D M Stearns

Summary

Affiliation: Northern Arizona University
Country: USA

Publications

  1. ncbi request reprint Chromium(III) tris(picolinate) is mutagenic at the hypoxanthine (guanine) phosphoribosyltransferase locus in Chinese hamster ovary cells
    Diane M Stearns
    Department of Chemistry, Northern Arizona University, P O Box 5698, Flagstaff, AZ 86011 5698, USA
    Mutat Res 513:135-42. 2002
  2. ncbi request reprint Cell cycle activation in postmitotic neurons is essential for DNA repair
    Elena I Schwartz
    Department of Pathology and Oncology, Georgetown University Medical Center, Washington, DC, USA
    Cell Cycle 6:318-29. 2007
  3. ncbi request reprint Is chromium a trace essential metal?
    D M Stearns
    Northern Arizona University, Department of Chemistry, Flagstaff 86011 5698, USA
    Biofactors 11:149-62. 2000
  4. ncbi request reprint Uranyl acetate induces hprt mutations and uranium-DNA adducts in Chinese hamster ovary EM9 cells
    Diane M Stearns
    Department of Chemistry and Biochemistry, Northern Arizona University, PO Box 5698, Flagstaff, AZ 86011 5698, USA
    Mutagenesis 20:417-23. 2005
  5. ncbi request reprint Characterization of nonmutagenic Cr(III)-DNA interactions
    Sean A Blankert
    Department of Chemistry, Northern Arizona University, P O Box 5698, Flagstaff, Arizona 86011 5698, USA
    Chem Res Toxicol 16:847-54. 2003
  6. ncbi request reprint Molecular analysis of hprt mutations generated in Chinese hamster ovary EM9 cells by uranyl acetate, by hydrogen peroxide, and spontaneously
    Virginia H Coryell
    Department of Chemistry and Biochemistry, Northern Arizona University, Flagstaff, Arizona 86011 5698, USA
    Mol Carcinog 45:60-72. 2006
  7. ncbi request reprint Molecular analysis of hprt mutations induced by chromium picolinate in CHO AA8 cells
    Virginia H Coryell
    Department of Chemistry and Biochemistry, Northern Arizona University, PO Box 5698, Flagstaff, AZ 86011 5698, United States
    Mutat Res 610:114-23. 2006
  8. ncbi request reprint Uranyl acetate causes DNA single strand breaks in vitro in the presence of ascorbate (vitamin C)
    Monica Yazzie
    Department of Chemistry, Northern Arizona University, Flagstaff, Arizona, 86011, USA
    Chem Res Toxicol 16:524-30. 2003
  9. ncbi request reprint Ultrastructural damage in chromium picolinate-treated cells: a TEM study. Transmission electron microscopy
    Kevin R Manygoats
    Department of Chemistry, Northern Arizona University, PO Box 5698, Flagstaff, AZ 86011 5698, USA
    J Biol Inorg Chem 7:791-8. 2002
  10. ncbi request reprint Synthesis of peptide-oligonucleotide conjugates for chromium coordination
    E R Civitello
    Department of Chemistry, Northern Arizona University, P.O. Box 5698, Flagstaff, Arizona 86011-5698, USA
    Bioconjug Chem 12:459-63. 2001

Collaborators

  • Inna I Kruman
  • M Gorospe
  • Virginia H Coryell
  • Monica Yazzie
  • Elena I Schwartz
  • Sean A Blankert
  • Kevin R Manygoats
  • E R Civitello
  • Soma Ghosh
  • Fu Dong Shi
  • Lubomir B Smilenov
  • Ronald A Baker
  • Tracy Osredkar
  • Mary A Price
  • Timothy L Vollmer
  • Alejandro Lencinas
  • Brian T Picard
  • Shania L Gamble
  • Edgar R Civitello
  • Robert E Lomas
  • Kristina K Wolf
  • R G Leniek
  • K A Hossler
  • K Haebe

Detail Information

Publications10

  1. ncbi request reprint Chromium(III) tris(picolinate) is mutagenic at the hypoxanthine (guanine) phosphoribosyltransferase locus in Chinese hamster ovary cells
    Diane M Stearns
    Department of Chemistry, Northern Arizona University, P O Box 5698, Flagstaff, AZ 86011 5698, USA
    Mutat Res 513:135-42. 2002
    ....
  2. ncbi request reprint Cell cycle activation in postmitotic neurons is essential for DNA repair
    Elena I Schwartz
    Department of Pathology and Oncology, Georgetown University Medical Center, Washington, DC, USA
    Cell Cycle 6:318-29. 2007
    ..Our data suggest that G(1) cell cycle components are involved in DNA repair and survival of postmitotic neurons...
  3. ncbi request reprint Is chromium a trace essential metal?
    D M Stearns
    Northern Arizona University, Department of Chemistry, Flagstaff 86011 5698, USA
    Biofactors 11:149-62. 2000
    ..Chromium3+ may act clinically by interfering with iron absorption, decreasing the high iron stores that are linked to diabetes and heart disease. If so, this would make chromium3+ a pharmacological agent, not an essential metal...
  4. ncbi request reprint Uranyl acetate induces hprt mutations and uranium-DNA adducts in Chinese hamster ovary EM9 cells
    Diane M Stearns
    Department of Chemistry and Biochemistry, Northern Arizona University, PO Box 5698, Flagstaff, AZ 86011 5698, USA
    Mutagenesis 20:417-23. 2005
    ..Data suggest that uranium could be chemically genotoxic and mutagenic through the formation of strand breaks and covalent U-DNA adducts. Thus the health risks for uranium exposure could go beyond those for radiation exposure...
  5. ncbi request reprint Characterization of nonmutagenic Cr(III)-DNA interactions
    Sean A Blankert
    Department of Chemistry, Northern Arizona University, P O Box 5698, Flagstaff, Arizona 86011 5698, USA
    Chem Res Toxicol 16:847-54. 2003
    ..This study provides the first structural evidence for Cr(III)-DNA adducts. A molecular understanding of Cr(III)-DNA interactions will be necessary before we can determine their relevance in Cr(VI)-induced cancers...
  6. ncbi request reprint Molecular analysis of hprt mutations generated in Chinese hamster ovary EM9 cells by uranyl acetate, by hydrogen peroxide, and spontaneously
    Virginia H Coryell
    Department of Chemistry and Biochemistry, Northern Arizona University, Flagstaff, Arizona 86011 5698, USA
    Mol Carcinog 45:60-72. 2006
    ..The unique mutation spectrum elicited by exposure to UA suggests that UA generates mutations in ways that are different from spontaneous and free radical as well as radiological mechanisms...
  7. ncbi request reprint Molecular analysis of hprt mutations induced by chromium picolinate in CHO AA8 cells
    Virginia H Coryell
    Department of Chemistry and Biochemistry, Northern Arizona University, PO Box 5698, Flagstaff, AZ 86011 5698, United States
    Mutat Res 610:114-23. 2006
    ..These data confirm previous studies showing that CrPic is mutagenic, and support the contention that further study is needed to verify the safety of CrPic for human consumption...
  8. ncbi request reprint Uranyl acetate causes DNA single strand breaks in vitro in the presence of ascorbate (vitamin C)
    Monica Yazzie
    Department of Chemistry, Northern Arizona University, Flagstaff, Arizona, 86011, USA
    Chem Res Toxicol 16:524-30. 2003
    ..These data suggest that uranium may be directly genotoxic and may, like chromium, react with DNA by more than one pathway...
  9. ncbi request reprint Ultrastructural damage in chromium picolinate-treated cells: a TEM study. Transmission electron microscopy
    Kevin R Manygoats
    Department of Chemistry, Northern Arizona University, PO Box 5698, Flagstaff, AZ 86011 5698, USA
    J Biol Inorg Chem 7:791-8. 2002
    ..The coordination of Cr(III) by picolinate ligands may alter the cellular chemistry of Cr(III) to make chromium picolinate a toxic form of Cr(III)...
  10. ncbi request reprint Synthesis of peptide-oligonucleotide conjugates for chromium coordination
    E R Civitello
    Department of Chemistry, Northern Arizona University, P.O. Box 5698, Flagstaff, Arizona 86011-5698, USA
    Bioconjug Chem 12:459-63. 2001
    ....

Research Grants6

  1. CHROMIUM(III) GENOTOXICITY--DIRECT AND INDIRECT PATHWAYS
    DIANE STEARNS; Fiscal Year: 2002
    ....
  2. Uptake and Mutagenicity of Moderately Soluble Hexavalent Chromium
    DIANE STEARNS; Fiscal Year: 2007
    ..Understanding the mode of action of these chromates will provide a foundation for human risk assessment. ..
  3. Comprehensive NAU/AZCC Cancer Research Partnership
    DIANE STEARNS; Fiscal Year: 2007
    ..Research activities include basic science, cancer education, and community outreach components. We propose 6 pilot projects, 4 full projects, and recruitment of 2 new faculty over the project lifetime. ..