Research Topics
| Jim RiviereSummaryAffiliation: North Carolina State University Country: USA Publications
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Publications
The future of veterinary therapeutics: a glimpse towards 2030Jim E Riviere
Center for Chemical Toxicology Research and Pharmacokinetics, Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
Vet J 174:462-71. 2007..Although this growth in technology would portend major advances over the next few decades, economic and regulatory constraints must still be overcome for these new drugs or therapeutic approaches to become common practice...
Acute vascular effects of nanoparticle infusion in isolated perfused skinJim E Riviere
Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, Raleigh, NC, USA
Nanomedicine 8:428-31. 2012..FROM THE CLINICAL EDITOR: In this study utilizing a perfused porcine skin flap, specific nanoparticle infusions were demonstrated to be associated with significant acute vascular physiological effects...
Pharmacokinetics of nanomaterials: an overview of carbon nanotubes, fullerenes and quantum dotsJim E Riviere
Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, Raleigh, NC 27606, USA
Wiley Interdiscip Rev Nanomed Nanobiotechnol 1:26-34. 2009..Finally, unlike many small organic drugs, nanomaterials may preferentially be trafficked in the body via the lymphatic system that has obvious immunological implications...- Percutaneous absorption of topical N,N-diethyl-m-toluamide (DEET): effects of exposure variables and coadministered toxicantsJim E Riviere
Center for Chemical Toxicology Research and Pharmacokinetics, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
J Toxicol Environ Health A 66:133-51. 2003.... - New technologies for application to veterinary therapeuticsJim E Riviere
Center for Chemical Toxicology Research and Pharmacokinetics, Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, 27606, USA
Handb Exp Pharmacol 199:191-210. 2010..Although this growth in technology portends major advances over the next few decades, economic and regulatory constraints must still be overcome for these new drugs or therapeutic approaches to become common practise... - Surfactant effects on skin absorption of model organic chemicals: implications for dermal risk assessment studiesJim E Riviere
Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, Raleigh, North Carolina 27606, USA
J Toxicol Environ Health A 73:725-37. 2010..The inert three-fiber MCF array predicted absorptive fluxes seen in the ex vivo IPPSF, suggesting lack of any biological effects of the surfactants on skin... - Membrane-coated fiber array approach for predicting skin permeability of chemical mixtures from different vehiclesJim E Riviere
Center for Chemical Toxicology Research and Pharmacokinetics CCTRP, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27606, USA
Toxicol Sci 99:153-61. 2007..These results suggested that the experimentally based MCF array approach can be used to predict skin absorption from chemical mixtures in different vehicles or formulations... - Gulf War related exposure factors influencing topical absorption of 14C-permethrinJim E Riviere
Center for Chemical Toxicology Research and Pharmacokinetics, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
Toxicol Lett 135:61-71. 2002..The toxicologic significance of this moderate increase in permethrin absorption remains unclear... - Prediction of dermal absorption from complex chemical mixtures: incorporation of vehicle effects and interactions into a QSPR frameworkJ E Riviere
Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
SAR QSAR Environ Res 18:31-44. 2007..The use of the MF in combination with a classic LFER based on penetrant properties significantly improved the ability to predict dermal absorption of compounds dosed in complex chemical mixtures... - Dermal absorption and distribution of topically dosed jet fuels jet-A, JP-8, and JP-8(100)J E Riviere
Center for Cutaneous Toxicology and Residue Pharmacology, College of Veterinary Medicine, Raleigh, North Carolina 27606, USA
Toxicol Appl Pharmacol 160:60-75. 1999..These studies demonstrated different absorption profiles for the three marker compounds, differential effects of jet fuel types on naphthalene and dodecane absorption, and uncoupling of perfusate absorption from skin disposition... - Use of methyl salicylate as a simulant to predict the percutaneous absorption of sulfur mustardJ E Riviere
Center for Cutaneous Toxicology and Residue Pharmacology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
J Appl Toxicol 21:91-9. 2001..05). Compared with other chemicals studied in this model, HD and MS cutaneous disposition were very similar, supporting the use of MS as a dermal simulant for HD exposure... - Potential and problems of developing transdermal patches for veterinary applicationsJ E Riviere
Center for Cutaneous Toxicology and Residue Pharmacology, Department of Farm Animal Health and Resource Management, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27613, USA
Adv Drug Deliv Rev 50:175-203. 2001..With efficient experimental designs and available transdermal patch technology, there are no obvious hurdles to the development of effective systems in many veterinary species... - Mixture component effects on the in vitro dermal absorption of pentachlorophenolJ E Riviere
Center for Cutaneous Toxicology and Residue Pharmacology, College of Veterinary Medicine, North Carolina State University, Raleigh 27606, USA
Arch Toxicol 75:329-34. 2001..These results suggest that dermal absorption estimates from a single chemical exposure may not reflect absorption seen after exposure as a chemical mixture and that absorption of both TCB and PCB are minimal in this model system... - Predicting skin permeability from complex chemical mixturesJim E Riviere
Center for Chemical Toxicology Research and Pharmacokinetics, 4700 Hillsborough Street, North Carolina State University, Raleigh, NC 27606, USA
Toxicol Appl Pharmacol 208:99-110. 2005.... - Predicting skin permeability from complex chemical mixtures: dependency of quantitative structure permeation relationships on biology of skin model usedJim E Riviere
Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, Raleigh, North Carolina 27606, USA
Toxicol Sci 119:224-32. 2011.... - Electrically-assisted transdermal drug deliveryJ E Riviere
Cutaneous Pharmacology and Toxicology Center, North Carolina State University, Raleigh 27606, USA
Pharm Res 14:687-97. 1997..The focus of this review is to put these different mechanisms in perspective and relate them to the drug and skin model system being investigated... - Dermal permeation of biocides and aromatic chemicals in three generic formulations of metalworking fluidsVikrant Vijay
Center for Chemical Toxicology Research and Pharmacokinetics CCTRP, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27606 8401, USA
J Toxicol Environ Health A 72:832-41. 2009..The dilution of these MWF formulations with water may increase dermal permeability of biocides, allowing for an enhanced risk for systemic toxicological effects and dermatitis potential... - Biodistribution of quantum dot nanoparticles in perfused skin: evidence of coating dependency and periodicity in arterial extractionHyun A Lee
Center for Chemical Toxicology Research and Pharmacokinetics, and Biomathematics Program, North Carolina State University, 4700 Hillsborough Street, Raleigh, North Carolina 27606, USA
Nano Lett 7:2865-70. 2007..Both QD had a unique periodicity in arterial extraction never observed with drug infusions, suggesting a potentially important nanomaterial behavior that could affect systemic disposition... - Comparative mixture effects of JP-8(100) additives on the dermal absorption and disposition of jet fuel hydrocarbons in different membrane model systemsFaqir Muhammad
Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, 700 Hillsborough Street, Raleigh, NC 27606, USA
Toxicol Lett 150:351-65. 2004..Finally, it is important to assess all components of a chemical mixture since the effects of single components administered alone or as pairs may be confounded when all are present in the complete mixture... - Sulfamethazine water medication pharmacokinetics and contamination in a commercial pig production unitSharon E Mason
Department of Population Health and Pathobiology, Center for Chemical Toxicology and Research Pharmacokinetics, North Carolina State University, Raleigh 27606, USA
J Food Prot 71:584-9. 2008..These results are of concern for producers and veterinarians, because in commercial farms, the entire barn is often treated,and environmental contamination could result in residues of an unknown duration... - Differential relationship between the carbon chain length of jet fuel aliphatic hydrocarbons and their ability to induce cytotoxicity vs. interleukin-8 release in human epidermal keratinocytesChi-Chung Chou
Center for Chemical Toxicology Research and Pharmacokinetics (CCTRP, North Carolina State University, 4700 Hillsborough Street, Raleigh, North Carolina 27606, USA
Toxicol Sci 69:226-33. 2002.... - Use of probabilistic modeling within a physiologically based pharmacokinetic model to predict sulfamethazine residue withdrawal times in edible tissues in swineJennifer Buur
Food Animal Residue Avoidance Databank, Center for Chemical Toxicology Research and Pharmacokinetics, College of Veterinary Medicine, North Carolina State University, NC 27606, USA
Antimicrob Agents Chemother 50:2344-51. 2006..These models can be used to calculate the parameters required by FDA and explore those conditions where the established withdrawal time may not be sufficient... - Application of linear solvation energy relationships to a custom-made polyaniline solid-phase microextraction fiber and three commercial fibersJames L Yeatts
Center for Chemical Toxicology Research and Pharmacokinetics CCTRP, North Carolina State University, College of Veterinary Medicine, 4700 Hillsborough Street, Raleigh, NC 27606, USA
J Chromatogr A 1188:108-17. 2008..The PANI fiber may offer greater flexibility in the choice of fibers to use for solid-phase microextraction... - Skin penetration and kinetics of pristine fullerenes (C60) topically exposed in industrial organic solventsXin R Xia
Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
Toxicol Appl Pharmacol 242:29-37. 2010..In vitro flow-through diffusion cell experiments were conducted in pig skin and fullerenes were not detected in the receptor solutions by 24 h. The limit of detection was 0.001 microg/mL of fullerenes in 2 mL of the receptor solutions... - Quantification of chemical mixture interactions modulating dermal absorption using a multiple membrane fiber arrayRonald E Baynes
Center for Chemical Toxicology Research and Pharmacokinetics, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, North Carolina 27606, USA
Chem Res Toxicol 21:591-9. 2008.... - Trace analysis of fullerenes in biological samples by simplified liquid-liquid extraction and high-performance liquid chromatographyXin Rui Xia
Center for Chemical Toxicology Research and Pharmacokinetics CCTRP, North Carolina State University, Raleigh, NC 27606, USA
J Chromatogr A 1129:216-22. 2006..Under optimal experimental conditions, the detection limit was 0.34 ng/mL and the recovery was in the range of 94-100% (n=5) at a concentration of 10 ng/mL nano-C60 in the biological media... - An experimentally based approach for predicting skin permeability of chemicals and drugs using a membrane-coated fiber arrayXin Rui Xia
Center for Chemical Toxicology Research and Pharmacokinetics CCTRP, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
Toxicol Appl Pharmacol 221:320-8. 2007..It is an experimentally based, high throughput approach that provides high prediction confidence and does not require literature data nor molecular structure information in contrast to the existing predictive models... - Intrinsic biological property of colloidal fullerene nanoparticles (nC60): lack of lethality after high dose exposure to human epidermal and bacterial cellsXin R Xia
Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
Toxicol Lett 197:128-34. 2010..05) from the control without nC60 nanoparticles. These results reveal that the intrinsic biological property of nC60 is non-toxic, confirming the prior non-toxic reports when using nC60 prepared with non-THF methods... - Disposition of melamine residues in blood and milk from dairy goats exposed to an oral bolus of melamineRonald E Baynes
Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, Raleigh, NC 27606, United States
Food Chem Toxicol 48:2542-6. 2010.... - Evaluation of perfused porcine skin as a model system to quantitate tissue distribution of fullerene nanoparticlesTeresa L Leavens
Center for Chemical Toxicology Research and Pharmacokinetics, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, United States
Toxicol Lett 197:1-6. 2010.... - Partitioning behavior of aromatic components in jet fuel into diverse membrane-coated fibersRonald E Baynes
Center for Chemical Toxicology Research and Pharmacokinetics, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27606, USA
J Toxicol Environ Health A 70:1879-87. 2007..This information may be incorporated into physiologically based pharmacokinetic (PBPK) models to provide a more accurate assessment of tissue dosimetry of related toxicants... - Predicting dermal permeability of biocides in commercial cutting fluids using a LSER approachVikrant Vijay
Center for Chemical Toxicology Research and Pharmacokinetics CCTRP, College of Veterinary Medicine, North Carolina State University, CCTRP CVM, 4700 Hillsborough Street, Raleigh, NC 27606, United States
Toxicol Lett 175:34-43. 2007..89 and 0.84, respectively. In conclusion, the LSER approach adequately predicted the dermal permeability of four biocides in commercial cutting fluids and also shed light on the chemical interactions resulting in reduced permeability... - Pharmacokinetics of melamine in pigs following intravenous administrationRonald E Baynes
Food Animal Residue Avoidance Databank, Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, College of Veterinary Medicine, Raleigh, NC 27606, USA
Food Chem Toxicol 46:1196-200. 2008.... - NDELA and nickel modulation of triazine disposition in skinRonald E Baynes
Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, Raleigh, NC, USA
Toxicol Ind Health 21:197-205. 2005..Workers should therefore not only be concerned about dermatotoxicity of these contaminants, but also the modulated dermal disposition of cutting fluid additives when these contaminants are present in cutting fluid formulations... - Skin toxicity of jet fuels: ultrastructural studies and the effects of substance PNancy A Monteiro-Riviere
Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, Raleigh, NC 27606, USA
Toxicol Appl Pharmacol 195:339-47. 2004..These studies provide a base upon which biochemical and immunological data collected in other model systems can be compared... - A compartment model for the membrane-coated fiber technique used for determining the absorption parameters of chemicals into lipophilic membranesXin Rui Xia
Center for Chemical Toxicology Research and Pharmacokinetics, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27606, USA
Pharm Res 21:1345-52. 2004..The purpose of this work was to develop a compartment model for the membrane-coated fiber (MCF) technique for determining the absorption parameters of chemicals into lipophilic membranes... - Effect of vehicles and sodium lauryl sulphate on xenobiotic permeability and stratum corneum partitioning in porcine skinDeon van der Merwe
Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, Raleigh, North Carolina 27606, USA
Toxicology 206:325-35. 2005.... - Determination of the partition coefficients and absorption kinetic parameters of chemicals in a lipophilic membrane/water system by using a membrane-coated fiber techniqueXin-Rui Xia
Center for Chemical Toxicology Research and Pharmacokinetics (CCTRP, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
Eur J Pharm Sci 24:15-23. 2005..It was demonstrated that the MCF technique could be used to determine the partition, diffusion and permeation coefficients, as well as the thickness of the boundary layer in a lipophilic membrane/water system... - Multi-walled carbon nanotube interactions with human epidermal keratinocytesNancy A Monteiro-Riviere
Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
Toxicol Lett 155:377-84. 2005.... - Pre-treatment effects of trichloroethylene on the dermal absorption of the biocide, triazineRonald E Baynes
Center for Chemical Toxicology Research and Pharmacokinetics CCTRP, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA
Toxicol Lett 159:252-60. 2005.... - Physicochemical determinants of linear alkylbenzene sulfonate (LAS) disposition in skin exposed to aqueous cutting fluid mixturesRonald E Baynes
Center for Chemical Toxicology Research and Pharmacokinetics CCTRP, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
Toxicol Ind Health 18:237-48. 2002..In summary, physicochemical interactions in these mixtures influenced availability of LAS for absorption and distribution in skin, and could ultimately influence toxicological responses in skin... - A novel in-vitro technique for studying percutaneous permeation with a membrane-coated fiber and gas chromatography/mass spectrometry: part I. Performances of the technique and determination of the permeation rates and partition coefficients of chemical mXin-Rui Xia
Center for Chemical Toxicology Research and Pharmacokinetics (CCTRP, College of Veterinary Medicine, Campus Box 8401, 4700 Hillsborough Street, North Carolina State University, Raleigh, North Carolina 27606, USA
Pharm Res 20:275-82. 2003..The initial permeation rate and equilibrium time can be obtained for each compound, which could serve as characteristic parameters regarding the skin permeability of the compound... - Analysis of N,N-diethyl-m-toluamide in porcine skin perfusates using solid-phase extraction disks and reversed-phase high-performance liquid chromatographyRonald E Baynes
North Carolina State University College of Veterinary Medicine, Center for Chemical Toxicology Research and Pharmacokinetics, 4700 Hillsborough St, Raleigh, NC 27606, USA
J Chromatogr B Analyt Technol Biomed Life Sci 780:45-52. 2002..1%. This method was used to analyze perfusate samples from skin (n=4) topically exposed to DEET-ethanol formulations. The data from these analyses determined that DEET permeability in porcine skin was 2.55 x 10(-5)+/-0.54 x 10(-5) cm/h... - Pyridostigmine bromide modulates the dermal disposition of [14C]permethrinRonald E Baynes
Center for Chemical Toxicology Research and Pharmacokinetics CCTRP, North Carolina State University, Raleigh 27606, USA
Toxicol Appl Pharmacol 181:164-73. 2002.... - Pyridostigmine bromide modulates topical irritant-induced cytokine release from human epidermal keratinocytes and isolated perfused porcine skinNancy A Monteiro-Riviere
Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
Toxicology 183:15-28. 2003..In conclusion, these studies suggest that systemic exposure to PB suppressed IL-8 release at multiple time points in two skin model systems. This interaction merits further study... - Effect of chemical interactions in pentachlorophenol mixtures on skin and membrane transportRonald E Baynes
Center for Chemical Toxicology Research and Pharmacokinetics, Department of Food Animal Health and Resource Management, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
Toxicol Sci 69:295-305. 2002.... - Surface coatings determine cytotoxicity and irritation potential of quantum dot nanoparticles in epidermal keratinocytesJessica P Ryman Rasmussen
Center for Chemical Toxicology Research and Pharmacokinetics, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27606, USA
J Invest Dermatol 127:143-53. 2007..These data indicate that QD surface coating is a primary determinant of cytotoxicity and immunotoxicity in HEKs, which is consistent across size. However, uptake of QDs by HEKs is independent of surface coating... - Regression method of the hydrophobicity ruler approach for determining octanol/water partition coefficients of very hydrophobic compoundsXiang Q Kong
Department of Environmental and Molecular Toxicology, North Carolina State University, Raleigh, NC 27606, USA
Chemosphere 66:1086-93. 2007..The critical experimental factors, the merits of the regression method were discussed... - Percutaneous absorption of 2,6-di-tert-butyl-4-nitrophenol (DBNP) in isolated perfused porcine skinAlfred O Inman
Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, 4700 Hillsborough Street, NC 27606, Raleigh, USA
Toxicol In Vitro 17:289-92. 2003..The highest mass of 14C-DBNP absorbed was only 0.5 microgram. The majority of the applied dose remained on the surface of the skin. This suggests that there is minimal dermal exposure of DBNP when exposed topically to skin... - Extrapolated withdrawal-interval estimator (EWE) algorithm: a quantitative approach to establishing extralabel withdrawal timesTomas Martin-Jimenez
Department of Veterinary Biosciences, College of Veterinary Medicine, University of Illinois, Urbana, Illinois 61802, USA
Regul Toxicol Pharmacol 36:131-7. 2002..Population models could be fitted to fragmentary data to predict residue concentrations in tissues, validate the EWE estimates, and obtain WDI estimates... - Naïve averaged, naïve pooled, and population pharmacokinetics of orally administered marbofloxacin in juvenile harbor sealsButch KuKanich
Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
J Am Vet Med Assoc 230:390-5. 2007..3 mg/lb) and to compare pharmacokinetic variables after pharmacokinetic analysis by naïve averaged, naïve pooled, and nonlinear mixed-effects modeling... - Elimination kinetics of tilmicosin following intramammary administration in lactating dairy cattleGeof W Smith
Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
J Am Vet Med Assoc 234:245-8. 2009..To determine elimination kinetics of tilmicosin in milk following intramammary administration in lactating dairy cattle... - Estimating meat withdrawal times in pigs exposed to melamine contaminated feed using a physiologically based pharmacokinetic modelJennifer L Buur
Food Animal Residue Avoidance Databank, Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, College of Veterinary Medicine, 4700 Hillsborough St Raleigh, NC 27606, USA
Regul Toxicol Pharmacol 51:324-31. 2008..PBPK models, such as this one, provide evidence of the usefulness in species extrapolation over a range of dosing scenarios and can be used to protect the food supply after accidental exposure in the face of little in the target species... - Variables influencing interactions of untargeted quantum dot nanoparticles with skin cells and identification of biochemical modulatorsJessica P Ryman Rasmussen
Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, 4700 Hillsborough Street, Raleigh, North Carolina 27606, USA
Nano Lett 7:1344-8. 2007..Biochemical inhibitors were identified that attenuate and potentiate QD-NHEK interactions. These results are important for understanding and controlling interactions of untargeted QD with cells... - Development of a physiologic-based pharmacokinetic model for estimating sulfamethazine concentrations in swine and application to prediction of violative residues in edible tissuesJennifer L Buur
Food Animal Residue Avoidance Databank, Center for Chemical Toxicology Research and Pharmacokinetics, Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh 27606, USA
Am J Vet Res 66:1686-93. 2005..CONCLUSIONS AND CLINICAL RELEVANCE: Use of this model enabled accurate prediction of sulfamethazine pharmacokinetics in swine and has applications for food safety and prediction of drug residues in edible tissues... - Effect of formulation and route of administration on tissue residues and withdrawal timesButch KuKanich
Food Animal Residue Avoidance Databank, Department of Biomedical Sciences, NC 27606, USA
J Am Vet Med Assoc 227:1574-7. 2005 - Aminoglycoside residues in food of animal originRonette Gehring
Food Animal Residue Avoidance Databank, Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
J Am Vet Med Assoc 227:63-6. 2005 - Penetration of intact skin by quantum dots with diverse physicochemical propertiesJessica P Ryman-Rasmussen
Center for Chemical Toxicology Research and Pharmacokinetics, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27606, USA
Toxicol Sci 91:159-65. 2006.... - Drugs approved for small ruminantsAlistair I Webb
Food Animal Residue Avoidance Databank, Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32611, USA
J Am Vet Med Assoc 224:520-3. 2004 - Elimination kinetics of ceftiofur hydrochloride after intramammary administration in lactating dairy cowsGeof W Smith
Food Animal Residue Avoidance Databank, Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
J Am Vet Med Assoc 224:1827-30. 2004..Elimination of ceftiofur may be correlated with milk production, and cows producing smaller volumes of milk may have prolonged withdrawal times... - Comparison of quantum dot biodistribution with a blood-flow-limited physiologically based pharmacokinetic modelHyun A Lee
College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27606, USA
Nano Lett 9:794-9. 2009..The model predicted the experimentally observed persistence of QDs in tissues but not early time profiles or different QD biodistribution. Therefore, more complex models will be needed to better predict QD biodistribution in vivo... - Mixed-effects modeling of the interspecies pharmacokinetic scaling of oxytetracyclineTomas Martin-Jimenez
College of Veterinary Medicine, University of Illinois, 2001 South Lincoln Avenue, Urbana, Illinois 61802, USA
J Pharm Sci 91:331-41. 2002..Furthermore, this approach allows decisions to be made based on the statistical significance of the parameter estimates and the adequacy of the models that are not possible with traditional approaches... - Evaluation of the advisory services provided by the Food Animal Residue Avoidance DatabankJiming Wang
Food Animal Residue Avoidance Databank, Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
J Am Vet Med Assoc 223:1596-8. 2003 - Extralabel use of nonsteroidal anti-inflammatory drugs in cattleGeof W Smith
Food Animal Residue Avoidance Databank, Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
J Am Vet Med Assoc 232:697-701. 2008 - Extralabel intramammary use of drugs in dairy cattleGeof W Smith
Food Animal Residue Avoidance Databank, Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
J Am Vet Med Assoc 226:1994-6. 2005 - Toxicity of jet fuel aliphatic and aromatic hydrocarbon mixtures on human epidermal keratinocytes: evaluation based on in vitro cytotoxicity and interleukin-8 releaseJen-Hung Yang
Department of Dermatology, Chung-Shan Medical University Hospital, Taichung, Taiwan, R.O.C
Arch Toxicol 80:508-23. 2006..The mixture effects must be considered when evaluating jet fuel toxicity to HEK... - Current update on drugs for game bird speciesMartha L Needham
Food Animal Residue Avoidance Databank, Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
J Am Vet Med Assoc 231:1506-8. 2007 - Extralabel use of penicillin in food animalsMichael A Payne
Food Animal Residue Avoidance Databank (FARAD, Environmental Toxicology Extension, College of Agricultural and Environmental Sciences, University of California, Davis, CA 95616, USA
J Am Vet Med Assoc 229:1401-3. 2006..Penicillin is one of the most commonly detected drug residues in tissues and milk, and is the antimicrobial for which information is most often sought through FARAD... - Update on FARAD food animal drug withholding recommendationsScott R R Haskell
FARAD, Department of Environmental Toxicology, College of Agricultural and Environmental Sciences, University of California, Davis, CA 95616, USA
J Am Vet Med Assoc 223:1277-8. 2003 - A time of changeJim E Riviere
J Vet Pharmacol Ther 29:1. 2006 - Current approved drugs for aquatic speciesScott R R Haskell
Food Animal Residue Avoidance Databank, Department of Environmental Toxicology, College of Agricultural and Environmental Sciences, University of California, Davis 95616, USA
J Am Vet Med Assoc 224:50-1. 2004
Research Grants
- Quantitating Absorption of Complex Chemical MixturesJim Riviere; Fiscal Year: 2005....
- Quantitating Absorption of Complex Chemical MixturesJim Riviere; Fiscal Year: 2007..abstract_text> ..
- Quantitating Absorption of Complex Chemical MixturesJim Riviere; Fiscal Year: 2009..abstract_text> ..