D Dluzen

Summary

Affiliation: Northeastern Ohio Universities College of Medicine
Country: USA

Publications

  1. ncbi Striatal dopamine output is compromised within +/- BDNF mice
    Dean E Dluzen
    Department of Anatomy, Northeastern Ohio University College of Medicine NEOUCOM, Rootstown, Ohio 44272 0095, USA
    Synapse 43:112-7. 2002
  2. ncbi Unconventional effects of estrogen uncovered
    Dean E Dluzen
    Department of Anatomy, Northeastern Ohio Universities College of Medicine NEOUCOM, 4209 State Route 44, PO Box 95, Rootstown, OH 44272 0095, USA
    Trends Pharmacol Sci 26:485-7. 2005
  3. pmc Markers associated with sex differences in methamphetamine-induced striatal dopamine neurotoxicity
    D E Dluzen
    Department of Anatomy and Neurobiology, NEOUCOM, Rootstown, OH 44272
    Curr Neuropharmacol 9:40-4. 2011
  4. ncbi Estrogen differentially modulates nicotine-evoked dopamine release from the striatum of male and female rats
    D E Dluzen
    Department of Anatomy, Northeastern Ohio Universities, College of Medicine, Rootstown 44272 0095, USA
    Neurosci Lett 230:140-2. 1997
  5. ncbi Age-related changes in nigrostriatal dopaminergic function in heterozygous mutant dopamine transporter knock-out mice
    Dean E Dluzen
    Department of Anatomy and Neurobiology, Northeastern Ohio Universities College of Medicine, Rootstown, OH 44272 0095, USA
    Neurosci Lett 476:66-9. 2010
  6. ncbi The effect of gender and the neurotrophin, BDNF, upon methamphetamine-induced neurotoxicity of the nigrostriatal dopaminergic system in mice
    Dean E Dluzen
    Department of Anatomy, Northeastern Ohio Universities College of Medicine, 4209 State Route 44, PO Box 95, Rootstown, OH 44272 0095, USA
    Neurosci Lett 359:135-8. 2004
  7. doi Relationships among gender, age, time, and temperature in methamphetamine-induced striatal dopaminergic neurotoxicity
    D E Dluzen
    Department of Anatomy and Neurobiology, Northeastern Ohio Universities College of Medicine and Pharmacy, Rootstown, OH 44272 0095, USA
    Neuroscience 167:985-93. 2010
  8. ncbi Age-related changes in nigrostriatal dopaminergic function are accentuated in +/- brain-derived neurotrophic factor mice
    D E Dluzen
    Department of Anatomy, Northeastern Ohio Universities College of Medicine, 4209 State Route 44, PO Box 95, Rootstown, OH 44272 0095, USA
    Neuroscience 128:201-8. 2004
  9. doi Sex differences in dopamine- and vesicular monoamine-transporter functions
    D E Dluzen
    Department of Anatomy, Northeastern Ohio Universities College of Medicine, Rootstown, Ohio, USA
    Ann N Y Acad Sci 1139:140-50. 2008
  10. ncbi Developmental and genetic influences upon gender differences in methamphetamine-induced nigrostriatal dopaminergic neurotoxicity
    Dean E Dluzen
    Department of Anatomy, Northeastern Ohio Universities College of Medicine NEOUCOM, Rootstown, Ohio 44272 0095, USA
    Ann N Y Acad Sci 1025:205-20. 2004

Collaborators

Detail Information

Publications53

  1. ncbi Striatal dopamine output is compromised within +/- BDNF mice
    Dean E Dluzen
    Department of Anatomy, Northeastern Ohio University College of Medicine NEOUCOM, Rootstown, Ohio 44272 0095, USA
    Synapse 43:112-7. 2002
    ..This difference was abolished following MA treatment. These results suggest that processes involved with the dynamics of DA release within the NSDA system may be compromised in +/- BDNF mutant mice...
  2. ncbi Unconventional effects of estrogen uncovered
    Dean E Dluzen
    Department of Anatomy, Northeastern Ohio Universities College of Medicine NEOUCOM, 4209 State Route 44, PO Box 95, Rootstown, OH 44272 0095, USA
    Trends Pharmacol Sci 26:485-7. 2005
    ..These findings suggest that the effects of estrogen on dopamine transporter function could result from a signal transduction interaction involving D(2) receptor-G protein coupling...
  3. pmc Markers associated with sex differences in methamphetamine-induced striatal dopamine neurotoxicity
    D E Dluzen
    Department of Anatomy and Neurobiology, NEOUCOM, Rootstown, OH 44272
    Curr Neuropharmacol 9:40-4. 2011
    ....
  4. ncbi Estrogen differentially modulates nicotine-evoked dopamine release from the striatum of male and female rats
    D E Dluzen
    Department of Anatomy, Northeastern Ohio Universities, College of Medicine, Rootstown 44272 0095, USA
    Neurosci Lett 230:140-2. 1997
    ..Peak nicotine-evoked dopamine output from estrogen treated females was significantly greater than that of estrogen treated males. These results may be related to the gender differences in response to nicotine and smoking behavior...
  5. ncbi Age-related changes in nigrostriatal dopaminergic function in heterozygous mutant dopamine transporter knock-out mice
    Dean E Dluzen
    Department of Anatomy and Neurobiology, Northeastern Ohio Universities College of Medicine, Rootstown, OH 44272 0095, USA
    Neurosci Lett 476:66-9. 2010
    ..These findings reveal the significance of interactions between a mutation of the dopamine transporter and aging upon NSDA function and the importance of isolating such variables when using knock-out models...
  6. ncbi The effect of gender and the neurotrophin, BDNF, upon methamphetamine-induced neurotoxicity of the nigrostriatal dopaminergic system in mice
    Dean E Dluzen
    Department of Anatomy, Northeastern Ohio Universities College of Medicine, 4209 State Route 44, PO Box 95, Rootstown, OH 44272 0095, USA
    Neurosci Lett 359:135-8. 2004
    ..These results suggest that alterations in BDNF do not alter basic gender differences in MA-induced NSDA neurotoxicity, but may produce a neuroprotection against MA which is relatively greater in males...
  7. doi Relationships among gender, age, time, and temperature in methamphetamine-induced striatal dopaminergic neurotoxicity
    D E Dluzen
    Department of Anatomy and Neurobiology, Northeastern Ohio Universities College of Medicine and Pharmacy, Rootstown, OH 44272 0095, USA
    Neuroscience 167:985-93. 2010
    ....
  8. ncbi Age-related changes in nigrostriatal dopaminergic function are accentuated in +/- brain-derived neurotrophic factor mice
    D E Dluzen
    Department of Anatomy, Northeastern Ohio Universities College of Medicine, 4209 State Route 44, PO Box 95, Rootstown, OH 44272 0095, USA
    Neuroscience 128:201-8. 2004
    ....
  9. doi Sex differences in dopamine- and vesicular monoamine-transporter functions
    D E Dluzen
    Department of Anatomy, Northeastern Ohio Universities College of Medicine, Rootstown, Ohio, USA
    Ann N Y Acad Sci 1139:140-50. 2008
    ....
  10. ncbi Developmental and genetic influences upon gender differences in methamphetamine-induced nigrostriatal dopaminergic neurotoxicity
    Dean E Dluzen
    Department of Anatomy, Northeastern Ohio Universities College of Medicine NEOUCOM, Rootstown, Ohio 44272 0095, USA
    Ann N Y Acad Sci 1025:205-20. 2004
    ....
  11. ncbi Gender differences in modulatory effects of tamoxifen upon the nigrostriatal dopaminergic system
    Dean E Dluzen
    Department of Anatomy, Northeastern Ohio Universities College of Medicine, NEOUCOM, 4209 State Route 44, PO Box 95, Rootstown, OH 44272 0095, USA
    Pharmacol Biochem Behav 80:27-33. 2005
    ....
  12. doi Differences in reserpine-induced striatal dopamine output and content between female and male mice: implications for sex differences in vesicular monoamine transporter 2 function
    D E Dluzen
    Department of Anatomy, Northeastern Ohio Universities College of Medicine, Rootstown, OH 44272 0095, USA
    Neuroscience 154:1488-96. 2008
    ..Such differences in VMAT2 function may be related to the gender differences observed in conditions like Parkinson's disease and drug addiction...
  13. ncbi Gender differences in methamphetamine use and responses: a review
    Dean E Dluzen
    Department of Anatomy, Northeastern Ohio Universities College of Medicine, Rootstown, OH 44272 0095, USA
    Gend Med 5:24-35. 2008
    ..However, these gender differences oftentimes are given only a cursory consideration in the analyses of these MA effects...
  14. ncbi Estrogen, testosterone, and gender differences
    Dean E Dluzen
    Department of Anatomy, Northeastern Ohio Universities College of Medicine, NEOUCOM, Rootstown, OH
    Endocrine 27:259-67. 2005
    ..Interpretations and implications of these results are discussed...
  15. ncbi Sex differences in methamphetamine-evoked striatal dopamine output are abolished following gonadectomy: comparisons with potassium-evoked output and responses in prepubertal mice
    Dean E Dluzen
    Department of Anatomy, Northeastern Ohio Universities College of Medicine, NEOUCOM, Rootstown, 44272 0095, USA
    Neuroendocrinology 82:78-86. 2005
    ....
  16. ncbi Estrogen as neuroprotectant of nigrostriatal dopaminergic system: laboratory and clinical studies
    Dean Dluzen
    Department of Anatomy, Northeastern Ohio Universities College of Medicine, Rootstown 44272, USA
    Endocrine 21:67-75. 2003
    ..Finally, in Part 3, we review the clinical literature related to this issue as a means for consideration of estrogen as a modulator, neuroprotectant, and therapy for Parkinson disease...
  17. ncbi Gender differences in methamphetamine-induced mRNA associated with neurodegeneration in the mouse nigrostriatal dopaminergic system
    Dean E Dluzen
    Department of Anatomy, Northeastern Ohio Universities College of Medicine, Rootstown, Ohio 44272 0095, USA
    Neuroendocrinology 77:232-8. 2003
    ....
  18. ncbi Modulation of olfactory bulb tyrosine hydroxylase and catecholamine transporter mRNA by estrogen
    Dean E Dluzen
    Department of Anatomy, Northeastern Ohio Universities College of Medicine NEOUCOM, 4209 State Route 44, PO Box 95, Rootstown 44272 0095, USA
    Brain Res Mol Brain Res 108:121-8. 2002
    ....
  19. ncbi Estrogen decreases corpus striatal neurotoxicity in response to 6-hydroxydopamine
    D Dluzen
    Department of Anatomy, Northeastern Ohio Universities, College of Medicine, Rootstown 44272 0095, USA
    Brain Res 767:340-4. 1997
    ..Such findings suggest that estrogen may function as an important modulatory factor capable of attenuating degeneration within the corpus striatum, and in this way serve as a neuroprotectant of the nigrostriatal dopaminergic system...
  20. ncbi The effects of nicotine on dopamine and DOPAC output from rat striatal tissue
    D E Dluzen
    Department of Anatomy, College of Medicine, Northeastern Ohio Universities, Rootstown 44272 0095, USA
    Eur J Pharmacol 341:23-32. 1998
    ....
  21. ncbi The effects of infusion of arginine vasopressin, oxytocin, or their antagonists into the olfactory bulb upon social recognition responses in male rats
    D E Dluzen
    Max Planck Institute of Psychiatry, Munich, Germany
    Peptides 19:999-1005. 1998
    ..Moreover, our results suggest that the underlying mechanisms by which peptides function within the olfactory bulb differ as a function of whether they are involved with the display versus preservation of recognition responses...
  22. ncbi Olfactory bulb norepinephrine depletion abolishes vasopressin and oxytocin preservation of social recognition responses in rats
    D E Dluzen
    Max Planck Institute of Psychiatry, Munich, Germany
    Neurosci Lett 254:161-4. 1998
    ..These results suggest that this capacity for these neuropeptides to preserve social recognition responses is mediated through the norepinephrine system of the olfactory bulb...
  23. ncbi Oxytocin induces preservation of social recognition in male rats by activating alpha-adrenoceptors of the olfactory bulb
    D E Dluzen
    Max Planck Institute of Psychiatry, Munich, Germany
    Eur J Neurosci 12:760-6. 2000
    ..Accordingly, this model affords the opportunity to study neuropeptide-catecholamine interactions, link these interactions with a specific behavioural outcome and identify a novel function/site of action for oxytocin in the male...
  24. ncbi Neuroprotective role of estrogen upon methamphetamine and related neurotoxins within the nigrostriatal dopaminergic system
    D E Dluzen
    Department of Anatomy, Northeastern Ohio Universities College of Medicine, Rootstown, OH 44272, USA
    Ann N Y Acad Sci 914:112-26. 2000
    ..The capacity and significance for steroid hormones to modulate neurotransmitter transporters has been recently reviewed...
  25. ncbi Gender differences in neurotoxicity of the nigrostriatal dopaminergic system: implications for Parkinson's disease
    D E Dluzen
    Department of Anatomy, Northeastern Ohio Universities College of Medicine NEOUCOM, 4209 State Rte 44, PO Box 95, Rootstown, OH 44272 0095, USA
    J Gend Specif Med 3:36-42. 2000
    ..Finally, some of the potential neurologic implications of manipulating estrogen in premenopausal and postmenopausal women are considered...
  26. ncbi Tamoxifen diminishes methamphetamine-induced striatal dopamine depletion in intact female and male mice
    D E Dluzen
    Department of Anatomy, Northeastern Ohio Universities College of Medicine NEOUCOM, Rootstown, OH 44272 0095, USA
    J Neuroendocrinol 13:618-24. 2001
    ..These effects are relatively specific for the nigrostriatal dopaminergic system. Such data suggest that TMX can function as a nigrostriatal dopaminergic neuroprotectant against MA-induced neurotoxicity in intact female and male mice...
  27. ncbi Methamphetamine-gonadal steroid hormonal interactions: effects upon acute toxicity and striatal dopamine concentrations
    Dean E Dluzen
    Department of Anatomy, Northeastern Ohio Universities College of Medicine NEOUCOM, Rootstown, OH, USA
    Neurotoxicol Teratol 24:267-73. 2002
    ..Accordingly, gonadal steroid hormones can function as critical modulators of both central and peripheral toxicological effects of MA...
  28. ncbi Estrogen, anti-estrogen, and gender: differences in methamphetamine neurotoxicity
    Dean E Dluzen
    Department of Anatomy, Northeastern Ohio Universities College of Medicine, Rootstown, Ohio 44272, USA
    Ann N Y Acad Sci 965:136-56. 2002
    ..Each of these factors, combined with our previous findings that E can inhibit DA transporter function, represent significant events contributing to E/gender-dependent effects on METH neurotoxicity...
  29. doi Parity decreases methamphetamine-induced striatal dopaminergic perturbation
    Dean E Dluzen
    Department of Anatomy and Neurobiology, Northeastern Ohio Universities College of Medicine and Pharmacy, 4209 State Route 44, P O Box 95, Rootstown, OH 44272 0095, USA
    Neurochem Int 59:101-3. 2011
    ..These results demonstrate that parity decreases MA-induced striatal dopaminergic neurotoxicity, and the degree of this neuroprotection is related to the number of pregnancies experienced...
  30. doi The effect of freezing and extraction upon striatal dopaminergic function
    Dean E Dluzen
    Department of Anatomy and Neurobiology, Northeastern Ohio Universities College of Medicine NEOUCOM, 4209 State Route 44, P O Box 95, Roostown, OH 44272 0095, USA
    J Neurosci Methods 198:23-8. 2011
    ....
  31. ncbi Estrogen, testosterone, and methamphetamine toxicity
    Dean E Dluzen
    Department of Anatomy, Northeastern Ohio Universities College of Medicine NEOUCOM, 4209 State Route 44, PO Box 95, Rootstown, OH 44272 0095, USA
    Ann N Y Acad Sci 1074:282-94. 2006
    ..Similarly, increased striatal dopamine depletion to methamphetamine is observed in gonadectomized male mice treated with testosterone...
  32. doi Sex differences in striatal dopaminergic function within heterozygous mutant dopamine transporter knock-out mice
    Jing Ji
    Department of Anatomy, Northeastern Ohio Universities College of Medicine NEOUCOM, Rootstown, OH 44272 0095, USA
    J Neural Transm 115:809-17. 2008
    ....
  33. ncbi Dose-response effects of estrogen and tamoxifen upon methamphetamine-induced behavioral responses and neurotoxicity of the nigrostriatal dopaminergic system in female mice
    Katherine R Mickley
    Department of Anatomy, Northeastern Ohio Universities College of Medicine, Rootstown, Ohio, USA
    Neuroendocrinology 79:305-16. 2004
    ....
  34. ncbi Effect of estrogen upon methamphetamine-induced neurotoxicity within the impaired nigrostriatal dopaminergic system
    Bin Liu
    Department of Anatomy, Northeastern Ohio Universities College of Medicine, Rootstown, Ohio 44272 0095, USA
    Synapse 60:354-61. 2006
    ..These results demonstrate that the capacity for estrogen to protect or worsen MA-induced neurotoxicity of dopaminergic neurons is limited to female mice and depends on the condition of the NSDA system...
  35. ncbi Tamoxifen increases methamphetamine-evoked dopamine output from superfused striatal tissue fragments of male mice
    Matthew C Willett
    Department of Anatomy, Northeastern Ohio Universities College of Medicine NEOUCOM, 4209 State Route 44, PO Box 95, Rootstown, OH 44272 0095, USA
    Brain Res 1029:186-94. 2004
    ..These effects of TMX appear to be relatively specific for MA-evoked DA output, as K+ -stimulated DA was not altered by TMX, and do not appear to exert these effects by altering dopamine transporter function...
  36. ncbi Effects of estrogen and related agents upon methamphetamine-induced neurotoxicity within an impaired nigrostriatal dopaminergic system of ovariectomized mice
    Bin Liu
    Department of Anatomy, Northeastern Ohio Universities College of Medicine, Rootstown, Ohio 44272 0095, USA
    Neuroendocrinology 83:295-302. 2006
    ..This study may provide an understanding of the variations in results on the effects of estrogen upon the NSDA neurodegenerative disorder, Parkinson's disease...
  37. ncbi Testosterone modulation of striatal dopamine output in orchidectomized mice
    Kamal Shemisa
    Department of Anatomy, Northeastern Ohio Universities College of Medicine NEOUCOM, Rootstown, Ohio 44272 0095, USA
    Synapse 60:347-53. 2006
    ..Such results have important implications with regard to understanding the sex differences that are present in nigrostriatal dopaminergic function within health and diseased states...
  38. ncbi Sex differences in methamphetamine-evoked striatal dopamine of mice are reversed by nomifensine
    Vidhya Kunnathur
    Department of Anatomy, Northeastern Ohio Universities College of Medicine, Rootstown, OH 44272 0095, United States
    Neurotoxicol Teratol 28:557-62. 2006
    ..In particular, the present findings have important implications in suggesting an alternative, non-traditional, mechanism for MA effects and indicate that such a function is limited to females...
  39. ncbi Castration increases nisoxetine-evoked norepinephrine levels in vivo within the olfactory bulb of male rats
    Yili Shang
    Department of Anatomy, Northeastern Ohio Universities College of Medicine NEOUCOM, Rootstown, OH 44272 0095, USA
    Neurosci Lett 328:81-4. 2002
    ....
  40. ncbi Dopamine transporter function differences between male and female CD-1 mice
    Sandeep D Bhatt
    Department of Anatomy, Northeastern Ohio Universities College of Medicine NEOUCOM, 4209 State Route 44, PO Box 95, Rootstown, Ohio 44272 0095, USA
    Brain Res 1035:188-95. 2005
    ..These findings have important implications for sex differences in NSDA functions and responses to neurotoxins which enter the neurons via the DAT...
  41. ncbi Oestrogen and nigrostriatal dopaminergic neurodegeneration: animal models and clinical reports of Parkinson's disease
    Bin Liu
    Department of Anatomy, Northeastern Ohio Universities College of Medicine, Rootstown, Ohio 44272 0095, USA
    Clin Exp Pharmacol Physiol 34:555-65. 2007
    ..5. Oestrogen was chosen as one of the 12 neuroprotective compounds to be attractive candidates for further clinical trials (Phase II or III) in 2003...
  42. doi Effects of a novel dopamine uptake inhibitor upon extracellular dopamine from superfused murine striatal tissue
    Werner J Geldenhuys
    Department of Pharmaceutical Sciences, College of Pharmacy, Northeastern Ohio Universities, Rootstown, OH 44272, USA
    Eur J Pharmacol 619:38-43. 2009
    ..In conclusion, the findings suggest that compound 1 may have the potential to serve as a lead candidate for therapeutics designed to treat drug abuse and possibly disorders like Parkinson's disease...
  43. doi Testosterone enhances dopamine depletion by methamphetamine in male, but not female, mice
    Chandani Lewis
    Department of Anatomy, Northeastern Ohio Universities College of Medicine NEOUCOM, 4209 State Route 44, PO Box 95, Rootstown, OH 44272 0095, United States
    Neurosci Lett 448:130-3. 2008
    ....
  44. ncbi Genetic alteration in the dopamine transporter differentially affects male and female nigrostriatal transporter systems
    Jing Ji
    Department of Anatomy, Northeastern Ohio Universities College of Medicine, Rootstown, OH 44272, USA
    Biochem Pharmacol 78:1401-11. 2009
    ..Such DAT/VMAT-2 interactions can be of significance to the gender differences observed in drug addiction and Parkinson's disease...
  45. ncbi Rotenone produces opposite effects upon mouse striatal dopamine function as a result of environmental temperature
    Karla C Crutchfield
    Department of Anatomy, Northeastern Ohio Universities College of Medicine, NEOUCOM, Rootstown, 44272, USA
    Neurotox Res 9:15-21. 2006
    ....
  46. ncbi Estrogen prevents neuroprotection by caffeine in the mouse 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease
    Kui Xu
    Department of Neurology, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Neurosci 26:535-41. 2006
    ....
  47. ncbi Differential protective properties of estradiol and tamoxifen against methamphetamine-induced nigrostriatal dopaminergic toxicity in mice
    Myreille D'Astous
    Molecular Endocrinology and Oncology Research Center, Laval University Medical Center, CHUL, and Faculty of Pharmacy, Laval University, Quebec City, Canada
    Neuroendocrinology 82:111-20. 2005
    ..While both treatments prevented the DA decrease, E protected more efficiently other dopaminergic parameters suggesting that overall E is more effective than tamoxifen as a neuroprotectant of the nigrostriatal dopaminergic system...
  48. ncbi Dopamine transporter as a marker of neuroprotection in methamphetamine-lesioned mice treated acutely with estradiol
    Myreille D'Astous
    Molecular Endocrinology and Oncology Research Center, Laval University Medical Center, CHUL, and Faculty of Pharmacy, Laval University, Quebec City, Que G1V 4G2, Canada
    Neuroendocrinology 79:296-304. 2004
    ....
  49. ncbi Methamphetamine-induced loss of striatal dopamine innervation in BDNF heterozygote mice does not further reduce D3 receptor concentrations
    Jeffrey N Joyce
    Sun Health Research Institute Christopher Center for Parkinson s Disease Research, Sun City, Arizona 85351, USA
    Synapse 52:11-9. 2004
    ..In addition, the reduction of D(3) receptor expression is associated with a decreased neurotoxic response to methamphetamine in BDNF +/- mice...
  50. ncbi Estrogen and Parkinson's disease
    Martin W I M Horstink
    Department of Neurology, University Medical Centre, Nijmegen, The Netherlands
    Adv Neurol 91:107-14. 2003
  51. ncbi Tamoxifen protects male mice nigrostriatal dopamine against methamphetamine-induced toxicity
    Mélanie Bourque
    Molecular Endocrinology and Oncology Research Center, Laval University Medical Center, CHUL, Quebec City, Quebec G1V 4G2, Canada
    Biochem Pharmacol 74:1413-23. 2007
    ..Since this is the only known hormonal protection of male mice against methamphetamine toxicity, these findings provide important new information on specific parameters of nigrostriatal dopaminergic function preserved by tamoxifen...
  52. pmc Gender differences in Parkinson's disease
    Charlotte A Haaxma
    Department of Neurology, Radboud University Nijmegen Medical Centre, 6500 HB, Nijmegen, The Netherlands
    J Neurol Neurosurg Psychiatry 78:819-24. 2007
    ..To investigate gender differences in basic disease characteristics, motor deterioration and nigrostriatal degeneration in Parkinson's disease (PD)...
  53. ncbi Protective effects of ginsenoside Rg2 against glutamate-induced neurotoxicity in PC12 cells
    Na Li
    Department of Physiology, Medical College of Qingdao University, Qingdao 266071, PR China
    J Ethnopharmacol 111:458-63. 2007
    ..In addition, the inhibitory effect of ginsenoside Rg2 against the formation of Abeta1-40 suggests that ginsenoside Rg2 may also represent a potential treatment strategy for Alzheimer's disease...