R Allada

Summary

Affiliation: Northwestern University
Country: USA

Publications

  1. ncbi request reprint Stopping time: the genetics of fly and mouse circadian clocks
    R Allada
    Department of Neurobiology, Evanston, IL 60208, USA
    Annu Rev Neurosci 24:1091-119. 2001
  2. pmc Circadian organization of behavior and physiology in Drosophila
    Ravi Allada
    Department of Neurobiology and Physiology, Northwestern University, Evanston, IL 60208, USA
    Annu Rev Physiol 72:605-24. 2010
  3. ncbi request reprint Casein kinase 2, circadian clocks, and the flight from mutagenic light
    Ravi Allada
    Department of Neurobiology and Physiology, Northwestern University, Evanston, IL 60208, USA
    Mol Cell Biochem 274:141-9. 2005
  4. pmc Unearthing the phylogenetic roots of sleep
    Ravi Allada
    Department of Neurobiology and Physiology, Northwestern University, 2205 Tech Dr, 2 160, Evanston, Illinois 60208, USA
    Curr Biol 18:R670-R679. 2008
  5. doi request reprint How flies time when they're having brunch
    Ravi Allada
    Department of Neurobiology and Physiology, Northwestern University, 2205 Tech Drive, 2 160, Evanston, IL 60201, USA
    Cell Metab 8:279-80. 2008
  6. ncbi request reprint A role for casein kinase 2alpha in the Drosophila circadian clock
    Jui Ming Lin
    Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois 60208, USA
    Nature 420:816-20. 2002
  7. pmc TIMELESS is an important mediator of CK2 effects on circadian clock function in vivo
    Rose Anne Meissner
    Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois 60208, USA
    J Neurosci 28:9732-40. 2008
  8. pmc The GABA(A) receptor RDL acts in peptidergic PDF neurons to promote sleep in Drosophila
    Brian Y Chung
    Department of Neurobiology and Physiology, Northwestern University, Evanston, IL 60208, USA
    Curr Biol 19:386-90. 2009
  9. pmc Perturbing dynamin reveals potent effects on the Drosophila circadian clock
    Valerie L Kilman
    Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois, United States of America
    PLoS ONE 4:e5235. 2009
  10. pmc Genetic analysis of ectopic circadian clock induction in Drosophila
    Valerie L Kilman
    Department of Neurobiology and Physiology, Center for Sleep and Circadian Biology, Northwestern University, Evanston, Illinois 60208, USA
    J Biol Rhythms 24:368-78. 2009

Collaborators

  • Valerie L Kilman
  • Fred Turek
  • P E Hardin
  • J M Siegel
  • Bridget C Lear
  • Jui Ming Lin
  • Luoying Zhang
  • Kevin P Keegan
  • Brian Y Chung
  • Rose Anne Meissner
  • Jena L Pitman
  • Bhaskar Kahali
  • Michael Rosbash
  • Jermaine J McGill
  • Jie Zhao
  • Elaine M Smith
  • Chunghun Lim
  • Suraj Pradhan
  • Ashok P Bidwai
  • J Russel Keath
  • Anasua Bose
  • Analyne Schroeder
  • Ying Peng
  • Guruswamy Mahesh
  • Yixiao Liu
  • Adam Seluzicki
  • Regina Trott
  • Ze ev Paroush
  • Clifton P Bishop
  • Jongbin Lee
  • Joonho Choe
  • Ji Ping Wang
  • Umesh Karandikar
  • Sophia Zhang
  • C Elaine Merrill
  • Indira M Raman
  • Mike McDonald
  • Patrick Emery
  • Brie Paddock
  • Kevin Keegan
  • Myai Emery-Le

Detail Information

Publications29

  1. ncbi request reprint Stopping time: the genetics of fly and mouse circadian clocks
    R Allada
    Department of Neurobiology, Evanston, IL 60208, USA
    Annu Rev Neurosci 24:1091-119. 2001
    ..Future studies of pacemaker mechanisms and their control of physiology and behavior will likely continue to rely on forward genetics...
  2. pmc Circadian organization of behavior and physiology in Drosophila
    Ravi Allada
    Department of Neurobiology and Physiology, Northwestern University, Evanston, IL 60208, USA
    Annu Rev Physiol 72:605-24. 2010
    ..These studies reveal a remarkable complexity to circadian pathways in this "simple" model organism...
  3. ncbi request reprint Casein kinase 2, circadian clocks, and the flight from mutagenic light
    Ravi Allada
    Department of Neurobiology and Physiology, Northwestern University, Evanston, IL 60208, USA
    Mol Cell Biochem 274:141-9. 2005
    ..The finding of a dual function of CK2 in clocks and in UV responses supports the notion that clocks evolved to assist organisms in avoiding the mutagenic effects of daily sunlight...
  4. pmc Unearthing the phylogenetic roots of sleep
    Ravi Allada
    Department of Neurobiology and Physiology, Northwestern University, 2205 Tech Dr, 2 160, Evanston, Illinois 60208, USA
    Curr Biol 18:R670-R679. 2008
    ..Taken together, these studies suggest an ancient origin for sleep and raise the possibility that model organism genetics may reveal the molecular mechanisms that guide sleep and wake...
  5. doi request reprint How flies time when they're having brunch
    Ravi Allada
    Department of Neurobiology and Physiology, Northwestern University, 2205 Tech Drive, 2 160, Evanston, IL 60201, USA
    Cell Metab 8:279-80. 2008
    ..In this issue of Cell Metabolism, Xu et al. (2008) explore the fruit fly as a model system to examine the links between clocks, feeding, and metabolism...
  6. ncbi request reprint A role for casein kinase 2alpha in the Drosophila circadian clock
    Jui Ming Lin
    Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois 60208, USA
    Nature 420:816-20. 2002
    ..These effects are probably direct, as CK2alpha specifically phosphorylates Per in vitro. We propose that CK2 is an evolutionary link between the divergent circadian systems of animals, plants and fungi...
  7. pmc TIMELESS is an important mediator of CK2 effects on circadian clock function in vivo
    Rose Anne Meissner
    Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois 60208, USA
    J Neurosci 28:9732-40. 2008
    ..The period lengthening effects in Tik heterozygotes are reduced in a tim(UL) mutant that disrupts a putative CK2 phosphorylation site. Together, these data indicate that TIM is an important mediator of CK2 effects on circadian rhythms...
  8. pmc The GABA(A) receptor RDL acts in peptidergic PDF neurons to promote sleep in Drosophila
    Brian Y Chung
    Department of Neurobiology and Physiology, Northwestern University, Evanston, IL 60208, USA
    Curr Biol 19:386-90. 2009
    ..In addition, RDL is detectable most strongly on the large subset of PDF+ pacemaker neurons. These results suggest that GABAergic inhibition of arousal-promoting PDF neurons is an important mode of sleep-wake regulation in vivo...
  9. pmc Perturbing dynamin reveals potent effects on the Drosophila circadian clock
    Valerie L Kilman
    Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois, United States of America
    PLoS ONE 4:e5235. 2009
    ..To address this question, we expressed a temperature-sensitive, dominant negative allele of the fly homolog of dynamin called shibire(ts1) (shi(ts1)), an active component in membrane vesicle scission...
  10. pmc Genetic analysis of ectopic circadian clock induction in Drosophila
    Valerie L Kilman
    Department of Neurobiology and Physiology, Center for Sleep and Circadian Biology, Northwestern University, Evanston, Illinois 60208, USA
    J Biol Rhythms 24:368-78. 2009
    ..While other factors may contribute, these results indicate that persistent Clock induction is uniquely capable of broadly inducing ectopic rhythms even in adults, consistent with a special role at the top of a clock gene hierarchy...
  11. pmc Clockwork orange encodes a transcriptional repressor important for circadian-clock amplitude in Drosophila
    Chunghun Lim
    Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois 60208, USA
    Curr Biol 17:1082-9. 2007
    ..Molecular analysis suggests that CWO acts, in part, by repressing CLK target genes. We propose that CWO acts as a transcriptional and behavioral rhythm amplifier...
  12. ncbi request reprint A dynamic role for the mushroom bodies in promoting sleep in Drosophila
    Jena L Pitman
    Department of Neurobiology and Physiology, Northwestern University, Evanston, Ilinois 60208, USA
    Nature 441:753-6. 2006
    ..Chemical ablation of the mushroom bodies also resulted in reduced sleep. These studies highlight a central role for the mushroom bodies in sleep regulation...
  13. ncbi request reprint A G protein-coupled receptor, groom-of-PDF, is required for PDF neuron action in circadian behavior
    Bridget C Lear
    Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois 60208, USA
    Neuron 48:221-7. 2005
    ..gop is expressed most strongly in the dorsal brain in regions that lie in proximity to PDF-containing nerve terminals. Taken together, these studies implicate GOP as a PDF receptor in Drosophila...
  14. ncbi request reprint The ion channel narrow abdomen is critical for neural output of the Drosophila circadian pacemaker
    Bridget C Lear
    Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois 60208, USA
    Neuron 48:965-76. 2005
    ..In na mutants, expression of potassium currents and the key neuropeptide PDF are elevated, the latter consistent with reduced release. These data implicate NA and the pacemaker neural network in controlling phase and rhythmicity...
  15. ncbi request reprint Circadian clocks: a tale of two feedback loops
    Ravi Allada
    Department of Neurobiology and Physiology, Northwestern University, Evanston, IL 60208, USA
    Cell 112:284-6. 2003
    ..In Drosophila, the first loop has been well characterized and controls rhythmic period expression. In this issue of Cell, define a role for a transcriptional activator and a repressor in the second feedback loop...
  16. ncbi request reprint In vivo circadian function of casein kinase 2 phosphorylation sites in Drosophila PERIOD
    Jui Ming Lin
    Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois 60208, USA
    J Neurosci 25:11175-83. 2005
    ..In many respects, mutation of these phosphorylation sites phenocopies mutation of the catalytic subunit of CK2. We propose that CK2 phosphorylation at these sites triggers PER nuclear localization...
  17. pmc The CRYPTOCHROME photoreceptor gates PDF neuropeptide signaling to set circadian network hierarchy in Drosophila
    Luoying Zhang
    Department of Neurobiology and Physiology, Northwestern University, Evanston, IL 60208, USA
    Curr Biol 19:2050-5. 2009
    ..On the basis of our findings, we propose that CRY can gate PDF signaling to determine behavioral phase and network hierarchy...
  18. pmc The neuropeptide PDF acts directly on evening pacemaker neurons to regulate multiple features of circadian behavior
    Bridget C Lear
    Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois, USA
    PLoS Biol 7:e1000154. 2009
    ..These studies define a key direct output circuit sufficient for multiple PDF dependent behaviors...
  19. pmc DN1(p) circadian neurons coordinate acute light and PDF inputs to produce robust daily behavior in Drosophila
    Luoying Zhang
    Department of Neurobiology and Physiology, Northwestern University, Evanston, IL 60208, USA
    Curr Biol 20:591-9. 2010
    ..The fruit fly Drosophila exhibits clock-driven activity increases that anticipate dawn and dusk and free-running rhythms under constant conditions. Flies also respond to the onset of light and dark with acute increases in activity...
  20. pmc Dominant-negative CK2alpha induces potent effects on circadian rhythmicity
    Elaine M Smith
    Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois, United States of America
    PLoS Genet 4:e12. 2008
    ..Taken together, these in vivo data implicate a central role of CK2alpha function in timing PER negative feedback in adult circadian neurons...
  21. pmc Meta-analysis of Drosophila circadian microarray studies identifies a novel set of rhythmically expressed genes
    Kevin P Keegan
    Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois, United States of America
    PLoS Comput Biol 3:e208. 2007
    ....
  22. ncbi request reprint Two oscillators are better than one: a circadian pacemaker escapes from the light
    Ravi Allada
    Department of Neurobiology and Physiology, Northwestern University, Evanston, IL 60208, USA
    Neuron 53:621-3. 2007
    ..demonstrate that, under certain genetic conditions, a novel cluster of pacemaker neurons can drive rhythmic behavior in constant light. Surprisingly, these neurons are distinct from those thought to drive rhythms in constant darkness...
  23. pmc An emerging link between general anesthesia and sleep
    Ravi Allada
    Department of Neurobiology and Physiology, Center for Sleep and Circadian Biology, Northwestern University, 2205 Tech Drive, 2 160, Evanston, IL 60208, USA
    Proc Natl Acad Sci U S A 105:2257-8. 2008
  24. ncbi request reprint Liver has rhythm
    Fred W Turek
    Center for Sleep and Circadian Biology, Northwestern University, Evanston, IL 60208 3520, USA
    Hepatology 35:743-5. 2002
  25. pmc Drosophila CK2 phosphorylates Hairy and regulates its activity in vivo
    Bhaskar Kahali
    Department of Biology, West Virginia University, 4220 Life Sciences Building, 53 Campus Drive, Morgantown, WV 26506, USA
    Biochem Biophys Res Commun 373:637-42. 2008
    ..Together, these studies suggest that CK2 contributes to repression by Hairy...
  26. ncbi request reprint Drosophila clock can generate ectopic circadian clocks
    Jie Zhao
    Howard Hughes Medical Institute, Department of Biology, Brandeis University, Waltham, MA 02454, USA
    Cell 113:755-66. 2003
    ..We propose that Clock is uniquely able to induce and organize the core elements of interdependent feedback loops necessary for circadian rhythms...
  27. pmc A recessive mutant of Drosophila Clock reveals a role in circadian rhythm amplitude
    Ravi Allada
    Howard Hughes Medical Institute and Department of Biology, Brandeis University, Waltham, MA 02454, USA
    EMBO J 22:3367-75. 2003
    ..Taken together with other data, we propose that Clk makes a major contribution to the strength and amplitude of circadian rhythms...
  28. ncbi request reprint Circadian rhythms in Drosophila
    Michael Rosbash
    Howard Hughes Medical Institute, Department of Biology, Brandeis University, Waltham, MA 02454, USA
    Novartis Found Symp 253:223-32; discussion 52-5, 102-9, 232-7 passim. 2003
    ..Results with the new recessive allele not only support the notion that Clock is an important clock gene but also indicate that it contributes more to the amplitude of the rhythm rather than the period...
  29. ncbi request reprint Drosophila CK2 regulates lateral-inhibition during eye and bristle development
    Anasua Bose
    Department of Biology, Life Sciences Building, 53 Campus Drive, West Virginia University Morgantown, WV 26506, USA
    Mech Dev 123:649-64. 2006
    ..Candidates for this regulation are the E(spl) repressors, the terminal effectors of this pathway...

Research Grants14

  1. Intercellular Signaling in the Circadian Clock
    Ravi Allada; Fiscal Year: 2010
    ..Given the potential conservation with humans, this work should provide insight into the mechanisms by which neuropeptides mediate normal and disrupted circadian rhythms in human disease. ..
  2. Function of the Novel Ion Channel narrow abdomen in Daily Rhythms
    Ravi Allada; Fiscal Year: 2007
    ..Given the conservation of clocks and NA, this proposal should illuminate human daily rhythms and their contribution to disease. ..
  3. Function of Casein Kinase 2 in the Circadian Clock
    Ravi Allada; Fiscal Year: 2007
    ..The discovery of a circadian function of CK2 in plants, animals, and fungi suggests these studies will be relevant to many biological systems, including humans. ..