Research Topics
Genomes and Genes | Jeffrey A YoderSummaryAffiliation: North Carolina State University Country: USA Publications
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Publications
Evidence for a transposition event in a second NITR gene cluster in zebrafishJeffrey A Yoder
Department of Molecular Biomedical Sciences and Center for Comparative Medicine and Translational Research, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
Immunogenetics 60:257-65. 2008..Sequence features of the chromosomal region encoding nitr13 suggest that this gene arose via retrotransposition...
Form, function and phylogenetics of NITRs in bony fishJeffrey A Yoder
Department of Molecular Biomedical Sciences and Center for Comparative Medicine and Translational Research, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
Dev Comp Immunol 33:135-44. 2009..It is likely that all teleost species encode NITRs which function within innate immunity to regulate cell mediated cytotoxicity...
Structural characteristics of zebrafish orthologs of adaptor molecules that associate with transmembrane immune receptorsJeffrey A Yoder
Department of Molecular Biomedical Sciences and Center for Comparative Medicine and Translational Research, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
Gene 401:154-64. 2007..Their genomic organizations have been characterized, cDNA transcripts have been recovered, phylogenetic relationships have been defined and their cell lineage-specific expression patterns have been established...
Developmental and tissue-specific expression of NITRsJeffrey A Yoder
Department of Molecular Biomedical Sciences and Center for Comparative Medicine and Translational Research, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
Immunogenetics 62:117-22. 2010..Sequence analyses of NITR amplicons identify known alleles and reveal additional alleles within the nitr1, nitr2, nitr3, and nitr5 families, reflecting the recent evolution of this gene family...
The medaka novel immune-type receptor (NITR) gene clusters reveal an extraordinary degree of divergence in variable domainsSalil Desai
Department of Molecular Biomedical Sciences and Center for Comparative Medicine and Translational Research, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
BMC Evol Biol 8:177. 2008....
Development and characterization of anti-nitr9 antibodiesRadhika N Shah
Department of Molecular Biomedical Sciences and Center for Comparative Medicine and Translational Research, College of Veterinary Medicine, North Carolina State University, 1060 William Moore Drive, Raleigh, NC 27607, USA Immunology Program, College of Veterinary Medicine, North Carolina State University, 1060 William Moore Drive, Raleigh, NC 27607, USA
Adv Hematol 2012:596925. 2012..g., NK) function...
Resolution of the novel immune-type receptor gene cluster in zebrafishJeffrey A Yoder
Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
Proc Natl Acad Sci U S A 101:15706-11. 2004..These studies resolve a complete immune gene cluster in zebrafish and indicate that the NITRs represent the most complex family of activating/inhibitory surface receptors thus far described...
Sp2 is a maternally inherited transcription factor required for embryonic developmentJianzhen Xie
Department of Molecular Biomedical Sciences and the Center for Comparative Medicine and Translational Research, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27606, USA
J Biol Chem 285:4153-64. 2010....
A photoactivatable small-molecule inhibitor for light-controlled spatiotemporal regulation of Rho kinase in live embryosAllison R Morckel
Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
Development 139:437-42. 2012....
Enhanced transcription of complement and coagulation genes in the absence of adaptive immunityDereje D Jima
Department of Molecular Biomedical Sciences and Center for Comparative Medicine and Translational Research, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough St, Raleigh, NC 27606, USA
Mol Immunol 46:1505-16. 2009..Subsequent analyses of orthologous coagulation and complement genes in Rag1(-/-) mice indicate increased transcription of the complement C4 gene in the Rag1(-/-) intestine...
A myristoylated alanine-rich C kinase substrate-related peptide suppresses cytokine mRNA and protein expression in LPS-activated canine neutrophilsJingjing Li
Comparative Biomedical Sciences Graduate Program, North Carolina State University, Raleigh, NC 27606, USA
Am J Respir Cell Mol Biol 48:314-21. 2013....
Expression and function of triggering receptor expressed on myeloid cells-1 (TREM-1) on canine neutrophilsJingjing Li
Comparative Biomedical Sciences Graduate Program, North Carolina State University, Raleigh, 27606, USA
Dev Comp Immunol 35:872-80. 2011..These results have direct application to veterinary diagnostics as well as the potential to enhance the utility of canine disease models in the assessment of potential therapeutics in the treatment of human sepsis...
The phylogenetic origins of natural killer receptors and recognition: relationships, possibilities, and realitiesJeffrey A Yoder
Department of Molecular Biomedical Sciences and Center for Comparative Medicine and Translational Research, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
Immunogenetics 63:123-41. 2011..Nevertheless, several lines of evidence suggest that NK-type function or its equivalent has sustained a long evolutionary history throughout vertebrate species...
Photocaged morpholino oligomers for the light-regulation of gene function in zebrafish and Xenopus embryosAlexander Deiters
Department of Chemistry, North Carolina State University, Raleigh, North Carolina 27695, United States
J Am Chem Soc 132:15644-50. 2010..Our results suggest that photocaged morpholinos are readily synthesized and highly efficacious tools for light-activated spatiotemporal control of gene expression in multiple contexts...
On the origins of adaptive immunity: innate immune receptors join the taleTimo K van den Berg
Department of Molecular Cell Biology, VU Medical Center, PO Box 7057, 1007 MB, Amsterdam, The Netherlands
Trends Immunol 25:11-6. 2004..We propose the existence of an evolutionary and functional link between innate and adaptive immune receptors that sheds light on the nature of the antigen receptor predecessor(s)...
Immunoglobulin variable regions in molecules exhibiting characteristics of innate and adaptive immune receptorsGary W Litman
Department of Pediatrics, University of South Florida College of Medicine, USF ACH Children s Research Institute, 830 First Street South, St Petersburg, FL 33701, USA
Immunol Res 38:294-304. 2007..Both families of molecules encode V domains that share some characteristics of adaptive immune receptors but likely mediate innate functions...
Immune-related, lectin-like receptors are differentially expressed in the myeloid and lymphoid lineages of zebrafishPatoula G Panagos
Department of Biology, University of South Florida, 4202 East Fowler Avenue, Tampa, FL 33620, USA
Immunogenetics 58:31-40. 2006..Illr genes are differentially expressed in the myeloid and lymphoid lineages, suggesting that they may play important roles in the immune functions of multiple hematopoietic cell lineages...
The zebrafish activating immune receptor Nitr9 signals via Dap12Sheng Wei
Immunology Program, H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Avenue, Tampa, FL 33612, USA
Immunogenetics 59:813-21. 2007....
Cloning novel immune-type inhibitory receptors from the rainbow trout, Oncorhynchus mykissJeffrey A Yoder
Immunology Program, H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA
Immunogenetics 54:662-70. 2002..Several probable scenarios that explain the origins of variant forms of NITRs are described...
The zebrafish as a model organism to study development of the immune systemDavid Traver
Division of Hematology, Children's Hospital, 320, Longwood Avenue, Boston, MA 02115, USA
Adv Immunol 81:253-330. 2003
Investigating the morphology, function and genetics of cytotoxic cells in bony fishJeffrey A Yoder
Department of Biology, University of South Florida, 4202 East Fowler Avenue SCA 110, Tampa, FL 33620, USA
Comp Biochem Physiol C Toxicol Pharmacol 138:271-80. 2004..This review summarizes the morphological and functional evidence for cytotoxic cells within bony fish and discusses future directions for examining cytotoxicity through genomics and transgenics...
Zebrafish as an immunological model systemJeffrey A Yoder
Department of Biology, University of South Florida, 4202 East Fowler Avenue, Tampa, FL 33620, USA
Microbes Infect 4:1469-78. 2002..Recent advances in mutation screening, the creation of genomic resources, including the Zebrafish Genome Project and the development of efficient transgenesis procedures, make this model increasingly attractive for immunological study...
