Pamela L Horn-Ross

..Few data sources can address breast cancer incidence trends according to pertinent characteristics like hormone therapy use history...

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..The purpose of this research was to develop such a database for use with food-frequency questionnaires in large epidemiologic studies...

..We take the opportunity to address the relationship between recent adult diet and breast cancer risk during the first two years of follow-up of the large California Teachers Study cohort...

..We evaluated the associations between dietary intake of seven specific compounds representing three classes of phytoestrogens (isoflavones, coumestans, and lignans) and the risk of endometrial cancer...

..Our findings suggest that thyroid cancer prevention via dietary modification of soy and/or phytoestrogen intake in other forms may be possible but warrants further research at this time...

..In addition, no ethnic differences in risk were observed. The authors conclude that iodine exposure appears to have, at most, a weak effect on the risk of papillary thyroid cancer...

..This paper describes the first application of this database and the primary sources of phytoestrogen consumption in non-Asian women...

..Phytoestrogens appear to have little effect on breast cancer risk at the levels commonly consumed by non-Asian US women: an average intake equivalent to less than one serving of tofu per week...

..Whether alcohol consumption influences ovarian cancer risk is unclear. Therefore, we investigated the association between alcohol intake at various ages and risk of ovarian cancer...

..Although dietary consumption of isoflavones may be associated with decreased ovarian cancer risk, most dietary factors are unlikely to play a major role in ovarian cancer development...

..Overall, our results show no convincing associations between dietary patterns and ovarian cancer risk...

..In light of these reports, we examined recent changes in breast cancer incidence and risk factor prevalence among non-Hispanic white women in the SFBA and other regions of California...

..Thus, while like others we found that dietary fat increases endometrial cancer risk, the evaluation of dietary patterns did not provide any additional information regarding risk...

..Variations in CYP11A1 may modify the effect of ET use on risk of postmenopausal endometrial cancer; however, larger studies are needed to explore these findings further...

..73; 95% confidence interval (CI), 0.52-0.97], but there was no trend with duration of use. Although it remains unclear how sex hormones influence thyroid carcinogenesis, these relationships warrant further investigation...

..One potential explanation for this inconsistency is that hormone therapy, which is associated with lower colon cancer risk, acts as a modifier of the physical activity/colon cancer relationship...

..To evaluate the reliability and validity of a food-frequency questionnaire (FFQ) and database designed to quantify phytoestrogen consumption...

..3), and melanoma (SIR = 2.1, 95% CI: 1.3, 3.2) limited to the first 5 years after diagnosis was observed. Women with papillary thyroid cancer are at increased risk of in situ, but not invasive, breast cancer, kidney cancer, and melanoma...

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..We estimated trends in breast cancer incidence rates for specific Asian populations in California to determine if disparities exist by immigrant status and age...

..Because few of the currently known risk factors for breast cancer are modifiable, these results underline the public health importance of promoting physically active lifestyles...

..Dietary vitamin D also was not associated with risk of lymphoid malignancies. These results support a protective effect of routine residential UVR exposure against lymphomagenesis through mechanisms possibly independent of vitamin D...

..Little is known about differences in risk for second primary breast cancers related to the estrogen and progesterone receptor (hormone receptor [HR]) status of the first tumor...

..The current investigation examined recent trends and racial/ethnic differences in the incidence and treatment of DCIS in California...

..A greater prevalence of goiter and thyroid nodules accounts for a substantial portion of the higher thyroid cancer incidence rates among SA women. Dietary patterns also contribute to the rate differences...

..The degree to which these methods are considered viable depends on further refinement to limit, or eliminate, their inherent selection biases without sacrificing their increased efficiency to locate minority populations...

..Self-reported indicators of residential proximity to high traffic volume were, however, associated with GIS traffic density measures...

..To date, literature addressing this question has been mixed, and the question has seldom been examined in large prospective study designs...

..Several large prospective studies, which eliminate recall bias, did not detect associations, but this relationship continues to be debated...

..Our results suggest that a low-fat diet may play a role in breast cancer prevention. We speculate that monounsaturated trans fats may have driven the discrepant associations between types of fat and breast cancer...

..These analyses were designed to describe characteristics associated with active and passive smoking in a large cohort of women in order to identify possible confounders of the relationship between smoking exposures and breast cancer risk...

..The combination of self-reports and secondary medical records provides more accurate and complete morbidity data than does use of either source alone...

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..Relative risks were calculated using Poisson regression to estimate which women with DCIS were likely to develop a second DCIS or invasive breast cancer...

..Our analyses suggest that breast cancer incidence is not elevated in areas of recent, high agricultural pesticide use in California...

..To evaluate the reproductive and lifestyle correlates of a surgically confirmed diagnosis of endometriosis or adenomyosis in a large prospective cohort...

..This large cohort study has followed female professional school employees for cancer incidence since 1995 and has collected extensive information on breast cancer risk factors...

..This study describes and evaluates characteristics associated with residential mobility in a sub-sample of the California Teachers Study (CTS) cohort...

..Long-term physical activity may affect breast cancer risk. Few prospective studies have evaluated in situ or invasive breast cancer risk, or breast cancer receptor subtypes, in relation to long-term activity...

..We investigated the association of NSAID use with risk of breast cancer in the California Teachers Study cohort, with special attention to risk of specific breast cancer subtypes and to type of NSAID used...

..An inverse association between alcohol intake and risk of renal cell cancer has been suggested in a few prospective studies, but each of these studies included a small number of cases...

..Most of the methods used in the Pooling Project may be adapted for examining associations with dietary and nondietary factors in pooled analyses of case-control studies or case-control and cohort studies combined...

..A priori definitions and factor analysis will be used to identify dietary patterns. The results of the proposed analyses will provide further understanding of the etiology of endometrial cancer. ..

..The results of this research will have important implications for improving our understanding of the etiology of this disease which disproportionately affects young women. ..