Mansoor M Amiji

Summary

Affiliation: Northeastern University
Country: USA

Publications

  1. ncbi Intratumoral administration of paclitaxel in an in situ gelling poloxamer 407 formulation
    Mansoor M Amiji
    Department of Pharmaceutical Sciences, School of Pharmacy, Northeastern University, Boston, MA 02115, USA
    Pharm Dev Technol 7:195-202. 2002
  2. ncbi Formulation and physiological factors influencing CNS delivery upon intranasal administration
    Tushar K Vyas
    Department of Pharmaceutical Sciences, School of Pharmacy, Northeastern University, 110 Mugar Lilfe Sciences Building, Boston, MA 02115, USA
    Crit Rev Ther Drug Carrier Syst 23:319-47. 2006
  3. ncbi Image-guided nanosystems for targeted delivery in cancer therapy
    A K Iyer
    Department of Pharmaceutical Sciences, School of Pharmacy, Northeastern University, Boston, MA 02115, USA
    Curr Med Chem 19:3230-40. 2012
  4. ncbi Role of hypoxia and glycolysis in the development of multi-drug resistance in human tumor cells and the establishment of an orthotopic multi-drug resistant tumor model in nude mice using hypoxic pre-conditioning
    Lara Milane
    Department of Pharmaceutical Sciences, School of Pharmacy, Northeastern University, 360 Huntington Avenue, Boston, MA 02115, USA
    Cancer Cell Int 11:3. 2011
  5. ncbi Augmentation of therapeutic efficacy in drug-resistant tumor models using ceramide coadministration in temporal-controlled polymer-blend nanoparticle delivery systems
    Lilian E van Vlerken
    Department of Pharmaceutical Sciences, School of Pharmacy, Northeastern University, Boston, Massachusetts 02115, USA
    AAPS J 12:171-80. 2010
  6. ncbi Inhibition of ABCB1 (MDR1) expression by an siRNA nanoparticulate delivery system to overcome drug resistance in osteosarcoma
    Michiro Susa
    Department of Orthopaedic Surgery, Massachusetts General Hospital, Boston, Massachusetts, USA
    PLoS ONE 5:e10764. 2010
  7. ncbi Modulation of drug resistance in ovarian adenocarcinoma by enhancing intracellular ceramide using tamoxifen-loaded biodegradable polymeric nanoparticles
    Harikrishna Devalapally
    Department of Pharmaceutical Sciences, School of Pharmacy, Northeastern University, Boston, MA 02115, USA
    Clin Cancer Res 14:3193-203. 2008
  8. ncbi Evaluations of combination MDR-1 gene silencing and paclitaxel administration in biodegradable polymeric nanoparticle formulations to overcome multidrug resistance in cancer cells
    Sunita Yadav
    Department of Pharmaceutical Sciences, School of Pharmacy, Northeastern University, Boston, MA 02115, USA
    Cancer Chemother Pharmacol 63:711-22. 2009
  9. ncbi Lipid-functionalized dextran nanosystems to overcome multidrug resistance in cancer: a pilot study
    Eisuke Kobayashi
    Sarcoma Biology Laboratory, Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, 100 Blossom St, Jackson 1115, Boston, MA 02114, USA
    Clin Orthop Relat Res 471:915-25. 2013
  10. ncbi Biodistribution and pharmacokinetic analysis of Paclitaxel and ceramide administered in multifunctional polymer-blend nanoparticles in drug resistant breast cancer model
    Lilian E van Vlerken
    Department of Pharmaceutical Sciences, Northeastern University, Department of Orthopedic Surgery, Massachusetts General Hospital, Boston, Massachusetts 02115, USA
    Mol Pharm 5:516-26. 2008

Research Grants

  1. ORAL GENE THERAPY WITH NiMOS FOR INFLAMMATORY BOWEL DISEASE
    Mansoor M Amiji; Fiscal Year: 2010
  2. LONG-CIRCULATING TUMOR-SELECTIVE DNA DELIVERY SYSTEMS
    Mansoor Amiji; Fiscal Year: 2005
  3. NANOTHERAPEUTIC STRATEGY FOR MULTIDRUG RESISTANT TUMORS
    Mansoor Amiji; Fiscal Year: 2009

Collaborators

Detail Information

Publications40

  1. ncbi Intratumoral administration of paclitaxel in an in situ gelling poloxamer 407 formulation
    Mansoor M Amiji
    Department of Pharmaceutical Sciences, School of Pharmacy, Northeastern University, Boston, MA 02115, USA
    Pharm Dev Technol 7:195-202. 2002
    ..The results of this study show significant benefit of paclitaxel for solid tumor when administered locally in an in situ gelling poloxamer 407 formulation...
  2. ncbi Formulation and physiological factors influencing CNS delivery upon intranasal administration
    Tushar K Vyas
    Department of Pharmaceutical Sciences, School of Pharmacy, Northeastern University, 110 Mugar Lilfe Sciences Building, Boston, MA 02115, USA
    Crit Rev Ther Drug Carrier Syst 23:319-47. 2006
    ..Finally, the article provides several strategies for effectively enhancing nose-to-brain transport of drug molecules through rational formulation design and optimization...
  3. ncbi Image-guided nanosystems for targeted delivery in cancer therapy
    A K Iyer
    Department of Pharmaceutical Sciences, School of Pharmacy, Northeastern University, Boston, MA 02115, USA
    Curr Med Chem 19:3230-40. 2012
    ....
  4. ncbi Role of hypoxia and glycolysis in the development of multi-drug resistance in human tumor cells and the establishment of an orthotopic multi-drug resistant tumor model in nude mice using hypoxic pre-conditioning
    Lara Milane
    Department of Pharmaceutical Sciences, School of Pharmacy, Northeastern University, 360 Huntington Avenue, Boston, MA 02115, USA
    Cancer Cell Int 11:3. 2011
    ..abstract:..
  5. ncbi Augmentation of therapeutic efficacy in drug-resistant tumor models using ceramide coadministration in temporal-controlled polymer-blend nanoparticle delivery systems
    Lilian E van Vlerken
    Department of Pharmaceutical Sciences, School of Pharmacy, Northeastern University, Boston, Massachusetts 02115, USA
    AAPS J 12:171-80. 2010
    ..This strategy has tremendous potential for effective treatment of refractory disease in cancer patients...
  6. ncbi Inhibition of ABCB1 (MDR1) expression by an siRNA nanoparticulate delivery system to overcome drug resistance in osteosarcoma
    Michiro Susa
    Department of Orthopaedic Surgery, Massachusetts General Hospital, Boston, Massachusetts, USA
    PLoS ONE 5:e10764. 2010
    ..However, for patients who progress after chemotherapy, its effectiveness diminishes due to the emergence of multi-drug resistance (MDR) after prolonged therapy...
  7. ncbi Modulation of drug resistance in ovarian adenocarcinoma by enhancing intracellular ceramide using tamoxifen-loaded biodegradable polymeric nanoparticles
    Harikrishna Devalapally
    Department of Pharmaceutical Sciences, School of Pharmacy, Northeastern University, Boston, MA 02115, USA
    Clin Cancer Res 14:3193-203. 2008
    ....
  8. ncbi Evaluations of combination MDR-1 gene silencing and paclitaxel administration in biodegradable polymeric nanoparticle formulations to overcome multidrug resistance in cancer cells
    Sunita Yadav
    Department of Pharmaceutical Sciences, School of Pharmacy, Northeastern University, Boston, MA 02115, USA
    Cancer Chemother Pharmacol 63:711-22. 2009
    ....
  9. ncbi Lipid-functionalized dextran nanosystems to overcome multidrug resistance in cancer: a pilot study
    Eisuke Kobayashi
    Sarcoma Biology Laboratory, Center for Sarcoma and Connective Tissue Oncology, Massachusetts General Hospital, 100 Blossom St, Jackson 1115, Boston, MA 02114, USA
    Clin Orthop Relat Res 471:915-25. 2013
    ..However, it is unclear whether doxorubicin (Dox) can be delivered by nanotechnologic approaches...
  10. ncbi Biodistribution and pharmacokinetic analysis of Paclitaxel and ceramide administered in multifunctional polymer-blend nanoparticles in drug resistant breast cancer model
    Lilian E van Vlerken
    Department of Pharmaceutical Sciences, Northeastern University, Department of Orthopedic Surgery, Massachusetts General Hospital, Boston, Massachusetts 02115, USA
    Mol Pharm 5:516-26. 2008
    ..Overall, these results are highly encouraging for development of multifunctional polymer-blend nanoparticle formulations that can be used for temporal-controlled administration of two drugs from a single formulation...
  11. ncbi Non-viral eNOS gene delivery and transfection with stents for the treatment of restenosis
    Luis A Brito
    Department of Pharmaceutical Sciences, Northeastern University, Boston, MA 02115, USA
    Biomed Eng Online 9:56. 2010
    ....
  12. ncbi In vitro and in vivo studies of local arterial gene delivery and transfection using lipopolyplexes-embedded stents
    Luis A Brito
    Department of Pharmaceutical Sciences, Northeastern University, Boston, MA 02115, USA
    J Biomed Mater Res A 93:325-36. 2010
    ..Based on these encouraging preliminary results, LPP-based formulations can serve as a safe and effective nonviral gene delivery system for effective treatment of coronary restenosis...
  13. ncbi A model predicting delivery of saquinavir in nanoparticles to human monocyte/macrophage (Mo/Mac) cells
    D Ece Gamsiz
    Department of Chemical Engineering, 342 Snell Engineering Center, 360 Huntington Avenue, Northeastern University, Boston, Massachusetts 02115, USA
    Biotechnol Bioeng 101:1072-82. 2008
    ..This simple model highlights the importance of relative kinetics of nanoparticle uptake and drug release in determining overall enhancement of intracellular drug concentration when dosing with nanoparticles...
  14. ncbi Multi-functional nanocarriers to overcome tumor drug resistance
    Lara S Jabr-Milane
    Department of Pharmaceutical Sciences, School of Pharmacy, Northeastern University, 110 Mugar Life Sciences Building, Boston, MA 02115, USA
    Cancer Treat Rev 34:592-602. 2008
    ..In preclinical studies, the use of multi-functional nanocarriers has shown significant promise in enhancing cancer therapy, especially against MDR tumors...
  15. ncbi Doxorubicin loaded Polymeric Nanoparticulate Delivery System to overcome drug resistance in osteosarcoma
    Michiro Susa
    Department of Orthopaedic Surgery, Massachusetts General Hospital, Boston, MA 02114, USA
    BMC Cancer 9:399. 2009
    ....
  16. ncbi Paclitaxel and ceramide co-administration in biodegradable polymeric nanoparticulate delivery system to overcome drug resistance in ovarian cancer
    Harikrishna Devalapally
    Department of Pharmaceutical Sciences, School of Pharmacy, Northeastern University, Boston, MA 02115, USA
    Int J Cancer 121:1830-8. 2007
    ..The results of this study show that combination of PTX and CER in biodegradable polymeric nanoparticles can serve as a very effective therapeutic strategy to overcome drug resistance in ovarian cancer...
  17. ncbi Role of nanotechnology in pharmaceutical product development
    Harikrishna Devalapally
    Department of Pharmaceutical Sciences, School of Pharmacy, Northeastern University, 110 Mugar Life Sciences Building, Boston, Massachusetts 02115, USA
    J Pharm Sci 96:2547-65. 2007
    ..This review summarizes some of the parameters and approaches that can be used to evaluate nanoparticulate drug delivery systems in early stages of formulation development...
  18. ncbi Nanoparticles: a promising modality in the treatment of sarcomas
    Michiro Susa
    Department of Orthopaedic Surgery, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Pharm Res 28:260-72. 2011
    ..In this review, we will discuss the application of nanoparticles for improving the treatment of sarcoma patients...
  19. ncbi Development of novel biodegradable polymeric nanoparticles-in-microsphere formulation for local plasmid DNA delivery in the gastrointestinal tract
    Mayank D Bhavsar
    Department of Pharmaceutical Sciences, School of Pharmacy, Northeastern University, 110 Mugar Life Sciences Building, Boston, MA 02115, USA
    AAPS PharmSciTech 9:288-94. 2008
    ..Based on these results, NiMOS show significant potential as novel gene delivery vehicle for therapeutic and vaccination purposes...
  20. ncbi Enhanced mucosal and systemic immune response with squalane oil-containing multiple emulsions upon intranasal and oral administration in mice
    Aliasgar Shahiwala
    Department of Pharmaceutical Sciences, School of Pharmacy, Northeastern University, Boston, MA 02115, USA
    J Drug Target 16:302-10. 2008
    ....
  21. ncbi 'Click' synthesis of dextran macrostructures for combinatorial-designed self-assembled nanoparticles encapsulating diverse anticancer therapeutics
    Sampath C Abeylath
    Department of Pharmaceutical Sciences, School of Pharmacy, Northeastern University, Boston, MA 02115, United States
    Bioorg Med Chem 19:6167-73. 2011
    ..The results show that with the appropriate selection of lipid-modified dextran, one can effectively tailor the self-assembled nano-formulation for intended therapeutic payload...
  22. ncbi Nanocarriers for systemic and mucosal vaccine delivery
    Aliasgar Shahiwala
    Department of Pharmaceutical Sciences, School of Pharmacy, Northeastern University, Boston, MA 02115, USA
    Recent Pat Drug Deliv Formul 1:1-9. 2007
    ..We have examined the United States patent literature to select inventions that specifically address this strategic approach for prevention of infectious diseases...
  23. ncbi Improved oral bioavailability and brain transport of Saquinavir upon administration in novel nanoemulsion formulations
    Tushar K Vyas
    Department of Pharmaceutical Sciences, School of Pharmacy, Northeastern University, 110 Mugar Life Sciences Building, Boston, MA 02115, USA
    Int J Pharm 347:93-101. 2008
    ..The results of this study show that oil-in-water nanoemulsions made with PUFA-rich oils may be very promising for HIV/AIDS therapy, in particular, for reducing the viral load in important anatomical reservoir sites...
  24. ncbi A review of nanocarrier-based CNS delivery systems
    Sandip B Tiwari
    Department of Pharmaceutical Sciences, School of Pharmacy, Northeastern University, Boston, MA 02115, USA
    Curr Drug Deliv 3:219-32. 2006
    ..This review article discusses the various barriers for drug delivery to the CNS and reviews the current state of nanocarriers for enhancing drug transport into the CNS...
  25. ncbi Brain delivery of proteins by the intranasal route of administration: a comparison of cationic liposomes versus aqueous solution formulations
    Mattia M Migliore
    Department of Pharmaceutical Sciences, Northeastern University, 312 Mugar Building, 360 Huntington Ave, Boston, Massachusetts 02115, USA
    J Pharm Sci 99:1745-61. 2010
    ..Cationic liposomes may provide a novel, noninvasive strategy for delivery of neuroactive proteins to the brain for treatment of central nervous system disorders...
  26. ncbi Challenges and opportunities in CNS delivery of therapeutics for neurodegenerative diseases
    Thomas M Barchet
    Department of Pharmaceutical Sciences, Northeastern University, School of Pharmacy, 110 Mugar Life Sciences Building, Boston, Massachussets, MA 02115, USA
    Expert Opin Drug Deliv 6:211-25. 2009
    ..As such, these delivery strategies have a very important role to play in the future in the translation of CNS therapeutics from bench to bedside...
  27. ncbi Gastrointestinal distribution and in vivo gene transfection studies with nanoparticles-in-microsphere oral system (NiMOS)
    Mayank D Bhavsar
    Department of Pharmaceutical Sciences, School of Pharmacy, Northeastern University, 110 Mugar Life Sciences Building, Boston, MA 02115, United States
    J Control Release 119:339-48. 2007
    ..Based on these preliminary results, NiMOS show significant potential as novel gene delivery vehicle for therapeutic and vaccination purposes...
  28. ncbi Polymeric nano- and microparticle technologies for oral gene delivery
    Mayank D Bhavsar
    Doctoral Candidate, Northeastern University, Department of Pharmaceutical Sciences, School of Pharmacy, 110 Mugar Life Sciences Building, Boston, MA 02115, USA
    Expert Opin Drug Deliv 4:197-213. 2007
    ....
  29. ncbi Intracellular delivery of saquinavir in biodegradable polymeric nanoparticles for HIV/AIDS
    Lipa K Shah
    Department of Pharmaceutical Sciences, School of Pharmacy, Northeastern University, 110 Mugar Life Sciences Building, Boston, Massachusetts 02115, USA
    Pharm Res 23:2638-45. 2006
    ..CONCLUSIONS: This study shows that PEO-PCL nanoparticles provide a versatile platform for encapsulation of saquinavir and subsequent intracellular delivery in Mo/Mac cells...
  30. ncbi Modulation of intracellular ceramide using polymeric nanoparticles to overcome multidrug resistance in cancer
    Lilian E van Vlerken
    Department of Pharmaceutical Sciences, School of Pharmacy, Northeastern University, Boston, Massachusetts, USA
    Cancer Res 67:4843-50. 2007
    ....
  31. ncbi Nanoparticulate drug carriers for delivery of HIV/AIDS therapy to viral reservoir sites
    Tushar K Vyas
    Department of Pharmaceutical Sciences, School of Pharmacy, Northeastern University, 110 Mugar Life Sciences Building, Boston, MA 02115, USA
    Expert Opin Drug Deliv 3:613-28. 2006
    ..The article also focuses on the future outlook and strategies for investigational drug formulations that use nanotherapeutic strategy for HIV/AIDS...
  32. ncbi Multi-functional polymeric nanoparticles for tumour-targeted drug delivery
    Lilian E van Vlerken
    Department of Pharmaceutical Sciences, School of Pharmacy, Northeastern University, Boston, MA 02115, USA
    Expert Opin Drug Deliv 3:205-16. 2006
    ..This review will discuss the properties of nanoparticles that allow for such multiple functionality, as well as recent scientific advances in the area of multi-functional nanoparticles for cancer therapeutics...
  33. ncbi Poly(ethylene glycol)-modified nanocarriers for tumor-targeted and intracellular delivery
    Lilian E van Vlerken
    Department of Pharmaceutical Sciences, School of Pharmacy, Northeastern University, 110 Mugar Life Sciences Building, Boston, Massachusetts 02115, USA
    Pharm Res 24:1405-14. 2007
    ..This review focuses on the recent developments surrounding such PEG/PEO-surface modification of polymeric nanocarriers to promote tumor-targeting capabilities, thereby enhancing efficacy of anti-cancer therapeutic strategies...
  34. ncbi Improved oral delivery of paclitaxel following administration in nanoemulsion formulations
    Sandip B Tiwari
    Department of Pharmaceutical Sciences, School of Pharmacy, Northeastern University, Boston, MA 02115, USA
    J Nanosci Nanotechnol 6:3215-21. 2006
    ..The results of this study suggest that nanoemulsions are promising novel formulations that can enhance the oral bioavailability of hydrophobic drugs, like paclitaxel...
  35. ncbi Formulation optimization for the nanoparticles-in-microsphere hybrid oral delivery system using factorial design
    Mayank D Bhavsar
    Department of Pharmaceutical Sciences, School of Pharmacy, Northeastern University, Boston, MA 02115, United States
    J Control Release 110:422-30. 2006
    ..Based on the statistical model we were also successful in producing NiMOS of less than 10 mum in size, which could be used as oral delivery system for therapeutic and antigenic macromolecules...
  36. ncbi Nanoparticle-based endodontic antimicrobial photodynamic therapy
    Tom C Pagonis
    Advanced Graduate Endodontics, Division of Endodontics, Harvard School of Dental Medicine, Boston, Massachusetts, USA
    J Endod 36:322-8. 2010
    ..To study the in vitro effects of poly(lactic-co-glycolic acid) (PLGA) nanoparticles loaded with the photosensitizer methylene blue (MB) and light against Enterococcus faecalis (ATCC 29212)...
  37. ncbi Hyaluronic acid based self-assembling nanosystems for CD44 target mediated siRNA delivery to solid tumors
    Shanthi Ganesh
    Department of Pharmaceutical Sciences, School of Pharmacy, Bouve College of Health Sciences, Northeastern University, Boston, MA 02115, USA
    Biomaterials 34:3489-502. 2013
    ..The HA based nanosystems thus portend to be promising siRNA delivery vectors for systemic targeting of CD44 overexpressing cancers including tumor initiating (stem-) cells and metastatic lesions...
  38. ncbi Therapeutic strategies for endothelial dysfunction
    Dipti D Deshpande
    Northeastern University, School of Pharmacy, Bouve College of Health Sciences, Boston, MA 02115, USA
    Expert Opin Biol Ther 11:1637-54. 2011
    ....
  39. ncbi Long-circulating polymeric nanovectors for tumor-selective gene delivery
    Sushma Kommareddy
    Department of Pharmaceutical Sciences, School of Pharmacy, Northeastern University, Boston MA 02115, USA
    Technol Cancer Res Treat 4:615-25. 2005
    ..In addition to the long circulating property, modifications to improve the target specificity of the particles and the limitations of steric protection will be analyzed...
  40. ncbi Poly(ethylene oxide)-modified poly(beta-amino ester) nanoparticles as a pH-sensitive biodegradable system for paclitaxel delivery
    Anupama Potineni
    Department of Pharmaceutical Sciences, School of Pharmacy, Northeastern University, 110 Mugar Life Sciences Building, Boston, MA 02115, USA
    J Control Release 86:223-34. 2003
    ..Results of this study demonstrate that PEO-modified poly-1 nanoparticles could provide increased therapeutic benefit by delivering the encapsulated drug to solid tumors...

Research Grants11

  1. ORAL GENE THERAPY WITH NiMOS FOR INFLAMMATORY BOWEL DISEASE
    Mansoor M Amiji; Fiscal Year: 2010
    ..In addition, NiMOS would be useful for other oral gene therapy strategies for treatment of diseases or oral DNA vaccination. ..
  2. LONG-CIRCULATING TUMOR-SELECTIVE DNA DELIVERY SYSTEMS
    Mansoor Amiji; Fiscal Year: 2005
    ..The results of this study will provide valuable information on the development of safe and efficacious nonviral vectors for in vivo DNA delivery specifically to solid tumor. ..
  3. NANOTHERAPEUTIC STRATEGY FOR MULTIDRUG RESISTANT TUMORS
    Mansoor Amiji; Fiscal Year: 2009
    ..The multimodal nanocarrier strategy proposed here would provide a translatable approach to overcome MDR in cancer patients. ..