Vimla Band

Summary

Affiliation: Northwestern University
Country: USA

Publications

  1. pmc Mammary epithelial cell transformation: insights from cell culture and mouse models
    Goberdhan Dimri
    Division of Cancer Biology, Department of Medicine, ENH Research Institute, Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Evanston, Illinois, USA
    Breast Cancer Res 7:171-9. 2005
  2. pmc Mel-18 acts as a tumor suppressor by repressing Bmi-1 expression and down-regulating Akt activity in breast cancer cells
    Wei jian Guo
    Division of Cancer Biology and Department of Medicine, ENH Research Institute, Evanston, IL 60201, USA
    Cancer Res 67:5083-9. 2007
  3. pmc Bmi-1 cooperates with H-Ras to transform human mammary epithelial cells via dysregulation of multiple growth-regulatory pathways
    Sonal Datta
    Division of Cancer Biology and Department of Medicine, Feinberg School of Medicine, Northwestern University, Evanston, IL 60201, USA
    Cancer Res 67:10286-95. 2007
  4. ncbi request reprint Binding of Cbl to a phospholipase Cgamma1-docking site on platelet-derived growth factor receptor beta provides a dual mechanism of negative regulation
    Alagarsamy Lakku Reddi
    Division of Molecular Oncology, Evanston Northwestern Healthcare Research Institute, Northwestern University, Evanston, Illinois 60201, USA
    J Biol Chem 282:29336-47. 2007
  5. ncbi request reprint The notch regulator MAML1 interacts with p53 and functions as a coactivator
    Yongtong Zhao
    Division of Cancer Biology, Department of Medicine, ENH Research Institute, Feinberg School of Medicine, Northwestern University, Evanston, Illinois 60201, USA
    J Biol Chem 282:11969-81. 2007
  6. ncbi request reprint Ada3 requirement for HAT recruitment to estrogen receptors and estrogen-dependent breast cancer cell proliferation
    Aleksandra Germaniuk-Kurowska
    Divisions of Cancer Biology, Evanston Northwestern Healthcare Research Institute, Northwestern University, Evanston, Illinois, USA
    Cancer Res 67:11789-97. 2007
  7. ncbi request reprint Modeling breast cancer-associated c-Src and EGFR overexpression in human MECs: c-Src and EGFR cooperatively promote aberrant three-dimensional acinar structure and invasive behavior
    Manjari Dimri
    Division of Molecular Oncology, Evanston Northwestern Healthcare Research Institute, Evanston, IL 60201, USA
    Cancer Res 67:4164-72. 2007
  8. doi request reprint Cyclooxygenase-2 expression during immortalization and breast cancer progression
    Xiangshan Zhao
    Division of Cancer Biology, Department of Medicine, Evanston Northwestern Healthcare Research Institute and Feinberg School of Medicine, Evanston, IL, USA
    Cancer Res 68:467-75. 2008
  9. ncbi request reprint An essential role of human Ada3 in p53 acetylation
    Alo Nag
    Division of Cancer Biology, Evanston Northwestern Healthcare Research Institute, IL 60201, USA
    J Biol Chem 282:8812-20. 2007
  10. pmc Upregulation of the let-7 microRNA with precocious development in lin-12/Notch hypermorphic Caenorhabditis elegans mutants
    Aharon Solomon
    Division of Molecular Oncology, Evanston Northwestern Healthcare Research Institute, Department of Medicine, Feinberg School of Medicine, USA
    Dev Biol 316:191-9. 2008

Research Grants

Collaborators

Detail Information

Publications28

  1. pmc Mammary epithelial cell transformation: insights from cell culture and mouse models
    Goberdhan Dimri
    Division of Cancer Biology, Department of Medicine, ENH Research Institute, Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Evanston, Illinois, USA
    Breast Cancer Res 7:171-9. 2005
    ....
  2. pmc Mel-18 acts as a tumor suppressor by repressing Bmi-1 expression and down-regulating Akt activity in breast cancer cells
    Wei jian Guo
    Division of Cancer Biology and Department of Medicine, ENH Research Institute, Evanston, IL 60201, USA
    Cancer Res 67:5083-9. 2007
    ..Thus, our studies suggest that Mel-18 and Bmi-1 may regulate the Akt pathway in breast cancer cells, and that Mel-18 functions as a tumor suppressor by repressing the expression of Bmi-1 and consequently down-regulating Akt activity...
  3. pmc Bmi-1 cooperates with H-Ras to transform human mammary epithelial cells via dysregulation of multiple growth-regulatory pathways
    Sonal Datta
    Division of Cancer Biology and Department of Medicine, Feinberg School of Medicine, Northwestern University, Evanston, IL 60201, USA
    Cancer Res 67:10286-95. 2007
    ....
  4. ncbi request reprint Binding of Cbl to a phospholipase Cgamma1-docking site on platelet-derived growth factor receptor beta provides a dual mechanism of negative regulation
    Alagarsamy Lakku Reddi
    Division of Molecular Oncology, Evanston Northwestern Healthcare Research Institute, Northwestern University, Evanston, Illinois 60201, USA
    J Biol Chem 282:29336-47. 2007
    ....
  5. ncbi request reprint The notch regulator MAML1 interacts with p53 and functions as a coactivator
    Yongtong Zhao
    Division of Cancer Biology, Department of Medicine, ENH Research Institute, Feinberg School of Medicine, Northwestern University, Evanston, Illinois 60201, USA
    J Biol Chem 282:11969-81. 2007
    ..elegans p53 homolog Cep-1. Thus, we present evidence for a novel coactivator function of MAML1 for p53, independent of its function as a coactivator of Notch signaling pathway...
  6. ncbi request reprint Ada3 requirement for HAT recruitment to estrogen receptors and estrogen-dependent breast cancer cell proliferation
    Aleksandra Germaniuk-Kurowska
    Divisions of Cancer Biology, Evanston Northwestern Healthcare Research Institute, Northwestern University, Evanston, Illinois, USA
    Cancer Res 67:11789-97. 2007
    ..Thus, our results show an important role of Ada3 in HAT recruitment to estrogen-responsive target gene promoters and for estrogen-dependent proliferation of breast cancer cells...
  7. ncbi request reprint Modeling breast cancer-associated c-Src and EGFR overexpression in human MECs: c-Src and EGFR cooperatively promote aberrant three-dimensional acinar structure and invasive behavior
    Manjari Dimri
    Division of Molecular Oncology, Evanston Northwestern Healthcare Research Institute, Evanston, IL 60201, USA
    Cancer Res 67:4164-72. 2007
    ....
  8. doi request reprint Cyclooxygenase-2 expression during immortalization and breast cancer progression
    Xiangshan Zhao
    Division of Cancer Biology, Department of Medicine, Evanston Northwestern Healthcare Research Institute and Feinberg School of Medicine, Evanston, IL, USA
    Cancer Res 68:467-75. 2008
    ....
  9. ncbi request reprint An essential role of human Ada3 in p53 acetylation
    Alo Nag
    Division of Cancer Biology, Evanston Northwestern Healthcare Research Institute, IL 60201, USA
    J Biol Chem 282:8812-20. 2007
    ....
  10. pmc Upregulation of the let-7 microRNA with precocious development in lin-12/Notch hypermorphic Caenorhabditis elegans mutants
    Aharon Solomon
    Division of Molecular Oncology, Evanston Northwestern Healthcare Research Institute, Department of Medicine, Feinberg School of Medicine, USA
    Dev Biol 316:191-9. 2008
    ..Importantly, the human microRNA let-7a was also upregulated in various human cell lines in response to Notch 1 activation, suggesting an evolutionarily conserved cross-talk between let-7 and the canonical lin-12/Notch signaling pathway...
  11. pmc Anticancer activity of Celastrol in combination with ErbB2-targeted therapeutics for treatment of ErbB2-overexpressing breast cancers
    Srikumar M Raja
    Department of Medicine, Evanston Northwestern Healthcare Research Institute, Northwestern University, Evanston, IL, USA
    Cancer Biol Ther 11:263-76. 2011
    ..These studies suggest the potential use of Michael acceptor-containing molecules as novel therapeutic modalities against ErbB2-driven breast cancer by targeting multiple biological attributes of the driver oncogene...
  12. ncbi request reprint The human orthologue of Drosophila ecdysoneless protein interacts with p53 and regulates its function
    Ying Zhang
    Division of Cancer Biology and Molecular Oncology, Department of Medicine, Evanston Northwestern Healthcare Research Institute and Feinberg School of Medicine, and Robert H Lurie Comprehensive Cancer Center, Evanston, Illinois 60201, USA
    Cancer Res 66:7167-75. 2006
    ..Our studies also represent the first demonstration of a biochemical function for hEcd protein and raise the possibility that altered hEcd levels and/or function may contribute to oncogenesis...
  13. pmc Centrobin: a novel daughter centriole-associated protein that is required for centriole duplication
    Chaozhong Zou
    Department of Medicine, Division of Cancer Biology, Evanston Northwestern Healthcare Research Institute, Northwestern University Feinberg School of Medicine, Evanston, IL 60201, USA
    J Cell Biol 171:437-45. 2005
    ..Furthermore, inhibition of centriole duplication by centrobin depletion led to impaired cytokinesis...
  14. ncbi request reprint Biochemical basis for the requirement of kinase activity for Cbl-dependent ubiquitinylation and degradation of a target tyrosine kinase
    Amiya K Ghosh
    Division of Molecular Oncology, Department of Medicine Evanston Northwestern Healthcare Research Institute, Feinberg School of Medicine and Robert H Lurie Comprehensive Cancer Center, Northwestern University, Evanston, Illinois 60201, USA
    J Biol Chem 279:36132-41. 2004
    ..Our results strongly suggest that promotion of association with Cbl is the primary mechanism by which the kinase activity of the targets of Cbl contributes to their susceptibility to Cbl...
  15. ncbi request reprint Hyperbaric oxygen inhibits benign and malignant human mammary epithelial cell proliferation
    Eric V Granowitz
    Department of Medicine, Baystate Medical Center, Tufts University School of Medicine, Springfield, MA 01199, USA
    Anticancer Res 25:3833-42. 2005
    ..Hyperbaric oxygenation (HBO) therapy is the administration of 100%-inhaled oxygen to patients at increased atmospheric pressure...
  16. pmc Shared as well as distinct roles of EHD proteins revealed by biochemical and functional comparisons in mammalian cells and C. elegans
    Manju George
    Division of Molecular Oncology, Evanston Northwestern Healthcare Research Institute, Department of Medicine, Feinberg School of Medicine, Northwestern University, Evanston, Illinois, USA
    BMC Cell Biol 8:3. 2007
    ..Certain members of this family have been studied in different cellular contexts; however, a lack of concurrent analyses of all four proteins has impeded an appreciation of their redundant versus distinct functions...
  17. pmc Induction of cancer cell death by self-assembling nanostructures incorporating a cytotoxic peptide
    Stephany M Standley
    Department of Medicine, Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Institute for BioNanotechnology in Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Cancer Res 70:3020-6. 2010
    ..Our results provide proof-of-principle that self-assembling PAs can be rationally designed to generate nanostructures that can efficiently deliver cytotoxic peptides to cancer cells...
  18. pmc BRCA2 suppresses cell proliferation via stabilizing MAGE-D1
    Xin Xia Tian
    Division of Cancer Biology, Evanston Northwestern Healthcare Research Institute, Department of Medicine, Northwestern University Feinberg School of Medicine, Evanston, Illinois 60201, USA
    Cancer Res 65:4747-53. 2005
    ....
  19. ncbi request reprint Human kallikrein 10, a predictive marker for breast cancer
    Ying Zhang
    Division of Cancer Biology, Department of Medicine, Evanston Northwestern Healthcare Research Institute and Feinberg School of Medicine, Northwestern University, 1001 University Place, Evanston, IL 60201, USA
    Biol Chem 387:715-21. 2006
    ..These results point to the paradoxical role of hK10 in human cancers and underscore the importance of further studies of this kallikrein...
  20. pmc Mel-18, a polycomb group protein, regulates cell proliferation and senescence via transcriptional repression of Bmi-1 and c-Myc oncoproteins
    Wei jian Guo
    Division of Cancer Biology and Department of Medicine, Evanston Northwestern Healthcare Research Institute, Evanston, IL 60201, USA
    Mol Biol Cell 18:536-46. 2007
    ..Finally, our data suggest that Mel-18 regulates Bmi-1 expression during senescence via down-regulation of c-Myc. These studies link c-Myc and polycomb function in cell proliferation and senescence...
  21. ncbi request reprint ErbB2 degradation mediated by the co-chaperone protein CHIP
    Pengcheng Zhou
    Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 278:13829-37. 2003
    ....
  22. pmc Human papillomavirus oncoprotein E6 inactivates the transcriptional coactivator human ADA3
    Ajay Kumar
    Division of Radiation and Cancer Biology, Department of Radiation Oncology, New England Medical Center, Boston, Massachusetts 02111, USA
    Mol Cell Biol 22:5801-12. 2002
    ..Given the likely role of the evolutionarily conserved hADA3 in multiple coactivator complexes, inactivation of its function may allow E6 to perturb numerous cellular pathways during HPV oncogenesis...
  23. ncbi request reprint Human papilloma virus 16 E6 oncoprotein inhibits retinoic X receptor-mediated transactivation by targeting human ADA3 coactivator
    Musheng Zeng
    Division of Radiation and Cancer Biology, Department of Radiation Oncology, New England Medical Center, Boston, Massachusetts 02111, USA
    J Biol Chem 277:45611-8. 2002
    ..Significantly, we demonstrate that E6 inhibits the RXR(alpha)-mediated transactivation of target genes, implying that perturbation of RXR-mediated transactivation by E6 could contribute to HPV oncogenesis...
  24. ncbi request reprint Cbl-mediated ubiquitinylation is required for lysosomal sorting of epidermal growth factor receptor but is dispensable for endocytosis
    Lei Duan
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 278:28950-60. 2003
    ....
  25. ncbi request reprint In vitro models of early neoplastic transformation of human mammary epithelial cells
    Vimla Band
    Department of Radiation Oncology, New England Medical Center, Boston, MA, USA
    Methods Mol Biol 223:237-48. 2003
  26. ncbi request reprint Cbl-mediated ubiquitinylation and negative regulation of Vav
    Yuko Miura-Shimura
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 278:38495-504. 2003
    ..Thus, our findings strongly support the role of Cbl, via its ubiquitin ligase activity, as a negative regulator of activated Vav...
  27. ncbi request reprint Human ADA3 binds to estrogen receptor (ER) and functions as a coactivator for ER-mediated transactivation
    Gaoyuan Meng
    Department of Radiation Oncology, New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    J Biol Chem 279:54230-40. 2004
    ....
  28. ncbi request reprint Human papillomavirus E6-induced degradation of E6TP1 is mediated by E6AP ubiquitin ligase
    Qingshen Gao
    Division of Radiation and Cancer Biology, Department of Radiation Oncology, New England Medical Center, Tufts University School of Medicine, 750 Washington Street, Boston, MA 02111, USA
    Cancer Res 62:3315-21. 2002
    ..These findings demonstrate that the E6-induced decrease in the levels of E6TP1 protein involves the E6AP-mediated ubiquitination followed by proteasome-dependent degradation...

Research Grants1

  1. THE ROLE OF A NOVEL GAP IN EPITHELIAL ONCOGENESIS
    Vimla Band; Fiscal Year: 2003
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