RANGASWAMY MEGANATHAN

Summary

Affiliation: Northern Illinois University
Country: USA

Publications

  1. ncbi request reprint Ubiquinone biosynthesis in microorganisms
    R Meganathan
    Department of Biological Sciences, Northern Illinois University, DeKalb, IL 60115, USA
    FEMS Microbiol Lett 203:131-9. 2001
  2. ncbi request reprint Biosynthesis of menaquinone (vitamin K2) and ubiquinone (coenzyme Q): a perspective on enzymatic mechanisms
    R Meganathan
    Department of Biological Sciences, Northern Illinois University, DeKalb, Illinois 60115, USA
    Vitam Horm 61:173-218. 2001
  3. ncbi request reprint Ubiquinone (coenzyme Q) biosynthesis in Escherichia coli: identification of the ubiF gene
    O Kwon
    Department of Biological Sciences, Northern Illinois University, DeKalb, IL 60115, USA
    FEMS Microbiol Lett 186:157-61. 2000
  4. pmc Menaquinone (vitamin K2) biosynthesis: localization and characterization of the menA gene from Escherichia coli
    K Suvarna
    Department of Biological Sciences, Northern Illinois University, DeKalb, Illinois 60115, USA
    J Bacteriol 180:2782-7. 1998
  5. pmc Vitamin K2 (menaquinone) biosynthesis in Escherichia coli: evidence for the presence of an essential histidine residue in o-succinylbenzoyl coenzyme A synthetase
    D K Bhattacharyya
    Department of Biological Sciences, Northern Illinois University, DeKalb 60115, USA
    J Bacteriol 179:6061-5. 1997
  6. pmc Menaquinone (vitamin K2) biosynthesis: overexpression, purification, and characterization of a new isochorismate synthase from Escherichia coli
    R Daruwala
    Department of Biological Sciences, Northern Illinois University, DeKalb 60115, USA
    J Bacteriol 179:3133-8. 1997
  7. pmc Menaquinone (vitamin K2) biosynthesis: overexpression, purification, and properties of o-succinylbenzoyl-coenzyme A synthetase from Escherichia coli
    O Kwon
    Department of Biological Sciences, Northern Illinois University, DeKalb 60115 2861, USA
    J Bacteriol 178:6778-81. 1996
  8. ncbi request reprint A new isochorismate synthase specifically involved in menaquinone (vitamin K2) biosynthesis encoded by the menF gene
    R Daruwala
    Department of Biological Sciences, Northern Illinois University, DeKalb 60115 2861, USA
    FEMS Microbiol Lett 140:159-63. 1996
  9. pmc Anaerobic biosynthesis of enterobactin Escherichia coli: regulation of entC gene expression and evidence against its involvement in menaquinone (vitamin K2) biosynthesis
    O Kwon
    Department of Biological Sciences, Northern Illinois University, De Kalb, 60115, USA
    J Bacteriol 178:3252-9. 1996
  10. ncbi request reprint Menaquinone (vitamin K2) biosynthesis: localization and characterization of the menE gene from Escherichia coli
    V Sharma
    Department of Biological Sciences, Northern Illinois University, DeKalb, 60115, USA
    Gene 168:43-8. 1996

Research Grants

  1. Studies on Vitamin K Biosynthesis
    RANGASWAMY MEGANATHAN; Fiscal Year: 2002

Collaborators

  • O Kwon
  • M E Hudspeth
  • D K Bhattacharyya
  • R Daruwala
  • V Sharma
  • K Suvarna
  • A Kotsakis
  • D Stevenson
  • C Palaniappan

Detail Information

Publications13

  1. ncbi request reprint Ubiquinone biosynthesis in microorganisms
    R Meganathan
    Department of Biological Sciences, Northern Illinois University, DeKalb, IL 60115, USA
    FEMS Microbiol Lett 203:131-9. 2001
    ..While the prenyl side chain is formed by the 2-C-methyl-D-erythritol 4-phosphate (non-mevalonate) pathway in E. coli, it is formed by the mevalonate pathway in the yeast...
  2. ncbi request reprint Biosynthesis of menaquinone (vitamin K2) and ubiquinone (coenzyme Q): a perspective on enzymatic mechanisms
    R Meganathan
    Department of Biological Sciences, Northern Illinois University, DeKalb, Illinois 60115, USA
    Vitam Horm 61:173-218. 2001
    ..The current status of the pathways with particular emphasis on the reaction mechanisms, is discussed in this review...
  3. ncbi request reprint Ubiquinone (coenzyme Q) biosynthesis in Escherichia coli: identification of the ubiF gene
    O Kwon
    Department of Biological Sciences, Northern Illinois University, DeKalb, IL 60115, USA
    FEMS Microbiol Lett 186:157-61. 2000
    ..The ubiF mutants, when complemented with this plasmid, regained the ability to grow on succinate and synthesize Q...
  4. pmc Menaquinone (vitamin K2) biosynthesis: localization and characterization of the menA gene from Escherichia coli
    K Suvarna
    Department of Biological Sciences, Northern Illinois University, DeKalb, Illinois 60115, USA
    J Bacteriol 180:2782-7. 1998
    ..The validity of an ORF-associated putative promoter sequence was confirmed by primer extension analyses...
  5. pmc Vitamin K2 (menaquinone) biosynthesis in Escherichia coli: evidence for the presence of an essential histidine residue in o-succinylbenzoyl coenzyme A synthetase
    D K Bhattacharyya
    Department of Biological Sciences, Northern Illinois University, DeKalb 60115, USA
    J Bacteriol 179:6061-5. 1997
    ..4-fold. Thus, His341 of OSB-CoA synthetase plays an important role in catalysis since it is probably involved in the binding of ATP to the enzyme...
  6. pmc Menaquinone (vitamin K2) biosynthesis: overexpression, purification, and characterization of a new isochorismate synthase from Escherichia coli
    R Daruwala
    Department of Biological Sciences, Northern Illinois University, DeKalb 60115, USA
    J Bacteriol 179:3133-8. 1997
    ..Preincubation of the enzyme with the substrate, chorismate, before NEM treatment resulted in complete protection of the enzyme from inactivation...
  7. pmc Menaquinone (vitamin K2) biosynthesis: overexpression, purification, and properties of o-succinylbenzoyl-coenzyme A synthetase from Escherichia coli
    O Kwon
    Department of Biological Sciences, Northern Illinois University, DeKalb 60115 2861, USA
    J Bacteriol 178:6778-81. 1996
    ..Thus, it appears that both the benzoyl carboxyl group and the succinyl side chain are required for activation of the aliphatic carboxyl group...
  8. ncbi request reprint A new isochorismate synthase specifically involved in menaquinone (vitamin K2) biosynthesis encoded by the menF gene
    R Daruwala
    Department of Biological Sciences, Northern Illinois University, DeKalb 60115 2861, USA
    FEMS Microbiol Lett 140:159-63. 1996
    ..The fluorescence spectrum generated by the formed salicylic acid was identical to that of authentic salicylic acid. The 5' end of the flanking menD gene has also be redefined...
  9. pmc Anaerobic biosynthesis of enterobactin Escherichia coli: regulation of entC gene expression and evidence against its involvement in menaquinone (vitamin K2) biosynthesis
    O Kwon
    Department of Biological Sciences, Northern Illinois University, De Kalb, 60115, USA
    J Bacteriol 178:3252-9. 1996
    ..Consistent with these findings, the entC+ strains were found to synthesize enterobactin anaerobically under iron-deficient conditions while the ent mutants failed to do so...
  10. ncbi request reprint Menaquinone (vitamin K2) biosynthesis: localization and characterization of the menE gene from Escherichia coli
    V Sharma
    Department of Biological Sciences, Northern Illinois University, DeKalb, 60115, USA
    Gene 168:43-8. 1996
    ..The region 5' of menB contains an an additional ORF of unknown function (orf241) and establishes the order of genes in the men cluster as menD, orf241, menB, menC and menE. All loci are transcribed counter-clockwise...
  11. pmc Menaquinone (vitamin K2) biosynthesis: cloning, nucleotide sequence, and expression of the menC gene from Escherichia coli
    V Sharma
    Department of Biological Sciences, Plant Molecular Biology Center, Northern Illinois University, DeKalb 60115
    J Bacteriol 175:4917-21. 1993
    ..Consistent with this suggestion, the menB promoter can initiate transcription of the menC gene...
  12. pmc Menaquinone (vitamin K2) biosynthesis: nucleotide sequence and expression of the menB gene from Escherichia coli
    V Sharma
    Department of Biological Sciences, Northern Illinois University, DeKalb 60115 2861
    J Bacteriol 174:5057-62. 1992
    ..However, multicopy plasmids containing menB fail to generate the expected levels of enzymatic activity...
  13. pmc Menaquinone (vitamin K2) biosynthesis: evidence that the Escherichia coli menD gene encodes both 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid synthase and alpha-ketoglutarate decarboxylase activities
    C Palaniappan
    Department of Biological Sciences, Northern Illinois University, DeKalb 60115
    J Bacteriol 174:8111-8. 1992
    ..Consistent with the requirement for TPP in the decarboxylation of alpha-ketoglutarate, the translated amino acid sequence contains the characteristic TPP-binding motif present in all well-characterized TPP-requiring enzymes...

Research Grants1

  1. Studies on Vitamin K Biosynthesis
    RANGASWAMY MEGANATHAN; Fiscal Year: 2002
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