Valentin A Pavlov

Summary

Affiliation: North Shore University Hospital
Country: USA

Publications

  1. doi request reprint The vagus nerve and the inflammatory reflex--linking immunity and metabolism
    Valentin A Pavlov
    Center for Biomedical Science, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY 11030, USA
    Nat Rev Endocrinol 8:743-54. 2012
  2. doi request reprint Brain acetylcholinesterase activity controls systemic cytokine levels through the cholinergic anti-inflammatory pathway
    Valentin A Pavlov
    Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY 11030, USA
    Brain Behav Immun 23:41-5. 2009
  3. ncbi request reprint The cholinergic anti-inflammatory pathway
    Valentin A Pavlov
    Laboratory of Biomedical Science, Institute for Medical Research North Shore LIJ Health System, Manhasset, NY 11030, USA
    Brain Behav Immun 19:493-9. 2005
  4. pmc Central muscarinic cholinergic regulation of the systemic inflammatory response during endotoxemia
    Valentin A Pavlov
    Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY 11030, USA
    Proc Natl Acad Sci U S A 103:5219-23. 2006
  5. ncbi request reprint Controlling inflammation: the cholinergic anti-inflammatory pathway
    V A Pavlov
    Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY 11030, USA
    Biochem Soc Trans 34:1037-40. 2006
  6. ncbi request reprint Selective alpha7-nicotinic acetylcholine receptor agonist GTS-21 improves survival in murine endotoxemia and severe sepsis
    Valentin A Pavlov
    Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, Manhasset, NY, USA
    Crit Care Med 35:1139-44. 2007
  7. pmc Modulation of TNF release by choline requires alpha7 subunit nicotinic acetylcholine receptor-mediated signaling
    William R Parrish
    Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, North Shore LIJ Health System, Manhasset, New York 11030, USA
    Mol Med 14:567-74. 2008
  8. ncbi request reprint Transcutaneous vagus nerve stimulation reduces serum high mobility group box 1 levels and improves survival in murine sepsis
    Jared M Huston
    Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, Manhasset, NY 11030, USA
    Crit Care Med 35:2762-8. 2007
  9. pmc Splenectomy inactivates the cholinergic antiinflammatory pathway during lethal endotoxemia and polymicrobial sepsis
    Jared M Huston
    Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, North Shore LIJ Health System, Manhasset, NY 11030, USA
    J Exp Med 203:1623-8. 2006
  10. pmc α7 nicotinic acetylcholine receptor (α7nAChR) expression in bone marrow-derived non-T cells is required for the inflammatory reflex
    Peder S Olofsson
    The Feinstein Institute for Medical Research, Laboratory of Biomedical Science, Manhasset, New York 11030, USA
    Mol Med 18:539-43. 2012

Collaborators

Detail Information

Publications21

  1. doi request reprint The vagus nerve and the inflammatory reflex--linking immunity and metabolism
    Valentin A Pavlov
    Center for Biomedical Science, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY 11030, USA
    Nat Rev Endocrinol 8:743-54. 2012
    ..This knowledge has led to the exploration of novel therapeutic approaches in the treatment of obesity-related disorders...
  2. doi request reprint Brain acetylcholinesterase activity controls systemic cytokine levels through the cholinergic anti-inflammatory pathway
    Valentin A Pavlov
    Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY 11030, USA
    Brain Behav Immun 23:41-5. 2009
    ..Our data also indicate that a clinically used centrally-acting acetylcholinesterase inhibitor can be utilized to suppress abnormal inflammation to therapeutic advantage...
  3. ncbi request reprint The cholinergic anti-inflammatory pathway
    Valentin A Pavlov
    Laboratory of Biomedical Science, Institute for Medical Research North Shore LIJ Health System, Manhasset, NY 11030, USA
    Brain Behav Immun 19:493-9. 2005
    ..We also discuss possible clinical implications of vagus nerve stimulation and cholinergic modalities in the treatment of inflammatory diseases...
  4. pmc Central muscarinic cholinergic regulation of the systemic inflammatory response during endotoxemia
    Valentin A Pavlov
    Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY 11030, USA
    Proc Natl Acad Sci U S A 103:5219-23. 2006
    ..The role of central muscarinic receptors in activating the cholinergic antiinflammatory pathway is of interest for the use of centrally acting muscarinic cholinergic enhancers as antiinflammatory agents...
  5. ncbi request reprint Controlling inflammation: the cholinergic anti-inflammatory pathway
    V A Pavlov
    Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY 11030, USA
    Biochem Soc Trans 34:1037-40. 2006
    ....
  6. ncbi request reprint Selective alpha7-nicotinic acetylcholine receptor agonist GTS-21 improves survival in murine endotoxemia and severe sepsis
    Valentin A Pavlov
    Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, Manhasset, NY, USA
    Crit Care Med 35:1139-44. 2007
    ..Here we studied whether GTS-21, a selective alpha7-nicotinic acetylcholine receptor agonist, inhibits proinflammatory cytokines in vitro and in vivo and improves survival in murine endotoxemia and severe sepsis...
  7. pmc Modulation of TNF release by choline requires alpha7 subunit nicotinic acetylcholine receptor-mediated signaling
    William R Parrish
    Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, North Shore LIJ Health System, Manhasset, New York 11030, USA
    Mol Med 14:567-74. 2008
    ..Collectively, these data characterize the anti-inflammatory efficacy of choline and demonstrate that the modulation of TNF release by choline requires alpha7nAChR-mediated signaling...
  8. ncbi request reprint Transcutaneous vagus nerve stimulation reduces serum high mobility group box 1 levels and improves survival in murine sepsis
    Jared M Huston
    Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, Manhasset, NY 11030, USA
    Crit Care Med 35:2762-8. 2007
    ..Here we developed a method of transcutaneous mechanical vagus nerve stimulation and then investigated whether this therapy can protect mice against sepsis lethality...
  9. pmc Splenectomy inactivates the cholinergic antiinflammatory pathway during lethal endotoxemia and polymicrobial sepsis
    Jared M Huston
    Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, North Shore LIJ Health System, Manhasset, NY 11030, USA
    J Exp Med 203:1623-8. 2006
    ....
  10. pmc α7 nicotinic acetylcholine receptor (α7nAChR) expression in bone marrow-derived non-T cells is required for the inflammatory reflex
    Peder S Olofsson
    The Feinstein Institute for Medical Research, Laboratory of Biomedical Science, Manhasset, New York 11030, USA
    Mol Med 18:539-43. 2012
    ..Together, these results indicate that α7nAChR expression in bone marrow-derived non-T cells is required for the integrity of the inflammatory reflex...
  11. ncbi request reprint ISO-1 binding to the tautomerase active site of MIF inhibits its pro-inflammatory activity and increases survival in severe sepsis
    Yousef Al-Abed
    Laboratory of Medicinal Chemistry, North Shore Long Island Jewish Institute for Medical Research, Manhasset, New York 11030, USA
    J Biol Chem 280:36541-4. 2005
    ....
  12. pmc Thyroxine is a potential endogenous antagonist of macrophage migration inhibitory factor (MIF) activity
    Yousef Al-Abed
    Centers for Biomedical Science, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY 11030, USA
    Proc Natl Acad Sci U S A 108:8224-7. 2011
    ..The data may also, in part, explain the low plasma T(4) concentrations in critically ill, euthyroid patients and suggest that targeting the imbalance between MIF and T(4) may be beneficial in improving outcome from sepsis...
  13. doi request reprint Acetylcholine-synthesizing T cells relay neural signals in a vagus nerve circuit
    Mauricio Rosas-Ballina
    Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, New York 11030, USA
    Science 334:98-101. 2011
    ..Thus, action potentials originating in the vagus nerve regulate T cells, which in turn produce the neurotransmitter, acetylcholine, required to control innate immune responses...
  14. ncbi request reprint Phenolic hydrazones are potent inhibitors of macrophage migration inhibitory factor proinflammatory activity and survival improving agents in sepsis
    Darrin R Dabideen
    Laboratory of Medicinal Chemistry, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, New York 11030, and The New York School of Medicine, New York, New York 10016, USA
    J Med Chem 50:1993-7. 2007
    ..The therapeutic importance of the MIF inhibition by 7 is demonstrated by the significant protection from the lethality of sepsis when administration of the compound was initiated in a clinically relevant time frame...
  15. pmc Identification of pigment epithelium-derived factor as an adipocyte-derived inflammatory factor
    Sangeeta S Chavan
    Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, Manhasset, New York 11030, United States of America
    Mol Med 18:1161-8. 2012
    ..Together, these findings suggest that PEDF secreted by adipocytes contributes to the onset and maintenance of chronic inflammation in obesity, and may be a therapeutic target in ameliorating insulin resistance...
  16. pmc The cholinergic anti-inflammatory pathway: a missing link in neuroimmunomodulation
    Valentin A Pavlov
    Laboratory of Biomedical Science, North Shore LIJ Research Institute, Manhasset, NY 11030, USA
    Mol Med 9:125-34. 2003
    ..The clinical implications of this novel mechanism also are discussed...
  17. pmc Neuro-immune interactions via the cholinergic anti-inflammatory pathway
    Margot Gallowitsch-Puerta
    Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY 11030, USA
    Life Sci 80:2325-9. 2007
    ..Knowledge related to the cholinergic anti-inflammatory pathway can be exploited in therapeutic approaches directed towards counteracting abnormal chronic and hyper-activated inflammatory responses...
  18. pmc Imbalance in seminal fluid MIF indicates male infertility
    Bayan Aljabari
    Laboratory of Medicinal Chemistry, The Feinstein Institute for Medical Research, Manhasset, NY 11030, USA
    Mol Med 13:199-202. 2007
    ..We identify an abnormal biphasic profile of MIF in the seminal fluid of patients with impaired sperm parameters. Our findings may be of interest for the development of a diagnostic method for fertility status...
  19. pmc Vagus nerve stimulation regulates hemostasis in swine
    Christopher J Czura
    Laboratory of Biomedical Science, Feinstein Institute for Medical Research, Manhasset, New York, USA
    Shock 33:608-13. 2010
    ..These data indicate that electrical stimulation of the vagus nerve attenuates peripheral hemorrhage in a porcine model of soft tissue injury and that this protective effect is associated with increased coagulation factor activity...
  20. pmc Alternative chemical modifications reverse the binding orientation of a pharmacophore scaffold in the active site of macrophage migration inhibitory factor
    Gregg V Crichlow
    Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Biol Chem 282:23089-95. 2007
    ..The crystal structures of the MIF inhibitor complexes provide insight for further structure-based drug design efforts...
  21. ncbi request reprint Novel oxa-spermine homologues: synthesis and cytotoxic properties
    Vladimir A Kuksa
    Department of Ophthalmology, School of Medicine, University of Washington, 1957 NE Pacific Avenue, Seattle, WA 98195 6485, USA
    Bioorg Med Chem 10:691-7. 2002
    ..Although the mechanism of action of these compound remains to be elucidated, it would appear that direct drug-DNA interactions are not involved in the mode of action of these drugs...