Jim Riviere

Summary

Affiliation: North Carolina State University
Country: USA

Publications

  1. ncbi request reprint The future of veterinary therapeutics: a glimpse towards 2030
    Jim E Riviere
    Center for Chemical Toxicology Research and Pharmacokinetics, Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
    Vet J 174:462-71. 2007
  2. pmc Acute vascular effects of nanoparticle infusion in isolated perfused skin
    Jim E Riviere
    Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, Raleigh, NC, USA
    Nanomedicine 8:428-31. 2012
  3. ncbi request reprint Electrically-assisted transdermal drug delivery
    J E Riviere
    Cutaneous Pharmacology and Toxicology Center, North Carolina State University, Raleigh 27606, USA
    Pharm Res 14:687-97. 1997
  4. doi request reprint Pharmacokinetics of nanomaterials: an overview of carbon nanotubes, fullerenes and quantum dots
    Jim E Riviere
    Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, Raleigh, NC 27606, USA
    Wiley Interdiscip Rev Nanomed Nanobiotechnol 1:26-34. 2009
  5. ncbi request reprint Percutaneous absorption of topical N,N-diethyl-m-toluamide (DEET): effects of exposure variables and coadministered toxicants
    Jim E Riviere
    Center for Chemical Toxicology Research and Pharmacokinetics, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    J Toxicol Environ Health A 66:133-51. 2003
  6. ncbi request reprint New technologies for application to veterinary therapeutics
    Jim E Riviere
    Center for Chemical Toxicology Research and Pharmacokinetics, Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, 27606, USA
    Handb Exp Pharmacol 199:191-210. 2010
  7. doi request reprint Surfactant effects on skin absorption of model organic chemicals: implications for dermal risk assessment studies
    Jim E Riviere
    Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, Raleigh, North Carolina 27606, USA
    J Toxicol Environ Health A 73:725-37. 2010
  8. ncbi request reprint Membrane-coated fiber array approach for predicting skin permeability of chemical mixtures from different vehicles
    Jim E Riviere
    Center for Chemical Toxicology Research and Pharmacokinetics CCTRP, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27606, USA
    Toxicol Sci 99:153-61. 2007
  9. ncbi request reprint Prediction of dermal absorption from complex chemical mixtures: incorporation of vehicle effects and interactions into a QSPR framework
    J E Riviere
    Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    SAR QSAR Environ Res 18:31-44. 2007
  10. ncbi request reprint Gulf War related exposure factors influencing topical absorption of 14C-permethrin
    Jim E Riviere
    Center for Chemical Toxicology Research and Pharmacokinetics, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    Toxicol Lett 135:61-71. 2002

Research Grants

Collaborators

Detail Information

Publications72

  1. ncbi request reprint The future of veterinary therapeutics: a glimpse towards 2030
    Jim E Riviere
    Center for Chemical Toxicology Research and Pharmacokinetics, Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
    Vet J 174:462-71. 2007
    ..Although this growth in technology would portend major advances over the next few decades, economic and regulatory constraints must still be overcome for these new drugs or therapeutic approaches to become common practice...
  2. pmc Acute vascular effects of nanoparticle infusion in isolated perfused skin
    Jim E Riviere
    Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, Raleigh, NC, USA
    Nanomedicine 8:428-31. 2012
    ..In contrast, infusion with nC(60) nanoparticles did not produce these effects. These observations suggest certain nanoparticle infusions may be associated with acute vascular physiologic effects that merit further attention...
  3. ncbi request reprint Electrically-assisted transdermal drug delivery
    J E Riviere
    Cutaneous Pharmacology and Toxicology Center, North Carolina State University, Raleigh 27606, USA
    Pharm Res 14:687-97. 1997
    ..The focus of this review is to put these different mechanisms in perspective and relate them to the drug and skin model system being investigated...
  4. doi request reprint Pharmacokinetics of nanomaterials: an overview of carbon nanotubes, fullerenes and quantum dots
    Jim E Riviere
    Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, Raleigh, NC 27606, USA
    Wiley Interdiscip Rev Nanomed Nanobiotechnol 1:26-34. 2009
    ..Finally, unlike many small organic drugs, nanomaterials may preferentially be trafficked in the body via the lymphatic system that has obvious immunological implications...
  5. ncbi request reprint Percutaneous absorption of topical N,N-diethyl-m-toluamide (DEET): effects of exposure variables and coadministered toxicants
    Jim E Riviere
    Center for Chemical Toxicology Research and Pharmacokinetics, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    J Toxicol Environ Health A 66:133-51. 2003
    ....
  6. ncbi request reprint New technologies for application to veterinary therapeutics
    Jim E Riviere
    Center for Chemical Toxicology Research and Pharmacokinetics, Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, 27606, USA
    Handb Exp Pharmacol 199:191-210. 2010
    ..Although this growth in technology portends major advances over the next few decades, economic and regulatory constraints must still be overcome for these new drugs or therapeutic approaches to become common practise...
  7. doi request reprint Surfactant effects on skin absorption of model organic chemicals: implications for dermal risk assessment studies
    Jim E Riviere
    Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, Raleigh, North Carolina 27606, USA
    J Toxicol Environ Health A 73:725-37. 2010
    ..The inert three-fiber MCF array predicted absorptive fluxes seen in the ex vivo IPPSF, suggesting lack of any biological effects of the surfactants on skin...
  8. ncbi request reprint Membrane-coated fiber array approach for predicting skin permeability of chemical mixtures from different vehicles
    Jim E Riviere
    Center for Chemical Toxicology Research and Pharmacokinetics CCTRP, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27606, USA
    Toxicol Sci 99:153-61. 2007
    ..These results suggested that the experimentally based MCF array approach can be used to predict skin absorption from chemical mixtures in different vehicles or formulations...
  9. ncbi request reprint Prediction of dermal absorption from complex chemical mixtures: incorporation of vehicle effects and interactions into a QSPR framework
    J E Riviere
    Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    SAR QSAR Environ Res 18:31-44. 2007
    ..The use of the MF in combination with a classic LFER based on penetrant properties significantly improved the ability to predict dermal absorption of compounds dosed in complex chemical mixtures...
  10. ncbi request reprint Gulf War related exposure factors influencing topical absorption of 14C-permethrin
    Jim E Riviere
    Center for Chemical Toxicology Research and Pharmacokinetics, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    Toxicol Lett 135:61-71. 2002
    ..The toxicologic significance of this moderate increase in permethrin absorption remains unclear...
  11. ncbi request reprint Dermal absorption and distribution of topically dosed jet fuels jet-A, JP-8, and JP-8(100)
    J E Riviere
    Center for Cutaneous Toxicology and Residue Pharmacology, College of Veterinary Medicine, Raleigh, North Carolina 27606, USA
    Toxicol Appl Pharmacol 160:60-75. 1999
    ..These studies demonstrated different absorption profiles for the three marker compounds, differential effects of jet fuel types on naphthalene and dodecane absorption, and uncoupling of perfusate absorption from skin disposition...
  12. ncbi request reprint Use of methyl salicylate as a simulant to predict the percutaneous absorption of sulfur mustard
    J E Riviere
    Center for Cutaneous Toxicology and Residue Pharmacology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
    J Appl Toxicol 21:91-9. 2001
    ..05). Compared with other chemicals studied in this model, HD and MS cutaneous disposition were very similar, supporting the use of MS as a dermal simulant for HD exposure...
  13. ncbi request reprint Potential and problems of developing transdermal patches for veterinary applications
    J E Riviere
    Center for Cutaneous Toxicology and Residue Pharmacology, Department of Farm Animal Health and Resource Management, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27613, USA
    Adv Drug Deliv Rev 50:175-203. 2001
    ..With efficient experimental designs and available transdermal patch technology, there are no obvious hurdles to the development of effective systems in many veterinary species...
  14. ncbi request reprint Mixture component effects on the in vitro dermal absorption of pentachlorophenol
    J E Riviere
    Center for Cutaneous Toxicology and Residue Pharmacology, College of Veterinary Medicine, North Carolina State University, Raleigh 27606, USA
    Arch Toxicol 75:329-34. 2001
    ..These results suggest that dermal absorption estimates from a single chemical exposure may not reflect absorption seen after exposure as a chemical mixture and that absorption of both TCB and PCB are minimal in this model system...
  15. pmc Predicting skin permeability from complex chemical mixtures: dependency of quantitative structure permeation relationships on biology of skin model used
    Jim E Riviere
    Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, Raleigh, North Carolina 27606, USA
    Toxicol Sci 119:224-32. 2011
    ....
  16. ncbi request reprint Predicting skin permeability from complex chemical mixtures
    Jim E Riviere
    Center for Chemical Toxicology Research and Pharmacokinetics, 4700 Hillsborough Street, North Carolina State University, Raleigh, NC 27606, USA
    Toxicol Appl Pharmacol 208:99-110. 2005
    ....
  17. ncbi request reprint Dermal permeation of biocides and aromatic chemicals in three generic formulations of metalworking fluids
    Vikrant Vijay
    Center for Chemical Toxicology Research and Pharmacokinetics CCTRP, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27606 8401, USA
    J Toxicol Environ Health A 72:832-41. 2009
    ..The dilution of these MWF formulations with water may increase dermal permeability of biocides, allowing for an enhanced risk for systemic toxicological effects and dermatitis potential...
  18. ncbi request reprint Biodistribution of quantum dot nanoparticles in perfused skin: evidence of coating dependency and periodicity in arterial extraction
    Hyun A Lee
    Center for Chemical Toxicology Research and Pharmacokinetics, and Biomathematics Program, North Carolina State University, 4700 Hillsborough Street, Raleigh, North Carolina 27606, USA
    Nano Lett 7:2865-70. 2007
    ..Both QD had a unique periodicity in arterial extraction never observed with drug infusions, suggesting a potentially important nanomaterial behavior that could affect systemic disposition...
  19. ncbi request reprint Comparative mixture effects of JP-8(100) additives on the dermal absorption and disposition of jet fuel hydrocarbons in different membrane model systems
    Faqir Muhammad
    Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, 700 Hillsborough Street, Raleigh, NC 27606, USA
    Toxicol Lett 150:351-65. 2004
    ..Finally, it is important to assess all components of a chemical mixture since the effects of single components administered alone or as pairs may be confounded when all are present in the complete mixture...
  20. ncbi request reprint Differential relationship between the carbon chain length of jet fuel aliphatic hydrocarbons and their ability to induce cytotoxicity vs. interleukin-8 release in human epidermal keratinocytes
    Chi Chung Chou
    Center for Chemical Toxicology Research and Pharmacokinetics CCTRP, North Carolina State University, 4700 Hillsborough Street, Raleigh, North Carolina 27606, USA
    Toxicol Sci 69:226-33. 2002
    ....
  21. ncbi request reprint Sulfamethazine water medication pharmacokinetics and contamination in a commercial pig production unit
    Sharon E Mason
    Department of Population Health and Pathobiology, Center for Chemical Toxicology and Research Pharmacokinetics, North Carolina State University, Raleigh 27606, USA
    J Food Prot 71:584-9. 2008
    ..These results are of concern for producers and veterinarians, because in commercial farms, the entire barn is often treated,and environmental contamination could result in residues of an unknown duration...
  22. pmc Use of probabilistic modeling within a physiologically based pharmacokinetic model to predict sulfamethazine residue withdrawal times in edible tissues in swine
    Jennifer Buur
    Food Animal Residue Avoidance Databank, Center for Chemical Toxicology Research and Pharmacokinetics, College of Veterinary Medicine, North Carolina State University, NC 27606, USA
    Antimicrob Agents Chemother 50:2344-51. 2006
    ..These models can be used to calculate the parameters required by FDA and explore those conditions where the established withdrawal time may not be sufficient...
  23. doi request reprint Quantification of chemical mixture interactions modulating dermal absorption using a multiple membrane fiber array
    Ronald E Baynes
    Center for Chemical Toxicology Research and Pharmacokinetics, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, North Carolina 27606, USA
    Chem Res Toxicol 21:591-9. 2008
    ....
  24. doi request reprint Skin penetration and kinetics of pristine fullerenes (C60) topically exposed in industrial organic solvents
    Xin R Xia
    Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    Toxicol Appl Pharmacol 242:29-37. 2010
    ..In vitro flow-through diffusion cell experiments were conducted in pig skin and fullerenes were not detected in the receptor solutions by 24 h. The limit of detection was 0.001 microg/mL of fullerenes in 2 mL of the receptor solutions...
  25. ncbi request reprint Trace analysis of fullerenes in biological samples by simplified liquid-liquid extraction and high-performance liquid chromatography
    Xin Rui Xia
    Center for Chemical Toxicology Research and Pharmacokinetics CCTRP, North Carolina State University, Raleigh, NC 27606, USA
    J Chromatogr A 1129:216-22. 2006
    ..Under optimal experimental conditions, the detection limit was 0.34 ng/mL and the recovery was in the range of 94-100% (n=5) at a concentration of 10 ng/mL nano-C60 in the biological media...
  26. doi request reprint Intrinsic biological property of colloidal fullerene nanoparticles (nC60): lack of lethality after high dose exposure to human epidermal and bacterial cells
    Xin R Xia
    Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    Toxicol Lett 197:128-34. 2010
    ..05) from the control without nC60 nanoparticles. These results reveal that the intrinsic biological property of nC60 is non-toxic, confirming the prior non-toxic reports when using nC60 prepared with non-THF methods...
  27. ncbi request reprint An experimentally based approach for predicting skin permeability of chemicals and drugs using a membrane-coated fiber array
    Xin Rui Xia
    Center for Chemical Toxicology Research and Pharmacokinetics CCTRP, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    Toxicol Appl Pharmacol 221:320-8. 2007
    ..It is an experimentally based, high throughput approach that provides high prediction confidence and does not require literature data nor molecular structure information in contrast to the existing predictive models...
  28. ncbi request reprint Disposition of melamine residues in blood and milk from dairy goats exposed to an oral bolus of melamine
    Ronald E Baynes
    Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, Raleigh, NC 27606, United States
    Food Chem Toxicol 48:2542-6. 2010
    ....
  29. doi request reprint Evaluation of perfused porcine skin as a model system to quantitate tissue distribution of fullerene nanoparticles
    Teresa L Leavens
    Center for Chemical Toxicology Research and Pharmacokinetics, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, United States
    Toxicol Lett 197:1-6. 2010
    ....
  30. ncbi request reprint Partitioning behavior of aromatic components in jet fuel into diverse membrane-coated fibers
    Ronald E Baynes
    Center for Chemical Toxicology Research and Pharmacokinetics, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27606, USA
    J Toxicol Environ Health A 70:1879-87. 2007
    ..This information may be incorporated into physiologically based pharmacokinetic (PBPK) models to provide a more accurate assessment of tissue dosimetry of related toxicants...
  31. doi request reprint Application of linear solvation energy relationships to a custom-made polyaniline solid-phase microextraction fiber and three commercial fibers
    James L Yeatts
    Center for Chemical Toxicology Research and Pharmacokinetics CCTRP, North Carolina State University, College of Veterinary Medicine, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    J Chromatogr A 1188:108-17. 2008
    ..The PANI fiber may offer greater flexibility in the choice of fibers to use for solid-phase microextraction...
  32. ncbi request reprint Predicting dermal permeability of biocides in commercial cutting fluids using a LSER approach
    Vikrant Vijay
    Center for Chemical Toxicology Research and Pharmacokinetics CCTRP, College of Veterinary Medicine, North Carolina State University, CCTRP CVM, 4700 Hillsborough Street, Raleigh, NC 27606, United States
    Toxicol Lett 175:34-43. 2007
    ..89 and 0.84, respectively. In conclusion, the LSER approach adequately predicted the dermal permeability of four biocides in commercial cutting fluids and also shed light on the chemical interactions resulting in reduced permeability...
  33. doi request reprint Pharmacokinetics of melamine in pigs following intravenous administration
    Ronald E Baynes
    Food Animal Residue Avoidance Databank, Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, College of Veterinary Medicine, Raleigh, NC 27606, USA
    Food Chem Toxicol 46:1196-200. 2008
    ....
  34. ncbi request reprint NDELA and nickel modulation of triazine disposition in skin
    Ronald E Baynes
    Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, Raleigh, NC, USA
    Toxicol Ind Health 21:197-205. 2005
    ..Workers should therefore not only be concerned about dermatotoxicity of these contaminants, but also the modulated dermal disposition of cutting fluid additives when these contaminants are present in cutting fluid formulations...
  35. ncbi request reprint Physicochemical determinants of linear alkylbenzene sulfonate (LAS) disposition in skin exposed to aqueous cutting fluid mixtures
    Ronald E Baynes
    Center for Chemical Toxicology Research and Pharmacokinetics CCTRP, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    Toxicol Ind Health 18:237-48. 2002
    ..In summary, physicochemical interactions in these mixtures influenced availability of LAS for absorption and distribution in skin, and could ultimately influence toxicological responses in skin...
  36. ncbi request reprint Skin toxicity of jet fuels: ultrastructural studies and the effects of substance P
    Nancy A Monteiro-Riviere
    Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, Raleigh, NC 27606, USA
    Toxicol Appl Pharmacol 195:339-47. 2004
    ..These studies provide a base upon which biochemical and immunological data collected in other model systems can be compared...
  37. ncbi request reprint A compartment model for the membrane-coated fiber technique used for determining the absorption parameters of chemicals into lipophilic membranes
    Xin Rui Xia
    Center for Chemical Toxicology Research and Pharmacokinetics, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27606, USA
    Pharm Res 21:1345-52. 2004
    ..The purpose of this work was to develop a compartment model for the membrane-coated fiber (MCF) technique for determining the absorption parameters of chemicals into lipophilic membranes...
  38. ncbi request reprint Effect of vehicles and sodium lauryl sulphate on xenobiotic permeability and stratum corneum partitioning in porcine skin
    Deon van der Merwe
    Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, Raleigh, North Carolina 27606, USA
    Toxicology 206:325-35. 2005
    ....
  39. ncbi request reprint Determination of the partition coefficients and absorption kinetic parameters of chemicals in a lipophilic membrane/water system by using a membrane-coated fiber technique
    Xin Rui Xia
    Center for Chemical Toxicology Research and Pharmacokinetics CCTRP, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    Eur J Pharm Sci 24:15-23. 2005
    ..It was demonstrated that the MCF technique could be used to determine the partition, diffusion and permeation coefficients, as well as the thickness of the boundary layer in a lipophilic membrane/water system...
  40. ncbi request reprint Multi-walled carbon nanotube interactions with human epidermal keratinocytes
    Nancy A Monteiro-Riviere
    Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    Toxicol Lett 155:377-84. 2005
    ....
  41. ncbi request reprint Pre-treatment effects of trichloroethylene on the dermal absorption of the biocide, triazine
    Ronald E Baynes
    Center for Chemical Toxicology Research and Pharmacokinetics CCTRP, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA
    Toxicol Lett 159:252-60. 2005
    ....
  42. ncbi request reprint A novel in-vitro technique for studying percutaneous permeation with a membrane-coated fiber and gas chromatography/mass spectrometry: part I. Performances of the technique and determination of the permeation rates and partition coefficients of chemical m
    Xin Rui Xia
    Center for Chemical Toxicology Research and Pharmacokinetics CCTRP, College of Veterinary Medicine, Campus Box 8401, 4700 Hillsborough Street, North Carolina State University, Raleigh, North Carolina 27606, USA
    Pharm Res 20:275-82. 2003
    ..To develop a novel in-vitro technique for rapid assessment of percutaneous absorption of chemical mixtures...
  43. ncbi request reprint Analysis of N,N-diethyl-m-toluamide in porcine skin perfusates using solid-phase extraction disks and reversed-phase high-performance liquid chromatography
    Ronald E Baynes
    North Carolina State University College of Veterinary Medicine, Center for Chemical Toxicology Research and Pharmacokinetics, 4700 Hillsborough St, Raleigh, NC 27606, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 780:45-52. 2002
    ..1%. This method was used to analyze perfusate samples from skin (n=4) topically exposed to DEET-ethanol formulations. The data from these analyses determined that DEET permeability in porcine skin was 2.55 x 10(-5)+/-0.54 x 10(-5) cm/h...
  44. ncbi request reprint Pyridostigmine bromide modulates the dermal disposition of [14C]permethrin
    Ronald E Baynes
    Center for Chemical Toxicology Research and Pharmacokinetics CCTRP, North Carolina State University, Raleigh 27606, USA
    Toxicol Appl Pharmacol 181:164-73. 2002
    ....
  45. ncbi request reprint Effect of chemical interactions in pentachlorophenol mixtures on skin and membrane transport
    Ronald E Baynes
    Center for Chemical Toxicology Research and Pharmacokinetics, Department of Food Animal Health and Resource Management, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
    Toxicol Sci 69:295-305. 2002
    ....
  46. ncbi request reprint Pyridostigmine bromide modulates topical irritant-induced cytokine release from human epidermal keratinocytes and isolated perfused porcine skin
    Nancy A Monteiro-Riviere
    Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    Toxicology 183:15-28. 2003
    ..In conclusion, these studies suggest that systemic exposure to PB suppressed IL-8 release at multiple time points in two skin model systems. This interaction merits further study...
  47. doi request reprint Assessing vehicle effects on skin absorption of non-volatile compounds using membrane-coated fiber arrays
    Daniela Karadzovska
    Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, Raleigh, NC, USA
    Cutan Ocul Toxicol 32:283-9. 2013
    ..In particular, three commercially available fiber coatings (polydimethylsiloxane, polyacrylate and carbowax) were shown to be representative of molecular interactions relevant to skin absorption...
  48. ncbi request reprint Regression method of the hydrophobicity ruler approach for determining octanol/water partition coefficients of very hydrophobic compounds
    Xiang Q Kong
    Department of Environmental and Molecular Toxicology, North Carolina State University, Raleigh, NC 27606, USA
    Chemosphere 66:1086-93. 2007
    ..The critical experimental factors, the merits of the regression method were discussed...
  49. ncbi request reprint Percutaneous absorption of 2,6-di-tert-butyl-4-nitrophenol (DBNP) in isolated perfused porcine skin
    Alfred O Inman
    Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, 4700 Hillsborough Street, NC 27606, Raleigh, USA
    Toxicol In Vitro 17:289-92. 2003
    ..The highest mass of 14C-DBNP absorbed was only 0.5 microgram. The majority of the applied dose remained on the surface of the skin. This suggests that there is minimal dermal exposure of DBNP when exposed topically to skin...
  50. ncbi request reprint Surface coatings determine cytotoxicity and irritation potential of quantum dot nanoparticles in epidermal keratinocytes
    Jessica P Ryman-Rasmussen
    Center for Chemical Toxicology Research and Pharmacokinetics, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27606, USA
    J Invest Dermatol 127:143-53. 2007
    ..These data indicate that QD surface coating is a primary determinant of cytotoxicity and immunotoxicity in HEKs, which is consistent across size. However, uptake of QDs by HEKs is independent of surface coating...
  51. ncbi request reprint Extrapolated withdrawal-interval estimator (EWE) algorithm: a quantitative approach to establishing extralabel withdrawal times
    Tomas Martin-Jimenez
    Department of Veterinary Biosciences, College of Veterinary Medicine, University of Illinois, Urbana, Illinois 61802, USA
    Regul Toxicol Pharmacol 36:131-7. 2002
    ..Population models could be fitted to fragmentary data to predict residue concentrations in tissues, validate the EWE estimates, and obtain WDI estimates...
  52. ncbi request reprint Variables influencing interactions of untargeted quantum dot nanoparticles with skin cells and identification of biochemical modulators
    Jessica P Ryman-Rasmussen
    Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, 4700 Hillsborough Street, Raleigh, North Carolina 27606, USA
    Nano Lett 7:1344-8. 2007
    ..Biochemical inhibitors were identified that attenuate and potentiate QD-NHEK interactions. These results are important for understanding and controlling interactions of untargeted QD with cells...
  53. doi request reprint Elimination kinetics of tilmicosin following intramammary administration in lactating dairy cattle
    Geof W Smith
    Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
    J Am Vet Med Assoc 234:245-8. 2009
    ..To determine elimination kinetics of tilmicosin in milk following intramammary administration in lactating dairy cattle...
  54. doi request reprint Estimating meat withdrawal times in pigs exposed to melamine contaminated feed using a physiologically based pharmacokinetic model
    Jennifer L Buur
    Food Animal Residue Avoidance Databank, Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, College of Veterinary Medicine, 4700 Hillsborough St Raleigh, NC 27606, USA
    Regul Toxicol Pharmacol 51:324-31. 2008
    ..PBPK models, such as this one, provide evidence of the usefulness in species extrapolation over a range of dosing scenarios and can be used to protect the food supply after accidental exposure in the face of little in the target species...
  55. ncbi request reprint Naïve averaged, naïve pooled, and population pharmacokinetics of orally administered marbofloxacin in juvenile harbor seals
    Butch KuKanich
    Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
    J Am Vet Med Assoc 230:390-5. 2007
    ..3 mg/lb) and to compare pharmacokinetic variables after pharmacokinetic analysis by naïve averaged, naïve pooled, and nonlinear mixed-effects modeling...
  56. ncbi request reprint Effect of formulation and route of administration on tissue residues and withdrawal times
    Butch KuKanich
    Food Animal Residue Avoidance Databank, Department of Biomedical Sciences, NC 27606, USA
    J Am Vet Med Assoc 227:1574-7. 2005
  57. ncbi request reprint Development of a physiologic-based pharmacokinetic model for estimating sulfamethazine concentrations in swine and application to prediction of violative residues in edible tissues
    Jennifer L Buur
    Food Animal Residue Avoidance Databank, Center for Chemical Toxicology Research and Pharmacokinetics, Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh 27606, USA
    Am J Vet Res 66:1686-93. 2005
    ..To develop a flow-limited, physiologic-based pharmacokinetic model for use in estimating concentrations of sulfamethazine after IV administration to swine...
  58. ncbi request reprint Mixed-effects modeling of the interspecies pharmacokinetic scaling of oxytetracycline
    Tomas Martin-Jimenez
    College of Veterinary Medicine, University of Illinois, 2001 South Lincoln Avenue, Urbana, Illinois 61802, USA
    J Pharm Sci 91:331-41. 2002
    ..Furthermore, this approach allows decisions to be made based on the statistical significance of the parameter estimates and the adequacy of the models that are not possible with traditional approaches...
  59. ncbi request reprint Penetration of intact skin by quantum dots with diverse physicochemical properties
    Jessica P Ryman-Rasmussen
    Center for Chemical Toxicology Research and Pharmacokinetics, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27606, USA
    Toxicol Sci 91:159-65. 2006
    ....
  60. ncbi request reprint Aminoglycoside residues in food of animal origin
    Ronette Gehring
    Food Animal Residue Avoidance Databank, Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
    J Am Vet Med Assoc 227:63-6. 2005
  61. ncbi request reprint Drugs approved for small ruminants
    Alistair I Webb
    Food Animal Residue Avoidance Databank, Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32611, USA
    J Am Vet Med Assoc 224:520-3. 2004
  62. doi request reprint Comparison of quantum dot biodistribution with a blood-flow-limited physiologically based pharmacokinetic model
    Hyun A Lee
    College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27606, USA
    Nano Lett 9:794-9. 2009
    ..The model predicted the experimentally observed persistence of QDs in tissues but not early time profiles or different QD biodistribution. Therefore, more complex models will be needed to better predict QD biodistribution in vivo...
  63. ncbi request reprint Elimination kinetics of ceftiofur hydrochloride after intramammary administration in lactating dairy cows
    Geof W Smith
    Food Animal Residue Avoidance Databank, Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
    J Am Vet Med Assoc 224:1827-30. 2004
    ..To determine the elimination kinetics of ceftiofur hydrochloride in milk after intramammary administration in lactating dairy cows...
  64. ncbi request reprint Evaluation of the advisory services provided by the Food Animal Residue Avoidance Databank
    Jiming Wang
    Food Animal Residue Avoidance Databank, Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
    J Am Vet Med Assoc 223:1596-8. 2003
  65. doi request reprint Extralabel use of nonsteroidal anti-inflammatory drugs in cattle
    Geof W Smith
    Food Animal Residue Avoidance Databank, Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
    J Am Vet Med Assoc 232:697-701. 2008
  66. ncbi request reprint Extralabel intramammary use of drugs in dairy cattle
    Geof W Smith
    Food Animal Residue Avoidance Databank, Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
    J Am Vet Med Assoc 226:1994-6. 2005
  67. ncbi request reprint Toxicity of jet fuel aliphatic and aromatic hydrocarbon mixtures on human epidermal keratinocytes: evaluation based on in vitro cytotoxicity and interleukin-8 release
    Jen Hung Yang
    Department of Dermatology, Chung Shan Medical University Hospital, Taichung, Taiwan, R O C
    Arch Toxicol 80:508-23. 2006
    ..The mixture effects must be considered when evaluating jet fuel toxicity to HEK...
  68. ncbi request reprint Current update on drugs for game bird species
    Martha L Needham
    Food Animal Residue Avoidance Databank, Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    J Am Vet Med Assoc 231:1506-8. 2007
  69. ncbi request reprint Update on FARAD food animal drug withholding recommendations
    Scott R R Haskell
    FARAD, Department of Environmental Toxicology, College of Agricultural and Environmental Sciences, University of California, Davis, CA 95616, USA
    J Am Vet Med Assoc 223:1277-8. 2003
  70. ncbi request reprint Extralabel use of penicillin in food animals
    Michael A Payne
    Food Animal Residue Avoidance Databank FARAD, Environmental Toxicology Extension, College of Agricultural and Environmental Sciences, University of California, Davis, CA 95616, USA
    J Am Vet Med Assoc 229:1401-3. 2006
    ..Penicillin is one of the most commonly detected drug residues in tissues and milk, and is the antimicrobial for which information is most often sought through FARAD...
  71. ncbi request reprint A time of change
    Jim E Riviere
    J Vet Pharmacol Ther 29:1. 2006
  72. ncbi request reprint Current approved drugs for aquatic species
    Scott R R Haskell
    Food Animal Residue Avoidance Databank, Department of Environmental Toxicology, College of Agricultural and Environmental Sciences, University of California, Davis 95616, USA
    J Am Vet Med Assoc 224:50-1. 2004

Research Grants8

  1. Quantitating Absorption of Complex Chemical Mixtures
    Jim Riviere; Fiscal Year: 2005
    ....
  2. Quantitating Absorption of Complex Chemical Mixtures
    Jim Riviere; Fiscal Year: 2007
    ..abstract_text> ..
  3. Quantitating Absorption of Complex Chemical Mixtures
    Jim Riviere; Fiscal Year: 2009
    ..abstract_text> ..