Anne Berg

..To examine different approaches to classifying seizure outcomes...

..g., focal pathology in favor of and persistent auras against stopping antiepileptic drugs), it is unclear how well these factors determine seizure outcome in this setting...

..Waiting any longer, however, would be a disservice to patient care and will continue the longstanding frustrations with the earlier system which, at this point in time, can be viewed as both antiquated and arbitrary...

..Little evidence guides practice regarding the reduction of antiepileptic drugs (AEDs) in individuals who achieve significant periods of remission after resective surgery...

..A head-to-head comparison of definitions could highlight these differences and motivate the development of consensus guidelines...

..To determine prospectively when in the course of epilepsy intractability becomes apparent...

..The change(s) should be based on agreed upon scientific criteria and processes. Any changes should represent major improvements and not merely incremental steps...

..Selected but essential methodological and statistical concepts are discussed along with the need to balance innovation and novelty against methodological rigor...

..To determine the frequency and determinants of subnormal global cognitive function in a representative, community-based sample of children prospectively identified at the time of initial diagnosis of epilepsy...

..The review considers the available evidence and gaps in our current knowledge of the subject...

..In young people of normal intelligence with idiopathic or cryptogenic childhood-onset epilepsy, substantial residual effects of epilepsy appear to be confined largely to slower processing speed...

..Identify prognostic factors for remission after second drug failure...

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..Maximizing seizure control is imperative for reducing the risks and consequences of epilepsy, including the cognitive and psychiatric comorbidities and even sudden death...

..The mounting evidence argues strongly for the recognition of epilepsy as part of a spectrum of disorders and against the notion that even uncomplicated epilepsy can a priori be considered benign...

..These need to be considered together in evaluating and managing young people with epilepsy and may help explain long-term social outcomes above and beyond poor seizure control...

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..Epidemiologic evidence suggests the natural history of refractory mesial temporal lobe epilepsy is complicated, yet little is known about the hippocampus from the nontertiary center perspective...

..This suggests an independent effect associated with the epilepsy itself...

..To evaluate mortality in children with newly diagnosed epilepsy, to determine the risk of death, and to identify predictors of death from the point of diagnosis...

..Such information is necessary for providing the epidemiologic and clinical context in which epilepsy surgery is currently performed in the United States and in other developed countries...

..The purpose of this study was to examine remission and relapse with respect to the epilepsy syndrome and other factors traditionally considered with respect to seizure outcome...

..g., epileptic encephalopathies, self-limited electroclinical syndromes) may serve as the basis for organizing knowledge about recognized forms of epilepsy and facilitate identification of new forms...

..Little is known about early prediction of intractable epilepsy (IE) in children. Such information could help guide the early use of new therapies in selected patients...

..We compared the classification of epilepsy syndromes made previously on the basis of information available at diagnosis with those made 2 years later in a cohort of children with newly diagnosed epilepsy...

..We describe the patterns in the use and yield of diagnostic imaging in children with newly diagnosed epilepsy in a community-based study...

..To examine the frequency of driving an automobile and characteristics associated with driving in individuals with refractory localization-related epilepsy...

..To determine the patterns and frequency of treatment and use of specific drugs for newly diagnosed pediatric epilepsy...

..To determine the risk and predictors of status epilepticus in children after they have been diagnosed with epilepsy...

..We examined the independent effects of syndrome type, seizure control, and etiology over time on adaptive behavior as measured by the Vineland Scales of Adaptive Behavior...

..Its advantage is that it allows one to track the individuals' outcome over time even as the condition fluctuates. The technique would also be applicable in virtually any remitting-relapsing disorder...

..This information could guide the design of future studies, resolve certain discrepancies in the literature, and provide more accurate information about long-term prognosis...

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..This suggests that behavioral and cognitive abnormalities may predate the onset of epilepsy and are not necessarily the direct consequences of epilepsy...

..The great majority of people (approximately 90%) who are seen for a first unprovoked seizure attain a one to two year remission within 4 or 5 years of the initial event...

..Long-term follow-up after appearance of intractable epilepsy (as determined by a variety of definitions) would provide helpful information necessary for refining meaningful definitions of intractability...

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..We believe that this study demonstrates the feasibility of implementing multicenter protocols for neurologic management, especially those involving localization, as well as protocols combining study results with clinical decision making...

..Health-related quality of life (HRQOL) improves after resective epilepsy surgery, but data are limited to short follow-up in mostly retrospective reports, with minimal consideration of other potential factors that might influence HRQOL...

..The remaining five subjects all had multiple seizures and were on medications. Treatment following the first seizure would not have altered mortality in any of the nine cases...

..Analyze determinates of employment changes from before to 2 years after surgery in refractory focal epilepsy patients...

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..To describe the clinical characteristics of children with a first-time nonfebrile seizure in the setting of mild illness and to test the hypothesis that these seizures are associated with illness characterized by diarrhea...

..This in turn could help lessen the burdens associated with childhood-and adolescent-onset epilepsy for the individual, the family, and society as a whole. ..

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