Talima Pearson

Summary

Affiliation: Northern Arizona University
Country: USA

Publications

  1. doi request reprint High prevalence and two dominant host-specific genotypes of Coxiella burnetii in U.S. milk
    Talima Pearson
    Center for Microbial Genetics and Genomics, Northern Arizona University, Flagstaff, AZ 86011 4073, USA
    BMC Microbiol 14:41. 2014
  2. pmc Phylogeographic reconstruction of a bacterial species with high levels of lateral gene transfer
    Talima Pearson
    Center for Microbial Genetics and Genomics, Northern Arizona University, Flagstaff, Arizona, USA
    BMC Biol 7:78. 2009
  3. pmc Bacillus anthracis in China and its relationship to worldwide lineages
    Tatum S Simonson
    Department of Biological Sciences, Northern Arizona University, Flagstaff, AZ 86011 5640, USA
    BMC Microbiol 9:71. 2009
  4. pmc A horizontal gene transfer event defines two distinct groups within Burkholderia pseudomallei that have dissimilar geographic distributions
    Apichai Tuanyok
    Department of Biological Sciences, Northern Arizona University, Flagstaff, AZ 86011 5640, USA
    J Bacteriol 189:9044-9. 2007
  5. pmc Global genetic population structure of Bacillus anthracis
    Matthew N Van Ert
    Department of Biological Sciences, Northern Arizona University, Flagstaff, Arizona, United States of America
    PLoS ONE 2:e461. 2007
  6. pmc Strain-specific single-nucleotide polymorphism assays for the Bacillus anthracis Ames strain
    Matthew N Van Ert
    Department of Biological Sciences, Northern Arizona University, Flagstaff, AZ 86011 5640, USA
    J Clin Microbiol 45:47-53. 2007
  7. pmc Phylogeography of Francisella tularensis: global expansion of a highly fit clone
    Amy J Vogler
    Center for Microbial Genetics and Genomics, Northern Arizona University, P O Box 4073, Flagstaff, AZ 86011, USA
    J Bacteriol 191:2474-84. 2009
  8. pmc Tandem repeat regions within the Burkholderia pseudomallei genome and their application for high resolution genotyping
    Jana M U'ren
    Northern Arizona University, Center for Microbial Genetics and Genomics, Flagstaff, Arizona 86011, USA
    BMC Microbiol 7:23. 2007
  9. pmc Molecular epidemiologic investigation of an anthrax outbreak among heroin users, Europe
    Erin P Price
    Northern Arizona University, Flagstaff, Arizona, USA
    Emerg Infect Dis 18:1307-13. 2012
  10. pmc BurkDiff: a real-time PCR allelic discrimination assay for Burkholderia pseudomallei and B. mallei
    Jolene R Bowers
    Translational Genomics Research Institute, Flagstaff, Arizona, United States of America
    PLoS ONE 5:e15413. 2010

Collaborators

Detail Information

Publications37

  1. doi request reprint High prevalence and two dominant host-specific genotypes of Coxiella burnetii in U.S. milk
    Talima Pearson
    Center for Microbial Genetics and Genomics, Northern Arizona University, Flagstaff, AZ 86011 4073, USA
    BMC Microbiol 14:41. 2014
    ..We collected A) 23 milk samples from a single bovine herd, B) 134 commercial bovine and caprine milk samples from across the U.S., and C) 400 bovine and caprine samples from six milk processing plants over three years...
  2. pmc Phylogeographic reconstruction of a bacterial species with high levels of lateral gene transfer
    Talima Pearson
    Center for Microbial Genetics and Genomics, Northern Arizona University, Flagstaff, Arizona, USA
    BMC Biol 7:78. 2009
    ..We compared and searched 43 whole genome sequences of B. pseudomallei and its closest relatives for single nucleotide polymorphisms in orthologous shared regions to use in phylogenetic reconstruction...
  3. pmc Bacillus anthracis in China and its relationship to worldwide lineages
    Tatum S Simonson
    Department of Biological Sciences, Northern Arizona University, Flagstaff, AZ 86011 5640, USA
    BMC Microbiol 9:71. 2009
    ..Canonical single nucleotide polymorphism (canSNP) and multiple locus VNTR analysis (MLVA) typing has been used to examine this archival collection of isolates...
  4. pmc A horizontal gene transfer event defines two distinct groups within Burkholderia pseudomallei that have dissimilar geographic distributions
    Apichai Tuanyok
    Department of Biological Sciences, Northern Arizona University, Flagstaff, AZ 86011 5640, USA
    J Bacteriol 189:9044-9. 2007
    ..In addition, clinical isolates are more likely to belong to group YLF, whereas environmental isolates are more likely to belong to group BTFC. These groups should be further characterized in an animal model...
  5. pmc Global genetic population structure of Bacillus anthracis
    Matthew N Van Ert
    Department of Biological Sciences, Northern Arizona University, Flagstaff, Arizona, United States of America
    PLoS ONE 2:e461. 2007
    ..Finally, the value of global genotypic analysis for investigating bioterrorist-mediated outbreaks of anthrax is demonstrated...
  6. pmc Strain-specific single-nucleotide polymorphism assays for the Bacillus anthracis Ames strain
    Matthew N Van Ert
    Department of Biological Sciences, Northern Arizona University, Flagstaff, AZ 86011 5640, USA
    J Clin Microbiol 45:47-53. 2007
    ..This evolutionary and genomics-based approach provides an effective means for the discovery of strain-specific SNPs in B. anthracis...
  7. pmc Phylogeography of Francisella tularensis: global expansion of a highly fit clone
    Amy J Vogler
    Center for Microbial Genetics and Genomics, Northern Arizona University, P O Box 4073, Flagstaff, AZ 86011, USA
    J Bacteriol 191:2474-84. 2009
    ..Phylogenetic analyses suggest a North American origin for this B-radiation clade and multiple dispersal events between North America and Eurasia. These findings indicate a complex transmission history for F. tularensis subsp. holarctica...
  8. pmc Tandem repeat regions within the Burkholderia pseudomallei genome and their application for high resolution genotyping
    Jana M U'ren
    Northern Arizona University, Center for Microbial Genetics and Genomics, Flagstaff, Arizona 86011, USA
    BMC Microbiol 7:23. 2007
    ..pseudomallei and 21 B. mallei isolates from around the world, as well as 95 lineages from a serial transfer experiment encompassing ~18,000 generations...
  9. pmc Molecular epidemiologic investigation of an anthrax outbreak among heroin users, Europe
    Erin P Price
    Northern Arizona University, Flagstaff, Arizona, USA
    Emerg Infect Dis 18:1307-13. 2012
    ..Our results suggest accidental contamination along the drug trafficking route through a cutting agent or animal hides used to smuggle heroin into Europe...
  10. pmc BurkDiff: a real-time PCR allelic discrimination assay for Burkholderia pseudomallei and B. mallei
    Jolene R Bowers
    Translational Genomics Research Institute, Flagstaff, Arizona, United States of America
    PLoS ONE 5:e15413. 2010
    ..Concordance of results with traditional speciation methods and no cross-reactivity to non-target species show BurkDiff is a robust, highly validated assay for the detection and differentiation of B. pseudomallei and B. mallei...
  11. pmc Development and validation of Burkholderia pseudomallei-specific real-time PCR assays for clinical, environmental or forensic detection applications
    Erin P Price
    Center for Microbial Genetics and Genomics, Northern Arizona University, Flagstaff, Arizona, United States of America
    PLoS ONE 7:e37723. 2012
    ..Using B. pseudomallei as a model, our study provides a framework for comprehensive quantitative validation of molecular assays and provides additional, highly validated B. pseudomallei assays for the scientific research community...
  12. doi request reprint Phylogenetic understanding of clonal populations in an era of whole genome sequencing
    Talima Pearson
    Center for Microbial Genetics and Genomics, Northern Arizona University, Flagstaff, AZ, USA
    Infect Genet Evol 9:1010-9. 2009
    ..Understanding the ways in which current and emerging technologies can be used to maximize phylogenetic knowledge is advantageous only with a complete understanding of the strengths and weaknesses of these methods...
  13. pmc Pre-Columbian origins for North American anthrax
    Leo J Kenefic
    Department of Biological Sciences, Northern Arizona University, Flagstaff, Arizona, United States of America
    PLoS ONE 4:e4813. 2009
    ..anthracis isolates. Continent-wide dispersal of WNA B. anthracis likely required movement by later European colonizers, but the continent's first inhabitants may have seeded the initial North American populations...
  14. pmc Within-host evolution of Burkholderia pseudomallei in four cases of acute melioidosis
    Erin P Price
    Northern Arizona University, Center for Microbial Genetics and Genomics, Flagstaff, Arizona, United States of America
    PLoS Pathog 6:e1000725. 2010
    ....
  15. pmc Fine-scale genetic diversity among Burkholderia pseudomallei soil isolates in northeast Thailand
    Heidie Hornstra
    Northern Arizona University, Department of Biological Sciences, Box 5640, Flagstaff, AZ 86011 5640, USA
    Appl Environ Microbiol 73:6678-81. 2007
    ..MLVA identified 19 genotypes within three clades, while MLST revealed two genotypes. These close genetic relationships imply a recent colonization followed by localized expansion, similar to what occurs in an outbreak situation...
  16. pmc Epidemiological tracking and population assignment of the non-clonal bacterium, Burkholderia pseudomallei
    Julia Dale
    Center for Microbial Genetics and Genomics, Northern Arizona University, Flagstaff, Arizona, USA
    PLoS Negl Trop Dis 5:e1381. 2011
    ....
  17. pmc Diversity of 16S-23S rDNA internal transcribed spacer (ITS) reveals phylogenetic relationships in Burkholderia pseudomallei and its near-neighbors
    Andrew P Liguori
    Department of Biological Sciences, Center for Microbial Genetics and Genomics, Northern Arizona University, Flagstaff, Arizona, United States of America
    PLoS ONE 6:e29323. 2011
    ..mallei is a clone of B. pseudomallei. Other B. pseudomallei near-neighbors possessed unique and monomorphic ITS types. Our data shed light on evolutionary patterns of B. pseudomallei and its near relative species...
  18. pmc Molecular investigations of a locally acquired case of melioidosis in Southern AZ, USA
    David M Engelthaler
    Translational Genomics Research Institute, Flagstaff, Arizona, United States of America
    PLoS Negl Trop Dis 5:e1347. 2011
    ..Advancements in new typing technologies provide genotyping resolution not previously available to public health investigators, allowing for more accurate source identification...
  19. pmc When outgroups fail; phylogenomics of rooting the emerging pathogen, Coxiella burnetii
    Talima Pearson
    Center for Microbial Genetics and Genomics, Northern Arizona University, Flagstaff, AZ, USA
    Syst Biol 62:752-62. 2013
    ..Using a phylogenomic approach, we created a robust, rooted phylogeny for C. burnetii. [Coxiella burnetii; paralog SNPs; pathogen evolution; phylogeny; recent radiation; root; rooting using duplicated genes.]. ..
  20. pmc Characterization of ceftazidime resistance mechanisms in clinical isolates of Burkholderia pseudomallei from Australia
    Derek S Sarovich
    Center for Microbial Genetics and Genomics, Northern Arizona University, Flagstaff, Arizona, United States of America
    PLoS ONE 7:e30789. 2012
    ..pseudomallei and to provide proven and clinically relevant signatures for monitoring the development of antibiotic resistance in this important pathogen...
  21. pmc Whole-genome-based phylogeny and divergence of the genus Brucella
    Jeffrey T Foster
    Center for Microbial Genetics and Genomics, Northern Arizona University, Flagstaff, AZ 86011 4073, USA
    J Bacteriol 191:2864-70. 2009
    ....
  22. pmc Cost-effective interrogation of single nucleotide polymorphisms using the mismatch amplification mutation assay and capillary electrophoresis
    Erin P Price
    Center for Microbial Genetics and Genomics, Northern Arizona University, Flagstaff, AZ 86011 4073, USA
    Electrophoresis 31:3881-8. 2010
    ..When real-time PCR technology and instrumentation is unavailable or the reagents are cost-prohibitive, CUMA is a powerful alternative for SNP genotyping...
  23. pmc Development of ceftazidime resistance in an acute Burkholderia pseudomallei infection
    Derek S Sarovich
    Center for Microbial Genetics and Genomics, Northern Arizona University, Flagstaff, AZ, USA
    Infect Drug Resist 5:129-32. 2012
    ..The ability to rapidly identify the emergence of CAZ resistant B. pseudomallei populations in melioidosis patients will allow timely alterations in treatment strategies, thereby improving patient outcomes for this serious disease...
  24. pmc Rapid typing of Coxiella burnetii
    Heidie M Hornstra
    Center for Microbial Genetics and Genomics, Northern Arizona University, Flagstaff, Arizona, United States of America
    PLoS ONE 6:e26201. 2011
    ..Furthermore, genotyping results based on assays from the signatures provided here are easily transferred between institutions, readily interpreted phylogenetically and simple to adapt to new genotyping technologies...
  25. pmc Use of a real-time PCR TaqMan assay for rapid identification and differentiation of Burkholderia pseudomallei and Burkholderia mallei
    Jana M U'ren
    Department of Biological Sciences, Northern Arizona University, Flagstaff, AZ 86011 5640, USA
    J Clin Microbiol 43:5771-4. 2005
    ..The assay rapidly identifies and discriminates between these two highly pathogenic bacteria and does not cross-react with genetic near neighbors, such as Burkholderia thailandensis and Burkholderia cepacia...
  26. pmc Genotyping of Brucella species using clade specific SNPs
    Jeffrey T Foster
    Center for Microbial Genetics and Genomics, Northern Arizona University, Flagstaff, AZ 86011 4073, USA
    BMC Microbiol 12:110. 2012
    ....
  27. ncbi request reprint Mutations, mutation rates, and evolution at the hypervariable VNTR loci of Yersinia pestis
    Amy J Vogler
    Department of Biological Sciences, Northern Arizona University, Flagstaff, AZ 86011 5640, USA
    Mutat Res 616:145-58. 2007
    ....
  28. pmc Melt analysis of mismatch amplification mutation assays (Melt-MAMA): a functional study of a cost-effective SNP genotyping assay in bacterial models
    Dawn N Birdsell
    Center for Microbial Genetics and Genomics, Northern Arizona University, Flagstaff, Arizona, United States of America
    PLoS ONE 7:e32866. 2012
    ..We detail the parameters most important for the successful application of Melt-MAMA, which should prove useful to the wider scientific community...
  29. pmc Whole genome sequence analysis of Cryptococcus gattii from the Pacific Northwest reveals unexpected diversity
    John D Gillece
    Pathogen Genomics Division, Translational Genomics Research Institute, Flagstaff, Arizona, United States of America
    PLoS ONE 6:e28550. 2011
    ..gattii molecular subtypes involved in the Pacific Northwest emergence and describes the tools that will further our understanding of this emerging pathogen...
  30. ncbi request reprint VNTR analysis of selected outbreaks of Burkholderia pseudomallei in Australia
    Talima Pearson
    Northern Arizona University, Center for Microbial Genetics and Genomics, Box 5640, Flagstaff, AZ 86011, USA
    Infect Genet Evol 7:416-23. 2007
    ..These methods provide the ability to generate robust evolutionary hypotheses that enable tracking of B. pseudomallei in forensic and epidemiological outbreaks at fine phylogenetic scales...
  31. pmc Molecular epidemiology of glanders, Pakistan
    Heidie Hornstra
    Northern Arizona University, Flagstaff, Arizona 86011 4073, USA
    Emerg Infect Dis 15:2036-9. 2009
    ..We show that recent outbreaks are genetically distinct from available whole genome sequences and that these genotypes are persistent and ubiquitous in Punjab, probably due to human-mediated movement of equines...
  32. pmc An attenuated strain of Bacillus anthracis (CDC 684) has a large chromosomal inversion and altered growth kinetics
    Richard T Okinaka
    Center for Microbial Genetics and Genomics, Northern Arizona University, Flagstaff, AZ 86011, USA
    BMC Genomics 12:477. 2011
    ..These phenotypes prompted Ezzell et al., (J. Clin. Microbiol. 28:223) to reclassify this isolate to Bacillus anthracis in 1990...
  33. pmc Phylogeography of Francisella tularensis subspecies holarctica from the country of Georgia
    Gvantsa Chanturia
    Center for Microbial Genetics and Genomics, Northern Arizona University, Flagstaff, AZ 86011 4073, USA
    BMC Microbiol 11:139. 2011
    ..In this study, we address this knowledge gap by describing the phylogenetic structure of F. tularensis subsp. holarctica isolates from the country of Georgia, and by placing these isolates into a global phylogeographic context...
  34. ncbi request reprint Microbial forensics: DNA fingerprinting of Bacillus anthracis (anthrax)
    Paul Keim
    Department of Biological Sciences, Northern Arizona University, USA
    Anal Chem 80:4791-9. 2008
  35. ncbi request reprint Anthrax molecular epidemiology and forensics: using the appropriate marker for different evolutionary scales
    Paul Keim
    Keim Genetics Laboratory, Department of Biological Sciences, Northern Arizona University, Flagstaff, AZ 86011 5640, USA
    Infect Genet Evol 4:205-13. 2004
    ..This approach mitigates the need for data weighting and provides both a deeply rooted phylogenetic hypothesis and high resolution discrimination among closely related isolates...
  36. pmc Phylogenetic discovery bias in Bacillus anthracis using single-nucleotide polymorphisms from whole-genome sequencing
    Talima Pearson
    Department of Biology, Northern Arizona University, Flagstaff, AZ 86011 5640, USA
    Proc Natl Acad Sci U S A 101:13536-41. 2004
    ..Our use of nonhomoplastic whole-genome SNP characters allows branch points and clade membership to be estimated with great precision, providing greater insight into epidemiological, ecological, and forensic questions...
  37. doi request reprint Yersinia pestis and the Plague of Justinian 541-543 AD: a genomic analysis
    David M Wagner
    Center for Microbial Genetics and Genomics and Department of Biological Sciences, Northern Arizona University, Flagstaff, AZ, USA
    Lancet Infect Dis 14:319-26. 2014
    ..To address this gap, we sequenced and analysed draft genomes of Y pestis obtained from two individuals who died in the first pandemic...