Rachael Thomas

Summary

Affiliation: North Carolina State University
Country: USA

Publications

  1. pmc An integrated 4249 marker FISH/RH map of the canine genome
    Matthew Breen
    Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    BMC Genomics 5:65. 2004
  2. doi request reprint Microarray-based cytogenetic profiling reveals recurrent and subtype-associated genomic copy number aberrations in feline sarcomas
    Rachael Thomas
    Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
    Chromosome Res 17:987-1000. 2009
  3. pmc Influence of genetic background on tumor karyotypes: evidence for breed-associated cytogenetic aberrations in canine appendicular osteosarcoma
    Rachael Thomas
    Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    Chromosome Res 17:365-77. 2009
  4. doi request reprint Characterization of canine osteosarcoma by array comparative genomic hybridization and RT-qPCR: signatures of genomic imbalance in canine osteosarcoma parallel the human counterpart
    Andrea Y Angstadt
    Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh, USA
    Genes Chromosomes Cancer 50:859-74. 2011
  5. pmc 'Putting our heads together': insights into genomic conservation between human and canine intracranial tumors
    Rachael Thomas
    Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
    J Neurooncol 94:333-49. 2009
  6. ncbi request reprint A cytogenetically characterized, genome-anchored 10-Mb BAC set and CGH array for the domestic dog
    Rachael Thomas
    Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    J Hered 98:474-84. 2007
  7. doi request reprint Refining tumor-associated aneuploidy through 'genomic recoding' of recurrent DNA copy number aberrations in 150 canine non-Hodgkin lymphomas
    Rachael Thomas
    Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
    Leuk Lymphoma 52:1321-35. 2011
  8. doi request reprint Extensive conservation of genomic imbalances in canine transmissible venereal tumors (CTVT) detected by microarray-based CGH analysis
    Rachael Thomas
    Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC, 27606, USA
    Chromosome Res 17:927-34. 2009
  9. pmc Molecular cytogenetic characterization of canine histiocytic sarcoma: A spontaneous model for human histiocytic cancer identifies deletion of tumor suppressor genes and highlights influence of genetic background on tumor behavior
    Benoit Hedan
    Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA
    BMC Cancer 11:201. 2011
  10. doi request reprint Anchoring the dog to its relatives reveals new evolutionary breakpoints across 11 species of the Canidae and provides new clues for the role of B chromosomes
    Shannon E Duke Becker
    Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, 1060 William Moore Drive, Raleigh, NC 27607, USA
    Chromosome Res 19:685-708. 2011

Collaborators

Detail Information

Publications14

  1. pmc An integrated 4249 marker FISH/RH map of the canine genome
    Matthew Breen
    Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    BMC Genomics 5:65. 2004
    ..Understanding the genetic basis of both phenotypic variation and disease susceptibility in the dog provides new ways in which to dissect the genetics of human health and biology...
  2. doi request reprint Microarray-based cytogenetic profiling reveals recurrent and subtype-associated genomic copy number aberrations in feline sarcomas
    Rachael Thomas
    Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
    Chromosome Res 17:987-1000. 2009
    ..Further characterization of these regions may ultimately permit molecular distinction between ISAS and non-ISAS, as a tool for predicting tumor behavior and prognosis, as well as refining means for therapeutic intervention...
  3. pmc Influence of genetic background on tumor karyotypes: evidence for breed-associated cytogenetic aberrations in canine appendicular osteosarcoma
    Rachael Thomas
    Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    Chromosome Res 17:365-77. 2009
    ..These data indicate for the first time that individual genetic backgrounds, as defined by breed in dogs, influence tumor karyotypes in a cancer with extensive genomic instability...
  4. doi request reprint Characterization of canine osteosarcoma by array comparative genomic hybridization and RT-qPCR: signatures of genomic imbalance in canine osteosarcoma parallel the human counterpart
    Andrea Y Angstadt
    Department of Molecular Biomedical Sciences, North Carolina State University, Raleigh, USA
    Genes Chromosomes Cancer 50:859-74. 2011
    ....
  5. pmc 'Putting our heads together': insights into genomic conservation between human and canine intracranial tumors
    Rachael Thomas
    Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
    J Neurooncol 94:333-49. 2009
    ....
  6. ncbi request reprint A cytogenetically characterized, genome-anchored 10-Mb BAC set and CGH array for the domestic dog
    Rachael Thomas
    Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    J Hered 98:474-84. 2007
    ..We outline the value of a combined aCGH/FISH approach, together with a well-annotated dog genome assembly, in canine and comparative cancer studies...
  7. doi request reprint Refining tumor-associated aneuploidy through 'genomic recoding' of recurrent DNA copy number aberrations in 150 canine non-Hodgkin lymphomas
    Rachael Thomas
    Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
    Leuk Lymphoma 52:1321-35. 2011
    ..Our data suggest that gene discovery in NHL may be enhanced through comparative studies exploiting the less complex association between CNAs and tumor pathogenesis in canine patients...
  8. doi request reprint Extensive conservation of genomic imbalances in canine transmissible venereal tumors (CTVT) detected by microarray-based CGH analysis
    Rachael Thomas
    Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC, 27606, USA
    Chromosome Res 17:927-34. 2009
    ..These data suggest that the CTVT genome demonstrates a vast degree of both structural and numerical reorganization that is maintained during transmission among the domestic dog population...
  9. pmc Molecular cytogenetic characterization of canine histiocytic sarcoma: A spontaneous model for human histiocytic cancer identifies deletion of tumor suppressor genes and highlights influence of genetic background on tumor behavior
    Benoit Hedan
    Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA
    BMC Cancer 11:201. 2011
    ..This process would identify evolutionarily conserved cytogenetic changes to highlight regions of particular importance to HS biology...
  10. doi request reprint Anchoring the dog to its relatives reveals new evolutionary breakpoints across 11 species of the Canidae and provides new clues for the role of B chromosomes
    Shannon E Duke Becker
    Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, 1060 William Moore Drive, Raleigh, NC 27607, USA
    Chromosome Res 19:685-708. 2011
    ..We propose that the complex karyotype rearrangements associated with speciation of the Canidae reflect unstable chromosome regions described by the fragile breakage model...
  11. pmc Growth requirements and chromosomal instability of induced pluripotent stem cells generated from adult canine fibroblasts
    Sehwon Koh
    Genomics Program, North Carolina State University, Raleigh, NC 27607, USA
    Stem Cells Dev 22:951-63. 2013
    ..The isolated iPSCs have similar characteristics to ESCs from other species, but the exact cellular mechanisms behind their unique co-dependency on both FGF2 and LIF are still unknown...
  12. pmc FLT3 mutations in canine acute lymphocytic leukemia
    Steven E Suter
    Center for Comparative Medicine and Translational Research, North Carolina State University, Raleigh, NC, USA
    BMC Cancer 11:38. 2011
    ..A small percentage of canine acute lymphocytic leukemias (ALL) also exhibit FLT3 ITD mutations...
  13. ncbi request reprint A novel canine lymphoma cell line: a translational and comparative model for lymphoma research
    William C Kisseberth
    Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA
    Leuk Res 31:1709-20. 2007
    ..This cell line and xenograft represent significant in vitro and in vivo models, respectively, for comparative and translational lymphoma research...
  14. pmc Construction of a 2-Mb resolution BAC microarray for CGH analysis of canine tumors
    Rachael Thomas
    Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27606, USA
    Genome Res 15:1831-7. 2005
    ..Here we provide examples of the varied applications of this resource to tumor cytogenetics, in combination with other molecular cytogenetic techniques...