Research Topics
| Talima PearsonSummaryAffiliation: Northern Arizona University Country: USA Publications
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Detail Information
Publications
Phylogeographic reconstruction of a bacterial species with high levels of lateral gene transferTalima Pearson
Center for Microbial Genetics and Genomics, Northern Arizona University, Flagstaff, Arizona, USA
BMC Biol 7:78. 2009..We compared and searched 43 whole genome sequences of B. pseudomallei and its closest relatives for single nucleotide polymorphisms in orthologous shared regions to use in phylogenetic reconstruction...- Bacillus anthracis in China and its relationship to worldwide lineagesTatum S Simonson
Department of Biological Sciences, Northern Arizona University, Flagstaff, AZ 86011 5640, USA
BMC Microbiol 9:71. 2009..Canonical single nucleotide polymorphism (canSNP) and multiple locus VNTR analysis (MLVA) typing has been used to examine this archival collection of isolates... - A horizontal gene transfer event defines two distinct groups within Burkholderia pseudomallei that have dissimilar geographic distributionsApichai Tuanyok
Department of Biological Sciences, Northern Arizona University, Flagstaff, AZ 86011 5640, USA
J Bacteriol 189:9044-9. 2007..In addition, clinical isolates are more likely to belong to group YLF, whereas environmental isolates are more likely to belong to group BTFC. These groups should be further characterized in an animal model... - Phylogeography of Francisella tularensis: global expansion of a highly fit cloneAmy J Vogler
Center for Microbial Genetics and Genomics, Northern Arizona University, P O Box 4073, Flagstaff, AZ 86011, USA
J Bacteriol 191:2474-84. 2009..Phylogenetic analyses suggest a North American origin for this B-radiation clade and multiple dispersal events between North America and Eurasia. These findings indicate a complex transmission history for F. tularensis subsp. holarctica... - Molecular epidemiologic investigation of an anthrax outbreak among heroin users, EuropeErin P Price
Northern Arizona University, Flagstaff, Arizona, USA
Emerg Infect Dis 18:1307-13. 2012..Our results suggest accidental contamination along the drug trafficking route through a cutting agent or animal hides used to smuggle heroin into Europe... - Global genetic population structure of Bacillus anthracisMatthew N Van Ert
Department of Biological Sciences, Northern Arizona University, Flagstaff, Arizona, United States of America
PLoS ONE 2:e461. 2007..Finally, the value of global genotypic analysis for investigating bioterrorist-mediated outbreaks of anthrax is demonstrated... - Strain-specific single-nucleotide polymorphism assays for the Bacillus anthracis Ames strainMatthew N Van Ert
Department of Biological Sciences, Northern Arizona University, Flagstaff, AZ 86011 5640, USA
J Clin Microbiol 45:47-53. 2007..This evolutionary and genomics-based approach provides an effective means for the discovery of strain-specific SNPs in B. anthracis... - BurkDiff: a real-time PCR allelic discrimination assay for Burkholderia pseudomallei and B. malleiJolene R Bowers
Translational Genomics Research Institute, Flagstaff, Arizona, United States of America
PLoS ONE 5:e15413. 2010..Concordance of results with traditional speciation methods and no cross-reactivity to non-target species show BurkDiff is a robust, highly validated assay for the detection and differentiation of B. pseudomallei and B. mallei... - Development and validation of Burkholderia pseudomallei-specific real-time PCR assays for clinical, environmental or forensic detection applicationsErin P Price
Center for Microbial Genetics and Genomics, Northern Arizona University, Flagstaff, Arizona, United States of America
PLoS ONE 7:e37723. 2012..Using B. pseudomallei as a model, our study provides a framework for comprehensive quantitative validation of molecular assays and provides additional, highly validated B. pseudomallei assays for the scientific research community... - Tandem repeat regions within the Burkholderia pseudomallei genome and their application for high resolution genotypingJana M U'ren
Northern Arizona University, Center for Microbial Genetics and Genomics, Flagstaff, Arizona 86011, USA
BMC Microbiol 7:23. 2007..pseudomallei and 21 B. mallei isolates from around the world, as well as 95 lineages from a serial transfer experiment encompassing ~18,000 generations... 
Phylogenetic understanding of clonal populations in an era of whole genome sequencingTalima Pearson
Center for Microbial Genetics and Genomics, Northern Arizona University, Flagstaff, AZ, USA
Infect Genet Evol 9:1010-9. 2009..Understanding the ways in which current and emerging technologies can be used to maximize phylogenetic knowledge is advantageous only with a complete understanding of the strengths and weaknesses of these methods...- Pre-Columbian origins for North American anthraxLeo J Kenefic
Department of Biological Sciences, Northern Arizona University, Flagstaff, Arizona, United States of America
PLoS ONE 4:e4813. 2009..anthracis isolates. Continent-wide dispersal of WNA B. anthracis likely required movement by later European colonizers, but the continent's first inhabitants may have seeded the initial North American populations... - Epidemiological tracking and population assignment of the non-clonal bacterium, Burkholderia pseudomalleiJulia Dale
Center for Microbial Genetics and Genomics, Northern Arizona University, Flagstaff, Arizona, USA
PLoS Negl Trop Dis 5:e1381. 2011.... - Fine-scale genetic diversity among Burkholderia pseudomallei soil isolates in northeast ThailandHeidie Hornstra
Northern Arizona University, Department of Biological Sciences, Box 5640, Flagstaff, AZ 86011 5640, USA
Appl Environ Microbiol 73:6678-81. 2007..MLVA identified 19 genotypes within three clades, while MLST revealed two genotypes. These close genetic relationships imply a recent colonization followed by localized expansion, similar to what occurs in an outbreak situation... - Molecular investigations of a locally acquired case of melioidosis in Southern AZ, USADavid M Engelthaler
Translational Genomics Research Institute, Flagstaff, Arizona, United States of America
PLoS Negl Trop Dis 5:e1347. 2011..Advancements in new typing technologies provide genotyping resolution not previously available to public health investigators, allowing for more accurate source identification... - Diversity of 16S-23S rDNA internal transcribed spacer (ITS) reveals phylogenetic relationships in Burkholderia pseudomallei and its near-neighborsAndrew P Liguori
Department of Biological Sciences, Center for Microbial Genetics and Genomics, Northern Arizona University, Flagstaff, Arizona, United States of America
PLoS ONE 6:e29323. 2011..mallei is a clone of B. pseudomallei. Other B. pseudomallei near-neighbors possessed unique and monomorphic ITS types. Our data shed light on evolutionary patterns of B. pseudomallei and its near relative species... - Within-host evolution of Burkholderia pseudomallei in four cases of acute melioidosisErin P Price
Northern Arizona University, Center for Microbial Genetics and Genomics, Flagstaff, Arizona, United States of America
PLoS Pathog 6:e1000725. 2010.... - Cost-effective interrogation of single nucleotide polymorphisms using the mismatch amplification mutation assay and capillary electrophoresisErin P Price
Center for Microbial Genetics and Genomics, Northern Arizona University, Flagstaff, AZ 86011 4073, USA
Electrophoresis 31:3881-8. 2010..When real-time PCR technology and instrumentation is unavailable or the reagents are cost-prohibitive, CUMA is a powerful alternative for SNP genotyping... - Development of ceftazidime resistance in an acute Burkholderia pseudomallei infectionDerek S Sarovich
Center for Microbial Genetics and Genomics, Northern Arizona University, Flagstaff, AZ, USA
Infect Drug Resist 5:129-32. 2012..The ability to rapidly identify the emergence of CAZ resistant B. pseudomallei populations in melioidosis patients will allow timely alterations in treatment strategies, thereby improving patient outcomes for this serious disease... - Whole-genome-based phylogeny and divergence of the genus BrucellaJeffrey T Foster
Center for Microbial Genetics and Genomics, Northern Arizona University, Flagstaff, AZ 86011 4073, USA
J Bacteriol 191:2864-70. 2009.... 
Genotyping of Brucella species using clade specific SNPsJeffrey T Foster
Center for Microbial Genetics and Genomics, Northern Arizona University, Flagstaff, AZ 86011 4073, USA
BMC Microbiol 12:110. 2012....- Melt analysis of mismatch amplification mutation assays (Melt-MAMA): a functional study of a cost-effective SNP genotyping assay in bacterial modelsDawn N Birdsell
Center for Microbial Genetics and Genomics, Northern Arizona University, Flagstaff, Arizona, United States of America
PLoS ONE 7:e32866. 2012..We detail the parameters most important for the successful application of Melt-MAMA, which should prove useful to the wider scientific community... - Mutations, mutation rates, and evolution at the hypervariable VNTR loci of Yersinia pestisAmy J Vogler
Department of Biological Sciences, Northern Arizona University, Flagstaff, AZ 86011 5640, USA
Mutat Res 616:145-58. 2007.... - Characterization of ceftazidime resistance mechanisms in clinical isolates of Burkholderia pseudomallei from AustraliaDerek S Sarovich
Center for Microbial Genetics and Genomics, Northern Arizona University, Flagstaff, Arizona, United States of America
PLoS ONE 7:e30789. 2012..pseudomallei and to provide proven and clinically relevant signatures for monitoring the development of antibiotic resistance in this important pathogen... - Whole genome sequence analysis of Cryptococcus gattii from the Pacific Northwest reveals unexpected diversityJohn D Gillece
Pathogen Genomics Division, Translational Genomics Research Institute, Flagstaff, Arizona, United States of America
PLoS ONE 6:e28550. 2011..gattii molecular subtypes involved in the Pacific Northwest emergence and describes the tools that will further our understanding of this emerging pathogen... - Molecular epidemiology of glanders, PakistanHeidie Hornstra
Northern Arizona University, Flagstaff, Arizona 86011 4073, USA
Emerg Infect Dis 15:2036-9. 2009..We show that recent outbreaks are genetically distinct from available whole genome sequences and that these genotypes are persistent and ubiquitous in Punjab, probably due to human-mediated movement of equines... - VNTR analysis of selected outbreaks of Burkholderia pseudomallei in AustraliaTalima Pearson
Northern Arizona University, Center for Microbial Genetics and Genomics, Box 5640, Flagstaff, AZ 86011, USA
Infect Genet Evol 7:416-23. 2007..These methods provide the ability to generate robust evolutionary hypotheses that enable tracking of B. pseudomallei in forensic and epidemiological outbreaks at fine phylogenetic scales... - Use of a real-time PCR TaqMan assay for rapid identification and differentiation of Burkholderia pseudomallei and Burkholderia malleiMatthew N Van Ert
Department of Biological Sciences, Northern Arizona University, Flagstaff, AZ 86011-5640, USA
J Clin Microbiol 43:5771-4. 2005..The assay rapidly identifies and discriminates between these two highly pathogenic bacteria and does not cross-react with genetic near neighbors, such as Burkholderia thailandensis and Burkholderia cepacia... - Anthrax molecular epidemiology and forensics: using the appropriate marker for different evolutionary scalesPaul Keim
Keim Genetics Laboratory, Department of Biological Sciences, Northern Arizona University, Flagstaff, AZ 86011 5640, USA
Infect Genet Evol 4:205-13. 2004..This approach mitigates the need for data weighting and provides both a deeply rooted phylogenetic hypothesis and high resolution discrimination among closely related isolates... - Rapid typing of Coxiella burnetiiHeidie M Hornstra
Center for Microbial Genetics and Genomics, Northern Arizona University, Flagstaff, Arizona, United States of America
PLoS ONE 6:e26201. 2011..Furthermore, genotyping results based on assays from the signatures provided here are easily transferred between institutions, readily interpreted phylogenetically and simple to adapt to new genotyping technologies... - An attenuated strain of Bacillus anthracis (CDC 684) has a large chromosomal inversion and altered growth kineticsRichard T Okinaka
Center for Microbial Genetics and Genomics, Northern Arizona University, Flagstaff, AZ 86011, USA
BMC Genomics 12:477. 2011..These phenotypes prompted Ezzell et al., (J. Clin. Microbiol. 28:223) to reclassify this isolate to Bacillus anthracis in 1990... - Phylogeography of Francisella tularensis subspecies holarctica from the country of GeorgiaGvantsa Chanturia
Center for Microbial Genetics and Genomics, Northern Arizona University, Flagstaff, AZ 86011 4073, USA
BMC Microbiol 11:139. 2011..In this study, we address this knowledge gap by describing the phylogenetic structure of F. tularensis subsp. holarctica isolates from the country of Georgia, and by placing these isolates into a global phylogeographic context... - Microbial forensics: DNA fingerprinting of Bacillus anthracis (anthrax)Paul Keim
Department of Biological Sciences, Northern Arizona University, USA
Anal Chem 80:4791-9. 2008 - Phylogenetic discovery bias in Bacillus anthracis using single-nucleotide polymorphisms from whole-genome sequencingTalima Pearson
Department of Biology, Northern Arizona University, Flagstaff, AZ 86011-5640, USA
Proc Natl Acad Sci U S A 101:13536-41. 2004..Our use of nonhomoplastic whole-genome SNP characters allows branch points and clade membership to be estimated with great precision, providing greater insight into epidemiological, ecological, and forensic questions...