Kevin P Williams

Summary

Affiliation: North Carolina Central University
Country: USA

Publications

  1. pmc Development of Fluorescence Polarization Assays for the Molecular Chaperone Hsp70 Family Members: Hsp72 and DnaK
    Laura Ricci
    Department of Pharmaceutical Sciences, Biomanufacturing Research Institute and Technology Enterprise, North Carolina Central University, 1801 Fayetteville Street, Durham, NC 27707, USA
    Curr Chem Genomics 2:90-5. 2008
  2. pmc Development and Implementation of a High Throughput Screen for the Human Sperm-Specific Isoform of Glyceraldehyde 3-Phosphate Dehydrogenase (GAPDHS)
    Jonathan Z Sexton
    Biomanufacturing Research Institute and Technology Enterprise, North Carolina Central University, Durham, NC 27707, USA
    Curr Chem Genomics 5:30-41. 2011
  3. pmc Quantitative high-throughput efficacy profiling of approved oncology drugs in inflammatory breast cancer models of acquired drug resistance and re-sensitization
    Kevin P Williams
    Biomanufacturing Research Institute and Technology Enterprise BRITE, North Carolina Central University, Durham, NC 27707, USA
    Cancer Lett 337:77-89. 2013
  4. pmc Recombinant human sperm-specific glyceraldehyde-3-phosphate dehydrogenase (GAPDHS) is expressed at high yield as an active homotetramer in baculovirus-infected insect cells
    David R Lamson
    Biomanufacturing Research Institute and Technology Enterprise, North Carolina Central University, Durham, NC 27707, USA
    Protein Expr Purif 75:104-13. 2011
  5. pmc Differential effects of arsenic trioxide on chemosensitization in human hepatic tumor and stellate cell lines
    Fatima Rangwala
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    BMC Cancer 12:402. 2012
  6. pmc Design and characterization of a photo-activatable hedgehog probe that mimics the natural lipidated form
    Alan J House
    Department of Pharmaceutical Sciences, Biomanufacturing Research Institute and Technology Enterprise, North Carolina Central University, Durham, NC, USA
    Arch Biochem Biophys 567:66-74. 2015

Collaborators

  • Gayathri R Devi
  • Fatima Rangwala
  • Michael A Morse
  • Alan J House
  • David R Lamson
  • Jonathan Z Sexton
  • Polina V Danshina
  • Li An Yeh
  • DEBORAH A O'BRIEN
  • Laura Ricci
  • Michael Tarpley
  • Laura R Daye
  • David S Lamson
  • Margie K Parker
  • Kezia Addo
  • Warren E Bealer
  • Khaddijatou Sanyang
  • Mark Hughes

Detail Information

Publications6

  1. pmc Development of Fluorescence Polarization Assays for the Molecular Chaperone Hsp70 Family Members: Hsp72 and DnaK
    Laura Ricci
    Department of Pharmaceutical Sciences, Biomanufacturing Research Institute and Technology Enterprise, North Carolina Central University, 1801 Fayetteville Street, Durham, NC 27707, USA
    Curr Chem Genomics 2:90-5. 2008
    ..We would predict that these assays will be suitable for identifying both selective chemical probes of Hsp70 family members and "pan" Hsp70 inhibitors...
  2. pmc Development and Implementation of a High Throughput Screen for the Human Sperm-Specific Isoform of Glyceraldehyde 3-Phosphate Dehydrogenase (GAPDHS)
    Jonathan Z Sexton
    Biomanufacturing Research Institute and Technology Enterprise, North Carolina Central University, Durham, NC 27707, USA
    Curr Chem Genomics 5:30-41. 2011
    ..8 to 42 ┬ÁM. These compounds may provide useful scaffolds as molecular tools to probe the role of GAPDHS in sperm motility and long term to develop potent and selective GAPDHS inhibitors leading to novel contraceptive agents...
  3. pmc Quantitative high-throughput efficacy profiling of approved oncology drugs in inflammatory breast cancer models of acquired drug resistance and re-sensitization
    Kevin P Williams
    Biomanufacturing Research Institute and Technology Enterprise BRITE, North Carolina Central University, Durham, NC 27707, USA
    Cancer Lett 337:77-89. 2013
    ..We suggest that our findings provide a unique IBC model system for gaining an understanding of acquired therapeutic resistance and the effect of redox adaptation on anti-cancer drug efficacy. ..
  4. pmc Recombinant human sperm-specific glyceraldehyde-3-phosphate dehydrogenase (GAPDHS) is expressed at high yield as an active homotetramer in baculovirus-infected insect cells
    David R Lamson
    Biomanufacturing Research Institute and Technology Enterprise, North Carolina Central University, Durham, NC 27707, USA
    Protein Expr Purif 75:104-13. 2011
    ....
  5. pmc Differential effects of arsenic trioxide on chemosensitization in human hepatic tumor and stellate cell lines
    Fatima Rangwala
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    BMC Cancer 12:402. 2012
    ..The aim was to compare the chemosensitization potential of arsenic trioxide (ATO) in combination with sorafenib or fluorouracil (5-FU), in both hepatic tumor cells and stromal cells...
  6. pmc Design and characterization of a photo-activatable hedgehog probe that mimics the natural lipidated form
    Alan J House
    Department of Pharmaceutical Sciences, Biomanufacturing Research Institute and Technology Enterprise, North Carolina Central University, Durham, NC, USA
    Arch Biochem Biophys 567:66-74. 2015
    ..We suggest that Bzm-ShhN can serve as a relatively facile and preferred source of ShhNp for in vitro assays and as a probe to identify novel Hh protein interactions. ..