A Bejsovec

Summary

Affiliation: Northwestern University
Country: USA

Publications

  1. ncbi Wnt signalling shows its versatility
    A Bejsovec
    Northwestern University Department of Biochemistry, Molecular Biology and Cell Biology 2153 Sheridan Road, Evanston, Illinois 60208, USA
    Curr Biol 9:R684-7. 1999
  2. ncbi Non-equivalent roles of Drosophila Frizzled and Dfrizzled2 in embryonic wingless signal transduction
    M M Moline
    Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, 2153 Sheridan Road, Evanston, Illinois, 60208 3500, USA
    Curr Biol 10:1127-30. 2000
  3. ncbi Directionality of wingless protein transport influences epidermal patterning in the Drosophila embryo
    M M Moline
    Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, IL 60208 3500, USA
    Development 126:4375-84. 1999
  4. ncbi Functional analysis of Wingless reveals a link between intercellular ligand transport and dorsal-cell-specific signaling
    H A Dierick
    Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, IL 60208 3500, USA
    Development 125:4729-38. 1998
  5. ncbi Wingless signaling generates pattern through two distinct mechanisms
    R Hays
    Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, IL 60208 3500, USA
    Development 124:3727-36. 1997
  6. ncbi Drosophila APC2 is a cytoskeletally-associated protein that regulates wingless signaling in the embryonic epidermis
    B M McCartney
    Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 3280, USA
    J Cell Biol 146:1303-18. 1999
  7. ncbi Drosophila APC2 and Armadillo participate in tethering mitotic spindles to cortical actin
    B M McCartney
    Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 3280, USA
    Nat Cell Biol 3:933-8. 2001
  8. ncbi Drosophila Tcf and Groucho interact to repress Wingless signalling activity
    R A Cavallo
    Department of Biology, University of North Carolina, Chapel Hill 27599, USA
    Nature 395:604-8. 1998
  9. ncbi Negative regulation of Armadillo, a Wingless effector in Drosophila
    L M Pai
    Department of Biology and Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill 27599 3280, USA
    Development 124:2255-66. 1997
  10. ncbi Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF
    M van de Wetering
    Department of Immunology, University Hospital, Utrecht, The Netherlands
    Cell 88:789-99. 1997

Collaborators

Detail Information

Publications16

  1. ncbi Wnt signalling shows its versatility
    A Bejsovec
    Northwestern University Department of Biochemistry, Molecular Biology and Cell Biology 2153 Sheridan Road, Evanston, Illinois 60208, USA
    Curr Biol 9:R684-7. 1999
    ..Recent studies have revealed that regulatory interactions at several steps in the pathway can modify its outcome, helping to explain how the same pathway can, in different contexts, have very different characteristics and consequences...
  2. ncbi Non-equivalent roles of Drosophila Frizzled and Dfrizzled2 in embryonic wingless signal transduction
    M M Moline
    Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, 2153 Sheridan Road, Evanston, Illinois, 60208 3500, USA
    Curr Biol 10:1127-30. 2000
    ..We conclude that wild-type Wg signaling requires efficient interaction between ligand and the Dfz2-proteoglycan receptor complex to promote the naked cuticle cell fate...
  3. ncbi Directionality of wingless protein transport influences epidermal patterning in the Drosophila embryo
    M M Moline
    Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, IL 60208 3500, USA
    Development 126:4375-84. 1999
    ....
  4. ncbi Functional analysis of Wingless reveals a link between intercellular ligand transport and dorsal-cell-specific signaling
    H A Dierick
    Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, IL 60208 3500, USA
    Development 125:4729-38. 1998
    ..Thus we have identified a region of Wingless that is required for both the transcytotic process and signal transduction in dorsal cell populations, revealing an unexpected link between these two aspects of Wg function...
  5. ncbi Wingless signaling generates pattern through two distinct mechanisms
    R Hays
    Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, IL 60208 3500, USA
    Development 124:3727-36. 1997
    ..Finally, we demonstrate that an 85 amino acid region not conserved in vertebrate Wnts is dispensable for Wg function and we discuss structural features of the Wingless protein required for its distinct biological activities...
  6. ncbi Drosophila APC2 is a cytoskeletally-associated protein that regulates wingless signaling in the embryonic epidermis
    B M McCartney
    Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 3280, USA
    J Cell Biol 146:1303-18. 1999
    ..We discuss the implications of our results for Wg signaling, and suggest a role for dAPC2 as a mediator of Wg effects on the cytoskeleton. We also speculate on more general roles that APCs may play in cytoskeletal dynamics...
  7. ncbi Drosophila APC2 and Armadillo participate in tethering mitotic spindles to cortical actin
    B M McCartney
    Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 3280, USA
    Nat Cell Biol 3:933-8. 2001
    ..Together, these data suggest that APC2, Armadillo and alpha-catenin provide an important link between spindles and cortical actin, and that this link is regulated by Zeste-white 3 kinase...
  8. ncbi Drosophila Tcf and Groucho interact to repress Wingless signalling activity
    R A Cavallo
    Department of Biology, University of North Carolina, Chapel Hill 27599, USA
    Nature 395:604-8. 1998
    ..Finally, mutations in the Drosophila groucho gene also suppress wingless and armadillo mutant phenotypes as Groucho physically interacts with dTcf and is required for its full repressor activity...
  9. ncbi Negative regulation of Armadillo, a Wingless effector in Drosophila
    L M Pai
    Department of Biology and Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill 27599 3280, USA
    Development 124:2255-66. 1997
    ..We discuss two models for the negative regulation of Armadillo in normal development and discuss how escape from this regulation contributes to tumorigenesis...
  10. ncbi Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF
    M van de Wetering
    Department of Immunology, University Hospital, Utrecht, The Netherlands
    Cell 88:789-99. 1997
    ..Epistasis analysis positions dTCF downstream of armadillo. The Armadillo-dTCF complex mediates Wingless signaling as a bipartite transcription factor...
  11. ncbi Segment polarity gene interactions modulate epidermal patterning in Drosophila embryos
    A Bejsovec
    Department of Molecular Biology, Princeton University, New Jersey 08544
    Development 119:501-17. 1993
    ....
  12. ncbi Signaling activities of the Drosophila wingless gene are separately mutable and appear to be transduced at the cell surface
    A Bejsovec
    Department of Molecular Biology, Princeton University, New Jersey 08544
    Genetics 139:309-20. 1995
    ..We conclude that wg signaling may involve complex interactions between the Wg ligand and its cell surface receptor molecule(s) and that some of this complexity resides within the Wg ligand itself...
  13. ncbi Roles of wingless in patterning the larval epidermis of Drosophila
    A Bejsovec
    Department of Zoology, University of Cambridge, UK
    Development 113:471-85. 1991
    ....
  14. ncbi Wnt signaling: an embarrassment of receptors
    A Bejsovec
    Department of Biology, Duke University, B336 LSRC Box 91000, Durham, North Carolina 27708, USA
    Curr Biol 10:R919-22. 2000
    ..Mutations disrupting LDL-receptor related proteins produce loss-of-function Wnt phenotypes, suggesting that these cell surface molecules may represent essential co-receptors for Wnt ligands...
  15. ncbi Secretion and movement of wingless protein in the epidermis of the Drosophila embryo
    F Gonzalez
    Department of Zoology, University of Cambridge, U K
    Mech Dev 35:43-54. 1991
    ..The protein can be found two or three cell diameters away from the cells in which it is synthesized. We discuss the possible mechanisms which are responsible for this spatial distribution and its regulation during embryogenesis...
  16. ncbi Flying at the head of the pack: Wnt biology in Drosophila
    A Bejsovec
    Department of Biology, Duke University, Durham, NC 27708 1000, USA
    Oncogene 25:7442-9. 2006
    ..Here, I review the history of these discoveries and highlight the utility of the fly in dissecting the molecular workings of Wnt signal transduction...