Doodipala Samba Reddy

Summary

Affiliation: North Carolina State University
Country: USA

Publications

  1. ncbi request reprint The clinical potentials of endogenous neurosteroids
    Doodipala S Reddy
    Department of Anatomy, Physiological Sciences and Radiology, North Carolina State University College of Veterinary Medicine, Raleigh 27606, USA
    Drugs Today (Barc) 38:465-85. 2002
  2. ncbi request reprint Is there a physiological role for the neurosteroid THDOC in stress-sensitive conditions?
    Doodipala S Reddy
    Department of Molecular Biomedical Sciences, North Carolina State University College of Veterinary Medicine, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    Trends Pharmacol Sci 24:103-6. 2003
  3. ncbi request reprint Role of neurosteroids in catamenial epilepsy
    Doodipala S Reddy
    Department of Molecular Biomedical Sciences, North Carolina State University, College of Veterinary Medicine, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    Epilepsy Res 62:99-118. 2004
  4. ncbi request reprint Anesthetic effects of progesterone are undiminished in progesterone receptor knockout mice
    Doodipala S Reddy
    Department of Molecular Biomedical Sciences, North Carolina State University College of Veterinary Medicine, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    Brain Res 1033:96-101. 2005
  5. ncbi request reprint Physiological role of adrenal deoxycorticosterone-derived neuroactive steroids in stress-sensitive conditions
    D S Reddy
    Department of Molecular Biomedical Sciences, North Carolina State University, College of Veterinary Medicine, Raleigh, 27606, USA
    Neuroscience 138:911-20. 2006
  6. ncbi request reprint Newer GABAergic agents for pharmacotherapy of infantile spasms
    Doodipala S Reddy
    Department of Molecular Biomedical Sciences, North Carolina State University, College of Veterinary Medicine, Raleigh, NC 27606, USA
    Drugs Today (Barc) 38:657-75. 2002
  7. pmc Differential anesthetic activity of ketamine and the GABAergic neurosteroid allopregnanolone in mice lacking progesterone receptor A and B subtypes
    D S Reddy
    Department of Molecular Biomedical Sciences, North Carolina State University College of Veterinary Medicine, Raleigh, North Carolina 27606, USA
    Methods Find Exp Clin Pharmacol 29:659-64. 2007
  8. pmc Mass spectrometric assay and physiological-pharmacological activity of androgenic neurosteroids
    Doodipala S Reddy
    North Carolina State University, Department of Molecular Biomedical Sciences, Raleigh, NC 27606, USA
    Neurochem Int 52:541-53. 2008
  9. ncbi request reprint A high-performance liquid chromatography-tandem mass spectrometry assay of the androgenic neurosteroid 3alpha-androstanediol (5alpha-androstane-3alpha,17beta-diol) in plasma
    Doodipala S Reddy
    Department of Molecular Biomedical Sciences, North Carolina State University, College of Veterinary Medicine, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    Steroids 70:879-85. 2005
  10. ncbi request reprint Anxiolytic activity of progesterone in progesterone receptor knockout mice
    Doodipala S Reddy
    Department of Molecular Biomedical Sciences, North Carolina State University College of Veterinary Medicine, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    Neuropharmacology 48:14-24. 2005

Research Grants

  1. Neuroactive Steroid Therapy of Catamenial Epilepsy
    DOODIPALA REDDY; Fiscal Year: 2007
  2. Progesterone Receptors and Seizure Susceptibility
    DOODIPALA REDDY; Fiscal Year: 2007

Detail Information

Publications16

  1. ncbi request reprint The clinical potentials of endogenous neurosteroids
    Doodipala S Reddy
    Department of Anatomy, Physiological Sciences and Radiology, North Carolina State University College of Veterinary Medicine, Raleigh 27606, USA
    Drugs Today (Barc) 38:465-85. 2002
    ..Future studies may provide important new evidence that may not only explain acute actions of stress, but also reveal the clinical importance of neurosteroid mechanisms during chronic stress...
  2. ncbi request reprint Is there a physiological role for the neurosteroid THDOC in stress-sensitive conditions?
    Doodipala S Reddy
    Department of Molecular Biomedical Sciences, North Carolina State University College of Veterinary Medicine, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    Trends Pharmacol Sci 24:103-6. 2003
    ..These results might have significant implications for human stress-sensitive conditions such as epilepsy, post-traumatic stress disorder and depression...
  3. ncbi request reprint Role of neurosteroids in catamenial epilepsy
    Doodipala S Reddy
    Department of Molecular Biomedical Sciences, North Carolina State University, College of Veterinary Medicine, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    Epilepsy Res 62:99-118. 2004
    ..A greater understanding of the molecular mechanisms is clearly needed for designing effective treatment and prevention strategies of catamenial epilepsy in women at risk...
  4. ncbi request reprint Anesthetic effects of progesterone are undiminished in progesterone receptor knockout mice
    Doodipala S Reddy
    Department of Molecular Biomedical Sciences, North Carolina State University College of Veterinary Medicine, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    Brain Res 1033:96-101. 2005
    ..Thus, the anesthetic activity of progesterone is not mediated by its interaction with PRs. The neurosteroid allopregnanolone partially mediates the anesthetic activity of progesterone by potentiation of GABA(A) receptor function...
  5. ncbi request reprint Physiological role of adrenal deoxycorticosterone-derived neuroactive steroids in stress-sensitive conditions
    D S Reddy
    Department of Molecular Biomedical Sciences, North Carolina State University, College of Veterinary Medicine, Raleigh, 27606, USA
    Neuroscience 138:911-20. 2006
    ....
  6. ncbi request reprint Newer GABAergic agents for pharmacotherapy of infantile spasms
    Doodipala S Reddy
    Department of Molecular Biomedical Sciences, North Carolina State University, College of Veterinary Medicine, Raleigh, NC 27606, USA
    Drugs Today (Barc) 38:657-75. 2002
    ..Future studies will hopefully identify rational antiseizure drugs that not only control infantile spasms but also abrogate its risk on the development of the brain...
  7. pmc Differential anesthetic activity of ketamine and the GABAergic neurosteroid allopregnanolone in mice lacking progesterone receptor A and B subtypes
    D S Reddy
    Department of Molecular Biomedical Sciences, North Carolina State University College of Veterinary Medicine, Raleigh, North Carolina 27606, USA
    Methods Find Exp Clin Pharmacol 29:659-64. 2007
    ..There was no marked gender-related difference to ketamine response in both genotypes. In conclusion, these results suggest that the neurosteroid allopregnanolone and ketamine produce differential anesthetic response in mice lacking PRs...
  8. pmc Mass spectrometric assay and physiological-pharmacological activity of androgenic neurosteroids
    Doodipala S Reddy
    North Carolina State University, Department of Molecular Biomedical Sciences, Raleigh, NC 27606, USA
    Neurochem Int 52:541-53. 2008
    ..The 3alpha-androstanediol assay is an important tool in this area because of the growing interest in the potential to use adjuvant aromatase inhibitor therapy to improve treatment of epilepsy...
  9. ncbi request reprint A high-performance liquid chromatography-tandem mass spectrometry assay of the androgenic neurosteroid 3alpha-androstanediol (5alpha-androstane-3alpha,17beta-diol) in plasma
    Doodipala S Reddy
    Department of Molecular Biomedical Sciences, North Carolina State University, College of Veterinary Medicine, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    Steroids 70:879-85. 2005
    ..This LC-MS-MS method allows accurate, high-throughput analysis of 3alpha-androstanediol in small amounts (200 microl) of plasma and possibly other biological samples...
  10. ncbi request reprint Anxiolytic activity of progesterone in progesterone receptor knockout mice
    Doodipala S Reddy
    Department of Molecular Biomedical Sciences, North Carolina State University College of Veterinary Medicine, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    Neuropharmacology 48:14-24. 2005
    ..These results provide direct evidence that the anxiolytic action of progesterone does not require PRs. However, PR activation by progesterone may influence the anxiolytic response since PRKO mice were more sensitive to progesterone...
  11. ncbi request reprint Pharmacology of catamenial epilepsy
    D S Reddy
    Department of Molecular Biomedical Sciences, North Carolina State University College of Veterinary Medicine, Raleigh, NC 27606, USA
    Methods Find Exp Clin Pharmacol 26:547-61. 2004
    ..Future studies are clearly warranted to determine the molecular pathophysiology and an effective treatment of catamenial epilepsy...
  12. ncbi request reprint Testosterone modulation of seizure susceptibility is mediated by neurosteroids 3alpha-androstanediol and 17beta-estradiol
    D S Reddy
    Department of Molecular Biomedical Sciences, North Carolina State University College of Veterinary Medicine, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    Neuroscience 129:195-207. 2004
    ..Thus, testosterone-derived neurosteroids 3alpha-Diol and 17beta-estradiol could contribute to the net cellular actions of testosterone on neural excitability and seizure susceptibility...
  13. ncbi request reprint Pharmacology of endogenous neuroactive steroids
    Doodipala Samba Reddy
    Department of Molecular Biomedical Sciences, North Carolina State University College of Veterinary Medicine, Raleigh, North Carolina 27606, USA
    Crit Rev Neurobiol 15:197-234. 2003
    ..Future research on inhibition or stimulation of specific neuroactive steroid synthesizing enzymes could provide an improved understanding and novel approaches for the treatment of anxiety, epilepsy, and depression...
  14. ncbi request reprint Anticonvulsant activity of the testosterone-derived neurosteroid 3alpha-androstanediol
    Doodipala S Reddy
    Department of Molecular Biomedical Sciences, North Carolina State University College of Veterinary Medicine, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    Neuroreport 15:515-8. 2004
    ..Testosterone-derived 3alpha-androstanediol might be an endogenous protective neurosteroid in the brain...
  15. ncbi request reprint Anticonvulsant activity of progesterone and neurosteroids in progesterone receptor knockout mice
    D S Reddy
    Department of Molecular Biomedical Sciences, North Carolina State University College of Veterinary Medicine, Raleigh, North Carolina 27606, USA
    J Pharmacol Exp Ther 310:230-9. 2004
    ..These studies provide strong evidence that the PR is not required for the antiseizure effects of progesterone, which mainly occurs through its conversion to the neurosteroid allopregnanolone...
  16. ncbi request reprint Perimenstrual catamenial epilepsy
    Doodipala S Reddy
    North Carolina State University, Department of Molecular Biomedical Sciences, College of Veterinary Medicine, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    Womens Health (Lond Engl) 3:195-206. 2007
    ..Natural progesterone and synthetic neurosteroid replacement appears to be a suitable therapeutic approach for catamenial epilepsy...

Research Grants2

  1. Neuroactive Steroid Therapy of Catamenial Epilepsy
    DOODIPALA REDDY; Fiscal Year: 2007
    ..The experiments proposed in this application will help develop a novel animal model for testing specific therapies for catamenial epilepsy, which is not successfully treated currently with conventional seizure control medications. ..
  2. Progesterone Receptors and Seizure Susceptibility
    DOODIPALA REDDY; Fiscal Year: 2007
    ....