Vladimir Torchilin

Summary

Affiliation: Northeastern University
Country: USA

Publications

  1. ncbi Design, synthesis, and characterization of pH-sensitive PEG-PE conjugates for stimuli-sensitive pharmaceutical nanocarriers: the effect of substitutes at the hydrazone linkage on the ph stability of PEG-PE conjugates
    Amit A Kale
    Department of Pharmaceutical Sciences and Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, Massachusetts 02115, USA
    Bioconjug Chem 18:363-70. 2007
  2. ncbi Antibody-modified liposomes for cancer chemotherapy
    Vladimir Torchilin
    Center for Pharmaceutical Biotechnology and Nanomedicine, Department of Pharmaceutical Sciences, Northeastern University, Boston, MA 02115, USA
    Expert Opin Drug Deliv 5:1003-25. 2008
  3. ncbi Interview with Vladimir P Torchilin: liposomal carriers for drug delivery
    Vladimir P Torchilin
    Department of Pharmaceutical Sciences, Northeastern University, Mugar Building, Room 312, 360 Huntington Avenue, Boston, MA, 02115, USA
    Ther Deliv 4:537-8. 2013
  4. ncbi Stimulus-responsive nanopreparations for tumor targeting
    Lin Zhu
    Department of Pharmaceutical Sciences and Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, 140 The Fenway, Boston, MA 02115, USA
    Integr Biol (Camb) 5:96-107. 2013
  5. ncbi Antinuclear antibodies with nucleosome-restricted specificity for targeted delivery of chemotherapeutic agents
    Vladimir P Torchilin
    Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, MA 02115, USA
    Ther Deliv 1:257-72. 2010
  6. ncbi TAT-liposomes: a novel intracellular drug carrier
    V P Torchilin
    Department of Pharmaceutical Sciences, Bouve College of Health Sciences, Northeastern University, Boston, MA 02115, USA
    Curr Protein Pept Sci 4:133-40. 2003
  7. ncbi Kinetic and thermodynamic approaches to the drug targeting phenomena
    Igor Meerovich
    Department of Pharmaceutical Sciences, Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, MA 02115, USA
    Curr Drug Discov Technol 8:287-300. 2011
  8. ncbi Micellar nanocarriers: pharmaceutical perspectives
    V P Torchilin
    Department of Pharmaceutical Sciences and Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Mugar Building, Room 312, 360 Huntington Avenue, Boston, Massachusetts 02115, USA
    Pharm Res 24:1-16. 2007
  9. ncbi Tat peptide-mediated intracellular delivery of pharmaceutical nanocarriers
    Vladimir P Torchilin
    Department of Pharmaceutical Sciences and Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, MA 02115, USA
    Adv Drug Deliv Rev 60:548-58. 2008
  10. ncbi Targeted pharmaceutical nanocarriers for cancer therapy and imaging
    Vladimir P Torchilin
    Department of Pharmaceutical Sciences and Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, MA 02115, USA
    AAPS J 9:E128-47. 2007

Research Grants

  1. LONG CIRCULATING POLYMER MODIFIED LIPOSOMES
    Vladimir Torchilin; Fiscal Year: 1999
  2. MULTIFUNCTIONAL STIMULI-SENSITIVE PHARMACEUTICAL NANOCARRIERS
    Vladimir P Torchilin; Fiscal Year: 2010
  3. Surface-modified pharmaceutical nanocarriers for subcellular targeting
    Vladimir P Torchilin; Fiscal Year: 2010
  4. MICELLAR CARRIERS FOR SPARINGLY SOLUBLE PHARMACEUTICALS
    Vladimir Torchilin; Fiscal Year: 2007
  5. Long-Circulating Polymer-Modified Liposomes
    Vladimir Torchilin; Fiscal Year: 2007
  6. MULTIFUNCTIONAL STIMULI-SENSITIVE PHARMACEUTICAL NANOCARRIERS
    Vladimir Torchilin; Fiscal Year: 2007
  7. Fifth International Nanomedicine and Drug Delivery
    Vladimir Torchilin; Fiscal Year: 2007
  8. MULTIFUNCTIONAL STIMULI-SENSITIVE PHARMACEUTICAL NANOCARRIERS
    Vladimir Torchilin; Fiscal Year: 2009
  9. Surface-modified pharmaceutical nanocarriers for subcellular targeting
    Vladimir Torchilin; Fiscal Year: 2009
  10. Layer-by-layer nanocarriers for highly efficient solubilization of insoluble drug
    Vladimir P Torchilin; Fiscal Year: 2010

Collaborators

Detail Information

Publications107 found, 100 shown here

  1. ncbi Design, synthesis, and characterization of pH-sensitive PEG-PE conjugates for stimuli-sensitive pharmaceutical nanocarriers: the effect of substitutes at the hydrazone linkage on the ph stability of PEG-PE conjugates
    Amit A Kale
    Department of Pharmaceutical Sciences and Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, Massachusetts 02115, USA
    Bioconjug Chem 18:363-70. 2007
    ....
  2. ncbi Antibody-modified liposomes for cancer chemotherapy
    Vladimir Torchilin
    Center for Pharmaceutical Biotechnology and Nanomedicine, Department of Pharmaceutical Sciences, Northeastern University, Boston, MA 02115, USA
    Expert Opin Drug Deliv 5:1003-25. 2008
    ..Liposomes, phospholipids, nanosized bubbles with a bilayered membrane structure, have drawn a lot of interest as pharmaceutical carriers for drugs and genes. In particular, liposomes are widely used for drug delivery into tumors...
  3. ncbi Interview with Vladimir P Torchilin: liposomal carriers for drug delivery
    Vladimir P Torchilin
    Department of Pharmaceutical Sciences, Northeastern University, Mugar Building, Room 312, 360 Huntington Avenue, Boston, MA, 02115, USA
    Ther Deliv 4:537-8. 2013
    ..Interview conducted by James Potticary, Assistant Commissioning Editor...
  4. ncbi Stimulus-responsive nanopreparations for tumor targeting
    Lin Zhu
    Department of Pharmaceutical Sciences and Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, 140 The Fenway, Boston, MA 02115, USA
    Integr Biol (Camb) 5:96-107. 2013
    ....
  5. ncbi Antinuclear antibodies with nucleosome-restricted specificity for targeted delivery of chemotherapeutic agents
    Vladimir P Torchilin
    Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, MA 02115, USA
    Ther Deliv 1:257-72. 2010
    ..Here, the data (accumulated predominantly in our laboratory over several years) on mAb 2C5-mediated tumor targeting of chemotherapeutic agents is reviewed...
  6. ncbi TAT-liposomes: a novel intracellular drug carrier
    V P Torchilin
    Department of Pharmaceutical Sciences, Bouve College of Health Sciences, Northeastern University, Boston, MA 02115, USA
    Curr Protein Pept Sci 4:133-40. 2003
    ..TAT peptide-liposomes can be considered as promising carriers for the non-endocytotic intracellular delivery of drugs and DNA...
  7. ncbi Kinetic and thermodynamic approaches to the drug targeting phenomena
    Igor Meerovich
    Department of Pharmaceutical Sciences, Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, MA 02115, USA
    Curr Drug Discov Technol 8:287-300. 2011
    ..This review makes an attempt to analyze the main factors that influence targeting on the kinetic or thermodynamic level that may provide the basis for a strategy to develop and improve drug delivery systems...
  8. ncbi Micellar nanocarriers: pharmaceutical perspectives
    V P Torchilin
    Department of Pharmaceutical Sciences and Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Mugar Building, Room 312, 360 Huntington Avenue, Boston, Massachusetts 02115, USA
    Pharm Res 24:1-16. 2007
    ..This review will discuss some recent trends in using micelles as pharmaceutical carriers...
  9. ncbi Tat peptide-mediated intracellular delivery of pharmaceutical nanocarriers
    Vladimir P Torchilin
    Department of Pharmaceutical Sciences and Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, MA 02115, USA
    Adv Drug Deliv Rev 60:548-58. 2008
    ....
  10. ncbi Targeted pharmaceutical nanocarriers for cancer therapy and imaging
    Vladimir P Torchilin
    Department of Pharmaceutical Sciences and Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, MA 02115, USA
    AAPS J 9:E128-47. 2007
    ..The importance of intracellular targeting of drug- and DNA-loaded pharmaceutical nanocarriers is specifically discussed, including intracellular delivery with cell-penetrating peptides...
  11. ncbi Tumor delivery of macromolecular drugs based on the EPR effect
    Vladimir Torchilin
    Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, MA 02115, USA
    Adv Drug Deliv Rev 63:131-5. 2011
    ....
  12. ncbi Targeted polymeric micelles for delivery of poorly soluble drugs
    V P Torchilin
    Department of Pharmaceutical Sciences, Northeastern University, Mugar Building, Room 312, 360 Huntington Avenue, Boston, Massachusetts 02115, USA
    Cell Mol Life Sci 61:2549-59. 2004
    ..This new family of pharmaceutical carriers can be used for the solubilization and targeted delivery of poorly soluble drugs to various pathological sites in the body...
  13. ncbi Recent advances with liposomes as pharmaceutical carriers
    Vladimir P Torchilin
    Department of Pharmaceutical Sciences, Northeastern University, 360 Huntington Avenue, Boston, Massachusetts 02115, USA
    Nat Rev Drug Discov 4:145-60. 2005
    ..For further successful development of this field, promising trends must be identified and exploited, albeit with a clear understanding of the limitations of these approaches...
  14. ncbi Tatp-mediated intracellular delivery of pharmaceutical nanocarriers
    V P Torchilin
    Department of Pharmaceutical Sciences and Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, MA 02115, USA
    Biochem Soc Trans 35:816-20. 2007
    ....
  15. ncbi Cell penetrating peptide-modified pharmaceutical nanocarriers for intracellular drug and gene delivery
    Vladimir P Torchilin
    Department of Pharmaceutical Sciences and Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, MA 02115
    Biopolymers 90:604-10. 2008
    ....
  16. ncbi Lipid-core micelles for targeted drug delivery
    Vladimir P Torchilin
    Department of Pharmaceutical Sciences, Northeastern University, Boston, MA 02115, USA
    Curr Drug Deliv 2:319-27. 2005
    ..Lipid-core micelles carrying various reporter (contrast) groups may become the imaging agents of choice in different imaging modalities...
  17. ncbi Multifunctional nanocarriers
    Vladimir P Torchilin
    Department of Pharmaceutical Sciences, Northeastern University, Mugar Building, Room 312, 360 Huntington Avenue, Boston, MA 02115, USA
    Adv Drug Deliv Rev 58:1532-55. 2006
    ....
  18. ncbi Preface. Fifth International Nanomedicine and Drug Delivery Symposium (NanoDDS'07)
    Vladimir P Torchilin
    Northeastern University, Mugar Building, Room 312, 360 Huntington Avenue, Boston, MA 02115, USA
    J Control Release 130:97. 2008
  19. ncbi Cell transfection in vitro and in vivo with nontoxic TAT peptide-liposome-DNA complexes
    Vladimir P Torchilin
    Department of Pharmaceutical Sciences, Northeastern University, 360 Huntington Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 100:1972-7. 2003
    ..This transfection system should be useful for various protocols of cell treatment in vitro or ex vivo as well as for localized in vivo gene therapy...
  20. ncbi Peptide and protein drug delivery to and into tumors: challenges and solutions
    Vladimir P Torchilin
    Department of Pharmaceutical Sciences, Bouve College of Health Sciences, 312 Mugar Bldg Northeastern University, 360 Huntington Ave, Boston, MA 02115, USA
    Drug Discov Today 8:259-66. 2003
    ..Furthermore, new approaches to intracellular drug delivery, including the use of transduction proteins and peptides, are being developed. These advances promise the delivery of a new generation of anticancer drugs...
  21. ncbi Recent approaches to intracellular delivery of drugs and DNA and organelle targeting
    Vladimir P Torchilin
    Department of Pharmaceutical Sciences, Northeastern University, Boston, Massachusetts 02115, USA
    Annu Rev Biomed Eng 8:343-75. 2006
    ..Examples of successful intracellular and organelle-specific delivery of biologically active molecules, including DNA, are presented; unanswered questions, challenges, and future trends are also discussed...
  22. ncbi Immunomicelles: targeted pharmaceutical carriers for poorly soluble drugs
    Vladimir P Torchilin
    Department of Pharmaceutical Sciences, Bouve College of Health Sciences, Northeastern University, 360 Huntington Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 100:6039-44. 2003
    ..This family of pharmaceutical carriers can be used for the solubilization and enhanced delivery of poorly soluble drugs to various pathological sites in the body...
  23. ncbi In vitro cytotoxicity of novel pro-apoptotic agent DM-PIT-1 in PEG-PE-based micelles alone and in combination with TRAIL
    Igor Skidan
    Department of Pharmaceutical Sciences and Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, MA 02115, USA
    Drug Deliv 16:45-51. 2009
    ..In conclusion, DM-PIT-1 micellar preparations can be used for targeted combination therapy against TRAIL-resistant cancers...
  24. ncbi Combination radiofrequency (RF) ablation and IV liposomal heat shock protein suppression: reduced tumor growth and increased animal endpoint survival in a small animal tumor model
    Wei Yang
    Laboratory for Minimally Invasive Tumor Therapies, Department of Radiology, Beth Israel Deaconess Medical Center Harvard Medical School, Boston, MA 02215, USA
    J Control Release 160:239-44. 2012
    ....
  25. ncbi TAT peptide-modified liposomes for intracellular delivery of drugs and DNA
    Vladimir P Torchilin
    Department of Pharmaceutical Sciences, School of Pharmacy, Bouve College of Health Sciences, Northeastern University, Boston, MA 02115, USA
    Cell Mol Biol Lett 7:265-7. 2002
  26. ncbi Intracellular delivery of nanoparticles with CPPs
    Rupa Sawant
    Research Associate Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, MA, USA
    Methods Mol Biol 683:431-51. 2011
    ..Due to nonselectivity of CPPs and wide distribution in nontarget areas, method for preparation of "smart" nanocarrier with hidden TATp function is also described...
  27. ncbi Radiofrequency ablation combined with liposomal quercetin to increase tumour destruction by modulation of heat shock protein production in a small animal model
    Wei Yang
    Minimally Invasive Tumor Therapies Laboratory, Department of Radiology, Beth Israel Deaconess Medical Center Harvard Medical School, 1 Deaconess Road, Boston, MA 02215, USA
    Int J Hyperthermia 27:527-38. 2011
    ..To investigate the effect of heat shock protein (HSP) modulation on tumour coagulation by combining radiofrequency (RF) ablation with adjuvant liposomal quercetin and/or doxorubicin in a rat tumour model...
  28. ncbi Micelles from lipid derivatives of water-soluble polymers as delivery systems for poorly soluble drugs
    Anatoly N Lukyanov
    Department of Pharmaceutical Sciences, School of Pharmacy, Bouve College of Health Sciences, Northeastern University, 360 Huntington Avenue, Boston, MA 02115, USA
    Adv Drug Deliv Rev 56:1273-89. 2004
    ..Available in vivo results on the efficiency of anticancer drugs incorporated into plain micelles and immunomicelles in animal models are also discussed...
  29. ncbi Multifunctional and stimuli-sensitive pharmaceutical nanocarriers
    Vladimir Torchilin
    Department of Pharmaceutical Sciences and Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, MA 02115, USA
    Eur J Pharm Biopharm 71:431-44. 2009
    ....
  30. ncbi Liposomal doxorubicin increases radiofrequency ablation-induced tumor destruction by increasing cellular oxidative and nitrative stress and accelerating apoptotic pathways
    Stephanie A Solazzo
    Laboratory for Minimally Invasive Tumor Therapies, Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave, Boston, MA 02215, USA
    Radiology 255:62-74. 2010
    ..To determine if oxidative and nitrative stress and/or apoptosis contribute to increased coagulation when combining radiofrequency (RF) ablation with liposomal doxorubicin...
  31. ncbi A HPLC method for the quantitative determination of N-(2-hydroxy-5-nitrophenylcarbamothioyl)-3,5-dimethylbenzamide in biological samples
    Igor Skidan
    Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, MA 02115, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 879:1610-6. 2011
    ....
  32. ncbi Environment-responsive multifunctional liposomes
    Amit A Kale
    Department of Pharmaceutical Sciences, Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, MA, USA
    Methods Mol Biol 605:213-42. 2010
    ..These results can be considered as an important step in the development of tumor-specific stimuli-sensitive drug and gene delivery systems...
  33. ncbi Enhanced transfection of tumor cells in vivo using "Smart" pH-sensitive TAT-modified pegylated liposomes
    Amit A Kale
    Department of Pharmaceutical Sciences and Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, MA 02115, USA
    J Drug Target 15:538-45. 2007
    ..This result can be considered as an important step in the development of tumor-specific stimuli-sensitive drug and gene delivery systems...
  34. ncbi Micelles from polyethylene glycol/phosphatidylethanolamine conjugates for tumor drug delivery
    Anatoly N Lukyanov
    Department of Pharmaceutical Sciences, Bouve College of Health Sciences, 312 Mugar Bldg, Northeastern University, Boston, MA 02115, USA
    J Control Release 91:97-102. 2003
    ..PEG-PE micelles selectively accumulated in Lewis lung carcinoma (LLC) tumors implanted in mice. Modification of the micelles with tumor specific antibodies further enhanced the efficiency of tumor accumulation...
  35. ncbi Quantum dot loaded immunomicelles for tumor imaging
    Aristarchos Papagiannaros
    Department of Pharmaceutical Sciences and Center for Pharmaceutical Biotechnology and Nanomedicine, 312 Mugar Life Sciences Building, Northeastern University, Boston, MA 02115, USA
    BMC Med Imaging 10:22. 2010
    ..Its production is simple and involves no special equipment. Its imaging potential is great since the fluorescence intensity in the tumor is twofold that of non-targeted QD-loaded PEG-PE micelles at one hour after injection...
  36. ncbi Quantum dots encapsulated in phospholipid micelles for imaging and quantification of tumors in the near-infrared region
    Aristarchos Papagiannaros
    Department of Pharmaceutical Sciences and Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, Massachusetts, USA
    Nanomedicine 5:216-24. 2009
    ..Overall, the QD-Ms seem to be a powerful and rapidly acting nanosized imaging agent that allows for effective visualization of tumors using NIR imaging...
  37. ncbi Photodynamic therapy of experimental B-16 melanoma in mice with tumor-targeted 5,10,15,20-tetraphenylporphin-loaded PEG-PE micelles
    Igor Skidan
    Department of Pharmaceutical Sciences, Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, MA 02115, USA
    J Drug Target 16:486-93. 2008
    ..Compared with controls, the weight of postmortem tumors was approx. 3.5- and 7.5-fold smaller with TPP-loaded PEG-PE micelles and TPP-loaded PEG-PE 2C5-immunomicelles, respectively...
  38. ncbi Polymeric micelles for delivery of poorly soluble drugs: preparation and anticancer activity in vitro of paclitaxel incorporated into mixed micelles based on poly(ethylene glycol)-lipid conjugate and positively charged lipids
    Junping Wang
    Department of Pharmaceutical Sciences, , Northeastern University, Boston, MA 02115, USA
    J Drug Target 13:73-80. 2005
    ..It seems that PEG-PE/ST/LL micelles, unlike micelles without the LL component, could escape from endosomes and enter the cytoplasm of BT-20 cancer cells thus increasing the anticancer efficiency of the micellar paclitaxel...
  39. ncbi Tat peptide-mediated intracellular delivery of liposomes
    Tatiana S Levchenko
    Department of Pharmaceutical Sciences, Northeastern University, 360 Huntington Avenue, Boston, Massachusetts 02115, USA
    Methods Enzymol 372:339-49. 2003
  40. ncbi ATP-containing immunoliposomes specific for cardiac myosin
    Wei Liang
    Department of Pharmaceutical Sciences, School of Pharmacy, Northeastern University, Boston, MA 02115, USA
    Curr Drug Deliv 1:1-7. 2004
    ..The preparation of myosin-specific ATP-loaded immunoliposomes represented an important step in the development of targeted delivery systems capable of providing energy support to ischemic myocardium in vivo...
  41. ncbi Small molecule inhibition of phosphatidylinositol-3,4,5-triphosphate (PIP3) binding to pleckstrin homology domains
    Benchun Miao
    Department of Biochemistry, Tufts University School of Medicine, Boston, MA 02111, USA
    Proc Natl Acad Sci U S A 107:20126-31. 2010
    ..Overall, our studies demonstrate the feasibility of developing specific small molecule antagonists of PIP3 signaling...
  42. ncbi TAT peptide-modified liposomes provide enhanced gene delivery to intracranial human brain tumor xenografts in nude mice
    Bhawna Gupta
    Department of Pharmaceutical Sciences and Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, MA 02115, USA
    Oncol Res 16:351-9. 2007
    ..No transfection (green fluorescence of the GFP) was noted in the normal brain adjacent to tumor...
  43. ncbi Mitochondria-targeted liposomes improve the apoptotic and cytotoxic action of sclareol
    Niravkumar R Patel
    Department of Pharmaceutical Sciences, Northeastern University, Boston, Massachusetts, USA
    J Liposome Res 20:244-9. 2010
    ..The results support the broad applicability of our nanocarrier-mediated subcellular targeting approach as a means to improve the effectiveness of certain anticancer therapeutics...
  44. ncbi Mixed PEG-PE/vitamin E tumor-targeted immunomicelles as carriers for poorly soluble anti-cancer drugs: improved drug solubilization and enhanced in vitro cytotoxicity
    Rupa R Sawant
    Department of Pharmaceutical Sciences and Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, 360 Huntington Avenue, Boston, MA 02115, USA
    Eur J Pharm Biopharm 70:51-7. 2008
    ..Drug-loaded mixed micelles and mAb 2C5-immunomicelles demonstrated significantly higher in vitro cytotoxicity than free drug against various cancer cell lines...
  45. ncbi Tumor-specific antibody-mediated targeted delivery of Doxil reduces the manifestation of auricular erythema side effect in mice
    Tamer A Elbayoumi
    Department of Pharmaceutical Sciences, Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, MA 02115, USA
    Int J Pharm 357:272-9. 2008
    ..Thus, targeting of Doxil with the anti-cancer mAb 2C5 not only can increase the tumor-specific accumulation of the drug, but also diminishes the cutaneous side effect of the original Doxil therapy...
  46. ncbi Fluorescence microscopy to follow the targeting of liposomes and micelles to cells and their intracellular fate
    Vladimir P Torchilin
    Department of Pharmaceutical Sciences, Northeastern University, Boston, MA 02115, USA
    Adv Drug Deliv Rev 57:95-109. 2005
    ..It was also used to confirm the successful transfection of cells with TAT-liposomes bearing the plasmid encoding for the Green Fluorescent Protein (GFP)...
  47. ncbi Self-assembling micelle-like nanoparticles based on phospholipid-polyethyleneimine conjugates for systemic gene delivery
    Young Tag Ko
    Department of Pharmaceutical Sciences, Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, MA 02115, USA
    J Control Release 133:132-8. 2009
    ..Intravenous injection of MNP loaded with plasmid DNA encoding for the Green Fluorescence Protein (GFP) resulted in an effective transfection of a distal tumor. Thus, MNP provide a promising tool for systemic gene therapy...
  48. ncbi Enhanced accumulation of long-circulating liposomes modified with the nucleosome-specific monoclonal antibody 2C5 in various tumours in mice: gamma-imaging studies
    Tamer A Elbayoumi
    Department of Pharmaceutical Sciences, Northeastern University, Mugar Building, Room 312, 360 Huntington Avenue, Boston, MA 02115, USA
    Eur J Nucl Med Mol Imaging 33:1196-205. 2006
    ..CONCLUSION: The 2C5 antibody-modified LCL effectively and specifically accumulate in various tumours and can serve as delivery vehicles for imaging agents, allowing for fast and efficient tumour visualization...
  49. ncbi Targeting glioma cells in vitro with ascorbate-conjugated pharmaceutical nanocarriers
    Stefano Salmaso
    Department of Pharmaceutical Sciences and Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, Massachusetts 02115, USA
    Bioconjug Chem 20:2348-55. 2009
    ....
  50. ncbi Intracellular transduction using cell-penetrating peptides
    Rupa Sawant
    Department of Pharmaceutical Sciences and Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Mugar Building, Room 312, 360 Huntington Avenue, Boston, MA 02115, USA
    Mol Biosyst 6:628-40. 2010
    ..This review highlights the mechanisms of CPP-mediated delivery and summarizes numerous examples illustrating the potential of CPPs in the fields of biology and medicine...
  51. ncbi Synthesis, functionalization and photo-Bergman chemistry of enediyne bioconjugates
    Paul LaBeaume
    Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA 02115, United States
    Bioorg Med Chem 17:6292-300. 2009
    ..The immunocompetence of antibody conjugates is retained, and application in the form of reagents for photodynamic therapy (PDT) advanced...
  52. ncbi Solubilization of poorly soluble PDT agent, meso-tetraphenylporphin, in plain or immunotargeted PEG-PE micelles results in dramatically improved cancer cell killing in vitro
    Aruna Roby
    Department of Pharmaceutical Sciences, Northeastern University, Boston, MA 02115, USA
    Eur J Pharm Biopharm 62:235-40. 2006
    ..The results of this study showed that TPP-containing PEG-PE micelles may represent a useful formulation of the photosensitizer for practical PDT...
  53. ncbi Transactivating transcriptional activator-mediated drug delivery
    Bhawna Gupta
    Department of Pharmaceutical Sciences, Northeastern University, Boston, MA 02115, USA
    Expert Opin Drug Deliv 3:177-90. 2006
    ..This review article attempts to bring together the available data on TAT-mediated intracellular uptake of a broad range of molecules and nanoparticles. It also considers potential practical applications of this approach...
  54. ncbi PEG-based micelles as carriers of contrast agents for different imaging modalities
    Vladimir P Torchilin
    Department of Pharmaceutical Sciences, School of Pharmacy, Bouve College of Health Sciences, Northeastern University, 360 Huntington Avenue, Boston, MA 02115, USA
    Adv Drug Deliv Rev 54:235-52. 2002
    ..Experimental CT-imaging performed in mice and rabbits demonstrated high potential of a micellar contrast agent...
  55. ncbi Preparation and in vitro synergistic anticancer effect of vitamin K3 and 1,8-diazabicyclo[5,4,0]undec-7-ene in poly(ethylene glycol)-diacyllipid micelles
    Junping Wang
    Department of Pharmaceutical Sciences, , Northeastern University, Mugar Building 312, 360 Huntington Avenue, Boston, MA 02115, USA
    Int J Pharm 272:129-35. 2004
    ..The synergism may be explained by the fact that the presence of DBU promotes the escape of drug-loaded micelles from the endosomes of cancer cells directly into the cytoplasm as demonstrated by fluorescent microscopy...
  56. ncbi PEG-PE micelles loaded with paclitaxel and surface-modified by a PBR-ligand: synergistic anticancer effect
    Tiziana Musacchio
    Department of Pharmaceutical Sciences and Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, Massachusetts 02115, USA
    Mol Pharm 6:468-79. 2009
    ..Thus, PBR-targeted nanopreparations may potentially serve as a new nanomedicine for targeted cancer therapy...
  57. ncbi Enhanced cytotoxicity of TATp-bearing paclitaxel-loaded micelles in vitro and in vivo
    Rupa R Sawant
    Department of Pharmaceutical Sciences and Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, 360 Huntington Avenue, Boston, MA 02115, USA
    Int J Pharm 374:114-8. 2009
    ....
  58. ncbi Enhanced binding and killing of target tumor cells by drug-loaded liposomes modified with tumor-specific phage fusion coat protein
    Tao Wang
    Department of Pharmaceutical Sciences and Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, MA 02115, USA
    Nanomedicine (Lond) 5:563-74. 2010
    ..To explore cancer cell-specific phage fusion pVIII coat protein, identified using phage display, for targeted delivery of drug-loaded liposomes to MCF-7 breast cancer cells...
  59. ncbi Paclitaxel-loaded polymeric micelles modified with MCF-7 cell-specific phage protein: enhanced binding to target cancer cells and increased cytotoxicity
    Tao Wang
    Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, Massachusetts 02115, USA
    Mol Pharm 7:1007-14. 2010
    ..Overall, cancer cell-specific phage proteins identified from phage display peptide libraries can serve as targeting ligands ("substitute antibody") for polymeric micelle-based pharmaceutical preparations...
  60. ncbi Polymeric micelles: polyethylene glycol-phosphatidylethanolamine (PEG-PE)-based micelles as an example
    Rupa R Sawant
    Department of Pharmaceutical Sciences and Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, MA, USA
    Methods Mol Biol 624:131-49. 2010
    ..Micelles carrying various contrast agents may become the imaging agents of choice in different imaging modalities. Here, we have discussed various protocols for preparation and evaluation of PEG-PE-based micelles...
  61. ncbi Highly sensitive microscale in vivo sensor enabled by electrophoretic assembly of nanoparticles for multiple biomarker detection
    Asanterabi Malima
    NSF NSEC Center for High Rate Nanomanufacturing, Northeastern University, Boston, MA 02115, USA
    Lab Chip 12:4748-54. 2012
    ..25 pg mL(-1); for nucleosomes, 62.5 pg mL(-1)), laying the foundation for potential early detection of various diseases...
  62. ncbi New ways of imaging uptake and intracellular fate of liposomal drug carrier systems inside individual cells, based on Raman microscopy
    Christian Matthäus
    Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massacusetts 02115, USA
    Mol Pharm 5:287-93. 2008
    ..Depending on the experimental setup, the technique may be applied to fixed or living cell organisms...
  63. ncbi Prostate cancer-specific monoclonal antibody 5D4 significantly enhances the cytotoxicity of doxorubicin-loaded liposomes against target cells in vitro
    Rishikesh M Sawant
    Department of Pharmaceutical Sciences, Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, MA 02115, USA
    J Drug Target 16:601-4. 2008
    ....
  64. ncbi Liposomes for targeted delivery of antithrombotic drugs
    Tamer A Elbayoumi
    Northeastern University, Department of Pharmaceutical Sciences, Center for Pharmaceutical Biotechnology and Nanomedicine, 360 Huntington Avenue, Boston, MA 02115, USA
    Expert Opin Drug Deliv 5:1185-98. 2008
    ..In particular, several attempts have been made to use liposomes as vehicles for antithrombotic agents...
  65. ncbi Current trends in liposome research
    Tamer A Elbayoumi
    Department of Pharmaceutical Sciences, College of Pharmacy Glendale, Midwestern University, Glendale, AZ, USA
    Methods Mol Biol 605:1-27. 2010
    ..This chapter provides a brief overview of various liposomal products currently under development at experimental and preclinical level...
  66. ncbi Near infrared planar tumor imaging and quantification using nanosized Alexa 750-labeled phospholipid micelles
    Aristarchos Papagiannaros
    Department of Pharmaceutical Sciences and Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, MA 02115, USA
    Int J Nanomedicine 4:123-31. 2009
    ..Some signal was also detected from the abdomen of the mice. As determined by microscopy analysis, other organs of accumulation were the liver and kidney, which corresponded well to the data from the whole body imaging animal studies...
  67. ncbi The architecture of ligand attachment to nanocarriers controls their specific interaction with target cells
    Rupa R Sawant
    Department of Pharmaceutical Sciences and Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, MA 02115, USA
    J Drug Target 16:596-600. 2008
    ....
  68. ncbi Liposome clearance in mice: the effect of a separate and combined presence of surface charge and polymer coating
    Tatiana S Levchenko
    Department of Pharmaceutical Sciences, Bouve College of Health Sciences, Northeastern University, Mugar Building 312, 360 Huntington Avenue, Boston, MA 02115, USA
    Int J Pharm 240:95-102. 2002
    ..The opsonins with different molecular size may be involved in the clearance of liposomes containing different charged lipids...
  69. ncbi Enhanced tumor visualization by gamma-scintigraphy with 111In-labeled polychelating-polymer-containing immunoliposomes
    Suna Erdogan
    Department of Pharmaceutical Sciences, School of Pharmacy, Northeastern University, Boston, Massachusetts 02115, USA
    Mol Pharm 3:525-30. 2006
    ....
  70. ncbi Monoclonal antibody 2C5-modified doxorubicin-loaded liposomes with significantly enhanced therapeutic activity against intracranial human brain U-87 MG tumor xenografts in nude mice
    Bhawna Gupta
    Department of Pharmaceutical Sciences and Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, MA 02115, USA
    Cancer Immunol Immunother 56:1215-23. 2007
    ..Thus, monoclonal antibody 2C5-modified LCL can specifically target the anticancer drugs to brain tumors, leading to improved therapeutic treatment of brain tumor in an intracranial model, in vivo...
  71. ncbi Gadolinium-loaded polychelating polymer-containing cancer cell-specific immunoliposomes
    Suna Erdogan
    Department of Pharmaceutical Sciences, Northeastern University, Boston, MA 02115, USA
    J Liposome Res 16:45-55. 2006
    ..Gd-loaded cancer cell-targeted immunoliposomes may represent promising agents for enhanced tumor MRI...
  72. ncbi "Smart" drug carriers: PEGylated TATp-modified pH-sensitive liposomes
    Amit A Kale
    Department of Pharmaceutical Sciences and Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, MA 02115, USA
    J Liposome Res 17:197-203. 2007
    ..This concept is shown here to work in cell cultures in vitro as well as in ischemic cardiac tissues in the Langendorff perfused rat heart model and in tumors in experimental mice in vivo...
  73. ncbi Intracellular delivery of large molecules and small particles by cell-penetrating proteins and peptides
    Bhawna Gupta
    Department of Pharmaceutical Sciences, Bouve College of Health Sciences, Northeastern University, Boston, MA 02115, USA
    Adv Drug Deliv Rev 57:637-51. 2005
    ....
  74. ncbi PEGylated dextran as long-circulating pharmaceutical carrier
    Anatoly N Lukyanov
    Department of Pharmaceutical Sciences, Bouve College of Health Sciences, 312 Mugar Building, Northeastern University, Boston, MA 02115, USA
    J Biomater Sci Polym Ed 15:621-30. 2004
    ..Dextran-PEG conjugates may represent a convenient platform for long-circulating pharmaceutical preparations...
  75. ncbi Polyethylene glycol-diacyllipid micelles demonstrate increased acculumation in subcutaneous tumors in mice
    Anatoly N Lukyanov
    Department of Pharmaceutical Sciences, Bouve College of Health Sciences, Northeastern University, Boston, Massachusetts 02115, USA
    Pharm Res 19:1424-9. 2002
    ..CONCLUSIONS: PEG-PE conjugates form very stable, long-circulating micelles. These micelles efficiently accumulate in tumors in vivo an may potentially be used as a tumor-specific delivery system for poorly soluble anticancer drugs...
  76. ncbi Cationic charge determines the distribution of liposomes between the vascular and extravascular compartments of tumors
    Robert B Campbell
    Edwin L. Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Cancer Res 62:6831-6. 2002
    ..Our results suggest that optimizing physicochemical properties of liposomes that exploit physiological features of tumors and control the intratumor distribution of these drug carriers should improve vascular-specific delivery...
  77. ncbi Intracellular targets for DNA delivery: nuclei and mitochondria
    Vladimir P Torchilin
    Department of Pharmaceutical Sciences, Bouve College of Health Sciences, Northeastern University, Boston, Massachusetts 02115, USA
    Somat Cell Mol Genet 27:49-64. 2002
    ..In this chapter we provide a brief description of our recent experiments in both of these important areas...
  78. ncbi Combined radiofrequency ablation and adjuvant liposomal chemotherapy: effect of chemotherapeutic agent, nanoparticle size, and circulation time
    Muneeb Ahmed
    Laboratory for Minimally Invasive Tumor Therapy, Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Vasc Interv Radiol 16:1365-71. 2005
    ....
  79. ncbi Cytoplasmic delivery of liposomes into MCF-7 breast cancer cells mediated by cell-specific phage fusion coat protein
    Tao Wang
    Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, Massachusetts 02115, USA
    Mol Pharm 7:1149-58. 2010
    ..Our results demonstrated an endosome-escaping property of the phage protein and provided an insight on mechanism of the enhanced cytotoxicity of phage-Doxil...
  80. ncbi Palmitoyl ascorbate-modified liposomes as nanoparticle platform for ascorbate-mediated cytotoxicity and paclitaxel co-delivery
    Rupa R Sawant
    Department of Pharmaceutical Sciences and Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, USA
    Eur J Pharm Biopharm 75:321-6. 2010
    ..Thus, nanoparticles incorporating PA provide a platform for enhancement of the anti-tumor activity of ascorbate...
  81. ncbi Increased accumulation of PEG-PE micelles in the area of experimental myocardial infarction in rabbits
    Anatoly N Lukyanov
    Department of Pharmaceutical Sciences, Bouve College of Health Sciences, Northeastern University, 360 Huntington Avenue, 312 Mugar Building, Boston, MA 02115, USA
    J Control Release 94:187-93. 2004
    ....
  82. ncbi Monoclonal antibody 2C5-mediated binding of liposomes to brain tumor cells in vitro and in subcutaneous tumor model in vivo
    Bhawna Gupta
    Northeastern University, Department of Pharmaceutical Sciences, Bouve College of Health Sciences, Boston, MA 02115, USA
    J Drug Target 13:337-43. 2005
    ..mAb 2C5 specifically recognizes brain tumor cells and can serve as a ligand to target drug carriers such as liposomes to brain tumor cells in vivo...
  83. ncbi DQAsome-mediated delivery of plasmid DNA toward mitochondria in living cells
    Gerard G M D'Souza
    Department of Pharmaceutical Sciences, Bouve College of Health Sciences, Northeastern University, Boston, MA 02115, USA
    J Control Release 92:189-97. 2003
    ..Free pDNA could not be detected anywhere else inside the cytosol of transfected cells demonstrating the target-selectivity of DQAsome-mediated DNA delivery to mitochondria...
  84. ncbi Enhanced cytotoxicity of monoclonal anticancer antibody 2C5-modified doxorubicin-loaded PEGylated liposomes against various tumor cell lines
    Tamer A Elbayoumi
    Department of Pharmaceutical Sciences, Northeastern University, Boston, MA 02115, USA
    Eur J Pharm Sci 32:159-68. 2007
    ..The IC50 values of mAb 2C5-Doxil with various murine and human cancer cells were 5-8-fold lower than those of control doxorubicin-loaded liposomes, Doxil or Doxil modified with a nonspecific IgG...
  85. ncbi Antinucleosome antibody-modified liposomes and lipid-core micelles for tumor-targeted delivery of therapeutic and diagnostic agents
    Tamer A Elbayoumi
    Department of Pharmaceutical Sciences, Northeastern University, Boston, MA 02115, USA
    J Liposome Res 17:1-14. 2007
    ..Pharmaceutical lipid-based nanoparticular carriers modified with mAb 2C5 could represent universal systems for tumor-specific delivery of various soluble and insoluble pharmaceuticals...
  86. ncbi Micellar formulations of pro-apoptotic DM-PIT-1 analogs and TRAIL in vitro and in vivo
    Robert D Riehle
    Department of Pharmaceutical Sciences, Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, MA 02115, USA
    Drug Deliv 20:78-85. 2013
    ..These results indicate the utility of delivering TRAIL and PI3K pathway inhibitors in a combined micellar preparation...
  87. ncbi Immunoconjugates and long circulating systems: origins, current state of the art and future directions
    Alexander Koshkaryev
    Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, MA 02115, USA
    Adv Drug Deliv Rev 65:24-35. 2013
    ..In this review we examined the evolution, current status and future directions in the area of therapeutical immunoconjugates and long-circulating immuno-targeted DDS...
  88. ncbi Surface modification of pharmaceutical nanocarriers with ascorbate residues improves their tumor-cell association and killing and the cytotoxic action of encapsulated paclitaxel in vitro
    Gerard G M D'Souza
    Department of Pharmaceutical Sciences and Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, Massachusetts 02115, USA
    Pharm Res 25:2567-72. 2008
    ..To evaluate the potential of ascorbate as a novel ligand in the preparation of pharmaceutical nanocarriers with enhanced tumor-cell specific binding and cytotoxicity...
  89. ncbi ATP-loaded liposomes for treatment of myocardial ischemia
    William C Hartner
    Departmentof Pharmaceutical Sciences, Northeastern University, Boston, MA 02115, USA
    Wiley Interdiscip Rev Nanomed Nanobiotechnol 1:530-9. 2009
    ..Therefore, ATP encapsulated in liposomes can provide an effective exogenous source for in vivo application which can protect ischemically damaged hearts...
  90. ncbi ATP-loaded liposomes for targeted treatment in models of myocardial ischemia
    Tatyana S Levchenko
    Department of Pharmaceutical Sciences, Bouve College of Health Sciences, Northeastern University, Boston, MA, USA
    Methods Mol Biol 605:361-75. 2010
    ..The expectation is that these methods will provide a basis for continued studies of effective ways to deliver energy substrates to the ischemic myocardium...
  91. ncbi Tumor-specific anti-nucleosome antibody improves therapeutic efficacy of doxorubicin-loaded long-circulating liposomes against primary and metastatic tumor in mice
    Tamer A Elbayoumi
    Department of Pharmaceutical Sciences, Northeastern University, Boston, Massachusetts 02115, USA
    Mol Pharm 6:246-54. 2009
    ..Our results clearly show the remarkable capability of 2C5-targeted Doxil to specifically deliver its cargo into various tumor manifestations (solid and metastatic) significantly increasing the efficacy of therapy...
  92. ncbi Polyethylene glycol-phosphatidylethanolamine conjugate (PEG-PE)-based mixed micelles: some properties, loading with paclitaxel, and modulation of P-glycoprotein-mediated efflux
    Rupa D Dabholkar
    Department of Pharmaceutical Sciences, University Institute of Chemical Technology, Mumbai, Maharashtra, India
    Int J Pharm 315:148-57. 2006
    ....
  93. ncbi Poly(malic acid) nanoconjugates containing various antibodies and oligonucleotides for multitargeting drug delivery
    Julia Y Ljubimova
    Cedars Sinai Medical Center, Department of Neurosurgery, 8631 West Third Street, Suite 800E, Los Angeles, CA 90048, USA
    Nanomedicine (Lond) 3:247-65. 2008
    ..Delivery of antisense oligonucleotides to a tumor-specific angiogenic marker using Polycefin resulted in significant inhibition of tumor angiogenesis and increase of animal survival...
  94. ncbi In vivo biodistribution of erythrocytes and polyethyleneglycol-phosphatidylethanolamine micelles carrying the antitumour agent dequalinium
    Carmen Lizano
    Departmento de Bioquimica y Biologia Molecular, Universidad de Alcala, Madrid, Spain
    Eur J Pharm Biopharm 56:153-7. 2003
    ..The further exploration of PEG-PE micelles as a fast acting release system for DQA appears warranted...
  95. ncbi Organelle-targeted nanocarriers: specific delivery of liposomal ceramide to mitochondria enhances its cytotoxicity in vitro and in vivo
    Sarathi V Boddapati
    Northeastern University, Bouve College of Health Sciences, Department of Pharmaceutical Sciences, Boston, Massachusetts, USA
    Nano Lett 8:2559-63. 2008
    ....
  96. ncbi Enhanced tumor MR imaging with gadolinium-loaded polychelating polymer-containing tumor-targeted liposomes
    Suna Erdogan
    Department of Pharmaceutical Sciences and Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, MA 02115, USA
    J Magn Reson Imaging 27:574-80. 2008
    ....
  97. ncbi Tumor-targeted liposomes: doxorubicin-loaded long-circulating liposomes modified with anti-cancer antibody
    Anatoly N Lukyanov
    Department of Pharmaceutical Sciences, Bouve College of Health Sciences, Northeastern University, Mugar Bldg 312, 360 Huntington Aveneu, Boston, MA 02115, USA
    J Control Release 100:135-44. 2004
    ..Doxorubicin-loaded long-circulating liposomes modified with the mAb 2C5 kill various tumor cells in vitro with the efficiency higher than non-targeted doxorubicin-loaded liposomes...
  98. ncbi Application of nanomedical approaches in experimental and clinical oncology
    Vladimir P Torchilin
    Anticancer Agents Med Chem 6:501. 2006
  99. ncbi Nanocarriers
    Vladimir P Torchilin
    Pharm Res 24:2333-4. 2007
    ..However, looking into the future of the field of drug delivery, we have to think about the development of the next generation of pharmaceutical nanocarriers combining different properties and allowing for multiple functions...
  100. ncbi Quantum dots spectrally distinguish multiple species within the tumor milieu in vivo
    Mark Stroh
    E.L. Steele Laboratory for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, 100 Blossom Street, Boston, MA 02114, USA
    Nat Med 11:678-82. 2005
    ..These examples show the versatility of quantum dots for studying tumor pathophysiology and creating avenues for treatment...
  101. ncbi Mitochondriotropic liposomes
    Sarathi V Boddapati
    Department of Pharmaceutical Sciences, Northeastern University, Boston, Massachusetts 02115, USA
    J Liposome Res 15:49-58. 2005
    ..In this study we present the first data demonstrating that conventional liposomes can be rendered mitochondria-specific via the attachment of known mitochondriotropic residues to the liposomal surface...

Research Grants33

  1. LONG CIRCULATING POLYMER MODIFIED LIPOSOMES
    Vladimir Torchilin; Fiscal Year: 1999
    ....
  2. MULTIFUNCTIONAL STIMULI-SENSITIVE PHARMACEUTICAL NANOCARRIERS
    Vladimir P Torchilin; Fiscal Year: 2010
    ....
  3. Surface-modified pharmaceutical nanocarriers for subcellular targeting
    Vladimir P Torchilin; Fiscal Year: 2010
    ....
  4. MICELLAR CARRIERS FOR SPARINGLY SOLUBLE PHARMACEUTICALS
    Vladimir Torchilin; Fiscal Year: 2007
    ....
  5. Long-Circulating Polymer-Modified Liposomes
    Vladimir Torchilin; Fiscal Year: 2007
    ..abstract_text> ..
  6. MULTIFUNCTIONAL STIMULI-SENSITIVE PHARMACEUTICAL NANOCARRIERS
    Vladimir Torchilin; Fiscal Year: 2007
    ....
  7. Fifth International Nanomedicine and Drug Delivery
    Vladimir Torchilin; Fiscal Year: 2007
    ..Achieving the aim of the conference will contribute to the development of novel nanoscale delivery technologies for diagnostics and therapeutics that address unmet clinical needs and bring together research from different areas. ..
  8. MULTIFUNCTIONAL STIMULI-SENSITIVE PHARMACEUTICAL NANOCARRIERS
    Vladimir Torchilin; Fiscal Year: 2009
    ....
  9. Surface-modified pharmaceutical nanocarriers for subcellular targeting
    Vladimir Torchilin; Fiscal Year: 2009
    ....
  10. Layer-by-layer nanocarriers for highly efficient solubilization of insoluble drug
    Vladimir P Torchilin; Fiscal Year: 2010
    ..The approach will be applied to several poorly soluble anticancer drugs, and the nanocolloids obtained will be additionally modified by various ligands to make them long-circulating, targeted, and capable of intracellular penetration. ..
  11. ANTIBODY-TARGETED POLYMERIC SYSTEMS FOR TUMOR IMAGING
    Vladimir Torchilin; Fiscal Year: 2006
    ..abstract_text> ..
  12. MICELLAR CARRIERS FOR SPARINGLY SOLUBLE PHARMACEUTICALS
    Vladimir Torchilin; Fiscal Year: 2002
    ..abstract_text> ..
  13. Long-Circulating Polymer-Modified Liposomes
    Vladimir Torchilin; Fiscal Year: 2004
    ..Specifically, liposomal drugs can be prepared for the treatment of the consequences of myocardial ischemia and for the inhibition of tumor growth. ..
  14. Surface-modified pharmaceutical nanocarriers for subcellular targeting
    Vladimir Torchilin; Fiscal Year: 2009
    ....