Heather B Patisaul

Summary

Affiliation: North Carolina State University
Country: USA

Publications

  1. pmc Accumulation and endocrine disrupting effects of the flame retardant mixture Firemaster® 550 in rats: an exploratory assessment
    Heather B Patisaul
    Department of Biology, North Carolina State University, Raleigh, NC 27695, USA
    J Biochem Mol Toxicol 27:124-36. 2013
  2. pmc Anxiogenic effects of developmental bisphenol A exposure are associated with gene expression changes in the juvenile rat amygdala and mitigated by soy
    Heather B Patisaul
    Department of Biology, North Carolina State University, Raleigh, North Carolina, United States of America
    PLoS ONE 7:e43890. 2012
  3. pmc Influence of ERβ selective agonism during the neonatal period on the sexual differentiation of the rat hypothalamic-pituitary-gonadal (HPG) axis
    Heather B Patisaul
    Department of Biology, North Carolina State University, Raleigh, NC 27695, USA
    Biol Sex Differ 3:2. 2012
  4. pmc Neonatal agonism of ERalpha masculinizes serotonergic (5-HT) projections to the female rat ventromedial nucleus of the hypothalamus (VMN) but does not impair lordosis
    Heather B Patisaul
    Department of Biology, North Carolina State University, Raleigh, NC 27695, USA
    Behav Brain Res 196:317-22. 2009
  5. pmc Prenatal bisphenol A exposure alters sex-specific estrogen receptor expression in the neonatal rat hypothalamus and amygdala
    Jinyan Cao
    Department of Biology, NCSU, Raleigh, North Carolina 27695, USA
    Toxicol Sci 133:157-73. 2013
  6. pmc Neonatal Bisphenol A exposure alters sexually dimorphic gene expression in the postnatal rat hypothalamus
    Jinyan Cao
    Department of Biology, North Carolina State University, Raleigh, NC 27695, USA
    Neurotoxicology 33:23-36. 2012
  7. pmc Impact of neonatal exposure to the ERalpha agonist PPT, bisphenol-A or phytoestrogens on hypothalamic kisspeptin fiber density in male and female rats
    Heather B Patisaul
    Department of Biology, North Carolina State University, 127 David Clark Labs, Raleigh, NC 27695, USA
    Neurotoxicology 30:350-7. 2009
  8. pmc Sex-specific expression of estrogen receptors α and β and Kiss1 in the postnatal rat amygdala
    Jinyan Cao
    Department of Biology, North Carolina State University, Raleigh, North Carolina 27695, USA
    J Comp Neurol 521:465-78. 2013
  9. pmc Neonatal exposure to genistein adversely impacts the ontogeny of hypothalamic kisspeptin signaling pathways and ovarian development in the peripubertal female rat
    Sandra M Losa
    North Carolina State University, Department of Biology, Raleigh, NC 27695, United States
    Reprod Toxicol 31:280-9. 2011
  10. pmc Systemic administration of diarylpropionitrile (DPN) or phytoestrogens does not affect anxiety-related behaviors in gonadally intact male rats
    Heather B Patisaul
    Department of Biology, North Carolina State University, Raleigh, NC 27695, USA
    Horm Behav 55:319-28. 2009

Collaborators

Detail Information

Publications25

  1. pmc Accumulation and endocrine disrupting effects of the flame retardant mixture Firemaster® 550 in rats: an exploratory assessment
    Heather B Patisaul
    Department of Biology, North Carolina State University, Raleigh, NC 27695, USA
    J Biochem Mol Toxicol 27:124-36. 2013
    ..Results of this study are the first to implicate FM 550 as an endocrine disruptor and an obesogen at environmentally relevant levels...
  2. pmc Anxiogenic effects of developmental bisphenol A exposure are associated with gene expression changes in the juvenile rat amygdala and mitigated by soy
    Heather B Patisaul
    Department of Biology, North Carolina State University, Raleigh, North Carolina, United States of America
    PLoS ONE 7:e43890. 2012
    ....
  3. pmc Influence of ERβ selective agonism during the neonatal period on the sexual differentiation of the rat hypothalamic-pituitary-gonadal (HPG) axis
    Heather B Patisaul
    Department of Biology, North Carolina State University, Raleigh, NC 27695, USA
    Biol Sex Differ 3:2. 2012
    ..abstract:..
  4. pmc Neonatal agonism of ERalpha masculinizes serotonergic (5-HT) projections to the female rat ventromedial nucleus of the hypothalamus (VMN) but does not impair lordosis
    Heather B Patisaul
    Department of Biology, North Carolina State University, Raleigh, NC 27695, USA
    Behav Brain Res 196:317-22. 2009
    ....
  5. pmc Prenatal bisphenol A exposure alters sex-specific estrogen receptor expression in the neonatal rat hypothalamus and amygdala
    Jinyan Cao
    Department of Biology, NCSU, Raleigh, North Carolina 27695, USA
    Toxicol Sci 133:157-73. 2013
    ..These results indicate that ESR expression in the neonatal brain of both sexes can be altered by low-dose prenatal BPA exposure...
  6. pmc Neonatal Bisphenol A exposure alters sexually dimorphic gene expression in the postnatal rat hypothalamus
    Jinyan Cao
    Department of Biology, North Carolina State University, Raleigh, NC 27695, USA
    Neurotoxicology 33:23-36. 2012
    ..Additionally, the discordant effects of EB and BPA indicate that BPA likely disrupts hypothalamic organization by a mechanism other than simply acting as an estrogen mimic...
  7. pmc Impact of neonatal exposure to the ERalpha agonist PPT, bisphenol-A or phytoestrogens on hypothalamic kisspeptin fiber density in male and female rats
    Heather B Patisaul
    Department of Biology, North Carolina State University, 127 David Clark Labs, Raleigh, NC 27695, USA
    Neurotoxicology 30:350-7. 2009
    ..None of the compounds affected KISS-ir in the male hypothalamus. Our results suggest that the organization of hypothalamic KISS fibers may be vulnerable to disruption by EDC exposure and that females might be more sensitive than males...
  8. pmc Sex-specific expression of estrogen receptors α and β and Kiss1 in the postnatal rat amygdala
    Jinyan Cao
    Department of Biology, North Carolina State University, Raleigh, North Carolina 27695, USA
    J Comp Neurol 521:465-78. 2013
    ..These data reveal that ER expression is region-specific within the neonatal amygdala. These differences likely contribute to sex differences in sociosexual behavior across the lifespan...
  9. pmc Neonatal exposure to genistein adversely impacts the ontogeny of hypothalamic kisspeptin signaling pathways and ovarian development in the peripubertal female rat
    Sandra M Losa
    North Carolina State University, Department of Biology, Raleigh, NC 27695, United States
    Reprod Toxicol 31:280-9. 2011
    ..MOFs were still present, however, in the EB and 10 mg/kg GEN groups beyond P24 indicating a disruption in the timing of ovarian development...
  10. pmc Systemic administration of diarylpropionitrile (DPN) or phytoestrogens does not affect anxiety-related behaviors in gonadally intact male rats
    Heather B Patisaul
    Department of Biology, North Carolina State University, Raleigh, NC 27695, USA
    Horm Behav 55:319-28. 2009
    ..The results suggest that the efficacy of ERbeta agonists may depend on gonadal status. Therefore the therapeutic potential of ERbeta selective agonists to treat mood disorders may be limited...
  11. pmc Neonatal agonism of ERβ impairs male reproductive behavior and attractiveness
    Alana W Sullivan
    Department of Biology, North Carolina State University, Raleigh NC 27695, USA
    Horm Behav 60:185-94. 2011
    ..DPN and GEN exposure only impaired behavior, suggesting that disrupted androgen secretion does not underlie the impairment...
  12. pmc The impact of neonatal bisphenol-A exposure on sexually dimorphic hypothalamic nuclei in the female rat
    Heather B Adewale
    Department of Biology, NC State University, Raleigh, NC 27695, United States
    Neurotoxicology 32:38-49. 2011
    ....
  13. pmc Disrupted female reproductive physiology following neonatal exposure to phytoestrogens or estrogen specific ligands is associated with decreased GnRH activation and kisspeptin fiber density in the hypothalamus
    Heather L Bateman
    Department of Zoology, North Carolina State University, Raleigh, NC 27695, USA
    Neurotoxicology 29:988-97. 2008
    ..The data suggest that decreased stimulation of GnRH neurons by KISS could be a mechanism by which EDCs can impair female reproductive function...
  14. pmc Neonatal bisphenol-a exposure alters rat reproductive development and ovarian morphology without impairing activation of gonadotropin-releasing hormone neurons
    Heather B Adewale
    Department of Biology, North Carolina State University, Raleigh, North Carolina, USA
    Biol Reprod 81:690-9. 2009
    ..Our data suggest that BPA disrupts ovarian development but not the ability of GnRH neurons to respond to steroid-positive feedback...
  15. doi request reprint Effects of environmental endocrine disruptors and phytoestrogens on the kisspeptin system
    Heather B Patisaul
    Department of Biology, North Carolina State University, Raleigh, NC 27695, USA
    Adv Exp Med Biol 784:455-79. 2013
    ....
  16. pmc Sex specific impact of perinatal bisphenol A (BPA) exposure over a range of orally administered doses on rat hypothalamic sexual differentiation
    Katherine A McCaffrey
    Department of Biology, North Carolina State University, Raleigh, NC 27695, United States
    Neurotoxicology 36:55-62. 2013
    ..Collectively these data demonstrate that early life oral exposure to BPA at levels well below the current No Observed Adverse Effect Level (NOAEL) of 50mg/kg/day can alter sex specific hypothalamic morphology in the rat...
  17. pmc Disrupted organization of RFamide pathways in the hypothalamus is associated with advanced puberty in female rats neonatally exposed to bisphenol A
    Sandra M Losa-Ward
    Department of Biology, North Carolina State University, Raleigh, North Carolina 27695, USA
    Biol Reprod 87:28. 2012
    ..RFRP3 perikarya were also decreased in females exposed to 50 μg/kg BPA. Data suggest that BPA-induced premature puberty results from decreased inhibition of GnRH neurons...
  18. pmc Sexually dimorphic expression of hypothalamic estrogen receptors α and β and Kiss1 in neonatal male and female rats
    Jinyan Cao
    Department of Biology, North Carolina State University, Raleigh, North Carolina 27695, USA
    J Comp Neurol 519:2954-77. 2011
    ..These detailed profiles of neonatal Kiss1 and ERs mRNA levels will help elucidate the relative roles each plays in the sex-specific, estrogen-dependent organization of gonadotropin signaling pathways...
  19. doi request reprint Neonatal exposure to endocrine active compounds or an ERbeta agonist increases adult anxiety and aggression in gonadally intact male rats
    Heather B Patisaul
    Department of Zoology, North Carolina State University, 127 David Clark Labs, Raleigh, NC 27695, USA
    Horm Behav 53:580-8. 2008
    ..These findings suggest that neonatal exposure to EACs with agonistic activity on ERbeta may influence affective behavior in adulthood, including anxiety and aggression...
  20. ncbi request reprint Influence of endocrine active compounds on the developing rodent brain
    Heather B Patisaul
    Department of Zoology, North Carolina State University, 127 David Clark Labs, Raleigh, NC 27695, USA
    Brain Res Rev 57:352-62. 2008
    ..Collectively, these findings emphasize the need to employ a comprehensive approach that addresses anatomical, functional and behavioral endpoints when evaluating the potential effects of EAC exposure...
  21. ncbi request reprint Sex differences in serotonergic but not gamma-aminobutyric acidergic (GABA) projections to the rat ventromedial nucleus of the hypothalamus
    Heather B Patisaul
    Department of Zoology, North Carolina State University, Raleigh, North Carolina 27695, USA
    Endocrinology 149:397-408. 2008
    ..The hormone-dependent organization of these 5-HT projection patterns may be an important developmental mechanism accounting for sex-specific behaviors in adulthood...
  22. ncbi request reprint Investigation of the Effects of Subchronic Low Dose Oral Exposure to Bisphenol A (BPA) and Ethinyl Estradiol (EE) on Estrogen Receptor Expression in the Juvenile and Adult Female Rat Hypothalamus
    Meghan E Rebuli
    Department of Biology, North Carolina State University, Raleigh, North Carolina 27695 Keck Center for Behavioral Biology, North Carolina State University, Raleigh, North Carolina 27695
    Toxicol Sci 140:190-203. 2014
    ..The possible consequences of long-term changes in hypothalamic ESR expression resulting from subchronic low dose BPA exposure on neuroendocrine effects are discussed and being addressed in ongoing, related work. ..
  23. pmc Reproductive consequences of developmental phytoestrogen exposure
    Wendy N Jefferson
    Reproductive Medicine Group, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, NIEHS NIH DHHS, MD E4 05, Research Triangle Park, North Carolina 27709, USA
    Reproduction 143:247-60. 2012
    ..The aim of this review is to examine the evidence that phytoestrogen exposure, particularly in the developmentally sensitive periods of life, has consequences for future reproductive health...
  24. pmc The pros and cons of phytoestrogens
    Heather B Patisaul
    Department of Biology, NC State University, Raleigh, NC 27695, USA
    Front Neuroendocrinol 31:400-19. 2010
    ..This review weighs the evidence for and against the purported health benefits and adverse effects of phytoestrogens...
  25. pmc Long-term effects of environmental endocrine disruptors on reproductive physiology and behavior
    Heather B Patisaul
    Department of Biology, North Carolina State University Raleigh, NC, USA
    Front Behav Neurosci 3:10. 2009
    ..This review provides an overview of how exposure to EDCs, particularly those that interfere with estrogen action, impacts reproductive physiology and behaviors in vertebrates...