Research Topics
Genomes and Genes
| Vimla BandSummaryAffiliation: Northwestern University Country: USA Publications
Research Grants
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Detail Information
Publications
Mammary epithelial cell transformation: insights from cell culture and mouse modelsGoberdhan Dimri
Division of Cancer Biology, Department of Medicine, ENH Research Institute, Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Evanston, Illinois, USA
Breast Cancer Res 7:171-9. 2005....- Mel-18 acts as a tumor suppressor by repressing Bmi-1 expression and down-regulating Akt activity in breast cancer cellsWei jian Guo
Division of Cancer Biology and Department of Medicine, ENH Research Institute, Evanston, IL 60201, USA
Cancer Res 67:5083-9. 2007..Thus, our studies suggest that Mel-18 and Bmi-1 may regulate the Akt pathway in breast cancer cells, and that Mel-18 functions as a tumor suppressor by repressing the expression of Bmi-1 and consequently down-regulating Akt activity... - Bmi-1 cooperates with H-Ras to transform human mammary epithelial cells via dysregulation of multiple growth-regulatory pathwaysSonal Datta
Division of Cancer Biology and Department of Medicine, Feinberg School of Medicine, Northwestern University, Evanston, IL 60201, USA
Cancer Res 67:10286-95. 2007.... 
The notch regulator MAML1 interacts with p53 and functions as a coactivatorYongtong Zhao
Division of Cancer Biology, Department of Medicine, ENH Research Institute, Feinberg School of Medicine, Northwestern University, Evanston, Illinois 60201, USA
J Biol Chem 282:11969-81. 2007..elegans p53 homolog Cep-1. Thus, we present evidence for a novel coactivator function of MAML1 for p53, independent of its function as a coactivator of Notch signaling pathway...- Binding of Cbl to a phospholipase Cgamma1-docking site on platelet-derived growth factor receptor beta provides a dual mechanism of negative regulationAlagarsamy Lakku Reddi
Division of Molecular Oncology, Evanston Northwestern Healthcare Research Institute, Northwestern University, Evanston, Illinois 60201, USA
J Biol Chem 282:29336-47. 2007.... - Ada3 requirement for HAT recruitment to estrogen receptors and estrogen-dependent breast cancer cell proliferationAleksandra Germaniuk-Kurowska
Divisions of Cancer Biology, Evanston Northwestern Healthcare Research Institute, Northwestern University, Evanston, Illinois, USA
Cancer Res 67:11789-97. 2007..Thus, our results show an important role of Ada3 in HAT recruitment to estrogen-responsive target gene promoters and for estrogen-dependent proliferation of breast cancer cells... - Modeling breast cancer-associated c-Src and EGFR overexpression in human MECs: c-Src and EGFR cooperatively promote aberrant three-dimensional acinar structure and invasive behaviorManjari Dimri
Division of Molecular Oncology, Evanston Northwestern Healthcare Research Institute, Evanston, IL 60201, USA
Cancer Res 67:4164-72. 2007.... 
Cyclooxygenase-2 expression during immortalization and breast cancer progressionXiangshan Zhao
Division of Cancer Biology, Department of Medicine, Evanston Northwestern Healthcare Research Institute and Feinberg School of Medicine, Evanston, IL, USA
Cancer Res 68:467-75. 2008....- An essential role of human Ada3 in p53 acetylationAlo Nag
Division of Cancer Biology, Evanston Northwestern Healthcare Research Institute, IL 60201, USA
J Biol Chem 282:8812-20. 2007.... - Upregulation of the let-7 microRNA with precocious development in lin-12/Notch hypermorphic Caenorhabditis elegans mutantsAharon Solomon
Division of Molecular Oncology, Evanston Northwestern Healthcare Research Institute, Department of Medicine, Feinberg School of Medicine, USA
Dev Biol 316:191-9. 2008..Importantly, the human microRNA let-7a was also upregulated in various human cell lines in response to Notch 1 activation, suggesting an evolutionarily conserved cross-talk between let-7 and the canonical lin-12/Notch signaling pathway... - Anticancer activity of Celastrol in combination with ErbB2-targeted therapeutics for treatment of ErbB2-overexpressing breast cancersSrikumar M Raja
Department of Medicine, Evanston Northwestern Healthcare Research Institute, Northwestern University, Evanston, IL, USA
Cancer Biol Ther 11:263-76. 2011..These studies suggest the potential use of Michael acceptor-containing molecules as novel therapeutic modalities against ErbB2-driven breast cancer by targeting multiple biological attributes of the driver oncogene... - The human orthologue of Drosophila ecdysoneless protein interacts with p53 and regulates its functionYing Zhang
Division of Cancer Biology and Molecular Oncology, Department of Medicine, Evanston Northwestern Healthcare Research Institute and Feinberg School of Medicine, and Robert H. Lurie Comprehensive Cancer Center, Evanston, Illinois 60201, USA
Cancer Res 66:7167-75. 2006..Our studies also represent the first demonstration of a biochemical function for hEcd protein and raise the possibility that altered hEcd levels and/or function may contribute to oncogenesis... - Centrobin: a novel daughter centriole-associated protein that is required for centriole duplicationChaozhong Zou
Department of Medicine, Division of Cancer Biology, Evanston Northwestern Healthcare Research Institute, Northwestern University Feinberg School of Medicine, Evanston, IL 60201, USA
J Cell Biol 171:437-45. 2005..Furthermore, inhibition of centriole duplication by centrobin depletion led to impaired cytokinesis... - Hyperbaric oxygen inhibits benign and malignant human mammary epithelial cell proliferationEric V Granowitz
Department of Medicine, Baystate Medical Center, Tufts University School of Medicine, Springfield, MA 01199, USA
Anticancer Res 25:3833-42. 2005..Hyperbaric oxygenation (HBO) therapy is the administration of 100%-inhaled oxygen to patients at increased atmospheric pressure... - Shared as well as distinct roles of EHD proteins revealed by biochemical and functional comparisons in mammalian cells and C. elegansManju George
Division of Molecular Oncology, Evanston Northwestern Healthcare Research Institute, Department of Medicine, Feinberg School of Medicine, Northwestern University, Evanston, Illinois, USA
BMC Cell Biol 8:3. 2007..Certain members of this family have been studied in different cellular contexts; however, a lack of concurrent analyses of all four proteins has impeded an appreciation of their redundant versus distinct functions... - Biochemical basis for the requirement of kinase activity for Cbl-dependent ubiquitinylation and degradation of a target tyrosine kinaseAmiya K Ghosh
Division of Molecular Oncology, Department of Medicine Evanston Northwestern Healthcare Research Institute, Feinberg School of Medicine and Robert H Lurie Comprehensive Cancer Center, Northwestern University, Evanston, Illinois 60201, USA
J Biol Chem 279:36132-41. 2004..Our results strongly suggest that promotion of association with Cbl is the primary mechanism by which the kinase activity of the targets of Cbl contributes to their susceptibility to Cbl... - Induction of cancer cell death by self-assembling nanostructures incorporating a cytotoxic peptideStephany M Standley
Department of Medicine, Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Institute for BioNanotechnology in Medicine, Northwestern University, Chicago, Illinois 60611, USA
Cancer Res 70:3020-6. 2010..Our results provide proof-of-principle that self-assembling PAs can be rationally designed to generate nanostructures that can efficiently deliver cytotoxic peptides to cancer cells... - BRCA2 suppresses cell proliferation via stabilizing MAGE-D1Xin Xia Tian
Division of Cancer Biology, Evanston Northwestern Healthcare Research Institute, Department of Medicine, Northwestern University Feinberg School of Medicine, Evanston, Illinois 60201, USA
Cancer Res 65:4747-53. 2005.... - Human kallikrein 10, a predictive marker for breast cancerYing Zhang
Division of Cancer Biology, Department of Medicine, Evanston Northwestern Healthcare Research Institute and Feinberg School of Medicine, Northwestern University, 1001 University Place, Evanston, IL 60201, USA
Biol Chem 387:715-21. 2006..These results point to the paradoxical role of hK10 in human cancers and underscore the importance of further studies of this kallikrein... - Mel-18, a polycomb group protein, regulates cell proliferation and senescence via transcriptional repression of Bmi-1 and c-Myc oncoproteinsWei jian Guo
Division of Cancer Biology and Department of Medicine, Evanston Northwestern Healthcare Research Institute, Evanston, IL 60201, USA
Mol Biol Cell 18:536-46. 2007..Finally, our data suggest that Mel-18 regulates Bmi-1 expression during senescence via down-regulation of c-Myc. These studies link c-Myc and polycomb function in cell proliferation and senescence... - ErbB2 degradation mediated by the co-chaperone protein CHIPPengcheng Zhou
Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 278:13829-37. 2003.... - Human papillomavirus oncoprotein E6 inactivates the transcriptional coactivator human ADA3Ajay Kumar
Division of Radiation and Cancer Biology, Department of Radiation Oncology, New England Medical Center, Boston, Massachusetts 02111, USA
Mol Cell Biol 22:5801-12. 2002..Given the likely role of the evolutionarily conserved hADA3 in multiple coactivator complexes, inactivation of its function may allow E6 to perturb numerous cellular pathways during HPV oncogenesis... - Human papilloma virus 16 E6 oncoprotein inhibits retinoic X receptor-mediated transactivation by targeting human ADA3 coactivatorMusheng Zeng
Division of Radiation and Cancer Biology, Department of Radiation Oncology, New England Medical Center, Boston, Massachusetts 02111, USA
J Biol Chem 277:45611-8. 2002..Significantly, we demonstrate that E6 inhibits the RXR(alpha)-mediated transactivation of target genes, implying that perturbation of RXR-mediated transactivation by E6 could contribute to HPV oncogenesis... - Cbl-mediated ubiquitinylation is required for lysosomal sorting of epidermal growth factor receptor but is dispensable for endocytosisLei Duan
Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 278:28950-60. 2003.... - In vitro models of early neoplastic transformation of human mammary epithelial cellsVimla Band
Department of Radiation Oncology, New England Medical Center, Boston, MA, USA
Methods Mol Biol 223:237-48. 2003 - Cbl-mediated ubiquitinylation and negative regulation of VavYuko Miura-Shimura
Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 278:38495-504. 2003..Thus, our findings strongly support the role of Cbl, via its ubiquitin ligase activity, as a negative regulator of activated Vav... - Human ADA3 binds to estrogen receptor (ER) and functions as a coactivator for ER-mediated transactivationGaoyuan Meng
Department of Radiation Oncology, New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
J Biol Chem 279:54230-40. 2004.... - Human papillomavirus E6-induced degradation of E6TP1 is mediated by E6AP ubiquitin ligaseQingshen Gao
Division of Radiation and Cancer Biology, Department of Radiation Oncology, New England Medical Center, Tufts University School of Medicine, 750 Washington Street, Boston, MA 02111, USA
Cancer Res 62:3315-21. 2002..These findings demonstrate that the E6-induced decrease in the levels of E6TP1 protein involves the E6AP-mediated ubiquitination followed by proteasome-dependent degradation...
Research Grants
- THE ROLE OF A NOVEL GAP IN EPITHELIAL ONCOGENESISVimla Band; Fiscal Year: 2003..abstract_text> ..