Kevin Tracey

Summary

Affiliation: North Shore University Hospital
Country: USA

Publications

  1. ncbi request reprint Immune cells exploit a neural circuit to enter the CNS
    Kevin J Tracey
    Laboratory of Biomedical Science, Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY 11030, USA
    Cell 148:392-4. 2012
  2. pmc Splenectomy inactivates the cholinergic antiinflammatory pathway during lethal endotoxemia and polymicrobial sepsis
    Jared M Huston
    Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, North Shore LIJ Health System, Manhasset, NY 11030, USA
    J Exp Med 203:1623-8. 2006
  3. pmc Systemic release of high mobility group box 1 (HMGB1) protein is associated with severe and fatal Plasmodium falciparum malaria
    Sarah J Higgins
    Sandra A Rotman Laboratory, McLaughlin Rotman Centre for Global Health, University Health Network University of Toronto, Toronto, ON, Canada
    Malar J 12:105. 2013
  4. pmc Fat meets the cholinergic antiinflammatory pathway
    Kevin J Tracey
    North Shore LIJ Research Institute, Manhassset, NY 11030, USA
    J Exp Med 202:1017-21. 2005
  5. doi request reprint Reflex control of immunity
    Kevin J Tracey
    Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, New York 11030, USA
    Nat Rev Immunol 9:418-28. 2009
  6. pmc Physiology and immunology of the cholinergic antiinflammatory pathway
    Kevin J Tracey
    The Feinstein Institute for Medical Research, Manhasset, New York 11030, USA
    J Clin Invest 117:289-96. 2007
  7. doi request reprint It takes guts to grow a brain: Increasing evidence of the important role of the intestinal microflora in neuro- and immune-modulatory functions during development and adulthood
    Betty Diamond
    Center for Autoimmune and Musculoskeletal Diseases, The Feinstein Institute for Medical Research, North Shore Long Island Jewish Health System, Manhasset, NY, USA
    Bioessays 33:588-91. 2011
  8. ncbi request reprint It takes nerve to dampen inflammation
    Christine N Metz
    Nat Immunol 6:756-7. 2005
  9. ncbi request reprint Elevated high-mobility group box 1 levels in patients with cerebral and myocardial ischemia
    Richard S Goldstein
    Department of Emergency Medicine, North Shore University Hospital, North Shore LIJ, Manhasset, NY 11030, USA
    Shock 25:571-4. 2006
  10. ncbi request reprint The vagus nerve and nicotinic receptors modulate experimental pancreatitis severity in mice
    David J van Westerloo
    Laboratory of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Gastroenterology 130:1822-30. 2006

Research Grants

  1. Macrophage Inactivation in Sepsis after Shock or Trauma
    Kevin J Tracey; Fiscal Year: 2010
  2. HMG in Post Operative and Traumatic Stress
    Kevin Tracey; Fiscal Year: 2007
  3. Macrophage Inactivation in Sepsis after Shock or Trauma
    Kevin Tracey; Fiscal Year: 2007
  4. GENERAL CLINICAL RESEARCH CENTER
    Kevin Tracey; Fiscal Year: 2009
  5. GENERAL CLINICAL RESEARCH CENTER
    Kevin J Tracey; Fiscal Year: 2010
  6. MACROPHAGE INACTIVATION IN SEPSIS AFTER TRAUMA OR SHOCK
    Kevin Tracey; Fiscal Year: 2006
  7. MACROPHAGE INACTIVATION IN SEPSIS AFTER TRAUMA OR SHOCK
    Kevin Tracey; Fiscal Year: 2001
  8. HMG-1 IN POST-OPERATIVE AND TRAUMATIC SEPSIS
    Kevin Tracey; Fiscal Year: 2004

Collaborators

Detail Information

Publications66

  1. ncbi request reprint Immune cells exploit a neural circuit to enter the CNS
    Kevin J Tracey
    Laboratory of Biomedical Science, Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY 11030, USA
    Cell 148:392-4. 2012
    ..Using a mouse model of MS, Arima et al. now show that this attack begins at a specific spinal cord location. T cell entry into the CNS is regulated by a reflex neural circuit originating from leg muscle contractions...
  2. pmc Splenectomy inactivates the cholinergic antiinflammatory pathway during lethal endotoxemia and polymicrobial sepsis
    Jared M Huston
    Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, North Shore LIJ Health System, Manhasset, NY 11030, USA
    J Exp Med 203:1623-8. 2006
    ....
  3. pmc Systemic release of high mobility group box 1 (HMGB1) protein is associated with severe and fatal Plasmodium falciparum malaria
    Sarah J Higgins
    Sandra A Rotman Laboratory, McLaughlin Rotman Centre for Global Health, University Health Network University of Toronto, Toronto, ON, Canada
    Malar J 12:105. 2013
    ..High mobility group box 1 (HMGB1) protein is an important mediator of inflammation implicated in sepsis pathophysiology...
  4. pmc Fat meets the cholinergic antiinflammatory pathway
    Kevin J Tracey
    North Shore LIJ Research Institute, Manhassset, NY 11030, USA
    J Exp Med 202:1017-21. 2005
    ..Here we discuss this new data and its potential implications for dietary intervention in the treatment of inflammatory diseases...
  5. doi request reprint Reflex control of immunity
    Kevin J Tracey
    Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, New York 11030, USA
    Nat Rev Immunol 9:418-28. 2009
    ..It might be possible to develop therapeutics that target neural networks for the treatment of inflammatory disorders...
  6. pmc Physiology and immunology of the cholinergic antiinflammatory pathway
    Kevin J Tracey
    The Feinstein Institute for Medical Research, Manhasset, New York 11030, USA
    J Clin Invest 117:289-96. 2007
    ..Herein is a review of this physiological, functional anatomical mechanism for neurological regulation of cytokine-dependent disease that begins to define an immunological homunculus...
  7. doi request reprint It takes guts to grow a brain: Increasing evidence of the important role of the intestinal microflora in neuro- and immune-modulatory functions during development and adulthood
    Betty Diamond
    Center for Autoimmune and Musculoskeletal Diseases, The Feinstein Institute for Medical Research, North Shore Long Island Jewish Health System, Manhasset, NY, USA
    Bioessays 33:588-91. 2011
    ..These observations necessitate a new look at the many interconnections of the immune system and the brain, suggesting new frontiers for research and new therapeutic strategies for neurodevelopmental diseases...
  8. ncbi request reprint It takes nerve to dampen inflammation
    Christine N Metz
    Nat Immunol 6:756-7. 2005
  9. ncbi request reprint Elevated high-mobility group box 1 levels in patients with cerebral and myocardial ischemia
    Richard S Goldstein
    Department of Emergency Medicine, North Shore University Hospital, North Shore LIJ, Manhasset, NY 11030, USA
    Shock 25:571-4. 2006
    ..8+/-10.9 ng/mL, vs. cerebral ischemia serum HMGB1, 218+/-18.8 ng/mL; P<0.001). These results suggest that systemic HMGB1 levels are elevated in human ischemic disease...
  10. ncbi request reprint The vagus nerve and nicotinic receptors modulate experimental pancreatitis severity in mice
    David J van Westerloo
    Laboratory of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Gastroenterology 130:1822-30. 2006
    ..This anti-inflammatory effect is mediated by an interaction of acetylcholine, the principal neurotransmitter of the vagus nerve, with macrophage cholinergic nicotinic receptors expressing the alpha7 subunit...
  11. ncbi request reprint HMGB1 activates replication of latent HIV-1 in a monocytic cell-line, but inhibits HIV-1 replication in primary macrophages
    Piotr Nowak
    Division of Clinical Virology, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Cytokine 34:17-23. 2006
    ..Our data suggest that extracellular HMGB1 has a dichotomic effect on the HIV-1 infection in monocytes but not in lymphocytes. Both activation of latent HIV-1 infection and inhibition of active replication can thus be seen in vitro...
  12. ncbi request reprint The cholinergic anti-inflammatory pathway
    Valentin A Pavlov
    Laboratory of Biomedical Science, Institute for Medical Research North Shore LIJ Health System, Manhasset, NY 11030, USA
    Brain Behav Immun 19:493-9. 2005
    ..We also discuss possible clinical implications of vagus nerve stimulation and cholinergic modalities in the treatment of inflammatory diseases...
  13. pmc Central muscarinic cholinergic regulation of the systemic inflammatory response during endotoxemia
    Valentin A Pavlov
    Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY 11030, USA
    Proc Natl Acad Sci U S A 103:5219-23. 2006
    ..The role of central muscarinic receptors in activating the cholinergic antiinflammatory pathway is of interest for the use of centrally acting muscarinic cholinergic enhancers as antiinflammatory agents...
  14. pmc The aqueous extract of a popular herbal nutrient supplement, Angelica sinensis, protects mice against lethal endotoxemia and sepsis
    Haichao Wang
    Department of Emergency Medicine, North Shore University Hospital, New York University School of Medicine, Manhasset, NY 11030, USA
    J Nutr 136:360-5. 2006
    ..sinensis contains water-soluble components that exert protective effects against lethal endotoxemia and experimental sepsis in part by attenuating systemic accumulation of a late proinflammatory cytokine, HMGB1...
  15. ncbi request reprint High mobility group box 1 (HMGB1)
    Huan Yang
    Laboratory of Biomedical Sciences, Institute for Medical Research, North Shore Long Island Jewish Health System, Manhasset, NY, USA
    Crit Care Med 33:S472-4. 2005
  16. ncbi request reprint Alpha-chemokine receptor blockade reduces high mobility group box 1 protein-induced lung inflammation and injury and improves survival in sepsis
    Xinchun Lin
    Department of Surgery, North Shore University Hospital, Long Island Jewish Medical Center, Manhasset, NY 11030, USA
    Am J Physiol Lung Cell Mol Physiol 289:L583-90. 2005
    ..These data demonstrate that alpha-chemokine receptor inhibition can reduce HMGB1-induced lung injury and lethality in established sepsis and may provide a novel treatment in this devastating disease...
  17. ncbi request reprint High-mobility group box 1 protein is an inflammatory mediator in necrotizing enterocolitis: protective effect of the macrophage deactivator semapimod
    Ruben Zamora
    Dept of Pediatric Surgery, Children s Hospital of Pittsburgh, PA 15213, USA
    Am J Physiol Gastrointest Liver Physiol 289:G643-52. 2005
    ....
  18. ncbi request reprint Suppressor alphabeta T lymphocytes control innate resistance to endotoxic shock
    Jessica Jones-Carson
    Departments of Medicine, and Microbiology, University of Colorado Health Sciences Center, Denver, USA
    J Infect Dis 192:1039-46. 2005
    ..These observations suggest that suppressor alphabeta T lymphocytes protect against the proinflammatory cascade unleashed during the innate stages of endotoxemia...
  19. ncbi request reprint ISO-1 binding to the tautomerase active site of MIF inhibits its pro-inflammatory activity and increases survival in severe sepsis
    Yousef Al-Abed
    Laboratory of Medicinal Chemistry, North Shore Long Island Jewish Institute for Medical Research, Manhasset, New York 11030, USA
    J Biol Chem 280:36541-4. 2005
    ....
  20. pmc Anti-HMGB1 neutralizing antibody ameliorates gut barrier dysfunction and improves survival after hemorrhagic shock
    Runkuan Yang
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, PA 15621, USA
    Mol Med 12:105-14. 2006
    ..These data support the notion that HMGB1 is a mediator of HS/R-induced gut barrier dysfunction and suggest that anti-HMGB1 antibodies warrant further evaluation as a therapeutic to ameliorate the morbidity of HS/R in trauma patients...
  21. pmc Splenic nerve is required for cholinergic antiinflammatory pathway control of TNF in endotoxemia
    Mauricio Rosas-Ballina
    Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY 11030, USA
    Proc Natl Acad Sci U S A 105:11008-13. 2008
    ....
  22. pmc Modulation of TNF release by choline requires alpha7 subunit nicotinic acetylcholine receptor-mediated signaling
    William R Parrish
    Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, North Shore LIJ Health System, Manhasset, New York 11030, USA
    Mol Med 14:567-74. 2008
    ..Collectively, these data characterize the anti-inflammatory efficacy of choline and demonstrate that the modulation of TNF release by choline requires alpha7nAChR-mediated signaling...
  23. ncbi request reprint From CNI-1493 to the immunological homunculus: physiology of the inflammatory reflex
    Stacey L Oke
    Feinstein Institute for Medical Research, North Shore LIJ Health System, 350 Community Drive, Manhasset, NY 11030, USA
    J Leukoc Biol 83:512-7. 2008
    ..Receptor-ligand engagement suppresses proinflammatory cytokines and prevents tissue damage. Herein is a review of some of the experimental studies that define the inflammatory reflex and its anatomic and physiologic components...
  24. ncbi request reprint Transcutaneous vagus nerve stimulation reduces serum high mobility group box 1 levels and improves survival in murine sepsis
    Jared M Huston
    Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, Manhasset, NY 11030, USA
    Crit Care Med 35:2762-8. 2007
    ..Here we developed a method of transcutaneous mechanical vagus nerve stimulation and then investigated whether this therapy can protect mice against sepsis lethality...
  25. ncbi request reprint Systemic inflammation and remote organ injury following trauma require HMGB1
    Ryan M Levy
    Dept of Surgery, F 1200 PUH, Univ of Pittsburgh, 200 Lothrop St, Pittsburgh, PA 15213, USA
    Am J Physiol Regul Integr Comp Physiol 293:R1538-44. 2007
    ..Collectively, these data demonstrate a critical role for a TLR4-HMGB1 pathway in the initiation of systemic inflammation and end-organ injury following isolated peripheral tissue injury...
  26. pmc Cholinergic anti-inflammatory pathway activity and High Mobility Group Box-1 (HMGB1) serum levels in patients with rheumatoid arthritis
    Richard S Goldstein
    The Feinstein Institute for Medical Research, and Department of Emergency Medicine, North Shore University Hospital, Manhasset, NY 11030, USA
    Mol Med 13:210-5. 2007
    ....
  27. pmc RR interval variability is inversely related to inflammatory markers: the CARDIA study
    Richard P Sloan
    Behavioral Medicine Program, Department of Psychiatry, Columbia University Medical Center, New York, NY 10032, USA
    Mol Med 13:178-84. 2007
    ..These findings are consistent with the hypothesis that diminished descending vagal anti-inflammatory signals can allow cytokine overproduction in humans...
  28. ncbi request reprint HMGB1 as a potential therapeutic target
    Haichao Wang
    Department of Emergency Medicine, North Shore University Hospital, New York University School of Medicine, USA
    Novartis Found Symp 280:73-85; discussion 85-91, 160-4. 2007
    ..Taken together, these experimental data establish HMGB1 as a late mediator of lethal endotoxaemia and sepsis with a wider therapeutic window for the clinical management of lethal systemic inflammatory diseases...
  29. pmc A cardiovascular drug rescues mice from lethal sepsis by selectively attenuating a late-acting proinflammatory mediator, high mobility group box 1
    Wei Li
    Department of Emergency Medicine, North Shore University Hospital, New York University School of Medicine, 350 Community Drive, Manhasset, NY 11030, USA
    J Immunol 178:3856-64. 2007
    ..Taken together, these data re-enforce the pathogenic role of HMGB1 in lethal sepsis, and support a therapeutic potential for TSNIIA-SS in the treatment of human sepsis...
  30. ncbi request reprint Selective alpha7-nicotinic acetylcholine receptor agonist GTS-21 improves survival in murine endotoxemia and severe sepsis
    Valentin A Pavlov
    Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, Manhasset, NY, USA
    Crit Care Med 35:1139-44. 2007
    ..Here we studied whether GTS-21, a selective alpha7-nicotinic acetylcholine receptor agonist, inhibits proinflammatory cytokines in vitro and in vivo and improves survival in murine endotoxemia and severe sepsis...
  31. ncbi request reprint High mobility group B1 protein suppresses the human plasmacytoid dendritic cell response to TLR9 agonists
    Petar J Popovic
    Division of Surgical Oncology, Department of Surgery and Molecular Medicine Institute, University of Pittsburgh, Pittsburgh, PA 15232, USA
    J Immunol 177:8701-7. 2006
    ..Our observations suggest that HMGB1 may play a critical role in regulating the immune response during chronic inflammation and tissue damage through modulation of PDC function...
  32. ncbi request reprint Dendritic cell activating peptides induce distinct cytokine profiles
    Gloria Telusma
    The Feinstein Institute for Medical Research, North Shore LIJ Health System, Manhasset, NY 11030, USA
    Int Immunol 18:1563-73. 2006
    ..These DC-activating peptides could serve as an adjuvant in immunotherapeutic or vaccine context and the selective activity of these different peptides suggests a means to customize the functional properties of DCs...
  33. ncbi request reprint The cholinergic anti-inflammatory pathway regulates the host response during septic peritonitis
    David J van Westerloo
    Laboratory of Experimental Internal Medicine and Department of Gastroenterology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Infect Dis 191:2138-48. 2005
    ..This anti-inflammatory effect is mediated by an interaction between acetylcholine, the principal neurotransmitter of the vagus nerve, and cholinergic nicotinic acetylcholine receptors on macrophages...
  34. pmc Cholinergic stimulation blocks endothelial cell activation and leukocyte recruitment during inflammation
    Rubina W Saeed
    Laboratory of Medicinal Biochemistry, Institute for Medical Research at North Shore LIJ, Manhasset, NY 11030, USA
    J Exp Med 201:1113-23. 2005
    ..These findings identify the endothelium, a key regulator of leukocyte trafficking during inflammation, as a target of anti-inflammatory cholinergic mediators...
  35. ncbi request reprint High mobility group box-1 as a therapeutic target downstream of tumor necrosis factor
    Christopher J Czura
    Laboratory of Biomedical Science, North Shore Long Island Jewish Research Institute, Manhasset, New York 11030, USA
    J Infect Dis 187:S391-6. 2003
    ..It will now be important to determine whether this wider window of activity can be translated into therapeutic advantage for human inflammatory disease...
  36. pmc Structural basis for the proinflammatory cytokine activity of high mobility group box 1
    Jianhua Li
    Laboratory of Biomedical Science, North Shore Long Island Jewish Research Institute, 350 Community Drive, Manhasset, NY 11030, USA
    Mol Med 9:37-45. 2003
    ..These results indicate that a proinflammatory domain of HMGB1 maps to the highly conserved DNA-binding B box, making this primary sequence a suitable target in the design of therapeutics...
  37. ncbi request reprint HMGB1 as a cytokine and therapeutic target
    Huan Yang
    Laboratory of Biomedical Science, North Shore Long Island Jewish Research Institute, Manhasset, New York 11030, USA
    J Endotoxin Res 8:469-72. 2002
    ..Thus, strategies that target HMGB1 with specific antibodies or antagonists have potential for treating lethal systemic inflammatory diseases characterized by excessive HMGB1 release...
  38. ncbi request reprint IFN-gamma induces high mobility group box 1 protein release partly through a TNF-dependent mechanism
    Beatriz Rendon-Mitchell
    Center of Immunology and Inflammation, North Shore Long Island Jewish Research Institute, Manhasset, NY 11030, USA
    J Immunol 170:3890-7. 2003
    ..These data suggest that IFN-gamma plays an important role in the regulation of HMGB1 release through a TNF- and Janus kinase 2-dependent mechanism...
  39. ncbi request reprint Activation of gene expression in human neutrophils by high mobility group box 1 protein
    Jong Sung Park
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Am J Physiol Cell Physiol 284:C870-9. 2003
    ..These findings indicate that HMGB1 is an effective stimulus of neutrophil activation that can contribute to development of a proinflammatory phenotype in diseases characterized by excessively high levels of HMGB1...
  40. ncbi request reprint Targeting high mobility group box 1 as a late-acting mediator of inflammation
    Christopher J Czura
    Laboratory of Biomedical Science, North Shore LIJ Research Institute, 350 Community Drive, Manhasset, NY 11030, USA
    Crit Care Med 31:S46-50. 2003
    ..A candidate mediator of delayed lethality is high mobility group box 1, a cellular and nuclear protein that is now recognized as a cytokine and experimental therapeutic target...
  41. pmc 3-Aminopropanal, formed during cerebral ischaemia, is a potent lysosomotropic neurotoxin
    Wei Li
    Division of Pathology II, Linkoping University Hospital, Sweden
    Biochem J 371:429-36. 2003
    ..These results may have implications for the development of new therapeutics designed to lessen secondary damage arising from focal cerebral ischaemia...
  42. ncbi request reprint Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation
    Hong Wang
    Laboratory of Biomedical Science, North Shore Long Island Jewish Research Institute, 350 Community Drive, Manhasset, New York 11030, USA
    Nature 421:384-8. 2003
    ..Thus, the nicotinic acetylcholine receptor alpha7 subunit is essential for inhibiting cytokine synthesis by the cholinergic anti-inflammatory pathway...
  43. ncbi request reprint HMGB1 as a DNA-binding cytokine
    Ulf Andersson
    Department of Medicine, Rheumatology Research Unit, Karolinska Hospital, Stockholm, Sweden
    J Leukoc Biol 72:1084-91. 2002
    ....
  44. ncbi request reprint Cholinergic antiinflammatory pathway inhibition of tumor necrosis factor during ischemia reperfusion
    Thomas R Bernik
    Division of Vascular Surgery, North Shore University, 300 Community Drive, Manhasset, NY 11030, USA
    J Vasc Surg 36:1231-6. 2002
    ..VNS protects against endotoxin-induced shock by inhibiting hepatic and cardiac synthesis of TNF. Here, the effects of VNS on suppression of ischemia-reperfusion injury and cytokine release were studied in a rat model of aortic occlusion...
  45. pmc Ethyl pyruvate prevents lethality in mice with established lethal sepsis and systemic inflammation
    Luis Ulloa
    Laboratory of Biomedical Science, North Shore LIJ Research Institute, 350 Community Drive, Manhasset, NY 11030, USA
    Proc Natl Acad Sci U S A 99:12351-6. 2002
    ..EP now warrants further evaluation as an experimental "rescue" therapeutic for sepsis and other potentially fatal systemic inflammatory disorders...
  46. ncbi request reprint HMGB-1, a DNA-binding protein with cytokine activity, induces brain TNF and IL-6 production, and mediates anorexia and taste aversion
    Davide Agnello
    Laboratory of Neuroimmunology, Mario Negri Institute for Pharmacological Research, 20157 Milano, Italy
    Cytokine 18:231-6. 2002
    ..In a model of endotoxemia, passive immunization with anti-HMG-1 antibodies attenuated the development of hypophagia, indicating that HMG-1 is a mediator of sickness behaviour associated with endotoxemia...
  47. ncbi request reprint Globin attenuates the innate immune response to endotoxin
    Huan Yang
    Laboratory of Biomedical Science, North Shore University Hospital New York University School of Medicine, New York 11030, USA
    Shock 17:485-90. 2002
    ..Thus, the heme-iron moiety of hemoglobin, and not the binding of LPS to globin, enhanced macrophage responses to LPS...
  48. pmc Neuroprotection in cerebral ischemia by neutralization of 3-aminopropanal
    Svetlana Ivanova
    Laboratory of Biomedical Science, North Shore Long Island Jewish Research Institute, Manhasset, NY 11030, USA
    Proc Natl Acad Sci U S A 99:5579-84. 2002
    ..These results implicate 3-aminopropanal as a therapeutic target for cerebral ischemia...
  49. pmc The cholinergic anti-inflammatory pathway: a missing link in neuroimmunomodulation
    Valentin A Pavlov
    Laboratory of Biomedical Science, North Shore LIJ Research Institute, Manhasset, NY 11030, USA
    Mol Med 9:125-34. 2003
    ..The clinical implications of this novel mechanism also are discussed...
  50. pmc Reversing established sepsis with antagonists of endogenous high-mobility group box 1
    Huan Yang
    Laboratory of Biomedical Science, North Shore Long Island Jewish Research Institute, 350 Community Drive, Manhasset, NY 11030, USA
    Proc Natl Acad Sci U S A 101:296-301. 2004
    ..These observations demonstrate that specific inhibition of endogenous HMGB1 therapeutically reverses lethality of established sepsis indicating that HMGB1 inhibitors can be administered in a clinically relevant time frame...
  51. ncbi request reprint Neural inhibition of inflammation: the cholinergic anti-inflammatory pathway
    Christopher J Czura
    Laboratory of Biomedical Science, North Shore LIJ Research Institute, Manhasset, NY 11030, USA
    J Endotoxin Res 9:409-13. 2003
    ..This newly identified physiological mechanism of maintaining immunological homeostasis suggests that novel therapeutics may effectively modulate inflammatory responses by activating the cholinergic anti-inflammatory pathway...
  52. ncbi request reprint High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal
    Michael T Lotze
    University of Pittsburgh School of Medicine, Room 411, 300 Technology Drive, Pittsburgh, Pennsylvania 15219, USA
    Nat Rev Immunol 5:331-42. 2005
    ..Here, we discuss these features of HMGB1 and summarize recent advances that have led to the preclinical development of therapeutics that modulate HMGB1 release and activity...
  53. pmc The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion
    Allan Tsung
    Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Exp Med 201:1135-43. 2005
    ..Together, these results demonstrate that HMGB1 is an early mediator of injury and inflammation in liver I/R and implicates TLR4 as one of the receptors that is involved in the process...
  54. ncbi request reprint Persistent elevation of high mobility group box-1 protein (HMGB1) in patients with severe sepsis and septic shock
    Jonas Sunden-Cullberg
    Department of Medicine, Center for Infectious Medicine, Karolinska Institute at Karolinska University Hospital Huddinge, Stockholm, Sweden
    Crit Care Med 33:564-73. 2005
    ....
  55. ncbi request reprint The cytokine activity of HMGB1
    Huan Yang
    Laboratory of Biomedical Science, Institute for Medical Research at North Shore Long Island Jewish System, Manhasset, NY 11030, USA
    J Leukoc Biol 78:1-8. 2005
    ..Finally, the therapeutic potential of blocking HMGB1 in the treatment of inflammatory diseases is discussed...
  56. ncbi request reprint The "cytokine profile": a code for sepsis
    Luis Ulloa
    Center of Immunology and Inflammation, North Shore LIJ Research Institute, 350 Community Drive, Manhasset, NY 11030, USA
    Trends Mol Med 11:56-63. 2005
    ..Future clinical trials might define patient populations and therapeutic strategies according to the profile of expression of cytokines...
  57. ncbi request reprint Suppression of HMGB1 release by stearoyl lysophosphatidylcholine:an additional mechanism for its therapeutic effects in experimental sepsis
    Guoqian Chen
    Department of Emergency Medicine, North Shore University Hospital, New York University School of Medicine, Manhasset, NY 11030, USA
    J Lipid Res 46:623-7. 2005
    ..Thus, stearoyl LPC confers protection against lethal experimental sepsis partly by facilitating the elimination of the invading pathogens and partly by inhibiting endotoxin-induced release of a late proinflammatory cytokine, HMGB1...
  58. ncbi request reprint Ethanol blocks leukocyte recruitment and endothelial cell activation in vivo and in vitro
    Rubina W Saeed
    Laboratories of Medical Biochemistry, North Shore Long Island Jewish Research Institute, 350 Community Drive, Manhasset, NY 11030, USA
    J Immunol 173:6376-83. 2004
    ....
  59. ncbi request reprint Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis
    Hong Wang
    The Center for Immunology and Inflammation, North Shore LIJ Research Institute, North Shore University Hospital, 350 Community Drive, Manhasset, New York 11030, USA
    Nat Med 10:1216-21. 2004
    ....
  60. ncbi request reprint Bacterial endotoxin stimulates macrophages to release HMGB1 partly through CD14- and TNF-dependent mechanisms
    Guoqian Chen
    Department of Emergency Medicine, North Shore University Hospital, New York University School of Medicine, 350 Community Drive, Manhasset, NY 11030, USA
    J Leukoc Biol 76:994-1001. 2004
    ..g., 10 ng/ml). Taken together, these data suggest that LPS stimulates macrophages to release HMGB1 partly through CD14- and TNF-dependent mechanisms...
  61. ncbi request reprint HMGB1 as a mediator of necrosis-induced inflammation and a therapeutic target in arthritis
    Ulf Andersson
    Department of Woman and Child Health, Karolinska Institutet, Astrid Lindgren Children s Hospital, Stockholm, Sweden
    Rheum Dis Clin North Am 30:627-37, xi. 2004
    ..Anti-HMGB1 may be studied in future clinical trials of diseases of excessive production of HMGB1, such as severe sepsis and arthritis...
  62. ncbi request reprint Recombinant HMGB1 with cytokine-stimulating activity
    Jianhua Li
    Laboratories of Biomedical Science, North Shore Long Island Jewish Research Institute, Manhasset, NY 11030, USA
    J Immunol Methods 289:211-23. 2004
    ..This strategy provides an important advance in methodology to facilitate future HMGB1 studies...
  63. ncbi request reprint HMGB1 in the immunology of sepsis (not septic shock) and arthritis
    Christopher J Czura
    Laboratory of Biomedical Science, North Shore LIJ Research Institute, Manhasset, New York, USA
    Adv Immunol 84:181-200. 2004
  64. ncbi request reprint High mobility group box protein 1: an endogenous signal for dendritic cell maturation and Th1 polarization
    Davorka Messmer
    Laboratory of Experimental Immunology, North Shore LIJ Research Institute, 350 Community Drive, Manhasset, NY 11030, USA
    J Immunol 173:307-13. 2004
    ..HMGB1 released by necrotic cells may be a signal of tissue or cellular injury that, when sensed by DCs, induces and/or enhances an immune reaction...
  65. ncbi request reprint Human genetics: an inflammatory issue
    Kevin J Tracey
    Nature 429:35-7. 2004
  66. pmc Pharmacological stimulation of the cholinergic antiinflammatory pathway
    Thomas R Bernik
    Laboratory of Biomedical Science, North Shore LIJ Research Institute, 350 Community Drive, Manhasset, NY 11030, USA
    J Exp Med 195:781-8. 2002
    ..Together, these results indicate that stimulation of the cholinergic antiinflammatory pathway by either pharmacological or electrical methods can attenuate the systemic inflammatory response to endotoxin-induced shock...

Research Grants24

  1. Macrophage Inactivation in Sepsis after Shock or Trauma
    Kevin J Tracey; Fiscal Year: 2010
    ..The Tracey laboratory, which has led the development of this field, is now particularly well suited to do these studies. ..
  2. HMG in Post Operative and Traumatic Stress
    Kevin Tracey; Fiscal Year: 2007
    ..HMGB1 will be isolated from sepsis serum, and the amount of acetylation and other modifications characterized to reveal the biochemical requirements for biological activity. ..
  3. Macrophage Inactivation in Sepsis after Shock or Trauma
    Kevin Tracey; Fiscal Year: 2007
    ..The Tracey laboratory, which has led the development of this field, is now particularly well suited to do these studies. ..
  4. GENERAL CLINICAL RESEARCH CENTER
    Kevin Tracey; Fiscal Year: 2009
    ..This proposal seeks continued funding for the Feinstein GCRC by NCRR. ..
  5. GENERAL CLINICAL RESEARCH CENTER
    Kevin J Tracey; Fiscal Year: 2010
    ..This proposal seeks continued funding for the Feinstein GCRC by NCRR. ..
  6. MACROPHAGE INACTIVATION IN SEPSIS AFTER TRAUMA OR SHOCK
    Kevin Tracey; Fiscal Year: 2006
    ..abstract_text> ..
  7. MACROPHAGE INACTIVATION IN SEPSIS AFTER TRAUMA OR SHOCK
    Kevin Tracey; Fiscal Year: 2001
    ....
  8. HMG-1 IN POST-OPERATIVE AND TRAUMATIC SEPSIS
    Kevin Tracey; Fiscal Year: 2004
    ..abstract_text> ..