RAJESHWAR BHAGWAN AWATRAMANI
Affiliation: Northwestern University
Poulin J, Caronia G, Hofer C, Cui Q, Helm B, Ramakrishnan C, et al
. Mapping projections of molecularly defined dopamine neuron subtypes using intersectional genetic approaches. Nat Neurosci. 2018;21:1260-1271 pubmed publisher
..Together, the genetic toolbox and DA neuron subtype projections presented here constitute a resource that will accelerate the investigation of this clinically significant neurotransmitter system. ..
Poulin J, Zou J, Drouin Ouellet J, Kim K, Cicchetti F, Awatramani R. Defining midbrain dopaminergic neuron diversity by single-cell gene expression profiling. Cell Rep. 2014;9:930-43 pubmed publisher
..Overall, this rapid, cost-effective approach enables the identification and classification of multiple dopamine neuron subtypes, with distinct molecular, anatomical, and functional properties. ..
Lin H, Oksuz I, Svaren J, Awatramani R. Egr2-dependent microRNA-138 is dispensable for peripheral nerve myelination. Sci Rep. 2018;8:3817 pubmed publisher
..Overall, our results demonstrate that miR-138 is an Egr2-dependent microRNA but is dispensable for Schwann cell myelination. ..
Nouri N, Patel M, Joksimovic M, Poulin J, Anderegg A, Taketo M, et al
. Excessive Wnt/beta-catenin signaling promotes midbrain floor plate neurogenesis, but results in vacillating dopamine progenitors. Mol Cell Neurosci. 2015;68:131-42 pubmed publisher
..Our findings will impact embryonic stem cell protocols that utilize Wnt pathway reagents to derive mDA neuron models and therapeutics for Parkinson's disease. ..
Lin H, Oksuz I, Hurley E, Wrabetz L, Awatramani R. Microprocessor complex subunit DiGeorge syndrome critical region gene 8 (Dgcr8) is required for schwann cell myelination and myelin maintenance. J Biol Chem. 2015;290:24294-307 pubmed publisher
..Together our data suggest that Dgcr8 is responsible for modulation of gene expression programs underlying myelin formation and maintenance as well as suppression of an injury-related gene expression program. ..
Nouri N, Awatramani R. A novel floor plate boundary defined by adjacent En1 and Dbx1 microdomains distinguishes midbrain dopamine and hypothalamic neurons. Development. 2017;144:916-927 pubmed publisher
..Our findings provide new insights into subdivisions in the mdFP, and will impact current strategies for the conversion of stem cells into DA neurons. ..