Bruce S Weir

Summary

Affiliation: North Carolina State University
Country: USA

Publications

  1. pmc Linkage disequilibrium in wild mice
    Cathy C Laurie
    Department of Biostatistics, University of Washington, Seattle, Washington, United States of America
    PLoS Genet 3:e144. 2007
  2. ncbi request reprint Bioinformatics and approaches to identifying polygenic susceptibility traits
    Bruce S Weir
    Bioinformatics Research Center, North Carolina State University, Raleigh, North Carolina 27695 7566, USA
    Ann Periodontol 7:1-7. 2002
  3. ncbi request reprint Allelic association patterns for a dense SNP map
    B S Weir
    Program in Statistical Genetics, Department of Statistics, North Carolina State University, Raleigh, North Carolina 27695 7566, USA
    Genet Epidemiol 27:442-50. 2004
  4. ncbi request reprint Allele frequency data for Profiler Plus Loci in Australia
    Bruce S Weir
    Program in Statistical Genetics, Department of Statistics, NC State University, Raleigh NC 27695 7566, USA
    J Forensic Sci 49:1121-3. 2004
  5. pmc Measures of human population structure show heterogeneity among genomic regions
    Bruce S Weir
    Program in Statistical Genetics, Department of Statistics, North Carolina State University, Raleigh, North Carolina 27695 7566, USA
    Genome Res 15:1468-76. 2005
  6. ncbi request reprint Association studies under general disease models
    D M Nielsen
    Program in Statistical Genetics, Department of Statistics, North Carolina State University, Raleigh, North Carolina 27695-7566, USA
    Theor Popul Biol 60:253-63. 2001
  7. pmc Effect of two- and three-locus linkage disequilibrium on the power to detect marker/phenotype associations
    Dahlia M Nielsen
    Program in Statistical Genetics, Department of Statistics, North Carolina State University, Raleigh, North Carolina 27695 7566, USA
    Genetics 168:1029-40. 2004
  8. ncbi request reprint It was one of my brothers
    Amy D Anderson
    Bioinformatics Research Center, North Carolina State University, Campus Box 7566, Raleigh, NC 27695 7566, USA
    Int J Legal Med 120:95-104. 2006
  9. ncbi request reprint Analysis of single nucleotide polymorphisms in candidate genes using the pedigree disequilibrium test
    S W Hardy
    Bioinformatics Research Center, North Carolina State University, Raleigh, North Carolina, USA
    Genet Epidemiol 21:S441-6. 2001
  10. ncbi request reprint Matching and partially-matching DNA profiles
    Bruce S Weir
    Program in Statistical Genetics, Department of Statistics, North Carolina State University, Raleigh, NC 7695 7566, USA
    J Forensic Sci 49:1009-14. 2004

Detail Information

Publications26

  1. pmc Linkage disequilibrium in wild mice
    Cathy C Laurie
    Department of Biostatistics, University of Washington, Seattle, Washington, United States of America
    PLoS Genet 3:e144. 2007
    ....
  2. ncbi request reprint Bioinformatics and approaches to identifying polygenic susceptibility traits
    Bruce S Weir
    Bioinformatics Research Center, North Carolina State University, Raleigh, North Carolina 27695 7566, USA
    Ann Periodontol 7:1-7. 2002
    ..Current thinking tends to focus on relatively conserved "haplotype blocks" instead of single genetic markers, although there is no consensus on the utility of this emphasis...
  3. ncbi request reprint Allelic association patterns for a dense SNP map
    B S Weir
    Program in Statistical Genetics, Department of Statistics, North Carolina State University, Raleigh, North Carolina 27695 7566, USA
    Genet Epidemiol 27:442-50. 2004
    ..A useful preliminary investigation of datasets of this type is provided by counting the numbers of distinct multi-locus genotypes in windows of a few markers...
  4. ncbi request reprint Allele frequency data for Profiler Plus Loci in Australia
    Bruce S Weir
    Program in Statistical Genetics, Department of Statistics, NC State University, Raleigh NC 27695 7566, USA
    J Forensic Sci 49:1121-3. 2004
  5. pmc Measures of human population structure show heterogeneity among genomic regions
    Bruce S Weir
    Program in Statistical Genetics, Department of Statistics, North Carolina State University, Raleigh, North Carolina 27695 7566, USA
    Genome Res 15:1468-76. 2005
    ..Furthermore, it may be that the best indications of selection will come from population-specific F(ST) values rather than the usually reported population-average values...
  6. ncbi request reprint Association studies under general disease models
    D M Nielsen
    Program in Statistical Genetics, Department of Statistics, North Carolina State University, Raleigh, North Carolina 27695-7566, USA
    Theor Popul Biol 60:253-63. 2001
    ..It is likely that these two-marker analyses will provide additional information in association mapping studies...
  7. pmc Effect of two- and three-locus linkage disequilibrium on the power to detect marker/phenotype associations
    Dahlia M Nielsen
    Program in Statistical Genetics, Department of Statistics, North Carolina State University, Raleigh, North Carolina 27695 7566, USA
    Genetics 168:1029-40. 2004
    ..Single-marker tests tend to prevail when pairwise LD is high. For moderate pairwise values and weak multilocus LD, either testing strategy may come out ahead, although it is also quite likely that neither has much power...
  8. ncbi request reprint It was one of my brothers
    Amy D Anderson
    Bioinformatics Research Center, North Carolina State University, Campus Box 7566, Raleigh, NC 27695 7566, USA
    Int J Legal Med 120:95-104. 2006
    ..We show that, under many circumstances, this upper bound itself provides an extremely quick and accurate estimate of the probability that at least one of the relatives matches the suspect's profile...
  9. ncbi request reprint Analysis of single nucleotide polymorphisms in candidate genes using the pedigree disequilibrium test
    S W Hardy
    Bioinformatics Research Center, North Carolina State University, Raleigh, North Carolina, USA
    Genet Epidemiol 21:S441-6. 2001
    ..Our results indicate that, using the PDT, functional disease-associated SNPs can be successfully identified with a dense map of moderately polymorphic SNPs...
  10. ncbi request reprint Matching and partially-matching DNA profiles
    Bruce S Weir
    Program in Statistical Genetics, Department of Statistics, North Carolina State University, Raleigh, NC 7695 7566, USA
    J Forensic Sci 49:1009-14. 2004
    ..It is very likely that two individuals with at least 9 matching loci among the 13 CODIS loci have already been typed...
  11. pmc A comparative study of sibship tests of linkage and/or association
    S A Monks
    Biostatistics Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Am J Hum Genet 63:1507-16. 1998
    ..We also examine the consequences of having some parental data in the sample...
  12. pmc Hardy-Weinberg testing for continuous data
    L M McIntyre
    Department of Statistics, North Carolina State University, Raleigh 27695 8203, USA
    Genetics 147:1965-75. 1997
    ..Results indicate that the power of T(CCS) is better than that of T(HD), but neither is as powerful as T(FET). The intraclass correlation test does not perform as well as the other tests examined in this article...
  13. pmc Estimating the total number of alleles using a sample coverage method
    S P Huang
    Program in Statistical Genetics, Department of Statistics, North Carolina State University, Raleigh, North Carolina 27695-7566, USA
    Genetics 159:1365-73. 2001
    ..Possible applications include improving the characterization of the prior distribution for the allele frequencies, adjusting the estimates of genetic diversity, and estimating the range of microsatellite alleles...
  14. pmc Conditional genotypic probabilities for microsatellite loci
    J Graham
    National Institute of Statistical Sciences, Department of Statistics, North Carolina State University, Raleigh, North Carolina 27695 8203, USA
    Genetics 155:1973-80. 2000
    ..However, Dirichlet-based estimators were less biased than the product-rule estimator, which ignores coancestry...
  15. pmc Genotypic probabilities for pairs of inbred relatives
    Wenlei Liu
    Department of Statistics, North Carolina State University, Raleigh, NC 27695 7566, USA
    Philos Trans R Soc Lond B Biol Sci 360:1379-85. 2005
    ..These results have application in affected-relative tests for linkage, and in methods for interpreting forensic genetic profiles...
  16. ncbi request reprint Comparison of Li-Wong and loglinear mixed models for the statistical analysis of oligonucleotide arrays
    Tzu Ming Chu
    Department of Statistics, North Carolina State University, Raleigh, NC 27695, USA
    Bioinformatics 20:500-6. 2004
    ..Advantages of both methods include the ability to directly assess and account for key sources of variability in the chip data and a means to automate statistical quality control...
  17. ncbi request reprint Estimating F-statistics
    B S Weir
    Program in Statistical Genetics, Department of Statistics, North Carolina State University, Raleigh, North Carolina 27695 7566, USA
    Annu Rev Genet 36:721-50. 2002
    ..The review concludes by relating functions of theta values to times of population divergence under a pure drift model...
  18. pmc Correlation-based inference for linkage disequilibrium with multiple alleles
    Dmitri V Zaykin
    National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Genetics 180:533-45. 2008
    ..We provide a computer program that evaluates approximate as well as "exact" permutational P-values...
  19. pmc Genome-wide detection and characterization of positive selection in human populations
    Pardis C Sabeti
    Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02139, USA
    Nature 449:913-8. 2007
    ....
  20. pmc A second generation human haplotype map of over 3.1 million SNPs
    Kelly A Frazer
    The Scripps Research Institute, 10550 North Torrey Pines Road MEM275, La Jolla, California 92037, USA
    Nature 449:851-61. 2007
    ..Finally, we demonstrate increased differentiation at non-synonymous, compared to synonymous, SNPs, resulting from systematic differences in the strength or efficacy of natural selection between populations...
  21. pmc A maximum-likelihood method for the estimation of pairwise relatedness in structured populations
    Amy D Anderson
    Department of Biostatistics, University of Washington, Seattle, Washington 98195, USA
    Genetics 176:421-40. 2007
    ..This estimator is shown to work quite well, even when the value of F(ST) is misspecified. Bootstrap confidence intervals are also examined and shown to exhibit close to nominal coverage when F(ST) is correctly specified...
  22. pmc Three major haplotypes of the beta2 adrenergic receptor define psychological profile, blood pressure, and the risk for development of a common musculoskeletal pain disorder
    Luda Diatchenko
    University of North Carolina, Center for Neurosensory Disorders, North Carolina, USA
    Am J Med Genet B Neuropsychiatr Genet 141:449-62. 2006
    ....
  23. pmc Evaluation of DNA pooling for the estimation of microsatellite allele frequencies: a case study using striped bass (Morone saxatilis)
    Garrick T Skalski
    Department of Ecology and Evolutionary Biology, University of Kansas, Lawrence, Kansas 66045, USA
    Genetics 173:863-75. 2006
    ..DNA pooling yields the most potential cost savings when a large number of loci are employed using a large number of individuals, a situation becoming increasingly common as microsatellite loci are developed in increasing numbers of taxa...
  24. ncbi request reprint Genetic relatedness analysis: modern data and new challenges
    Bruce S Weir
    Department of Biostatistics, University of Washington, Box 357232, Seattle, Washington 98195 7232, USA
    Nat Rev Genet 7:771-80. 2006
    ....
  25. pmc Prediction of multi-locus inbreeding coefficients and relation to linkage disequilibrium in random mating populations
    William G Hill
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, West Mains Road, Edinburgh, EH9 3JT, UK
    Theor Popul Biol 72:179-85. 2007
    ..The results can be applied to predict multi-locus identity in, for example, gene mapping...
  26. pmc The 2004 Genetics Society of America Medal
    Bruce S Weir
    Genetics 166:647-8. 2004