HEATHER PATISAUL

Summary

Affiliation: North Carolina State University
Country: USA

Publications

  1. ncbi request reprint Genistein affects ER beta- but not ER alpha-dependent gene expression in the hypothalamus
    Heather B Patisaul
    Center for Behavioral Neuroscience, Emory University, Atlanta, Georgia 30329, USA
    Endocrinology 143:2189-97. 2002
  2. pmc Long-term effects of environmental endocrine disruptors on reproductive physiology and behavior
    Heather B Patisaul
    Department of Biology, North Carolina State University Raleigh, NC, USA
    Front Behav Neurosci 3:10. 2009
  3. doi request reprint Effects of environmental endocrine disruptors and phytoestrogens on the kisspeptin system
    Heather B Patisaul
    Department of Biology, North Carolina State University, Raleigh, NC 27695, USA
    Adv Exp Med Biol 784:455-79. 2013
  4. pmc The pros and cons of phytoestrogens
    Heather B Patisaul
    Department of Biology, NC State University, Raleigh, NC 27695, USA
    Front Neuroendocrinol 31:400-19. 2010
  5. pmc Impact of neonatal exposure to the ERalpha agonist PPT, bisphenol-A or phytoestrogens on hypothalamic kisspeptin fiber density in male and female rats
    Heather B Patisaul
    Department of Biology, North Carolina State University, 127 David Clark Labs, Raleigh, NC 27695, USA
    Neurotoxicology 30:350-7. 2009
  6. pmc Systemic administration of diarylpropionitrile (DPN) or phytoestrogens does not affect anxiety-related behaviors in gonadally intact male rats
    Heather B Patisaul
    Department of Biology, North Carolina State University, Raleigh, NC 27695, USA
    Horm Behav 55:319-28. 2009
  7. pmc Neonatal agonism of ERalpha masculinizes serotonergic (5-HT) projections to the female rat ventromedial nucleus of the hypothalamus (VMN) but does not impair lordosis
    Heather B Patisaul
    Department of Biology, North Carolina State University, Raleigh, NC 27695, USA
    Behav Brain Res 196:317-22. 2009
  8. pmc Disrupted female reproductive physiology following neonatal exposure to phytoestrogens or estrogen specific ligands is associated with decreased GnRH activation and kisspeptin fiber density in the hypothalamus
    Heather L Bateman
    Department of Zoology, North Carolina State University, Raleigh, NC 27695, USA
    Neurotoxicology 29:988-97. 2008
  9. doi request reprint Neonatal exposure to endocrine active compounds or an ERbeta agonist increases adult anxiety and aggression in gonadally intact male rats
    Heather B Patisaul
    Department of Zoology, North Carolina State University, 127 David Clark Labs, Raleigh, NC 27695, USA
    Horm Behav 53:580-8. 2008
  10. ncbi request reprint Sex differences in serotonergic but not gamma-aminobutyric acidergic (GABA) projections to the rat ventromedial nucleus of the hypothalamus
    Heather B Patisaul
    Department of Zoology, North Carolina State University, Raleigh, North Carolina 27695, USA
    Endocrinology 149:397-408. 2008

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Genistein affects ER beta- but not ER alpha-dependent gene expression in the hypothalamus
    Heather B Patisaul
    Center for Behavioral Neuroscience, Emory University, Atlanta, Georgia 30329, USA
    Endocrinology 143:2189-97. 2002
    ..These results suggest that at this dose, genistein has antiestrogenic action through ER beta in the paraventricular nucleus but negligible activity through ER alpha in the brain...
  2. pmc Long-term effects of environmental endocrine disruptors on reproductive physiology and behavior
    Heather B Patisaul
    Department of Biology, North Carolina State University Raleigh, NC, USA
    Front Behav Neurosci 3:10. 2009
    ..This review provides an overview of how exposure to EDCs, particularly those that interfere with estrogen action, impacts reproductive physiology and behaviors in vertebrates...
  3. doi request reprint Effects of environmental endocrine disruptors and phytoestrogens on the kisspeptin system
    Heather B Patisaul
    Department of Biology, North Carolina State University, Raleigh, NC 27695, USA
    Adv Exp Med Biol 784:455-79. 2013
    ....
  4. pmc The pros and cons of phytoestrogens
    Heather B Patisaul
    Department of Biology, NC State University, Raleigh, NC 27695, USA
    Front Neuroendocrinol 31:400-19. 2010
    ..This review weighs the evidence for and against the purported health benefits and adverse effects of phytoestrogens...
  5. pmc Impact of neonatal exposure to the ERalpha agonist PPT, bisphenol-A or phytoestrogens on hypothalamic kisspeptin fiber density in male and female rats
    Heather B Patisaul
    Department of Biology, North Carolina State University, 127 David Clark Labs, Raleigh, NC 27695, USA
    Neurotoxicology 30:350-7. 2009
    ..None of the compounds affected KISS-ir in the male hypothalamus. Our results suggest that the organization of hypothalamic KISS fibers may be vulnerable to disruption by EDC exposure and that females might be more sensitive than males...
  6. pmc Systemic administration of diarylpropionitrile (DPN) or phytoestrogens does not affect anxiety-related behaviors in gonadally intact male rats
    Heather B Patisaul
    Department of Biology, North Carolina State University, Raleigh, NC 27695, USA
    Horm Behav 55:319-28. 2009
    ..The results suggest that the efficacy of ERbeta agonists may depend on gonadal status. Therefore the therapeutic potential of ERbeta selective agonists to treat mood disorders may be limited...
  7. pmc Neonatal agonism of ERalpha masculinizes serotonergic (5-HT) projections to the female rat ventromedial nucleus of the hypothalamus (VMN) but does not impair lordosis
    Heather B Patisaul
    Department of Biology, North Carolina State University, Raleigh, NC 27695, USA
    Behav Brain Res 196:317-22. 2009
    ....
  8. pmc Disrupted female reproductive physiology following neonatal exposure to phytoestrogens or estrogen specific ligands is associated with decreased GnRH activation and kisspeptin fiber density in the hypothalamus
    Heather L Bateman
    Department of Zoology, North Carolina State University, Raleigh, NC 27695, USA
    Neurotoxicology 29:988-97. 2008
    ..The data suggest that decreased stimulation of GnRH neurons by KISS could be a mechanism by which EDCs can impair female reproductive function...
  9. doi request reprint Neonatal exposure to endocrine active compounds or an ERbeta agonist increases adult anxiety and aggression in gonadally intact male rats
    Heather B Patisaul
    Department of Zoology, North Carolina State University, 127 David Clark Labs, Raleigh, NC 27695, USA
    Horm Behav 53:580-8. 2008
    ..These findings suggest that neonatal exposure to EACs with agonistic activity on ERbeta may influence affective behavior in adulthood, including anxiety and aggression...
  10. ncbi request reprint Sex differences in serotonergic but not gamma-aminobutyric acidergic (GABA) projections to the rat ventromedial nucleus of the hypothalamus
    Heather B Patisaul
    Department of Zoology, North Carolina State University, Raleigh, North Carolina 27695, USA
    Endocrinology 149:397-408. 2008
    ..The hormone-dependent organization of these 5-HT projection patterns may be an important developmental mechanism accounting for sex-specific behaviors in adulthood...
  11. ncbi request reprint Influence of endocrine active compounds on the developing rodent brain
    Heather B Patisaul
    Department of Zoology, North Carolina State University, 127 David Clark Labs, Raleigh, NC 27695, USA
    Brain Res Rev 57:352-62. 2008
    ..Collectively, these findings emphasize the need to employ a comprehensive approach that addresses anatomical, functional and behavioral endpoints when evaluating the potential effects of EAC exposure...
  12. ncbi request reprint Differential disruption of nuclear volume and neuronal phenotype in the preoptic area by neonatal exposure to genistein and bisphenol-A
    Heather B Patisaul
    CIIT Centers for Health Research, 6 Davis Drive, RTP, NC 27709, United States
    Neurotoxicology 28:1-12. 2007
    ..These results suggest that acute exposure to EACs during a critical developmental period can independently alter nuclear volumes of sexually dimorphic nuclei and their phenotypic profiles in a region specific manner...
  13. ncbi request reprint Neonatal genistein or bisphenol-A exposure alters sexual differentiation of the AVPV
    Heather B Patisaul
    CIIT Centers for Health Research, 6 Davis Drive, RTP, NC 27709, USA
    Neurotoxicol Teratol 28:111-8. 2006
    ..These results suggest that acute exposure to EACs during a critical developmental period alters AVPV development...
  14. pmc Neonatal bisphenol-a exposure alters rat reproductive development and ovarian morphology without impairing activation of gonadotropin-releasing hormone neurons
    Heather B Adewale
    Department of Biology, North Carolina State University, Raleigh, North Carolina, USA
    Biol Reprod 81:690-9. 2009
    ..Our data suggest that BPA disrupts ovarian development but not the ability of GnRH neurons to respond to steroid-positive feedback...
  15. pmc Aryl hydrocarbon receptor activation in lactotropes and gonadotropes interferes with estradiol-dependent and -independent preprolactin, glycoprotein alpha and luteinizing hormone beta gene expression
    Jinyan Cao
    Molecular and Cellular Biology Graduate Program, 435 Morrill I North, University of Massachusetts Amherst, 637 North Pleasant Street, Amherst, MA 01003 9298, United States
    Mol Cell Endocrinol 333:151-9. 2011
    ..These findings provide important insights into how TCDD disrupts female reproductive functions...
  16. ncbi request reprint A soy supplement and tamoxifen inhibit sexual behavior in female rats
    Heather B Patisaul
    Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA
    Horm Behav 45:270-7. 2004
    ..These results demonstrate that both the soy supplement and TAMOX act as estrogen antagonists on both proceptive and receptive behavior in female rats...
  17. ncbi request reprint Dietary soy supplements produce opposite effects on anxiety in intact male and female rats in the elevated plus-maze
    Heather B Patisaul
    Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA
    Behav Neurosci 119:587-94. 2005
    ..The results suggest that the soy supplements have sex- and cycle-specific effects on anxiety...
  18. ncbi request reprint Neurobehavioral actions of coumestrol and related isoflavonoids in rodents
    Patricia L Whitten
    Center for Behavioral Neuroscience, Emory University, Atlanta, GA 30329, USA
    Neurotoxicol Teratol 24:47-54. 2002
    ..This work demonstrates that even small, physiologically relevant exposure levels can alter estrogen-dependent gene expression in the brain and complex behavior...

Research Grants5

  1. Endocrine Disruption of the Hypothalamic Signaling That Regulates Puberty
    Heather B Patisaul; Fiscal Year: 2010
    ..AIM 4: Characterize the impact of neonatal BPA, GEN, DPN or PPT on AVPV volume, AVPV ER and kisspeptin content, and hormone-stimulated GnRH neuronal activation post-puberty. ..
  2. Endocrine Disruption of the Hypothalamic Signaling That Regulates Puberty
    HEATHER PATISAUL; Fiscal Year: 2007
    ..AIM 4: Characterize the impact of neonatal BPA, GEN, DPN or PPT on AVPV volume, AVPV ER and kisspeptin content, and hormone-stimulated GnRH neuronal activation post-puberty. ..
  3. Endocrine Disruption of the Hypothalamic Signaling That Regulates Puberty
    HEATHER PATISAUL; Fiscal Year: 2009
    ..AIM 4: Characterize the impact of neonatal BPA, GEN, DPN or PPT on AVPV volume, AVPV ER and kisspeptin content, and hormone-stimulated GnRH neuronal activation post-puberty. ..
  4. Endocrine Disruption of the Hypothalamic Signaling That Regulates Puberty
    Heather B Patisaul; Fiscal Year: 2010
    ..AIM 4: Characterize the impact of neonatal BPA, GEN, DPN or PPT on AVPV volume, AVPV ER and kisspeptin content, and hormone-stimulated GnRH neuronal activation post-puberty. ..