A Sehgal

Summary

Affiliation: Northwest Hospital
Country: USA

Publications

  1. ncbi request reprint Application of the differential hybridization of Atlas Human expression arrays technique in the identification of differentially expressed genes in human glioblastoma multiforme tumor tissue
    A Sehgal
    Deke Slayton Center for Brain Cancer Studies, Northwest Hospital, Seattle, Washington, USA
    J Surg Oncol 67:234-41. 1998
  2. ncbi request reprint Isolation and characterization of a novel gene from human glioblastoma multiforme tumor tissue
    A Sehgal
    Deke Slayton Center for Brain Cancer Studies, Northwest Hospital, Seattle, WA, USA
    Int J Cancer 71:565-72. 1997
  3. ncbi request reprint Cloning, sequence, and developmental expression analysis of C4-2, a potential brain tumor-suppressor gene
    A Sehgal
    Deke Slayton Center for Brain Cancer Studies, Northwest Hospital, Seattle, Washington, USA
    J Surg Oncol 65:249-57. 1997
  4. ncbi request reprint Molecular changes during the genesis of human gliomas
    A Sehgal
    Deke Slayton Center for Brain Cancer Studies, Northwest Hospital, Seattle, Washington, USA
    Semin Surg Oncol 14:3-12. 1998
  5. ncbi request reprint Cell adhesion molecule Nr-CAM is over-expressed in human brain tumors
    A Sehgal
    Deke Slayton Center for Brain Cancer Studies, Pacific Northwest Cancer Foundation, Northwest Hospital, Seattle, WA 98125, USA
    Int J Cancer 76:451-8. 1998
  6. ncbi request reprint Molecular characterization of CXCR-4: a potential brain tumor-associated gene
    A Sehgal
    Pacific Northwest Cancer Foundation, Northwest Hospital, Seattle, Washington 98125, USA
    J Surg Oncol 69:239-48. 1998
  7. ncbi request reprint CXCR-4, a chemokine receptor, is overexpressed in and required for proliferation of glioblastoma tumor cells
    A Sehgal
    Pacific Northwest Cancer Foundation, Northwest Hospital, Seattle, Washington 98125, USA
    J Surg Oncol 69:99-104. 1998
  8. ncbi request reprint Reduced connexin43 expression in high-grade human brain glioma cells
    R P Huang
    Molecular Medicine, Northwest Hospital, Seattle, Washington 98125, USA
    J Surg Oncol 70:21-4. 1999
  9. ncbi request reprint Assignment of the GOV (Glioblastoma overexpressed) gene to human chromosome band 19p13.2 by fluorescence in situ hybridization
    X N Chen
    Medical Genetics Birth Defects Center, Ahmanson Department of Pediatrics, Cedars Sinai Medical Center, UCLA School of Medicine, Los Angeles CA, USA
    Cytogenet Cell Genet 83:230-1. 1998
  10. ncbi request reprint New short period mutations of the Drosophila clock gene per
    M K Baylies
    Howard Hughes Medical Institute, Rockefeller University, New York, New York 10021
    Neuron 9:575-81. 1992

Collaborators

Detail Information

Publications14

  1. ncbi request reprint Application of the differential hybridization of Atlas Human expression arrays technique in the identification of differentially expressed genes in human glioblastoma multiforme tumor tissue
    A Sehgal
    Deke Slayton Center for Brain Cancer Studies, Northwest Hospital, Seattle, Washington, USA
    J Surg Oncol 67:234-41. 1998
    ..Our objective was to identify genes that showed altered expression between normal brain tissue (NBT) and glioblastoma multiforme tumor tissue (GMTT)...
  2. ncbi request reprint Isolation and characterization of a novel gene from human glioblastoma multiforme tumor tissue
    A Sehgal
    Deke Slayton Center for Brain Cancer Studies, Northwest Hospital, Seattle, WA, USA
    Int J Cancer 71:565-72. 1997
    ..We also show that D2-2 is expressed 28-fold higher in fetal brain (20 weeks) than in adult brain. Sequence analysis of a 2.0-kb fragment for D2-2 shows no homology to known sequences in the data base...
  3. ncbi request reprint Cloning, sequence, and developmental expression analysis of C4-2, a potential brain tumor-suppressor gene
    A Sehgal
    Deke Slayton Center for Brain Cancer Studies, Northwest Hospital, Seattle, Washington, USA
    J Surg Oncol 65:249-57. 1997
    ..Previously, we reported the isolation of C4-2 as a potential tumor suppressor gene in human brain tumors. To understand the function of this gene, we investigated its molecular characterization and expression during development...
  4. ncbi request reprint Molecular changes during the genesis of human gliomas
    A Sehgal
    Deke Slayton Center for Brain Cancer Studies, Northwest Hospital, Seattle, Washington, USA
    Semin Surg Oncol 14:3-12. 1998
    ..Taken together, these findings point to the accumulation of multiple genetic mutations coupled with extensive changes in gene expression in the etiology of human gliomas...
  5. ncbi request reprint Cell adhesion molecule Nr-CAM is over-expressed in human brain tumors
    A Sehgal
    Deke Slayton Center for Brain Cancer Studies, Pacific Northwest Cancer Foundation, Northwest Hospital, Seattle, WA 98125, USA
    Int J Cancer 76:451-8. 1998
    ..Our results suggest that hNr-CAM is over-expressed in malignant brain tumors and can serve as a novel marker for brain tumor detection and perhaps therapy...
  6. ncbi request reprint Molecular characterization of CXCR-4: a potential brain tumor-associated gene
    A Sehgal
    Pacific Northwest Cancer Foundation, Northwest Hospital, Seattle, Washington 98125, USA
    J Surg Oncol 69:239-48. 1998
    ..We have previously reported the isolation of a G protein-coupled receptor, CXCR-4, that is overexpressed in glioblastoma multiforme tumor tissue (GMTT), as compared to normal brain tissue (NBT)...
  7. ncbi request reprint CXCR-4, a chemokine receptor, is overexpressed in and required for proliferation of glioblastoma tumor cells
    A Sehgal
    Pacific Northwest Cancer Foundation, Northwest Hospital, Seattle, Washington 98125, USA
    J Surg Oncol 69:99-104. 1998
    ....
  8. ncbi request reprint Reduced connexin43 expression in high-grade human brain glioma cells
    R P Huang
    Molecular Medicine, Northwest Hospital, Seattle, Washington 98125, USA
    J Surg Oncol 70:21-4. 1999
    ..To further investigate the role of cx43 in the development of human gliomas, we performed the present study on human glioma grades I-IV...
  9. ncbi request reprint Assignment of the GOV (Glioblastoma overexpressed) gene to human chromosome band 19p13.2 by fluorescence in situ hybridization
    X N Chen
    Medical Genetics Birth Defects Center, Ahmanson Department of Pediatrics, Cedars Sinai Medical Center, UCLA School of Medicine, Los Angeles CA, USA
    Cytogenet Cell Genet 83:230-1. 1998
  10. ncbi request reprint New short period mutations of the Drosophila clock gene per
    M K Baylies
    Howard Hughes Medical Institute, Rockefeller University, New York, New York 10021
    Neuron 9:575-81. 1992
    ..Possibly mutations in the region eliminate a regulatory function provided by this segment, or substantially increase stability of the mutant protein...
  11. ncbi request reprint Developmental expression patterns of CFTR in ferret tracheal surface airway and submucosal gland epithelia
    A Sehgal
    University of Pennsylvania Medical Center, Department of Molecular and Cellular Engineering, Philadelphia, Pennsylvania, USA
    Am J Respir Cell Mol Biol 15:122-31. 1996
    ..Such findings suggest that differentiation of gland progenitor cells to CFTR-expressing submucosal gland cells occurs very early within submucosal gland development and morphogenesis...
  12. ncbi request reprint Gene transfer and molecular cloning of the human NGF receptor
    M V Chao
    Science 232:518-21. 1986
    ..The sequences encoding the NGF receptor were molecularly cloned using the human Alu repetitive sequence as a probe. A cosmid clone that contained the human NGF receptor gene allowed efficient transfection and expression of the receptor...
  13. pmc A constitutive promoter directs expression of the nerve growth factor receptor gene
    A Sehgal
    Department of Cell Biology and Anatomy, Cornell University Medical College, New York, New York 10021
    Mol Cell Biol 8:3160-7. 1988
    ..The intron-exon structure of the receptor gene indicated that structural features are precisely divided into discrete domains...
  14. pmc Waiting times for radiotherapy: variation over time and between cancer networks in southeast England
    D Robinson
    Thames Cancer Registry, Division of Cancer Studies, Guy s King s and St Thomas School of Medicine, Capital House, 42 Weston Street, London SE1 3QD, UK
    Br J Cancer 92:1201-8. 2005
    ....