E M John

Summary

Affiliation: Northern California Cancer Center
Country: USA

Publications

  1. ncbi request reprint Medical radiation exposure and breast cancer risk: findings from the Breast Cancer Family Registry
    Esther M John
    Northern California Cancer Center, Fremont, CA 94538, USA
    Int J Cancer 121:386-94. 2007
  2. pmc Common breast cancer susceptibility alleles are associated with tumour subtypes in BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2
    Anna Marie Mulligan
    Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, 2 Worts Causeway, Cambridge, CB1 8RN, UK
    Breast Cancer Res 13:R110. 2011
  3. pmc Exploring the link between MORF4L1 and risk of breast cancer
    Griselda Martrat
    Translational Research Laboratory, Catalan Institute of Oncology, Bellvitge Institute for Biomedical Research IDIBELL, Gran Via 199, L Hospitalet del Llobregat 08908, Spain
    Breast Cancer Res 13:R40. 2011
  4. pmc Recent changes in breast cancer incidence and risk factor prevalence in San Francisco Bay area and California women: 1988 to 2004
    Theresa H M Keegan
    Northern California Cancer Center, 2201 Walnut Ave, Suite 300, Fremont, CA 94538, USA
    Breast Cancer Res 9:R62. 2007
  5. pmc The Breast Cancer Family Registry: an infrastructure for cooperative multinational, interdisciplinary and translational studies of the genetic epidemiology of breast cancer
    Esther M John
    Clinical and Genetic Epidemiology Research Branch, Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland, USA
    Breast Cancer Res 6:R375-89. 2004
  6. ncbi request reprint Sun exposure, vitamin D receptor gene polymorphisms, and risk of advanced prostate cancer
    Esther M John
    Northern California Cancer Center, Fremont, California 94538, USA
    Cancer Res 65:5470-9. 2005
  7. ncbi request reprint Migration history, acculturation, and breast cancer risk in Hispanic women
    Esther M John
    Northern California Cancer Center, Suite 300, 2201 Walnut Avenue, Fremont, CA 94538, USA
    Cancer Epidemiol Biomarkers Prev 14:2905-13. 2005
  8. ncbi request reprint Prevalence of pathogenic BRCA1 mutation carriers in 5 US racial/ethnic groups
    Esther M John
    Northern California Cancer Center, Fremont, CA 94538 2334, USA
    JAMA 298:2869-76. 2007
  9. ncbi request reprint Vitamin D and breast cancer risk: the NHANES I Epidemiologic follow-up study, 1971-1975 to 1992. National Health and Nutrition Examination Survey
    E M John
    Northern California Cancer Center, Union City 94587, USA
    Cancer Epidemiol Biomarkers Prev 8:399-406. 1999
  10. ncbi request reprint Sun exposure, vitamin D receptor gene polymorphisms, and breast cancer risk in a multiethnic population
    Esther M John
    Northern California Cancer Center, Fremont, CA 94538, USA
    Am J Epidemiol 166:1409-19. 2007

Research Grants

Detail Information

Publications44

  1. ncbi request reprint Medical radiation exposure and breast cancer risk: findings from the Breast Cancer Family Registry
    Esther M John
    Northern California Cancer Center, Fremont, CA 94538, USA
    Int J Cancer 121:386-94. 2007
    ..Given the widespread and increasing use of medical diagnostic radiation, continued surveillance of breast cancer risk is warranted, particularly in women at specific genetic risk, such as those carrying mutations in BRCA1 or BRCA2...
  2. pmc Common breast cancer susceptibility alleles are associated with tumour subtypes in BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2
    Anna Marie Mulligan
    Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, 2 Worts Causeway, Cambridge, CB1 8RN, UK
    Breast Cancer Res 13:R110. 2011
    ..It is currently unknown how these alleles are associated with different breast cancer subtypes in BRCA1 and BRCA2 mutation carriers defined by estrogen (ER) or progesterone receptor (PR) status of the tumour...
  3. pmc Exploring the link between MORF4L1 and risk of breast cancer
    Griselda Martrat
    Translational Research Laboratory, Catalan Institute of Oncology, Bellvitge Institute for Biomedical Research IDIBELL, Gran Via 199, L Hospitalet del Llobregat 08908, Spain
    Breast Cancer Res 13:R40. 2011
    ..To gain deeper insight into this pathway and its influence on cancer risk, we searched for novel components through protein physical interaction screens...
  4. pmc Recent changes in breast cancer incidence and risk factor prevalence in San Francisco Bay area and California women: 1988 to 2004
    Theresa H M Keegan
    Northern California Cancer Center, 2201 Walnut Ave, Suite 300, Fremont, CA 94538, USA
    Breast Cancer Res 9:R62. 2007
    ..In light of these reports, we examined recent changes in breast cancer incidence and risk factor prevalence among non-Hispanic white women in the SFBA and other regions of California...
  5. pmc The Breast Cancer Family Registry: an infrastructure for cooperative multinational, interdisciplinary and translational studies of the genetic epidemiology of breast cancer
    Esther M John
    Clinical and Genetic Epidemiology Research Branch, Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland, USA
    Breast Cancer Res 6:R375-89. 2004
    ....
  6. ncbi request reprint Sun exposure, vitamin D receptor gene polymorphisms, and risk of advanced prostate cancer
    Esther M John
    Northern California Cancer Center, Fremont, California 94538, USA
    Cancer Res 65:5470-9. 2005
    ..46 to 0.67. Our findings support the hypothesis that sun exposure and VDR polymorphisms together play important roles in the etiology of prostate cancer...
  7. ncbi request reprint Migration history, acculturation, and breast cancer risk in Hispanic women
    Esther M John
    Northern California Cancer Center, Suite 300, 2201 Walnut Avenue, Fremont, CA 94538, USA
    Cancer Epidemiol Biomarkers Prev 14:2905-13. 2005
    ..We examined the influence of migration history and acculturation on breast cancer risk in Hispanic women ages 35 to 79 years...
  8. ncbi request reprint Prevalence of pathogenic BRCA1 mutation carriers in 5 US racial/ethnic groups
    Esther M John
    Northern California Cancer Center, Fremont, CA 94538 2334, USA
    JAMA 298:2869-76. 2007
    ..Information on the prevalence of pathogenic BRCA1 mutation carriers in racial/ethnic minority populations is limited...
  9. ncbi request reprint Vitamin D and breast cancer risk: the NHANES I Epidemiologic follow-up study, 1971-1975 to 1992. National Health and Nutrition Examination Survey
    E M John
    Northern California Cancer Center, Union City 94587, USA
    Cancer Epidemiol Biomarkers Prev 8:399-406. 1999
    ..These data support the hypothesis that sunlight and dietary vitamin D reduce the risk of breast cancer...
  10. ncbi request reprint Sun exposure, vitamin D receptor gene polymorphisms, and breast cancer risk in a multiethnic population
    Esther M John
    Northern California Cancer Center, Fremont, CA 94538, USA
    Am J Epidemiol 166:1409-19. 2007
    ..Localized breast cancer was not associated with sun exposure or VDR genotype. This study supports the hypothesis that sunlight exposure reduces risk of advanced breast cancer among women with light skin pigmentation...
  11. ncbi request reprint Lifetime physical activity and breast cancer risk in a multiethnic population: the San Francisco Bay area breast cancer study
    Esther M John
    Northern California Cancer Center, Union City, California 94587, USA
    Cancer Epidemiol Biomarkers Prev 12:1143-52. 2003
    ..Because few of the currently known risk factors for breast cancer are modifiable, these results underline the public health importance of promoting physically active lifestyles...
  12. ncbi request reprint Sun exposure and prostate cancer risk: evidence for a protective effect of early-life exposure
    Esther M John
    Northern California Cancer Center, Fremont, CA 94538, USA
    Cancer Epidemiol Biomarkers Prev 16:1283-6. 2007
    ..47; 95% confidence interval, 0.23-0.99). These findings suggest that, in addition to sun exposure in adulthood, sun exposure in early life protects against prostate cancer...
  13. ncbi request reprint Sources of phytoestrogen exposure among non-Asian women in California, USA
    P L Horn-Ross
    Northern California Cancer Center, Union City 94587, USA
    Cancer Causes Control 11:299-302. 2000
    ..This paper describes the first application of this database and the primary sources of phytoestrogen consumption in non-Asian women...
  14. ncbi request reprint Assessing phytoestrogen exposure in epidemiologic studies: development of a database (United States)
    P L Horn-Ross
    Northern California Cancer Center, Union City 94587, USA
    Cancer Causes Control 11:289-98. 2000
    ..The purpose of this research was to develop such a database for use with food-frequency questionnaires in large epidemiologic studies...
  15. pmc Second primary breast cancer occurrence according to hormone receptor status
    Allison W Kurian
    Northern California Cancer Center, 2201 Walnut Ave, Fremont, CA 94538 2334, USA
    J Natl Cancer Inst 101:1058-65. 2009
    ..Little is known about differences in risk for second primary breast cancers related to the estrogen and progesterone receptor (hormone receptor [HR]) status of the first tumor...
  16. ncbi request reprint Phytoestrogen consumption and breast cancer risk in a multiethnic population: the Bay Area Breast Cancer Study
    P L Horn-Ross
    Northern California Cancer Center, Union City, CA 94587, USA
    Am J Epidemiol 154:434-41. 2001
    ..Phytoestrogens appear to have little effect on breast cancer risk at the levels commonly consumed by non-Asian US women: an average intake equivalent to less than one serving of tofu per week...
  17. pmc Family history of breast cancer and all-cause mortality after breast cancer diagnosis in the Breast Cancer Family Registry
    Ellen T Chang
    Northern California Cancer Center, Fremont, 94538, USA
    Breast Cancer Res Treat 117:167-76. 2009
    ..Therefore, clinical management should not depend on family history of breast cancer...
  18. pmc Lifetime physical activity and risk of endometrial cancer
    Esther M John
    Cancer Prevention Institute of California, 2201 Walnut Avenue, Suite 300, Fremont, CA 94538, USA
    Cancer Epidemiol Biomarkers Prev 19:1276-83. 2010
    ..The role of moderate physical activity and life patterns of activity in reducing endometrial cancer risk remains uncertain...
  19. pmc Breast cancer incidence patterns among California Hispanic women: differences by nativity and residence in an enclave
    Theresa H M Keegan
    Northern California Cancer Center, 2201 Walnut Avenue, Suite 300, Fremont, CA 94538, USA
    Cancer Epidemiol Biomarkers Prev 19:1208-18. 2010
    ....
  20. pmc Past recreational physical activity, body size, and all-cause mortality following breast cancer diagnosis: results from the Breast Cancer Family Registry
    Theresa H M Keegan
    Northern California Cancer Center, 2201 Walnut Ave, Suite 300, Fremont, CA 94536, USA
    Breast Cancer Res Treat 123:531-42. 2010
    ..90-2.15; HR for obese = 1.77, 95% CI: 1.11-2.82). BMI associations did not appear to differ by race/ethnicity. Our findings suggest that physical activity and BMI exert independent effects on overall mortality after breast cancer...
  21. ncbi request reprint Phytoestrogen intake and endometrial cancer risk
    Pamela L Horn-Ross
    Northern California Cancer Center, Union City, CA 94587, USA
    J Natl Cancer Inst 95:1158-64. 2003
    ..We evaluated the associations between dietary intake of seven specific compounds representing three classes of phytoestrogens (isoflavones, coumestans, and lignans) and the risk of endometrial cancer...
  22. ncbi request reprint Residential sunlight exposure is associated with a decreased risk of prostate cancer
    Esther M John
    Northern California Cancer Center, Union City, CA 94587, USA
    J Steroid Biochem Mol Biol 89:549-52. 2004
    ..These data support the hypothesis that sunlight exposure reduces the risk of prostate cancer and have important implications for prostate cancer prevention...
  23. pmc Availability and accuracy of medical record information on language usage of cancer patients from a multi-ethnic population
    Laura A McClure
    Northern California Cancer Center, 2201 Walnut Avenue, Fremont, CA 94538, USA
    J Immigr Minor Health 12:480-8. 2010
    ..However, for the data to be useful for research and reducing language barriers in medical care, the information must be collected in a consistent and accurate manner...
  24. ncbi request reprint An inverse association between ovarian cysts and breast cancer in the breast cancer family registry
    Julia A Knight
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada
    Int J Cancer 118:197-202. 2006
    ..Further study of ovarian cysts may increase our understanding of hormonal and other mechanisms of breast cancer etiology...
  25. doi request reprint Dietary fat, cooking fat, and breast cancer risk in a multiethnic population
    Jun Wang
    Department of Medicine, Tufts Medical Center, Boston, Massachusetts 02111, USA
    Nutr Cancer 60:492-504. 2008
    ..Our results suggest that a low-fat diet may play a role in breast cancer prevention. We speculate that monounsaturated trans fats may have driven the discrepant associations between types of fat and breast cancer...
  26. ncbi request reprint Obesity before age 30 years and risk of advanced prostate cancer
    Whitney R Robinson
    Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC 27599 7435, USA
    Am J Epidemiol 161:1107-14. 2005
    ....
  27. ncbi request reprint Oral contraceptive use and risk of early-onset breast cancer in carriers and noncarriers of BRCA1 and BRCA2 mutations
    Roger L Milne
    Centre for Genetic Epidemiology, The University of Melbourne, Level 2, 723 Swanston Street, Carlton, Victoria 3053, Australia
    Cancer Epidemiol Biomarkers Prev 14:350-6. 2005
    ..Recent oral contraceptive use has been associated with a small increase in breast cancer risk and a substantial decrease in ovarian cancer risk. The effects on risks for women with germ line mutations in BRCA1 or BRCA2 are unclear...
  28. pmc Admixture mapping identifies 8q24 as a prostate cancer risk locus in African-American men
    Matthew L Freedman
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 103:14068-73. 2006
    ..Thus, admixture mapping indicates a major, still-unidentified risk gene for prostate cancer at 8q24, motivating intense work to find it...
  29. ncbi request reprint Genetic ancestry and risk factors for breast cancer among Latinas in the San Francisco Bay Area
    Elad Ziv
    Division of General Internal Medicine, University of California San Francisco, Box 1732, San Francisco, CA 94143, USA
    Cancer Epidemiol Biomarkers Prev 15:1878-85. 2006
    ..We reasoned that if genetic ancestry is associated with known breast cancer risk factors, then the results of genetic association studies would be confounded...
  30. ncbi request reprint Prevalence of BRCA1 mutation carriers among U.S. non-Hispanic Whites
    Alice S Whittemore
    Department of Health Research and Policy, Stanford University School of Medicine, Redwood Building, Room T204, Stanford, CA 94503 5405, USA
    Cancer Epidemiol Biomarkers Prev 13:2078-83. 2004
    ..S. Whites (506,206 non-Ashkenazim and 44,307 Ashkenazim) carry germ line BRCA1 mutations. These estimates may be useful in guiding resource allocation for genetic testing and genetic counseling and in planning preventive interventions...
  31. ncbi request reprint Segregation analysis of prostate cancer in 1,719 white, African-American and Asian-American families in the United States and Canada
    Gail Gong
    Stanford University School of Medicine, Department of Health Research and Policy, CA 94305 5405, USA
    Cancer Causes Control 13:471-82. 2002
    ..However, higher observed frequencies in brothers than fathers may merely reflect the strong temporal changes in US incidence rates...
  32. doi request reprint Genetic variation in IGFBP2 and IGFBP5 is associated with breast cancer in populations of African descent
    Chad P Garner
    Department of Epidemiology, University of California Irvine, 224 Irvine Hall, Irvine, CA, 92697 7550, USA
    Hum Genet 123:247-55. 2008
    ..0038 and P = 0.01 in African-Americans and Nigerians, respectively. This study is the first to report associations between genetic variants in IGFBP2 and IGFBP5 and breast cancer risk...
  33. ncbi request reprint Androgen receptor and prostate-specific antigen gene polymorphisms and breast cancer in African-American women
    Wei Wang
    USC Norris Comprehensive Cancer Center, University of Southern California, Room 6419, 1441 Eastlake Avenue, Los Angeles, CA 90089 9175, USA
    Cancer Epidemiol Biomarkers Prev 14:2990-4. 2005
    ..Our data, however, are unable to provide evidence that PSA is the pathway through which the protective effect of androgens operates...
  34. ncbi request reprint BRCA1 and BRCA2 mutation carriers, oral contraceptive use, and breast cancer before age 50
    Robert W Haile
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, 1441 Eastlake Avenue, MS 9175, Los Angeles, CA 90089 9175, USA
    Cancer Epidemiol Biomarkers Prev 15:1863-70. 2006
    ..Understanding the effect of oral contraceptives on risk of breast cancer in BRCA1 or BRCA2 mutation carriers is important because oral contraceptive use is a common, modifiable practice...
  35. ncbi request reprint BRCA2 mutation-associated breast cancers exhibit a distinguishing phenotype based on morphology and molecular profiles from tissue microarrays
    Anita L Bane
    Department of Pathology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, 600 University Avenue, Toronto, Ontario, Canada
    Am J Surg Pathol 31:121-8. 2007
    ....
  36. ncbi request reprint Alcohol metabolism, alcohol intake, and breast cancer risk: a sister-set analysis using the Breast Cancer Family Registry
    Mary Beth Terry
    Department of Epidemiology, Mailman School of Public Health, Columbia University, 722 West 168th Street, Room 724, New York, NY 10032, USA
    Breast Cancer Res Treat 106:281-8. 2007
    ..However, only 19% and 42% of sisters were discordant by ADH1B and ADH1C, respectively, and even fewer were discordant by both genotype and alcohol intake, making it difficult to detect differences if they existed...
  37. ncbi request reprint Breast and ovarian cancer in relatives of cancer patients, with and without BRCA mutations
    Jennifer S Lee
    Division of Epidemiology, Department of Health Research and Policy, Stanford University School of Medicine, HRP Redwood Building, Stanford, California 94305 5405, USA
    Cancer Epidemiol Biomarkers Prev 15:359-63. 2006
    ..Little is known about how their risks vary with the patient's cancer site, carrier status for predisposing genetic mutations, or age at cancer diagnosis...
  38. pmc Multiple regions within 8q24 independently affect risk for prostate cancer
    Christopher A Haiman
    Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90089, USA
    Nat Genet 39:638-44. 2007
    ..None of the prostate cancer risk variants aligns to a known gene or alters the coding sequence of an encoded protein...
  39. ncbi request reprint A variant in the cytochrome p450 oxidoreductase gene is associated with breast cancer risk in African Americans
    Christopher A Haiman
    Departments of Preventive Medicine and Pathology, Keck School of Medicine, University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90089, USA
    Cancer Res 67:3565-8. 2007
    ..03) and stronger in those with advanced disease (411 cases and 877 controls; OR, 2.60; 95% CI, 1.56-4.34; P = 0.0002). These data suggest that African Americans harbor an allele at the POR locus that may increase breast cancer risk...
  40. ncbi request reprint UDP-Glucuronosyltransferase 1A1 gene polymorphisms and total bilirubin levels in an ethnically diverse cohort of women
    Andrew L Hong
    Department of Medicine, Section of Hematology Oncology, University of Chicago, 5841 S Maryland Ave, MC 2115, Chicago, IL 60637, USA
    Drug Metab Dispos 35:1254-61. 2007
    ..These data have implications for the design of epidemiologic studies of cancer susceptibility and pharmacogenetic studies for adverse drug reactions in populations of African ancestry...
  41. ncbi request reprint The CHEK2*1100delC allelic variant and risk of breast cancer: screening results from the Breast Cancer Family Registry
    Jonine L Bernstein
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, 3rd Floor, 307 East 63rd Street, New York, New York 10021, USA
    Cancer Epidemiol Biomarkers Prev 15:348-52. 2006
    ..63; 95% CI, 1.25-10.52). These data supporting the biological relevance of CHEK2 in breast carcinogenesis suggest that further studies examining the joint roles of CHEK2*1100delC carrier status and radiation exposure may be warranted...
  42. ncbi request reprint The AIB1 polyglutamine repeat does not modify breast cancer risk in BRCA1 and BRCA2 mutation carriers
    Amanda B Spurdle
    The Queensland Institute of Medical Research, Brisbane, Australia
    Cancer Epidemiol Biomarkers Prev 15:76-9. 2006
    ..Given the large sample size, with more than adequate power to detect previously reported effects, we conclude that the AIB1 glutamine repeat does not substantially modify risk of breast cancer in BRCA1 and BRCA2 mutation carriers...
  43. pmc Mitochondrial DNA G10398A variant is not associated with breast cancer in African-American women
    Veronica Wendy Setiawan
    Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA
    Cancer Genet Cytogenet 181:16-9. 2008
    ..18, 95% CI = 0.76-1.82, P = 0.46). Our results do not support the hypothesis that the mtDNA G10398A polymorphism is, as has previously been reported, a marker of breast cancer risk in African Americans...
  44. ncbi request reprint No increased risk of breast cancer associated with alcohol consumption among carriers of BRCA1 and BRCA2 mutations ages <50 years
    Valerie McGuire
    Department of Health Research and Policy, Stanford University School of Medicine, Health Research and Stanford, CA 94305 5405, USA
    Cancer Epidemiol Biomarkers Prev 15:1565-7. 2006

Research Grants2

  1. Body size and breast cancer risk in a multiethnic population
    Esther John; Fiscal Year: 2007
    ..This study will make an important contribution towards a better understanding of breast cancer etiology, and the role of body size in particular, in understudied populations such as African-Americans and Hispanics. ..