David L Schwartz

Summary

Affiliation: North Shore University Hospital
Country: USA

Publications

  1. ncbi request reprint Adaptive radiotherapy for head and neck cancer--dosimetric results from a prospective clinical trial
    David L Schwartz
    Department of Radiation Medicine, Hofstra North Shore LIJ School of Medicine, New Hyde Park, NY 10040, USA
    Radiother Oncol 106:80-4. 2013
  2. doi request reprint Adaptive radiotherapy for head-and-neck cancer: initial clinical outcomes from a prospective trial
    David L Schwartz
    Department of Radiation Medicine, Hofstra North Shore Long Island Jewish School of Medicine, New Hyde Park, NY 11040, USA
    Int J Radiat Oncol Biol Phys 83:986-93. 2012
  3. doi request reprint Current progress in adaptive radiation therapy for head and neck cancer
    David L Schwartz
    Department of Radiation Medicine, North Shore LIJ Health System, New Hyde Park, NY 11040, USA
    Curr Oncol Rep 14:139-47. 2012
  4. pmc HIF-1-dependent stromal adaptation to ischemia mediates in vivo tumor radiation resistance
    David L Schwartz
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Mol Cancer Res 9:259-70. 2011
  5. pmc Prospective imaging assessment of mortality risk after head-and-neck radiotherapy
    Benjamin J Moeller
    Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 78:667-74. 2010
  6. doi request reprint Outcomes of patients with tonsillar carcinoma treated with post-tonsillectomy radiation therapy
    Gokcen Yildirim
    The University of Texas M D Anderson Cancer Center, Department of Radiation Oncology, Unit 97, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Head Neck 32:473-80. 2010
  7. ncbi request reprint Candidate dosimetric predictors of long-term swallowing dysfunction after oropharyngeal intensity-modulated radiotherapy
    David L Schwartz
    Department of Radiation Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77030 4009, USA
    Int J Radiat Oncol Biol Phys 78:1356-65. 2010
  8. ncbi request reprint Patterns of disease recurrence following treatment of oropharyngeal cancer with intensity modulated radiation therapy
    Adam S Garden
    Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 85:941-7. 2013
  9. ncbi request reprint FDG-PET/CT-guided intensity modulated head and neck radiotherapy: a pilot investigation
    David L Schwartz
    Department of Radiation Oncology, University of Washington, Seattle, Washington, 1660 S Columbian Way 174, Seattle, WA 98108 1597, USA
    Head Neck 27:478-87. 2005
  10. doi request reprint Unilateral radiotherapy for the treatment of tonsil cancer
    Gregory M Chronowski
    Department of Radiation Oncology, University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Int J Radiat Oncol Biol Phys 83:204-9. 2012

Detail Information

Publications37

  1. ncbi request reprint Adaptive radiotherapy for head and neck cancer--dosimetric results from a prospective clinical trial
    David L Schwartz
    Department of Radiation Medicine, Hofstra North Shore LIJ School of Medicine, New Hyde Park, NY 10040, USA
    Radiother Oncol 106:80-4. 2013
    ..To conduct a clinical trial evaluating adaptive head and neck radiotherapy (ART)...
  2. doi request reprint Adaptive radiotherapy for head-and-neck cancer: initial clinical outcomes from a prospective trial
    David L Schwartz
    Department of Radiation Medicine, Hofstra North Shore Long Island Jewish School of Medicine, New Hyde Park, NY 11040, USA
    Int J Radiat Oncol Biol Phys 83:986-93. 2012
    ..To present pilot toxicity and survival outcomes for a prospective trial investigating adaptive radiotherapy (ART) for oropharyngeal squamous cell carcinoma...
  3. doi request reprint Current progress in adaptive radiation therapy for head and neck cancer
    David L Schwartz
    Department of Radiation Medicine, North Shore LIJ Health System, New Hyde Park, NY 11040, USA
    Curr Oncol Rep 14:139-47. 2012
    ..This review summarizes investigational challenges impacting development of head and neck ART, describes findings from early clinical testing of an automated ART platform, and highlights emerging directions of ongoing research...
  4. pmc HIF-1-dependent stromal adaptation to ischemia mediates in vivo tumor radiation resistance
    David L Schwartz
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Mol Cancer Res 9:259-70. 2011
    ..We applied a multimodality preclinical imaging platform to mechanistically characterize tumor response to radiation, with a focus on HIF-1-dependent resistance pathways...
  5. pmc Prospective imaging assessment of mortality risk after head-and-neck radiotherapy
    Benjamin J Moeller
    Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 78:667-74. 2010
    ..Unresolved questions include whether functional or anatomic imaging might improve mortality risk assessment for this disease. We addressed these issues in a prospective institutional trial...
  6. doi request reprint Outcomes of patients with tonsillar carcinoma treated with post-tonsillectomy radiation therapy
    Gokcen Yildirim
    The University of Texas M D Anderson Cancer Center, Department of Radiation Oncology, Unit 97, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Head Neck 32:473-80. 2010
    ..Our aim was to evaluate the therapeutic outcomes of patients with squamous cell carcinoma of the tonsil that underwent tonsillectomies followed by radiotherapy...
  7. ncbi request reprint Candidate dosimetric predictors of long-term swallowing dysfunction after oropharyngeal intensity-modulated radiotherapy
    David L Schwartz
    Department of Radiation Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77030 4009, USA
    Int J Radiat Oncol Biol Phys 78:1356-65. 2010
    ..To investigate long-term swallowing function in oropharyngeal cancer patients treated with intensity-modulated radiotherapy (IMRT), and to identify novel dose-limiting criteria predictive for dysphagia...
  8. ncbi request reprint Patterns of disease recurrence following treatment of oropharyngeal cancer with intensity modulated radiation therapy
    Adam S Garden
    Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 85:941-7. 2013
    ..To report mature results of a large cohort of patients diagnosed with squamous cell carcinoma of the oropharynx who were treated with intensity modulated radiation therapy (IMRT)...
  9. ncbi request reprint FDG-PET/CT-guided intensity modulated head and neck radiotherapy: a pilot investigation
    David L Schwartz
    Department of Radiation Oncology, University of Washington, Seattle, Washington, 1660 S Columbian Way 174, Seattle, WA 98108 1597, USA
    Head Neck 27:478-87. 2005
    ..The intent of this study was to examine the use of registered FDG-PET/CT imaging to guide head and neck intensity modulated radiotherapy (IMRT) planning...
  10. doi request reprint Unilateral radiotherapy for the treatment of tonsil cancer
    Gregory M Chronowski
    Department of Radiation Oncology, University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Int J Radiat Oncol Biol Phys 83:204-9. 2012
    ..D. Anderson Cancer Center with unilateral radiotherapy techniques that irradiate the involved tonsil region and ipsilateral neck only...
  11. doi request reprint Intensity-modulated radiotherapy for cervical node squamous cell carcinoma metastases from unknown head-and-neck primary site: M. D. Anderson Cancer Center outcomes and patterns of failure
    Steven J Frank
    Department of Radiation Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 78:1005-10. 2010
    ....
  12. pmc Radiosensitization and stromal imaging response correlates for the HIF-1 inhibitor PX-478 given with or without chemotherapy in pancreatic cancer
    David L Schwartz
    Department of Radiation Oncology, M D Anderson Cancer Center, Houston, Texas 77030, USA
    Mol Cancer Ther 9:2057-67. 2010
    ....
  13. doi request reprint Hypothyroidism in older patients with head and neck cancer after treatment with radiation: a population-based study
    Grace L Smith
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Head Neck 31:1031-8. 2009
    ..In patients with head and neck cancer, radiation treatment (RT) is a risk factor for hypothyroidism. However, the specific magnitude of risk after RT in older patients is not known...
  14. doi request reprint Anaplastic thyroid cancer: Clinical outcomes with conformal radiotherapy
    Aarti Bhatia
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Head Neck 32:829-36. 2010
    ..The aim of this study was to review institutional outcomes for anaplastic thyroid cancer treated with conformal 3-dimensional radiotherapy (3DRT) or intensity-modulated radiotherapy (IMRT)...
  15. pmc The selective hypoxia inducible factor-1 inhibitor PX-478 provides in vivo radiosensitization through tumor stromal effects
    David L Schwartz
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Unit 97, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Mol Cancer Ther 8:947-58. 2009
    ..Successful translation of targeted HIF-1 radiosensitization to the clinical setting will require specific consideration of tumor microenvironmental effects and mechanisms...
  16. pmc Parotid gland dose in intensity-modulated radiotherapy for head and neck cancer: is what you plan what you get?
    Jennifer C O'Daniel
    Department of Radiation Physics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 69:1290-6. 2007
    ..To quantify the differences between planned and delivered parotid gland and target doses, and to assess the benefits of daily bone alignment for head and neck cancer patients treated with intensity-modulated radiotherapy (IMRT)...
  17. ncbi request reprint Metabolic imaging biomarkers of postradiotherapy xerostomia
    Blake Cannon
    Department of Radiation Physics, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Int J Radiat Oncol Biol Phys 83:1609-16. 2012
    ..We investigated quantitative measurement of parotid gland FDG uptake as a potential biomarker for post-RT xerostomia...
  18. pmc Prospective risk-adjusted [18F]Fluorodeoxyglucose positron emission tomography and computed tomography assessment of radiation response in head and neck cancer
    Benjamin J Moeller
    Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA
    J Clin Oncol 27:2509-15. 2009
    ..We conducted a prospective trial to identify patient populations likely to benefit from the addition of functional imaging to the assessment of radiotherapy response...
  19. pmc Simple carotid-sparing intensity-modulated radiotherapy technique and preliminary experience for T1-2 glottic cancer
    David I Rosenthal
    Department of Radiation Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 77:455-61. 2010
    ..To investigate the dosimetry and feasibility of carotid-sparing intensity-modulated radiotherapy (IMRT) for early glottic cancer and to report preliminary clinical experience...
  20. doi request reprint Comparison of 2D radiographic images and 3D cone beam computed tomography for positioning head-and-neck radiotherapy patients
    Heng Li
    Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 71:916-25. 2008
    ..To assess the benefit of patient-specific headrest...
  21. ncbi request reprint Technology insight: PET and PET/CT in head and neck tumor staging and radiation therapy planning
    Steven J Frank
    University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Nat Clin Pract Oncol 2:526-33. 2005
    ..The use of PET/CT for staging and detecting both primary and recurrent head and neck cancer is valuable; however, its application in radiation treatment planning should be viewed as investigational...
  22. ncbi request reprint Outcomes after radiotherapy for squamous cell carcinoma of the eyelid
    Janjira Petsuksiri
    Division of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer 112:111-8. 2008
    ..Squamous cell carcinoma (SCC) of the eyelid is a rare malignancy with metastatic potential. In the current study, the outcomes of patients with SCC of the eyelid were evaluated after definitive and postoperative radiation therapy...
  23. doi request reprint IMRT reirradiation of head and neck cancer-disease control and morbidity outcomes
    Erik P Sulman
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Int J Radiat Oncol Biol Phys 73:399-409. 2009
    ..Limited data are available regarding the use of intensity-modulated radiotherapy (IMRT) for this indication. We reviewed our initial experience using IMRT for previously irradiated head and neck cancer patients...
  24. ncbi request reprint Postoperative radiotherapy for advanced medullary thyroid cancer--local disease control in the modern era
    David L Schwartz
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Head Neck 30:883-8. 2008
    ..The purpose of this study is to catalog modern-era postoperative radiotherapy (external beam radiotherapy [EBRT]) outcomes for advanced medullary thyroid cancer...
  25. pmc Postoperative external beam radiotherapy for differentiated thyroid cancer: outcomes and morbidity with conformal treatment
    David L Schwartz
    Department of Radiation Oncology, UT MD Anderson Cancer Center, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 74:1083-91. 2009
    ..To review institutional outcomes for patients treated for differentiated thyroid cancer with postoperative conformal external beam radiotherapy (EBRT)...
  26. ncbi request reprint The effect of dental artifacts, contrast media, and experience on interobserver contouring variations in head and neck anatomy
    David I Rosenthal
    Department of Radiation Physics, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Am J Clin Oncol 30:191-8. 2007
    ..To investigate interobserver variability in the delineation of head-and-neck (H&N) anatomic structures on CT images, including the effects of image artifacts and observer experience...
  27. ncbi request reprint FDG-PET/CT imaging for preradiotherapy staging of head-and-neck squamous cell carcinoma
    David L Schwartz
    Department of Radiation Oncology, University of Washington School of Medicine, Seattle, WA 98108, USA
    Int J Radiat Oncol Biol Phys 61:129-36. 2005
    ..This pilot study prospectively examined the use of registered 18-F-fluorodeoxyglucose (FDG)-positron emission tomography (PET)/CT for preradiotherapy staging of the neck...
  28. pmc Long-term radiotherapy outcomes for nasal cavity and septal cancers
    Matthew W Allen
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 71:401-6. 2008
    ..Carcinoma of the nasal cavity and septum has historically been associated with a poor prognosis. This report updates the long-term outcomes for radiotherapy (RT) of this disease site at the University of Texas M.D. Anderson Cancer Center...
  29. ncbi request reprint Intensity-modulated radiotherapy: is xerostomia still prevalent?
    Mark S Chambers
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030 4009, USA
    Curr Oncol Rep 7:131-6. 2005
    ....
  30. ncbi request reprint Tumor delineation using PET in head and neck cancers: threshold contouring and lesion volumes
    Eric C Ford
    University of Washington, Department of Radiation Oncology, 1959 N E Pacific Street, Seattle, Washington 98195, USA
    Med Phys 33:4280-8. 2006
    ..The appropriate threshold level depends on lesion size and image reconstruction parameters. These effects should be carefully considered when using PET contour and/or volume information for radiotherapy applications...
  31. doi request reprint Comparative dosimetry of volumetric modulated arc therapy and limited-angle static intensity-modulated radiation therapy for early-stage larynx cancer
    Adam C Riegel
    Department of Radiation Medicine, North Shore LIJ Health System, New Hyde, Park, NY, USA
    Med Dosim 38:66-9. 2013
    ..The respective clinical significance of carotid and normal tissue sparing will require prospective evaluation...
  32. ncbi request reprint Postradiotherapy surveillance practice for head and neck squamous cell carcinoma--too much for too little?
    David L Schwartz
    Department of Radiation Oncology, Seattle VA PSHCS, 1660 S Columbian Way 174, Seattle, Washington, 98108, USA
    Head Neck 25:990-9. 2003
    ..We cataloged follow-up for a specified patient cohort treated at three neighboring university, community, and Veterans Administration institutions...
  33. pmc DNA repair biomarker profiling of head and neck cancer: Ku80 expression predicts locoregional failure and death following radiotherapy
    Benjamin J Moeller
    Department of Radiation Oncology, University of Texas M D Anderson Cancer Center, Houston, Texas, USA
    Clin Cancer Res 17:2035-43. 2011
    ..We examined whether differential expression of double-strand DNA break (DSB) repair proteins in HNSCC, the chief mediators of DNA repair following irradiation, predict for treatment outcomes...
  34. pmc Targeted therapy of VEGFR2 and EGFR significantly inhibits growth of anaplastic thyroid cancer in an orthotopic murine model
    Maria K Gule
    Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030 4009, USA
    Clin Cancer Res 17:2281-91. 2011
    ..Several reports have examined agents that target these receptors. However, with the misidentification of as many as 60% of all commonly used ATC cell lines, the significance of these past findings is unclear...
  35. ncbi request reprint Radiation therapy does not impact local complication rates after free flap reconstruction for head and neck cancer
    Seungtaek Choi
    Department of Radiation Oncology, University of Washington, Seattle, USA
    Arch Otolaryngol Head Neck Surg 130:1308-12. 2004
    ....
  36. ncbi request reprint Staging of head and neck squamous cell cancer with extended-field FDG-PET
    David L Schwartz
    Department of Radiation Oncology, Division of Nuclear Medicine, VA Puget Sound Health Care System and University of Washington, Seattle 98108, USA
    Arch Otolaryngol Head Neck Surg 129:1173-8. 2003
    ..The effectiveness of FDG-PET for the detection of distant metastatic or synchronous disease remains unproven...