Jung Ying Tzeng

Summary

Affiliation: North Carolina State University
Country: USA

Publications

  1. pmc On the Aggregation of Multimarker Information for Marker-Set and Sequencing Data Analysis: Genotype Collapsing vs. Similarity Collapsing
    Monnat Pongpanich
    Bioinformatics Research Center, North Carolina State University Raleigh, NC, USA
    Front Genet 2:110. 2011
  2. pmc Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccolo
    P F Sullivan
    Department of Genetics, University of North Carolina, Chapel Hill, NC 27599 7264, USA
    Mol Psychiatry 14:359-75. 2009
  3. pmc Combining an evolution-guided clustering algorithm and haplotype-based LRT in family association studies
    Mei Hsien Lee
    Department of Public Health and Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei 10055, Taiwan
    BMC Genet 12:48. 2011
  4. pmc Haplotype-based pharmacogenetic analysis for longitudinal quantitative traits in the presence of dropout
    Jung Ying Tzeng
    Department of Statistics, North Carolina State University, Raleigh, North Carolina, USA
    J Biopharm Stat 20:334-50. 2010
  5. pmc A comprehensive approach to haplotype-specific analysis by penalized likelihood
    Jung Ying Tzeng
    Department of Statistics, North Carolina State University, Campus Box 7566, Raleigh NC 27695, USA
    Eur J Hum Genet 18:95-103. 2010
  6. pmc Gene-trait similarity regression for multimarker-based association analysis
    Jung Ying Tzeng
    Department of Statistics, North Carolina State University, Raleigh, North Carolina 27695, USA
    Biometrics 65:822-32. 2009
  7. pmc Haplotype-based association analysis via variance-components score test
    Jung Ying Tzeng
    Department of Statistics, North Carolina State University, Raleigh, NC 27695, USA
    Am J Hum Genet 81:927-38. 2007
  8. pmc Regression-based association analysis with clustered haplotypes through use of genotypes
    Jung Ying Tzeng
    Department of Statistics and Bioinformatics Research Center, North Carolina State University, Raleigh, NC 27695, USA
    Am J Hum Genet 78:231-42. 2006
  9. ncbi request reprint Evolutionary-based grouping of haplotypes in association analysis
    Jung Ying Tzeng
    Department of Statistics and Bioinformatics Research Center, North Carolina State University, Raleigh, USA
    Genet Epidemiol 28:220-31. 2005
  10. pmc Studying gene and gene-environment effects of uncommon and common variants on continuous traits: a marker-set approach using gene-trait similarity regression
    Jung Ying Tzeng
    Department of Statistics, North Carolina State University, Raleigh, NC 27695, USA
    Am J Hum Genet 89:277-88. 2011

Research Grants

Collaborators

Detail Information

Publications16

  1. pmc On the Aggregation of Multimarker Information for Marker-Set and Sequencing Data Analysis: Genotype Collapsing vs. Similarity Collapsing
    Monnat Pongpanich
    Bioinformatics Research Center, North Carolina State University Raleigh, NC, USA
    Front Genet 2:110. 2011
    ..We find that it is reasonably robust across all simulated scenarios...
  2. pmc Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccolo
    P F Sullivan
    Department of Genetics, University of North Carolina, Chapel Hill, NC 27599 7264, USA
    Mol Psychiatry 14:359-75. 2009
    ..With the integrated replication effort, we present a specific hypothesis for further studies...
  3. pmc Combining an evolution-guided clustering algorithm and haplotype-based LRT in family association studies
    Mei Hsien Lee
    Department of Public Health and Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei 10055, Taiwan
    BMC Genet 12:48. 2011
    ..Here based on family data we propose to cluster long haplotypes of linked SNPs in a biological sense, so that the number of haplotypes can be reduced and the power of statistical tests of association can be increased...
  4. pmc Haplotype-based pharmacogenetic analysis for longitudinal quantitative traits in the presence of dropout
    Jung Ying Tzeng
    Department of Statistics, North Carolina State University, Raleigh, North Carolina, USA
    J Biopharm Stat 20:334-50. 2010
    ..The proposed methods are easy to implement, computationally efficient, and provide an optimal balance between false positives and false negatives in detecting genetic effects...
  5. pmc A comprehensive approach to haplotype-specific analysis by penalized likelihood
    Jung Ying Tzeng
    Department of Statistics, North Carolina State University, Campus Box 7566, Raleigh NC 27695, USA
    Eur J Hum Genet 18:95-103. 2010
    ....
  6. pmc Gene-trait similarity regression for multimarker-based association analysis
    Jung Ying Tzeng
    Department of Statistics, North Carolina State University, Raleigh, North Carolina 27695, USA
    Biometrics 65:822-32. 2009
    ....
  7. pmc Haplotype-based association analysis via variance-components score test
    Jung Ying Tzeng
    Department of Statistics, North Carolina State University, Raleigh, NC 27695, USA
    Am J Hum Genet 81:927-38. 2007
    ..The broad coverage and the fast and easy implementation of this method make the VC strategy an effective tool for haplotype analysis, even in modern genomewide association studies...
  8. pmc Regression-based association analysis with clustered haplotypes through use of genotypes
    Jung Ying Tzeng
    Department of Statistics and Bioinformatics Research Center, North Carolina State University, Raleigh, NC 27695, USA
    Am J Hum Genet 78:231-42. 2006
    ..Through simulation studies, we assessed the performance of the proposed approach and demonstrate its validity and power in testing for haplotype-trait association...
  9. ncbi request reprint Evolutionary-based grouping of haplotypes in association analysis
    Jung Ying Tzeng
    Department of Statistics and Bioinformatics Research Center, North Carolina State University, Raleigh, USA
    Genet Epidemiol 28:220-31. 2005
    ..Simulation results indicate power increases for performing tests on the haplotype clusters when compared to tests using original haplotypes or the truncated haplotype distribution...
  10. pmc Studying gene and gene-environment effects of uncommon and common variants on continuous traits: a marker-set approach using gene-trait similarity regression
    Jung Ying Tzeng
    Department of Statistics, North Carolina State University, Raleigh, NC 27695, USA
    Am J Hum Genet 89:277-88. 2011
    ..These features make it an ideal tool for evaluating associations between phenotype and marker sets defined by linkage disequilibrium (LD) blocks, genes, or pathways in whole-genome analysis...
  11. pmc Evaluating haplotype effects in case-control studies via penalized-likelihood approaches: prospective or retrospective analysis?
    Megan L Koehler
    Department of Statistics, North Carolina State University, Raleigh, North Carolina 27695, USA
    Genet Epidemiol 34:892-911. 2010
    ..An application of these methods to the Genetic Analysis Workshop 15 rheumatoid arthritis data is provided...
  12. pmc A regression-based association test for case-control studies that uses inferred ancestral haplotype similarity
    Youfang Liu
    Bioinformatics Research Center, North Carolina State University, Raleigh, NC 27569 7566, USA
    Ann Hum Genet 73:520-6. 2009
    ..We applied our method to the Genetic Analysis Workshop 15 simulated SNP data and successfully pinpointed a stretch of SNPs that covers the fine-scale region where the causal locus is located...
  13. pmc A quality control algorithm for filtering SNPs in genome-wide association studies
    Monnat Pongpanich
    Bioinformatics Research Center, North Carolina State University, Raleigh, NC 27695 7566, USA
    Bioinformatics 26:1731-7. 2010
    ..The rationale of the expert filters is sensible and concrete, but its implementation requires arbitrary thresholds and does not jointly consider all QC features...
  14. pmc On the identification of disease mutations by the analysis of haplotype similarity and goodness of fit
    Jung Ying Tzeng
    Department of Statistics, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Am J Hum Genet 72:891-902. 2003
    ..We show that both approaches can be powerful, but under quite different conditions. Moreover, we show that the power of both approaches can be enhanced by clustering rare haplotypes from the distributions before performing a test...
  15. pmc Heritability and genomics of gene expression in peripheral blood
    Fred A Wright
    1 Bioinformatics Research Center, North Carolina State University, Raleigh, North Carolina, USA 2 Department of Statistics, North Carolina State University, Raleigh, North Carolina, USA 3 Department of Biological Sciences, North Carolina State University, Raleigh, North Carolina, USA 4
    Nat Genet 46:430-7. 2014
    ..Our results provide a new resource toward understanding the genetic control of transcription. ..
  16. ncbi request reprint A two-stage design for multiple testing in large-scale association studies
    Shu Hui Wen
    Department of Public Health, College of Medicine, Tzu Chi University, Hua lien, 97004, Taiwan
    J Hum Genet 51:523-32. 2006
    ..We also report the analytical form of its overall FPR, which may be useful in guiding study design to achieve a high TPR while retaining the desired FPR...

Research Grants2

  1. Genome-wide Haplotype Association Analysis in Mental Disorders
    Jung Ying Tzeng; Fiscal Year: 2009
    ..These tools can facilitate scientists' understanding of complex diseases and eventually lead to better design of prevention, detection and treatment strategies to improve human health. ..
  2. Genome-wide Haplotype Association Analysis in Mental Disorders
    Jung Ying Tzeng; Fiscal Year: 2010
    ..These tools can facilitate scientists'understanding of complex diseases and eventually lead to better design of prevention, detection and treatment strategies to improve human health. ..