J Bass

Summary

Affiliation: Northwestern University
Country: USA

Publications

  1. doi request reprint Circadian topology of metabolism
    Joseph Bass
    Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Nature 491:348-56. 2012
  2. pmc Furin-mediated processing in the early secretory pathway: sequential cleavage and degradation of misfolded insulin receptors
    J Bass
    Howard Hughes Medical Institute, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 97:11905-9. 2000
  3. pmc Circadian integration of metabolism and energetics
    Joseph Bass
    Department of Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
    Science 330:1349-54. 2010
  4. pmc Folding of insulin receptor monomers is facilitated by the molecular chaperones calnexin and calreticulin and impaired by rapid dimerization
    J Bass
    The Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
    J Cell Biol 141:637-46. 1998
  5. pmc Sleep-wake regulation is altered in leptin-resistant (db/db) genetically obese and diabetic mice
    A D Laposky
    Department of Neurobiology and Physiology, Northwestern University, Center for Sleep and Circadian Biology, Evanston, Illinois, USA
    Am J Physiol Regul Integr Comp Physiol 295:R2059-66. 2008
  6. ncbi request reprint Furin mediates enhanced production of fibrillogenic ABri peptides in familial British dementia
    S H Kim
    Department of Neurobiology, Pharmacology and Physiology, The University of Chicago, Abbott 316, 947 East 58th Street, Chicago, Illinois 60637, USA
    Nat Neurosci 2:984-8. 1999
  7. doi request reprint Circadian clocks in fuel harvesting and energy homeostasis
    K M Ramsey
    Division of Endocrinology, Metabolism and Molecular Medicine, Feinberg School of Medicine and Department of Neurobiology and Physiology, Northwestern University, Chicago, Illinois 60611 3015, USA
    Cold Spring Harb Symp Quant Biol 76:63-72. 2011

Collaborators

Detail Information

Publications7

  1. doi request reprint Circadian topology of metabolism
    Joseph Bass
    Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Nature 491:348-56. 2012
    ..Biological clocks capture the imagination because of their tie to geophysical time, and tools are now in hand to analyse their function in health and disease at the cellular and molecular level...
  2. pmc Furin-mediated processing in the early secretory pathway: sequential cleavage and degradation of misfolded insulin receptors
    J Bass
    Howard Hughes Medical Institute, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 97:11905-9. 2000
    ..Together, these results suggest that processing and degradation occur sequentially for mutant proreceptors...
  3. pmc Circadian integration of metabolism and energetics
    Joseph Bass
    Department of Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
    Science 330:1349-54. 2010
    ..Here, we review advances in understanding the interrelationship among circadian disruption, sleep deprivation, obesity, and diabetes and implications for rational therapeutics for these conditions...
  4. pmc Folding of insulin receptor monomers is facilitated by the molecular chaperones calnexin and calreticulin and impaired by rapid dimerization
    J Bass
    The Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
    J Cell Biol 141:637-46. 1998
    ..Together, these studies demonstrate a chaperone function for Cnx/Crt in HIR folding in vivo and also provide evidence that folding efficiency and homodimerization are counterbalanced...
  5. pmc Sleep-wake regulation is altered in leptin-resistant (db/db) genetically obese and diabetic mice
    A D Laposky
    Department of Neurobiology and Physiology, Northwestern University, Center for Sleep and Circadian Biology, Evanston, Illinois, USA
    Am J Physiol Regul Integr Comp Physiol 295:R2059-66. 2008
    ..In summary, leptin may represent an important molecular component in the integration of sleep, circadian rhythms, and energy metabolism...
  6. ncbi request reprint Furin mediates enhanced production of fibrillogenic ABri peptides in familial British dementia
    S H Kim
    Department of Neurobiology, Pharmacology and Physiology, The University of Chicago, Abbott 316, 947 East 58th Street, Chicago, Illinois 60637, USA
    Nat Neurosci 2:984-8. 1999
    ..Collectively, our results support the view that enhanced furin-mediated processing of mutant BRI generates fibrillogenic peptides that initiate the pathogenesis of FBD...
  7. doi request reprint Circadian clocks in fuel harvesting and energy homeostasis
    K M Ramsey
    Division of Endocrinology, Metabolism and Molecular Medicine, Feinberg School of Medicine and Department of Neurobiology and Physiology, Northwestern University, Chicago, Illinois 60611 3015, USA
    Cold Spring Harb Symp Quant Biol 76:63-72. 2011
    ..Experimental genetic studies have pointed toward extensive interplay between circadian and metabolic systems and offer a means to dissect the impact of local tissue molecular clocks on fuel utilization across the sleep-wake cycle...

Research Grants8

  1. MOLECULAR COMPONENTS OF INSULIN RECEPTOR BIOGENESIS
    Joseph Bass; Fiscal Year: 2003
    ..abstract_text> ..
  2. MOLECULAR COMPONENENTS OF INSULIN RECEPTOR BIOGENESIS
    Joseph Bass; Fiscal Year: 2003
    ..Steiner, in addition to Drs. Graeme Bell, Susan Lindquist and other excellent scientists at the University of Chicago will promote his continued development as an independent researcher. ..
  3. Impact of Sleep on Feeding and the Metabolic Syndrome
    Joseph Bass; Fiscal Year: 2006
    ..Insight gained from these studies will provide new strategies to prevent metabolic complications associated with sleep deprivation and uncover novel metabolic targets for treatment of obesity and its co-morbidities. ..
  4. Molecular Basis of Circadian Desynchrony in Cardiometabolic Disease
    Shin Ichiro Imai; Fiscal Year: 2010
    ..Specific Aim 3: To test the hypothesis that high-fat diet disrupts the novel circadian-metabolic feedback loop involving NAD+ biogenesis and the NAD+-dependent deacetylase SIRT1. (End of Abstract) ..