus normal myometrium
    Erica E Marsh
    Division of Reproductive Biology Research, Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Fertil Steril 89:1771-6. 2008
    ..To determine whether microRNAs (miRNAs) are differentially expressed in human leiomyoma versus matched myometrial tissue...
  70. ncbi request reprint Regional rearrangements in chromosome 15q21 cause formation of cryptic promoters for the CYP19 (aromatase) gene
    Masashi Demura
    Division of Reproductive Biology Research, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Hum Mol Genet 16:2529-41. 2007
    ..Taken together, small rearrangements may create cryptic promoters that direct inappropriate transcription of CYP19 or other critical genes...
  71. ncbi request reprint Treatment of endometriosis and chronic pelvic pain with letrozole and norethindrone acetate: a pilot study
    Radhika K Ailawadi
    Department of Obstetrics and Gynecology, University of Illinois at Chicago, Chicago, Illinois, USA
    Fertil Steril 81:290-6. 2004
    ..To determine the role of an aromatase inhibitor, letrozole, in the treatment of reproductive-age women with endometriosis and associated chronic pelvic pain...
  72. ncbi request reprint Intact progesterone receptors are essential to counteract the proliferative effect of estradiol in a genetically engineered mouse model of endometriosis
    Zongjuan Fang
    Department of Obstetrics and Gynecology, Northwestern University, 333 East Superior Street, Chicago, IL 60611, USA
    Fertil Steril 82:673-8. 2004
    ..To determine the role of P and its nuclear receptor PR in the growth of ectopic uterine tissue of mice with or without a disrupted PR gene...
  73. ncbi request reprint A modified baboon model for endometriosis
    Asgerally T Fazleabas
    Department of Obstetrics and Gynecology, University of Illinois at Chicago, 60612 7313, USA
    Ann N Y Acad Sci 955:308-17; discussion 340-2, 396-406. 2002
    ....
  74. ncbi request reprint Steroid hormones and leiomyomas
    Erica E Marsh
    Division of Reproductive Biology Research, Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Robert H Lurie Medical Research Center, 303 East Superior Street, 4 123, Chicago, IL 60611, USA
    Obstet Gynecol Clin North Am 33:59-67. 2006
    ....
  75. ncbi request reprint Aromatase inhibitors: the next generation of therapeutics for endometriosis?
    Erkut Attar
    Division of Reproductive Biology Research, Department of Obstetrics and Gynecology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Fertil Steril 85:1307-18. 2006
    ..The side-effect profile of AIs administered in combination with an oral contraceptive or a progestin is remarkably benign. We review herein the published clinical evidence for the use of AIs in the treatment of endometriosis...
  76. ncbi request reprint Ovulation induction in women with infertility: a new indication for aromatase inhibitors
    Serdar E Bulun
    Department of Obstetrics and Gynecology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Fertil Steril 80:1338; discussion 1339. 2003
  77. ncbi request reprint Vascular endothelial growth factor up-regulates cyclooxygenase-2 expression in human endothelial cells
    Mitsutoshi Tamura
    Department of Ostetrics and Gynecology, The University of Illinois at Chicago, 820 South Wood Street, Chicago, IL 60612, USA
    J Clin Endocrinol Metab 87:3504-7. 2002
    ..These observations are of particular importance given the recent demonstrations of critical requirement of COX-2 isoenzyme for tumor growth and angiogenesis...
  78. doi request reprint Estrogen receptor-beta mediates cyclooxygenase-2 expression and vascular prostanoid levels in human placental villous endothelial cells
    Emily J Su
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
    Am J Obstet Gynecol 200:427.e1-8. 2009
    ..Previously, we demonstrated that villous endothelial cells express estrogen receptor-beta (ESR2), and we sought to determine its role in the mediation of fetoplacental vascular function...
  79. ncbi request reprint Anastrazole and oral contraceptives: a novel treatment for endometriosis
    Lisa L Amsterdam
    Indiana University School of Medicine, Indianapolis, Indiana, USA
    Fertil Steril 84:300-4. 2005
    ..To establish the use of aromatase inhibitors as a therapeutic option for endometriosis...

Research Grants18

  1. Breast Cancer-Proximal Stroma Interaction and Aromatase
    Serdar Bulun; Fiscal Year: 2002
    ....
  2. Breast Cancer-Proximal Stroma Interaction & Aromatase
    Serdar Bulun; Fiscal Year: 2009
    ..noncarrier controls. Proposed studies may lead to new pilot trials of treatment and prevention using p38/JNK inhibitors in BRCA1 mutation carriers. ..
  3. Breast Cancer-Proximal Stroma Interaction & Aromatase
    Serdar Bulun; Fiscal Year: 2007
    ..noncarrier controls. Proposed studies may lead to new pilot trials of treatment and prevention using p38/JNK inhibitors in BRCA1 mutation carriers. ..
  4. MECHANISMS OF ESTROGEN BIOSYNTHESIS IN ENDOMETRIOSIS
    Serdar Bulun; Fiscal Year: 2007
    ..Investigation of local feedback mechanisms responsible for interactions between estrogen biosynthesis, tissue growth, and inflammation will lead to the rational design of novel drug treatments. ..
  5. ESTROGEN BIOSYNTHESIS AND UTERINE LEIOMYOMATA
    Serdar Bulun; Fiscal Year: 2007
    ..We predict that these studies will establish the critical role of P450arom in uterine leiomyomata and lead to identification of novel therapeutic targets. ..
  6. MECHANISMS OF ESTROGEN BIOSYNTHESIS IN ENDOMETRIOSIS
    Serdar Bulun; Fiscal Year: 2006
    ..Investigation of local feedback mechanisms responsible for interactions between estrogen biosynthesis, tissue growth, and inflammation will lead to the rational design of novel drug treatments. ..
  7. ESTROGEN BIOSYNTHESIS AND UTERINE LEIOMYOMATA
    Serdar Bulun; Fiscal Year: 2006
    ..We predict that these studies will establish the critical role of P450arom in uterine leiomyomata and lead to identification of novel therapeutic targets. ..
  8. Breast Cancer-Proximal Stroma Interaction and Aromatase
    Serdar Bulun; Fiscal Year: 2006
    ....
  9. MECHANISMS OF ESTROGEN BIOSYNTHESIS IN ENDOMETRIOSIS
    Serdar Bulun; Fiscal Year: 2005
    ..Investigation of local feedback mechanisms responsible for interactions between estrogen biosynthesis, tissue growth, and inflammation will lead to the rational design of novel drug treatments. ..
  10. Breast Cancer-Proximal Stroma Interaction and Aromatase
    Serdar Bulun; Fiscal Year: 2005
    ....
  11. MECHANISMS OF ESTROGEN BIOSYNTHESIS IN ENDOMETRIOSIS
    Serdar Bulun; Fiscal Year: 2002
    ..The role of aromatase inhibitors in the treatment of endometriosis (in comparison with conventional treatments) will also be characterized in this model. ..
  12. MECHANISMS OF ESTROGEN BIOSYNTHESIS IN ENDOMETRIOSIS
    Serdar Bulun; Fiscal Year: 2004
    ..Investigation of local feedback mechanisms responsible for interactions between estrogen biosynthesis, tissue growth, and inflammation will lead to the rational design of novel drug treatments. ..
  13. ESTROGEN BIOSYNTHESIS AND UTERINE LEIOMYOMATA
    Serdar Bulun; Fiscal Year: 2005
    ..We predict that these studies will establish the critical role of P450arom in uterine leiomyomata and lead to identification of novel therapeutic targets. ..
  14. Breast Cancer-Proximal Stroma Interaction and Aromatase
    Serdar Bulun; Fiscal Year: 2004
    ....
  15. Breast Cancer-Proximal Stroma Interaction and Aromatase
    Serdar Bulun; Fiscal Year: 2003
    ....
  16. Breast Cancer-Proximal Stroma Interaction & Aromatase
    Serdar E Bulun; Fiscal Year: 2010
    ..noncarrier controls. Proposed studies may lead to new pilot trials of treatment and prevention using p38/JNK inhibitors in BRCA1 mutation carriers. ..