D E Dluzen

Summary

Affiliation: Northeastern Ohio Universities College of Medicine
Country: USA

Publications

  1. ncbi Estrogen as a neuroprotectant against MPTP-induced neurotoxicity in C57/B1 mice
    D E Dluzen
    Department of Anatomy, Northeastern Ohio Universities, College of Medicine, Rootstown 44272 0095, USA
    Neurotoxicol Teratol 18:603-6. 1996
  2. ncbi Age-related changes in monoamines within the olfactory bulbs of the Fischer 344 male rat
    D E Dluzen
    Department of Anatomy, Northeastern Ohio Universities College of Medicine, Rootstown 44272 0095, USA
    Mech Ageing Dev 91:37-45. 1996
  3. ncbi Evaluation of nigrostriatal dopaminergic function in adult +/+ and +/- BDNF mutant mice
    D E Dluzen
    Department of Anatomy, Northeastern Ohio Universities College of Medicine NEOUCOM, Rootstown, Ohio 44272, USA
    Exp Neurol 170:121-8. 2001
  4. ncbi Tamoxifen diminishes methamphetamine-induced striatal dopamine depletion in intact female and male mice
    D E Dluzen
    Department of Anatomy, Northeastern Ohio Universities College of Medicine NEOUCOM, Rootstown, OH 44272 0095, USA
    J Neuroendocrinol 13:618-24. 2001
  5. ncbi Age-related changes in nigrostriatal dopaminergic function are accentuated in +/- brain-derived neurotrophic factor mice
    D E Dluzen
    Department of Anatomy, Northeastern Ohio Universities College of Medicine, 4209 State Route 44, PO Box 95, Rootstown, OH 44272 0095, USA
    Neuroscience 128:201-8. 2004
  6. ncbi Effects of neonatal and prepubertal hormonal manipulations upon estrogen neuroprotection of the nigrostriatal dopaminergic system within female and male mice
    L I Anderson
    Department of Anatomy, Northeastern Ohio Universities College of Medicine, 4209 State Route 44, PO Box 95, Rootstown, OH 44272-0095, USA
    Neuroscience 130:369-82. 2005
  7. ncbi Gender differences in neurotoxicity of the nigrostriatal dopaminergic system: implications for Parkinson's disease
    D E Dluzen
    Department of Anatomy, Northeastern Ohio Universities College of Medicine NEOUCOM, 4209 State Rte 44, PO Box 95, Rootstown, OH 44272 0095, USA
    J Gend Specif Med 3:36-42. 2000
  8. ncbi Sex differences in dopamine- and vesicular monoamine-transporter functions
    D E Dluzen
    Department of Anatomy, Northeastern Ohio Universities College of Medicine, Rootstown, Ohio, USA
    Ann N Y Acad Sci 1139:140-50. 2008
  9. ncbi Neuroprotective role of estrogen upon methamphetamine and related neurotoxins within the nigrostriatal dopaminergic system
    D E Dluzen
    Department of Anatomy, Northeastern Ohio Universities College of Medicine, Rootstown, OH 44272, USA
    Ann N Y Acad Sci 914:112-26. 2000
  10. ncbi Tamoxifen abolishes estrogen's neuroprotective effect upon methamphetamine neurotoxicity of the nigrostriatal dopaminergic system
    X Gao
    Department of Anatomy, Northeastern Ohio Universities College of Medicine, Rootstown, OH 44272-0095, USA
    Neuroscience 103:385-94. 2001

Collaborators

Detail Information

Publications21

  1. ncbi Estrogen as a neuroprotectant against MPTP-induced neurotoxicity in C57/B1 mice
    D E Dluzen
    Department of Anatomy, Northeastern Ohio Universities, College of Medicine, Rootstown 44272 0095, USA
    Neurotoxicol Teratol 18:603-6. 1996
    ..These results suggest that estrogen may serve as a neuroprotectant against an agent that is toxic to the nigrostriatal dopaminergic system in both male and female animal models of Parkinsonism...
  2. ncbi Age-related changes in monoamines within the olfactory bulbs of the Fischer 344 male rat
    D E Dluzen
    Department of Anatomy, Northeastern Ohio Universities College of Medicine, Rootstown 44272 0095, USA
    Mech Ageing Dev 91:37-45. 1996
    ....
  3. ncbi Evaluation of nigrostriatal dopaminergic function in adult +/+ and +/- BDNF mutant mice
    D E Dluzen
    Department of Anatomy, Northeastern Ohio Universities College of Medicine NEOUCOM, Rootstown, Ohio 44272, USA
    Exp Neurol 170:121-8. 2001
    ..Collectively these data show increased levels of striatal dopamine concentrations associated with altered behavioral responses involving the nigrostriatal dopaminergic system within the heterozygous BDNF mutant mice...
  4. ncbi Tamoxifen diminishes methamphetamine-induced striatal dopamine depletion in intact female and male mice
    D E Dluzen
    Department of Anatomy, Northeastern Ohio Universities College of Medicine NEOUCOM, Rootstown, OH 44272 0095, USA
    J Neuroendocrinol 13:618-24. 2001
    ..These effects are relatively specific for the nigrostriatal dopaminergic system. Such data suggest that TMX can function as a nigrostriatal dopaminergic neuroprotectant against MA-induced neurotoxicity in intact female and male mice...
  5. ncbi Age-related changes in nigrostriatal dopaminergic function are accentuated in +/- brain-derived neurotrophic factor mice
    D E Dluzen
    Department of Anatomy, Northeastern Ohio Universities College of Medicine, 4209 State Route 44, PO Box 95, Rootstown, OH 44272 0095, USA
    Neuroscience 128:201-8. 2004
    ....
  6. ncbi Effects of neonatal and prepubertal hormonal manipulations upon estrogen neuroprotection of the nigrostriatal dopaminergic system within female and male mice
    L I Anderson
    Department of Anatomy, Northeastern Ohio Universities College of Medicine, 4209 State Route 44, PO Box 95, Rootstown, OH 44272-0095, USA
    Neuroscience 130:369-82. 2005
    ..For the female, it appears that the presences of gonadal steroids at these two developmental periods are needed for the display of an E-dependent neuroprotectant response within the adult...
  7. ncbi Gender differences in neurotoxicity of the nigrostriatal dopaminergic system: implications for Parkinson's disease
    D E Dluzen
    Department of Anatomy, Northeastern Ohio Universities College of Medicine NEOUCOM, 4209 State Rte 44, PO Box 95, Rootstown, OH 44272 0095, USA
    J Gend Specif Med 3:36-42. 2000
    ..Finally, some of the potential neurologic implications of manipulating estrogen in premenopausal and postmenopausal women are considered...
  8. ncbi Sex differences in dopamine- and vesicular monoamine-transporter functions
    D E Dluzen
    Department of Anatomy, Northeastern Ohio Universities College of Medicine, Rootstown, Ohio, USA
    Ann N Y Acad Sci 1139:140-50. 2008
    ....
  9. ncbi Neuroprotective role of estrogen upon methamphetamine and related neurotoxins within the nigrostriatal dopaminergic system
    D E Dluzen
    Department of Anatomy, Northeastern Ohio Universities College of Medicine, Rootstown, OH 44272, USA
    Ann N Y Acad Sci 914:112-26. 2000
    ..The capacity and significance for steroid hormones to modulate neurotransmitter transporters has been recently reviewed...
  10. ncbi Tamoxifen abolishes estrogen's neuroprotective effect upon methamphetamine neurotoxicity of the nigrostriatal dopaminergic system
    X Gao
    Department of Anatomy, Northeastern Ohio Universities College of Medicine, Rootstown, OH 44272-0095, USA
    Neuroscience 103:385-94. 2001
    ....
  11. ncbi Estrogen differentially modulates nicotine-evoked dopamine release from the striatum of male and female rats
    D E Dluzen
    Department of Anatomy, Northeastern Ohio Universities, College of Medicine, Rootstown 44272 0095, USA
    Neurosci Lett 230:140-2. 1997
    ..Peak nicotine-evoked dopamine output from estrogen treated females was significantly greater than that of estrogen treated males. These results may be related to the gender differences in response to nicotine and smoking behavior...
  12. ncbi Differences in reserpine-induced striatal dopamine output and content between female and male mice: implications for sex differences in vesicular monoamine transporter 2 function
    D E Dluzen
    Department of Anatomy, Northeastern Ohio Universities College of Medicine, Rootstown, OH 44272 0095, USA
    Neuroscience 154:1488-96. 2008
    ..Such differences in VMAT2 function may be related to the gender differences observed in conditions like Parkinson's disease and drug addiction...
  13. ncbi Inactivation of one copy of the mouse neurotrophin-3 gene induces cardiac sympathetic deficits
    G M Story
    Anatomy, Northeastern Ohio Universities College of Medicine, Rootstown, Ohio 44272 0095, USA
    Physiol Genomics 2:129-36. 2000
    ..Thus deletion of one copy of the NT3 gene translates into anatomical, biochemical, and functional deficits in cardiac sympathetic innervation of postnatal mice, thereby indicating a gene-dosage effect for the NT3 gene...
  14. ncbi Aging and sex differences in striatal dopaminergic function
    J L McDermott
    Department of Anatomy, Northeastern Ohio Universities College of Medicine, 4209 State Route 44, P O Box 95, Rootstown, OH 44272 0095, USA
    Neuroscience 149:401-8. 2007
    ..Such extreme changes may be related to the presence (at 2 and 6 months) versus absence (at 18 and 24 months) of estrous cycles/gonadal steroid hormonal functions in female mice...
  15. ncbi Acute effects of estrogen upon methamphetamine induced neurotoxicity of the nigrostriatal dopaminergic system
    T M Gajjar
    Department of Anatomy, Northeastern Ohio Universities College of Medicine, Rootstown, OH 44272, USA
    J Neural Transm 110:1215-24. 2003
    ..5 hour of MA insult as assessed by measures of DOPAC/DA, but fails to prevent depletion of DA when given after MA insult. The data suggest that estrogen may exert this rapid neuroprotective effect through a non-genomic mechanism...
  16. ncbi Sex differences in K+-evoked striatal dopamine output from superfused striatal tissue fragments of reserpine-treated CD-1 mice
    J Ji
    Department of Anatomy, Northeastern Ohio Universities College of Medicine, 4209 State Route 44, Rootstown, OH 44272, USA
    J Neuroendocrinol 19:725-31. 2007
    ..Such findings have important implications for understanding some of the bases for sex differences in neurotoxicity and neurodegeneration of the nigrostriatal dopaminergic system...
  17. ncbi Nisoxetine infusion into the olfactory bulb enhances the capacity for male rats to identify conspecifics
    Y Shang
    Department of Anatomy, Northeastern Ohio Universities College of Medicine, 4209 State Route 44, P.O. Box 95, Rootstown, OH 44272-0095, USA
    Neuroscience 104:957-64. 2001
    ..These results also show that inhibition of norepinephrine uptake may represent an important mechanism involved with the enhancement of social identification and suggest a possible novel effect for the antidepressant nisoxetine...
  18. ncbi The effects of nicotine on dopamine and DOPAC output from rat striatal tissue
    D E Dluzen
    Department of Anatomy, College of Medicine, Northeastern Ohio Universities, Rootstown 44272 0095, USA
    Eur J Pharmacol 341:23-32. 1998
    ....
  19. ncbi Age-related size reduction of foramina in the cribriform plate
    J K Kalmey
    Department of Anatomy, Northeastern Ohio Universities College of Medicine, Rootstown 44272 0095, USA
    Anat Rec 251:326-9. 1998
    ..Such decreases in patent foramina may be associated with impaired olfactory function in the aged...
  20. ncbi Alterations in nigrostriatal dopaminergic function within BDNF mutant mice
    D E Dluzen
    Department of Anatomy, Northeastern Ohio Universities College of Medicine, Roostown 44272 0095, USA
    Exp Neurol 160:500-7. 1999
    ..These latter findings may indicate some subtle changes in catecholamine functions resulting from a heterozygous BDNF mutation...
  21. ncbi Estrogen, but not testosterone, attenuates methamphetamine-evoked dopamine output from superfused striatal tissue of female and male mice
    R E Myers
    Department of Anatomy Northeastern Ohio Universities College of Medicine (NEOUCOM, 4209 State Route 44, PO Box 95, Rootstown 44272-0095, USA
    Neuropharmacology 44:624-32. 2003
    ....