APKAR APKARIAN

Summary

Affiliation: Northwestern University
Country: USA

Publications

  1. pmc Corticostriatal functional connectivity predicts transition to chronic back pain
    Marwan N Baliki
    Department of Physiology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA
    Nat Neurosci 15:1117-9. 2012
  2. pmc Brain morphological signatures for chronic pain
    Marwan N Baliki
    Department of Physiology, Northwestern University, Chicago, Illinois, United States of America
    PLoS ONE 6:e26010. 2011
  3. doi request reprint Predicting transition to chronic pain
    A Vania Apkarian
    Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Curr Opin Neurol 26:360-7. 2013
  4. pmc A brain signature for acute pain
    A Vania Apkarian
    Department of Physiology, Feinberg School of Medicine, Northwestern University, 303 E Chicago Avenue, Tarry Building 5 703, Chicago, IL 60611, USA
    Trends Cogn Sci 17:309-10. 2013
  5. pmc Lidocaine patch (5%) is no more potent than placebo in treating chronic back pain when tested in a randomised double blind placebo controlled brain imaging study
    Javeria A Hashmi
    Department of Physiology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Mol Pain 8:29. 2012
  6. pmc Inflammatory and neuropathic pain animals exhibit distinct responses to innocuous thermal and motoric challenges
    Rami Jabakhanji
    Department of Physiology, Northwestern University Feinberg School of Medicine, 303 East Chicago Ave, Chicago IL, 60611, USA
    Mol Pain 2:1. 2006
  7. pmc A preliminary fMRI study of analgesic treatment in chronic back pain and knee osteoarthritis
    Marwan N Baliki
    Department of Physiology, Northwestern University, Feinberg School of Medicine, 303 East Chicago Ave, Chicago IL 60611, USA
    Mol Pain 4:47. 2008
  8. pmc Single subject pharmacological-MRI (phMRI) study: modulation of brain activity of psoriatic arthritis pain by cyclooxygenase-2 inhibitor
    M Baliki
    Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Mol Pain 1:32. 2005
  9. pmc Spared nerve injury rats exhibit thermal hyperalgesia on an automated operant dynamic thermal escape task
    Marwan Baliki
    Department of Physiology, Northwestern University Medical School, Chicago, IL, 60611, USA
    Mol Pain 1:18. 2005
  10. pmc Identifying directed links in large scale functional networks: application to brain fMRI
    Guillermo A Cecchi
    Computational Biology Center, T, J, Watson IBM Research Center, Yorktwon Heights, New York, USA
    BMC Cell Biol 8:S5. 2007

Research Grants

  1. CORTICAL PATHOPHYSIOLOGY OF PAIN
    APKAR APKARIAN; Fiscal Year: 2000
  2. CORTICAL PATHOPHYSIOLOGY OF PAIN
    APKAR VANIA APKARIAN; Fiscal Year: 2010
  3. Chronic Pain and Emotional Learning and Memory
    APKAR VANIA APKARIAN; Fiscal Year: 2010
  4. CORTICAL PATHOPHYSIOLOGY OF PAIN
    APKAR APKARIAN; Fiscal Year: 2009
  5. Chronic Pain and Emotional Learning and Memory
    APKAR APKARIAN; Fiscal Year: 2009
  6. Characterizing temporal dynamics of spontaneous pain
    APKAR APKARIAN; Fiscal Year: 2007
  7. CORTICAL PATHOPHYSIOLOGY OF PAIN
    APKAR APKARIAN; Fiscal Year: 2006
  8. Cortical Dynamics for Pain Perception in Behaving Rats
    APKAR APKARIAN; Fiscal Year: 2005
  9. CORTICAL PATHOPHYSIOLOGY OF PAIN
    APKAR APKARIAN; Fiscal Year: 2005
  10. Cortical Dynamics for Pain Perception in Behaving Rats
    APKAR APKARIAN; Fiscal Year: 2004

Collaborators

Detail Information

Publications32

  1. pmc Corticostriatal functional connectivity predicts transition to chronic back pain
    Marwan N Baliki
    Department of Physiology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois, USA
    Nat Neurosci 15:1117-9. 2012
    ..Initially greater functional connectivity of nucleus accumbens with prefrontal cortex predicted pain persistence, implying that corticostriatal circuitry is causally involved in the transition from acute to chronic pain...
  2. pmc Brain morphological signatures for chronic pain
    Marwan N Baliki
    Department of Physiology, Northwestern University, Chicago, Illinois, United States of America
    PLoS ONE 6:e26010. 2011
    ..The results show an exuberance of brain anatomical reorganization peculiar to each condition and as such reflecting the unique maladaptive physiology of different types of chronic pain...
  3. doi request reprint Predicting transition to chronic pain
    A Vania Apkarian
    Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Curr Opin Neurol 26:360-7. 2013
    ..Yet, despite more than 30 years of research, there is little agreement on the neural mechanisms that mediate the transition from acute to chronic pain...
  4. pmc A brain signature for acute pain
    A Vania Apkarian
    Department of Physiology, Feinberg School of Medicine, Northwestern University, 303 E Chicago Avenue, Tarry Building 5 703, Chicago, IL 60611, USA
    Trends Cogn Sci 17:309-10. 2013
    ..This is a strong demonstration of the existence of a pain signature and raises important questions regarding what pain and perception are. ..
  5. pmc Lidocaine patch (5%) is no more potent than placebo in treating chronic back pain when tested in a randomised double blind placebo controlled brain imaging study
    Javeria A Hashmi
    Department of Physiology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Mol Pain 8:29. 2012
    ..Functional MRI was used to identify brain activity for fluctuations of spontaneous pain, at baseline and at two time points after start of treatment (6 hours and 2 weeks)...
  6. pmc Inflammatory and neuropathic pain animals exhibit distinct responses to innocuous thermal and motoric challenges
    Rami Jabakhanji
    Department of Physiology, Northwestern University Feinberg School of Medicine, 303 East Chicago Ave, Chicago IL, 60611, USA
    Mol Pain 2:1. 2006
    ..This suggests that the angle-track and thermal-track may be useful in assessing automatically the global impact of different types of pain on behavior...
  7. pmc A preliminary fMRI study of analgesic treatment in chronic back pain and knee osteoarthritis
    Marwan N Baliki
    Department of Physiology, Northwestern University, Feinberg School of Medicine, 303 East Chicago Ave, Chicago IL 60611, USA
    Mol Pain 4:47. 2008
    ..Moreover, lidocaine patch treatment modulates distinct brain circuitry in each condition, yet in OA we observe divergent results with fMRI and with questionnaire based instruments...
  8. pmc Single subject pharmacological-MRI (phMRI) study: modulation of brain activity of psoriatic arthritis pain by cyclooxygenase-2 inhibitor
    M Baliki
    Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Mol Pain 1:32. 2005
    ..This approach may have diagnostic and prognostic utility...
  9. pmc Spared nerve injury rats exhibit thermal hyperalgesia on an automated operant dynamic thermal escape task
    Marwan Baliki
    Department of Physiology, Northwestern University Medical School, Chicago, IL, 60611, USA
    Mol Pain 1:18. 2005
    ..It is argued that the dynamic thermal operant task reveals the relevance of the neuropathic injury associated pain-like behavior in relation to the whole organism...
  10. pmc Identifying directed links in large scale functional networks: application to brain fMRI
    Guillermo A Cecchi
    Computational Biology Center, T, J, Watson IBM Research Center, Yorktwon Heights, New York, USA
    BMC Cell Biol 8:S5. 2007
    ..The method provides a snapshot of the ongoing dynamics of the brain without sacrificing resolution, as the analysis is tractable even for very large numbers of voxels...
  11. pmc Pain perception in relation to emotional learning
    A Vania Apkarian
    Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60610, USA
    Curr Opin Neurobiol 18:464-8. 2008
    ..This review is a discussion of the rationale and evidence for the interaction between these modalities, emphasizing underlying mechanisms...
  12. pmc Towards a theory of chronic pain
    A Vania Apkarian
    Department of Physiology, Northwestern University, Feinberg School of Medicine, 303 East Chicago Avenue, Chicago, IL 60611, USA
    Prog Neurobiol 87:81-97. 2009
    ....
  13. ncbi request reprint Prefrontal cortical hyperactivity in patients with sympathetically mediated chronic pain
    A V Apkarian
    Department of Physiology, Northwestern University Medical School, 303 E Chicago Avenue, Chicago, IL 60611, USA
    Neurosci Lett 311:193-7. 2001
    ..These findings provide evidence for abnormal brain responses to pain in patients with chronic SMP, which engages prefrontal/limbic networks more extensively than in acute pain-states...
  14. ncbi request reprint Chronic back pain is associated with decreased prefrontal and thalamic gray matter density
    A Vania Apkarian
    Department of Physiology and Institute of Neuroscience, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Neurosci 24:10410-5. 2004
    ..Our results imply that CBP is accompanied by brain atrophy and suggest that the pathophysiology of chronic pain includes thalamocortical processes...
  15. ncbi request reprint Chronic pain patients are impaired on an emotional decision-making task
    A Vania Apkarian
    Department of Physiology, Northwestern University Medical School, 303 E Chicago Avenue, Chicago, IL 60611, USA
    Pain 108:129-36. 2004
    ..Our evidence indicates that chronic pain is associated with a specific cognitive deficit, which may impact everyday behavior especially in risky, emotionally laden, situations...
  16. pmc Expression of IL-1beta in supraspinal brain regions in rats with neuropathic pain
    A Vania Apkarian
    Department of Physiology, Northwestern University, Feinberg School of Medicine, 303 East Chicago Ave, Chicago, IL 60611, USA
    Neurosci Lett 407:176-81. 2006
    ..The results indicate that neuro-immune activation in neuropathic pain conditions includes supraspinal brain regions, suggesting cytokine modulation of supraspinal circuitry of pain in neuropathic conditions...
  17. ncbi request reprint Human brain mechanisms of pain perception and regulation in health and disease
    A Vania Apkarian
    Department of Physiology, Northwestern University Medical School, 303 E Chicago Avenue, Ward 5 003, Chicago, IL 60611, USA
    Eur J Pain 9:463-84. 2005
    ..These neural mechanisms may then contribute to interindividual variations and disabilities associated with chronic pain conditions...
  18. pmc The brain in chronic CRPS pain: abnormal gray-white matter interactions in emotional and autonomic regions
    Paul Y Geha
    Department of Physiology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
    Neuron 60:570-81. 2008
    ..These abnormalities encompass emotional, autonomic, and pain perception regions, implying that they likely play a critical role in the global clinical picture of CRPS...
  19. ncbi request reprint Neurological effects of chronic pain
    Marwan N Baliki
    Northwestern University, Chicago, IL 60611, USA
    J Pain Palliat Care Pharmacother 21:59-61. 2007
    ..Studies of neurobiological changes that occur in patients with chronic pain are described. These include grey matter loss, effects on emotional processing and learning...
  20. pmc Predicting value of pain and analgesia: nucleus accumbens response to noxious stimuli changes in the presence of chronic pain
    Marwan N Baliki
    Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Neuron 66:149-60. 2010
    ..Therefore, in contrast to somatosensory pathways, which reflect sensory properties of acute noxious stimuli, NAc activity in humans encodes its predicted value and anticipates its analgesic potential on chronic pain...
  21. pmc Morphological and functional reorganization of rat medial prefrontal cortex in neuropathic pain
    Alexia E Metz
    Department of Physiology, Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, Chicago, IL 60611, USA
    Proc Natl Acad Sci U S A 106:2423-8. 2009
    ....
  22. ncbi request reprint Chronic pain and the emotional brain: specific brain activity associated with spontaneous fluctuations of intensity of chronic back pain
    Marwan N Baliki
    Department of Physiology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Neurosci 26:12165-73. 2006
    ....
  23. ncbi request reprint Cortical pathophysiology of chronic pain
    A Vania Apkarian
    Department of Physiology and Neuroscience Institute, Department of Surgery, and Department of Anesthesia, Northwestern University Medical School, Tarry Bldg 5 703, Chicago, IL 60611, USA
    Novartis Found Symp 261:239-45; discussion 245-61. 2004
    ..An overview of the mechanisms that may be pertinent to the observed results is included...
  24. doi request reprint Beyond feeling: chronic pain hurts the brain, disrupting the default-mode network dynamics
    Marwan N Baliki
    Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Neurosci 28:1398-403. 2008
    ..These findings demonstrate that chronic pain has a widespread impact on overall brain function, and suggest that disruptions of the DMN may underlie the cognitive and behavioral impairments accompanying chronic pain...
  25. pmc Prefrontal cortex and spinal cord mediated anti-neuropathy and analgesia induced by sarcosine, a glycine-T1 transporter inhibitor
    Maria V Centeno
    Department of Physiology, Feinberg School of Medicine, Northwestern University, 303 E Chicago Ave, Chicago, IL 60611, USA
    Pain 145:176-83. 2009
    ..The results suggest that such an approach may provide a novel venue for treating clinical pain conditions...
  26. pmc D-cycloserine reduces neuropathic pain behavior through limbic NMDA-mediated circuitry
    Magali Millecamps
    Department of Physiology, Feinberg School of Medicine, Northwestern University, 303 E Chicago Ave, Chicago, IL 60611, USA
    Pain 132:108-23. 2007
    ..These findings indicate that limbic NMDA-mediated circuitry is involved in long-term reduction in neuropathic pain behavior...
  27. ncbi request reprint Beneficial effects of hematopoietic growth factor therapy in chronic ischemic stroke in rats
    Li Ru Zhao
    Department of Neurology, Northwestern University, Feinberg School of Medicine, Chicago, Ill, USA
    Stroke 38:2804-11. 2007
    ..We have previously observed that SCF and G-CSF have neuroprotective and functional effects on acute brain ischemia. In the present study, the beneficial effects of SCF and G-CSF on chronic brain ischemia were determined...
  28. ncbi request reprint Dynamics of pain: fractal dimension of temporal variability of spontaneous pain differentiates between pain States
    Jennifer M Foss
    Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    J Neurophysiol 95:730-6. 2006
    ..These results show that measures of variability of spontaneous pain differentiate between chronic pain conditions, and thus may have mechanistic and clinical utility...
  29. ncbi request reprint The characteristics of cyclical and non-cyclical mastalgia: a prospective study using a modified McGill Pain Questionnaire
    Seema A Khan
    Department of Surgery, Northwestern University, Chicago, IL 60611, USA
    Breast Cancer Res Treat 75:147-57. 2002
    ..96). Studies of breast pain should include both groups to better understand and characterize these differences, particularly with regard to a possible connection with breast cancer risk...
  30. ncbi request reprint Brain imaging findings in neuropathic pain
    Paul Y Geha
    Northwestern University Feinberg School of Medicine, Department of Physiology, 303 East Chicago Avenue, Chicago, IL 60611, USA
    Curr Pain Headache Rep 9:184-8. 2005
    ..Overall, the reasons for the limited contribution of these techniques to the science of chronic pain are presented in this article...
  31. ncbi request reprint Spontaneous pain and brain activity in neuropathic pain: functional MRI and pharmacologic functional MRI studies
    Marwan N Baliki
    Northwestern University Feinberg School of Medicine, Department of Physiology, Chicago, IL 60611, USA
    Curr Pain Headache Rep 11:171-7. 2007
    ....
  32. ncbi request reprint Mastalgia and breast cancer: a protective association?
    Seema A Khan
    Department of Surgery, Northwestern Medical School, Chicago, IL 60611, USA
    Cancer Detect Prev 26:192-6. 2002
    ..Further investigation of this possible protective association is warranted...

Research Grants19

  1. CORTICAL PATHOPHYSIOLOGY OF PAIN
    APKAR APKARIAN; Fiscal Year: 2000
    ..Overall the studies are designed to examine chronic pain by functional imaging, brain biochemistry, and cognitive abilities. The results, if successful, have the potential of being used in the clinic as diagnostic or prognostic tools. ..
  2. CORTICAL PATHOPHYSIOLOGY OF PAIN
    APKAR VANIA APKARIAN; Fiscal Year: 2010
    ..We also plan to build models for predicting chronic pain based on brain parameters measured in the subacute stage. ..
  3. Chronic Pain and Emotional Learning and Memory
    APKAR VANIA APKARIAN; Fiscal Year: 2010
    ..Moreover, we seek to identify the role of endogenous cytokines, as markers for plasticity and learning, in the chronic pain. . ..
  4. CORTICAL PATHOPHYSIOLOGY OF PAIN
    APKAR APKARIAN; Fiscal Year: 2009
    ..We also plan to build models for predicting chronic pain based on brain parameters measured in the subacute stage. ..
  5. Chronic Pain and Emotional Learning and Memory
    APKAR APKARIAN; Fiscal Year: 2009
    ..Moreover, we seek to identify the role of endogenous cytokines, as markers for plasticity and learning, in the chronic pain. . ..
  6. Characterizing temporal dynamics of spontaneous pain
    APKAR APKARIAN; Fiscal Year: 2007
    ....
  7. CORTICAL PATHOPHYSIOLOGY OF PAIN
    APKAR APKARIAN; Fiscal Year: 2006
    ..In Aim 4 we study the reversibility of cognitive deficits, chemical concentration decreases and gray matter density decreases in OAP and PHN patients before and after pain therapy. ..
  8. Cortical Dynamics for Pain Perception in Behaving Rats
    APKAR APKARIAN; Fiscal Year: 2005
    ..abstract_text> ..
  9. CORTICAL PATHOPHYSIOLOGY OF PAIN
    APKAR APKARIAN; Fiscal Year: 2005
    ..In Aim 4 we study the reversibility of cognitive deficits, chemical concentration decreases and gray matter density decreases in OAP and PHN patients before and after pain therapy. ..
  10. Cortical Dynamics for Pain Perception in Behaving Rats
    APKAR APKARIAN; Fiscal Year: 2004
    ..abstract_text> ..
  11. CORTICAL PATHOPHYSIOLOGY OF PAIN
    APKAR APKARIAN; Fiscal Year: 2004
    ..In Aim 4 we study the reversibility of cognitive deficits, chemical concentration decreases and gray matter density decreases in OAP and PHN patients before and after pain therapy. ..
  12. CORTICAL PATHOPHYSIOLOGY OF PAIN
    APKAR APKARIAN; Fiscal Year: 2003
    ..In Aim 4 we study the reversibility of cognitive deficits, chemical concentration decreases and gray matter density decreases in OAP and PHN patients before and after pain therapy. ..
  13. Cortical Dynamics for Pain Perception in Behaving Rats
    APKAR APKARIAN; Fiscal Year: 2003
    ..abstract_text> ..
  14. Cortical Dynamics for Pain Perception in Behaving Rats
    APKAR APKARIAN; Fiscal Year: 2002
    ..abstract_text> ..
  15. CORTICAL PATHOPHYSIOLOGY OF PAIN
    APKAR APKARIAN; Fiscal Year: 2002
    ..Overall the studies are designed to examine chronic pain by functional imaging, brain biochemistry, and cognitive abilities. The results, if successful, have the potential of being used in the clinic as diagnostic or prognostic tools. ..
  16. CORTICAL PATHOPHYSIOLOGY OF PAIN
    APKAR APKARIAN; Fiscal Year: 2001
    ..Overall the studies are designed to examine chronic pain by functional imaging, brain biochemistry, and cognitive abilities. The results, if successful, have the potential of being used in the clinic as diagnostic or prognostic tools. ..
  17. CORTICAL PATHOPHYSIOLOGY OF PAIN
    APKAR VANIA APKARIAN; Fiscal Year: 2010
    ..We also plan to build models for predicting chronic pain based on brain parameters measured in the subacute stage. ..