Justin R Yates
Affiliation: Northern Kentucky University
Yates J, Chitwood M, Evans K, Kappesser J, Murray C, Paradella Bradley T, et al
. Group I metabotropic glutamate receptor antagonists impair discriminability of reinforcer magnitude, but not risky choice, in a probability-discounting task. Behav Brain Res. 2019;: pubmed publisher
..Instead, blocking these receptors appears to impair discriminability of reinforcers of varying magnitudes in PD. ..
Yates J, Gunkel B, Rogers K, Breitenstein K, Hughes M, Johnson A, et al
. Effects of N-methyl-d-aspartate receptor (NMDAr) uncompetitive antagonists in a delay discounting paradigm using a concurrent-chains procedure. Behav Brain Res. 2018;349:125-129 pubmed publisher
..Memantine (7.5 mg/kg) decreased SRM only. These results show that this variant of the concurrent-chains procedure can be used to study the effects of pharmacological manipulations on distinct aspects of DD. ..
Yates J, Breitenstein K, Gunkel B, Hughes M, Johnson A, Rogers K, et al
. Effects of NMDA receptor antagonists on probability discounting depend on the order of probability presentation. Pharmacol Biochem Behav. 2016;150-151:31-38 pubmed publisher
..03mg/kg) increased risk taking in rats on an ascending schedule. These results show that probability presentation order modulates the effects of NMDA receptor ligands on risky decision making. ..
Yates J. Dissecting drug effects in preclinical models of impulsive choice: emphasis on glutamatergic compounds. Psychopharmacology (Berl). 2018;235:607-626 pubmed publisher
..Using these approaches can help further our understanding of the neurochemical underpinnings of delay discounting. ..
Yates J, Gunkel B, Rogers K, Hughes M, Prior N. Effects of N-methyl-D-aspartate receptor ligands on sensitivity to reinforcer magnitude and delayed reinforcement in a delay-discounting procedure. Psychopharmacology (Berl). 2017;234:461-473 pubmed publisher
..These results emphasize the utility in employing quantitative methods to assess drug effects in delay discounting. ..
Yates J, Rogers K, Gunkel B, Prior N, Hughes M, Sharpe S, et al
. Effects of Group I metabotropic glutamate receptor antagonists on sensitivity to reinforcer magnitude and delayed reinforcement in a delay-discounting task in rats: Contribution of delay presentation order. Behav Brain Res. 2017;322:29-33 pubmed publisher
..These results show that mGluR1 is an important mediator of impulsive choice, and they provide further evidence that delay order presentation is an important variable that influences drug effects in delay discounting. ..
Lee Stubbeman B, Brown C, Yates J, Bardgett M. Early-life risperidone enhances locomotor responses to amphetamine during adulthood. Eur J Pharmacol. 2017;812:256-263 pubmed publisher
..These results suggest that early-life treatment with atypical antipsychotic drugs, like risperidone, permanently alters forebrain catecholamine function and increases sensitivity to drugs that target such function. ..