Nancy A Monteiro-Riviere

Summary

Affiliation: North Carolina State University
Country: USA

Publications

  1. ncbi A linear dilution microfluidic device for cytotoxicity assays
    Glenn M Walker
    Joint Department of Biomedical Engineering at The University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC 27695 7115, USA
    Lab Chip 7:226-32. 2007
  2. ncbi Lack of hydroxylated fullerene toxicity after intravenous administration to female Sprague-Dawley rats
    Nancy A Monteiro-Riviere
    Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, Raleigh, North Carolina 27607, USA
    J Toxicol Environ Health A 75:367-73. 2012
  3. ncbi Surfactant effects on carbon nanotube interactions with human keratinocytes
    Nancy A Monteiro-Riviere
    Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, Raleigh, North Carolina 27606, USA
    Nanomedicine 1:293-9. 2005
  4. ncbi Interactions of aluminum nanoparticles with human epidermal keratinocytes
    Nancy A Monteiro-Riviere
    Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    J Appl Toxicol 30:276-85. 2010
  5. ncbi Limitations and relative utility of screening assays to assess engineered nanoparticle toxicity in a human cell line
    N A Monteiro-Riviere
    Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    Toxicol Appl Pharmacol 234:222-35. 2009
  6. ncbi Multi-walled carbon nanotube interactions with human epidermal keratinocytes
    Nancy A Monteiro-Riviere
    Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    Toxicol Lett 155:377-84. 2005
  7. ncbi Skin toxicity of jet fuels: ultrastructural studies and the effects of substance P
    Nancy A Monteiro-Riviere
    Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, Raleigh, NC 27606, USA
    Toxicol Appl Pharmacol 195:339-47. 2004
  8. ncbi Safety evaluation of sunscreen formulations containing titanium dioxide and zinc oxide nanoparticles in UVB sunburned skin: an in vitro and in vivo study
    N A Monteiro-Riviere
    Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, Raleigh, North Carolina 27606, USA
    Toxicol Sci 123:264-80. 2011
  9. ncbi Pyridostigmine bromide modulates topical irritant-induced cytokine release from human epidermal keratinocytes and isolated perfused porcine skin
    Nancy A Monteiro-Riviere
    Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    Toxicology 183:15-28. 2003
  10. ncbi Efficacy of topical phenol decontamination strategies on severity of acute phenol chemical burns and dermal absorption: in vitro and in vivo studies in pig skin
    N A Monteiro-Riviere
    Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, 4700 Hillsborough Street, Raleigh, North Carolina 27606, USA
    Toxicol Ind Health 17:95-104. 2001

Research Grants

  1. Comparative In Vivo Biodistribution of Characterized Manufactured Nanomaterials
    Nancy A Monteiro Riviere; Fiscal Year: 2010

Collaborators

Detail Information

Publications71

  1. ncbi A linear dilution microfluidic device for cytotoxicity assays
    Glenn M Walker
    Joint Department of Biomedical Engineering at The University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC 27695 7115, USA
    Lab Chip 7:226-32. 2007
    ....
  2. ncbi Lack of hydroxylated fullerene toxicity after intravenous administration to female Sprague-Dawley rats
    Nancy A Monteiro-Riviere
    Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, Raleigh, North Carolina 27607, USA
    J Toxicol Environ Health A 75:367-73. 2012
    ..Minor histopathology changes are seen, primarily in one animal. No clinically significant chemistry changes were observed after treatment. These experiments suggest that this fullerol was well tolerated after iv administration to rats...
  3. ncbi Surfactant effects on carbon nanotube interactions with human keratinocytes
    Nancy A Monteiro-Riviere
    Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, Raleigh, North Carolina 27606, USA
    Nanomedicine 1:293-9. 2005
    ..These results suggest that the surfactant-MWCNT interaction is more complex than simple dispersion alone and should be investigated to determine the mode of interaction...
  4. ncbi Interactions of aluminum nanoparticles with human epidermal keratinocytes
    Nancy A Monteiro-Riviere
    Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    J Appl Toxicol 30:276-85. 2010
    ....
  5. ncbi Limitations and relative utility of screening assays to assess engineered nanoparticle toxicity in a human cell line
    N A Monteiro-Riviere
    Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    Toxicol Appl Pharmacol 234:222-35. 2009
    ..Therefore, more than one assay may be required when determining nanoparticle toxicity for risk assessment...
  6. ncbi Multi-walled carbon nanotube interactions with human epidermal keratinocytes
    Nancy A Monteiro-Riviere
    Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    Toxicol Lett 155:377-84. 2005
    ....
  7. ncbi Skin toxicity of jet fuels: ultrastructural studies and the effects of substance P
    Nancy A Monteiro-Riviere
    Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, Raleigh, NC 27606, USA
    Toxicol Appl Pharmacol 195:339-47. 2004
    ..These studies provide a base upon which biochemical and immunological data collected in other model systems can be compared...
  8. ncbi Safety evaluation of sunscreen formulations containing titanium dioxide and zinc oxide nanoparticles in UVB sunburned skin: an in vitro and in vivo study
    N A Monteiro-Riviere
    Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, Raleigh, North Carolina 27606, USA
    Toxicol Sci 123:264-80. 2011
    ..In summary, UVB-damaged skin slightly enhanced TiO(2) NP or ZnO NP penetration in sunscreen formulations but no transdermal absorption was detected...
  9. ncbi Pyridostigmine bromide modulates topical irritant-induced cytokine release from human epidermal keratinocytes and isolated perfused porcine skin
    Nancy A Monteiro-Riviere
    Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    Toxicology 183:15-28. 2003
    ..In conclusion, these studies suggest that systemic exposure to PB suppressed IL-8 release at multiple time points in two skin model systems. This interaction merits further study...
  10. ncbi Efficacy of topical phenol decontamination strategies on severity of acute phenol chemical burns and dermal absorption: in vitro and in vivo studies in pig skin
    N A Monteiro-Riviere
    Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, 4700 Hillsborough Street, Raleigh, North Carolina 27606, USA
    Toxicol Ind Health 17:95-104. 2001
    ..The assessment of percutaneous absorption of phenol found the PEG 400, 70% IPA, and 15-min water treatments significantly (P < 0.05) reduced phenol absorption relative to no treatment...
  11. ncbi Effect of selective lipid extraction from different body regions on epidermal barrier function
    N A Monteiro-Riviere
    Center for Cutaneous Toxicology and Residue Pharmacology, North Carolina State University, Raleigh, USA
    Pharm Res 18:992-8. 2001
    ..To assess the effects of selective lipid extraction and tape stripping on transepidermal water loss (TEWL) at three body regions in the pig...
  12. ncbi Effects of short-term high-dose and low-dose dermal exposure to Jet A, JP-8 and JP-8 + 100 jet fuels
    N Monteiro-Riviere
    Center for Cutaneous Toxicology and Residue Pharmacology, North Carolina State University, Raleigh, NC 27606, USA
    J Appl Toxicol 21:485-94. 2001
    ....
  13. ncbi Comparative in vitro percutaneous absorption of nonylphenol and nonylphenol ethoxylates (NPE-4 and NPE-9) through human, porcine and rat skin
    N A Monteiro-Riviere
    Center for Cutaneous Toxicology and Residue Pharmacology, North Carolina State University, Raleigh 27606, USA
    Toxicol Ind Health 16:49-57. 2000
    ..These studies suggest that NP, NPE-4 and NPE-9 were minimally absorbed across skin from all three species. Fractional absorption was concentration-dependent, making the actual absorbed flux constant across all doses...
  14. ncbi Immunohistochemical characterization of the basement membrane epitopes in bis(2-chloroethyl) sulfide-induced toxicity in mouse ear skin
    N A Monteiro-Riviere
    Center for Cutaneous Toxicology and Residue Pharmacology, Department of Clinical Sciences, North Carolina State University, Raleigh, NC 27606, USA
    J Appl Toxicol 19:313-28. 1999
    ....
  15. ncbi Ultrastructural characterization of sulfur mustard-induced vesication in isolated perfused porcine skin
    N A Monteiro-Riviere
    Cutaneous Pharmacology and Toxicology Center, North Carolina State University, Raleigh 27606, USA
    Microsc Res Tech 37:229-41. 1997
    ..In conclusion, the IPPSF appears to be an appropriate in vitro model with which to study the pathogenesis of vesicant-induced toxicity...
  16. ncbi Endocytic mechanisms and toxicity of a functionalized fullerene in human cells
    Leshuai W Zhang
    Center for Chemical Toxicology Research and Pharmacokinetics, Department of Clinical Science, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    Toxicol Lett 191:149-57. 2009
    ..A scavenger receptor inhibitor completely blocked the uptake of Baa-Lys(FITC)-(Lys)(8)-OH, suggesting a specific endocytic pathway was strongly involved in Baa-Lys(FITC)-(Lys)(8)-OH cellular uptake...
  17. ncbi Percutaneous absorption of topical N,N-diethyl-m-toluamide (DEET): effects of exposure variables and coadministered toxicants
    Jim E Riviere
    Center for Chemical Toxicology Research and Pharmacokinetics, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    J Toxicol Environ Health A 66:133-51. 2003
    ....
  18. ncbi Fabrication of microneedles using two photon polymerization for transdermal delivery of nanomaterials
    Anand Doraiswamy
    Joint Department of Biomedical Engineering, North Carolina State University, Raleigh 27695, USA
    J Nanosci Nanotechnol 10:6305-12. 2010
    ..Our results suggest that two photon polymerization may be used to create microneedle arrays for transdermal delivery of nanoscale pharmacologic agents...
  19. ncbi Gulf War related exposure factors influencing topical absorption of 14C-permethrin
    Jim E Riviere
    Center for Chemical Toxicology Research and Pharmacokinetics, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    Toxicol Lett 135:61-71. 2002
    ..The toxicologic significance of this moderate increase in permethrin absorption remains unclear...
  20. ncbi Biological interactions of quantum dot nanoparticles in skin and in human epidermal keratinocytes
    Leshuai W Zhang
    Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    Toxicol Appl Pharmacol 228:200-11. 2008
    ....
  21. ncbi Pyridostigmine bromide modulates the dermal disposition of [14C]permethrin
    Ronald E Baynes
    Center for Chemical Toxicology Research and Pharmacokinetics CCTRP, North Carolina State University, Raleigh 27606, USA
    Toxicol Appl Pharmacol 181:164-73. 2002
    ....
  22. ncbi Evaluation of perfused porcine skin as a model system to quantitate tissue distribution of fullerene nanoparticles
    Teresa L Leavens
    Center for Chemical Toxicology Research and Pharmacokinetics, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, United States
    Toxicol Lett 197:1-6. 2010
    ....
  23. ncbi An experimentally based approach for predicting skin permeability of chemicals and drugs using a membrane-coated fiber array
    Xin Rui Xia
    Center for Chemical Toxicology Research and Pharmacokinetics CCTRP, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    Toxicol Appl Pharmacol 221:320-8. 2007
    ..It is an experimentally based, high throughput approach that provides high prediction confidence and does not require literature data nor molecular structure information in contrast to the existing predictive models...
  24. ncbi Multiphoton microscopy of transdermal quantum dot delivery using two photon polymerization-fabricated polymer microneedles
    Shaun D Gittard
    Joint Department of Biomedical Engineering, University of North Carolina State University, Campus Box 7115, Raleigh, NC 27695 7115, USA
    Faraday Discuss 149:171-85; discussion 227-45. 2011
    ..The microneedle device was used to inject quantum dots into porcine skin; imaging of the quantum dots was performed using multiphoton microscopy...
  25. ncbi Cyclic tensile strain increases interactions between human epidermal keratinocytes and quantum dot nanoparticles
    Jillian G Rouse
    Center for Chemical Toxicology Research and Pharmacokinetics, Department of Clinical Sciences, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    Toxicol In Vitro 22:491-7. 2008
    ..Application of physiological load conditions can increase cell membrane permeability, thereby increasing the concentration of QD nanoparticles in cells...
  26. ncbi Effects of mechanical flexion on the penetration of fullerene amino acid-derivatized peptide nanoparticles through skin
    Jillian G Rouse
    Center for Chemical Toxicology Research and Pharmacokinetics, Department of Clinical Sciences, North Carolina State University, 4700 Hillsborough Street, Raleigh, North Carolina 27606, USA
    Nano Lett 7:155-60. 2007
    ..TEM analysis revealed fullerene-peptide localization within the intercellular spaces of the stratum granulosum...
  27. ncbi A compartment model for the membrane-coated fiber technique used for determining the absorption parameters of chemicals into lipophilic membranes
    Xin Rui Xia
    Center for Chemical Toxicology Research and Pharmacokinetics, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27606, USA
    Pharm Res 21:1345-52. 2004
    ..The purpose of this work was to develop a compartment model for the membrane-coated fiber (MCF) technique for determining the absorption parameters of chemicals into lipophilic membranes...
  28. ncbi Skin penetration and kinetics of pristine fullerenes (C60) topically exposed in industrial organic solvents
    Xin R Xia
    Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    Toxicol Appl Pharmacol 242:29-37. 2010
    ..In vitro flow-through diffusion cell experiments were conducted in pig skin and fullerenes were not detected in the receptor solutions by 24 h. The limit of detection was 0.001 microg/mL of fullerenes in 2 mL of the receptor solutions...
  29. ncbi Silver nanoparticles do not influence stem cell differentiation but cause minimal toxicity
    Meghan E Samberg
    Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, NC, USA
    Nanomedicine (Lond) 7:1197-209. 2012
    ..To evaluate the toxicity and cellular uptake of both undifferentiated and differentiated human adipose-derived stem cells (hASCs) exposed to silver nanoparticles (Ag-NPs), and to assess their effect on hASC differentiation...
  30. ncbi Fullerene-based amino acid nanoparticle interactions with human epidermal keratinocytes
    Jillian G Rouse
    Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    Toxicol In Vitro 20:1313-20. 2006
    ..04 mg/mL initiate less cytokine activity and maintain cell viability. In HEK, Baa concentrations of 0.4 and 0.04 mg/mL decrease cell viability and initiate a pro-inflammatory response...
  31. ncbi Dermatotoxicity of cutting fluid mixtures:in vitro and in vivo studies
    Nancy A Monteiro-Riviere
    Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, Raleigh, North Carolina 27606, USA
    Cutan Ocul Toxicol 25:235-47. 2006
    ..These findings will however require further clinical studies to validate these acute dermal effects as well as human cumulative irritation following exposure to similar cutting fluid formulations in the workplace...
  32. ncbi Antibacterial efficacy of silver nanoparticles of different sizes, surface conditions and synthesis methods
    Meghan E Samberg
    Clinical Sciences, Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    Nanotoxicology 5:244-53. 2011
    ..coli at concentrations between 64.0-1024.0 μg/ml. Ag-resistant E. coli died only when treated with unwashed Ag-nps or its supernatant, both of which contained formaldehyde...
  33. ncbi Intrinsic biological property of colloidal fullerene nanoparticles (nC60): lack of lethality after high dose exposure to human epidermal and bacterial cells
    Xin R Xia
    Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    Toxicol Lett 197:128-34. 2010
    ..05) from the control without nC60 nanoparticles. These results reveal that the intrinsic biological property of nC60 is non-toxic, confirming the prior non-toxic reports when using nC60 prepared with non-THF methods...
  34. ncbi Mechanisms of quantum dot nanoparticle cellular uptake
    Leshuai W Zhang
    Center for Chemical Toxicology Research and Pharmacokinetics, Department of Clinical Science, North Carolina State University, Raleigh, North Carolina 27606, USA
    Toxicol Sci 110:138-55. 2009
    ..The surface coating, size, and charge of QD nanoparticles are important parameters in determining how nanoparticle uptake occurs in mammalian cells for cancer diagnosis and treatment, and drug delivery...
  35. ncbi Fabrication of polymer microneedles using a two-photon polymerization and micromolding process
    Shaun D Gittard
    Joint Department of Biomedical Engineering, University of North Carolina and North Carolina State University, Raleigh, North Carolina, USA
    J Diabetes Sci Technol 3:304-11. 2009
    ..In this study polymer microneedles for transdermal delivery were created using a two-photon polymerization (2PP) microfabrication and subsequent polydimethylsiloxane (PDMS) micromolding process...
  36. ncbi In vitro biocompatibility of titanium alloy discs made using direct metal fabrication
    Carla Maria Haslauer
    Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC 27695, USA
    Med Eng Phys 32:645-52. 2010
    ..EBM FFF may be considered as an option for the fabrication of custom orthopedic implants...
  37. ncbi Evaluation of silver nanoparticle toxicity in skin in vivo and keratinocytes in vitro
    Meghan E Samberg
    Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, Raleigh, North Carolina, USA
    Environ Health Perspect 118:407-13. 2010
    ..Objectives: This study was designed to assess the potential cytotoxicity of Ag-nps in human epidermal keratinocytes (HEKs) and their inflammatory and penetrating potential into porcine skin in vivo...
  38. ncbi Biodistribution of quantum dot nanoparticles in perfused skin: evidence of coating dependency and periodicity in arterial extraction
    Hyun A Lee
    Center for Chemical Toxicology Research and Pharmacokinetics, and Biomathematics Program, North Carolina State University, 4700 Hillsborough Street, Raleigh, North Carolina 27606, USA
    Nano Lett 7:2865-70. 2007
    ..Both QD had a unique periodicity in arterial extraction never observed with drug infusions, suggesting a potentially important nanomaterial behavior that could affect systemic disposition...
  39. ncbi Surface coatings determine cytotoxicity and irritation potential of quantum dot nanoparticles in epidermal keratinocytes
    Jessica P Ryman Rasmussen
    Center for Chemical Toxicology Research and Pharmacokinetics, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27606, USA
    J Invest Dermatol 127:143-53. 2007
    ..These data indicate that QD surface coating is a primary determinant of cytotoxicity and immunotoxicity in HEKs, which is consistent across size. However, uptake of QDs by HEKs is independent of surface coating...
  40. ncbi Acute vascular effects of nanoparticle infusion in isolated perfused skin
    Jim E Riviere
    Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, Raleigh, NC, USA
    Nanomedicine 8:428-31. 2012
    ..FROM THE CLINICAL EDITOR: In this study utilizing a perfused porcine skin flap, specific nanoparticle infusions were demonstrated to be associated with significant acute vascular physiological effects...
  41. ncbi Atomic layer deposition-based functionalization of materials for medical and environmental health applications
    Roger J Narayan
    Joint Department of Biomedical Engineering, University of North Carolina and North Carolina State University, 2147 Burlington Engineering Labs, Raleigh, NC 27695 7115, USA
    Philos Transact A Math Phys Eng Sci 368:2033-64. 2010
    ..The results of this work indicate that nanoporous alumina membranes may be modified using atomic layer deposition for use in a variety of medical and environmental health applications...
  42. ncbi Atomic layer deposition of titanium dioxide on cellulose acetate for enhanced hemostasis
    G Kevin Hyde
    Department of Chemical and Bimolecular Engineering, North Carolina State University, Raleigh, NC, USA
    Biotechnol J 6:213-23. 2011
    ..These results suggest that atomic layer deposition is an appropriate method for improving the biological properties of hemostatic agents and other blood-contacting biomaterials...
  43. ncbi Expression of proinflammatory cytokines by human mesenchymal stem cells in response to cyclic tensile strain
    Ruwan D Sumanasinghe
    Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, North Carolina 27695 7115, USA
    J Cell Physiol 219:77-83. 2009
    ..IL-6 and IL-8 expressions by hMSCs were induced by cyclic tensile strain and osteogenic differentiating media, indicating that IL-6 and IL-8 may be functioning as autocrine signals during osteogenic differentiation of hMSCs...
  44. ncbi Determination of the partition coefficients and absorption kinetic parameters of chemicals in a lipophilic membrane/water system by using a membrane-coated fiber technique
    Xin-Rui Xia
    Center for Chemical Toxicology Research and Pharmacokinetics (CCTRP, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    Eur J Pharm Sci 24:15-23. 2005
    ..It was demonstrated that the MCF technique could be used to determine the partition, diffusion and permeation coefficients, as well as the thickness of the boundary layer in a lipophilic membrane/water system...
  45. ncbi Biological interactions of functionalized single-wall carbon nanotubes in human epidermal keratinocytes
    Leshuai W Zhang
    Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, Raleigh, North Carolina 27606, USA
    Int J Toxicol 26:103-13. 2007
    ..These data showed that the lower concentration of 0.000005 mg/ml of AHA-SWNTs maintains cell viability and induces a mild cytotoxicity, but 0.05 mg/ml of AHA-SWNTs demonstrated an irritation response by the increase in IL-8...
  46. ncbi Variables influencing interactions of untargeted quantum dot nanoparticles with skin cells and identification of biochemical modulators
    Jessica P Ryman Rasmussen
    Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, 4700 Hillsborough Street, Raleigh, North Carolina 27606, USA
    Nano Lett 7:1344-8. 2007
    ..Biochemical inhibitors were identified that attenuate and potentiate QD-NHEK interactions. These results are important for understanding and controlling interactions of untargeted QD with cells...
  47. ncbi Percutaneous absorption of 2,6-di-tert-butyl-4-nitrophenol (DBNP) in isolated perfused porcine skin
    Alfred O Inman
    Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, 4700 Hillsborough Street, NC 27606, Raleigh, USA
    Toxicol In Vitro 17:289-92. 2003
    ..The highest mass of 14C-DBNP absorbed was only 0.5 microgram. The majority of the applied dose remained on the surface of the skin. This suggests that there is minimal dermal exposure of DBNP when exposed topically to skin...
  48. ncbi Trace analysis of fullerenes in biological samples by simplified liquid-liquid extraction and high-performance liquid chromatography
    Xin Rui Xia
    Center for Chemical Toxicology Research and Pharmacokinetics CCTRP, North Carolina State University, Raleigh, NC 27606, USA
    J Chromatogr A 1129:216-22. 2006
    ..Under optimal experimental conditions, the detection limit was 0.34 ng/mL and the recovery was in the range of 94-100% (n=5) at a concentration of 10 ng/mL nano-C60 in the biological media...
  49. ncbi In vitro biodistribution of silver nanoparticles in isolated perfused porcine skin flaps
    Teresa L Leavens
    Center for Chemical Toxicology Research and Pharmacokinetics, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27607, USA
    J Appl Toxicol 32:913-9. 2012
    ..Four hours after infusion of the Ag nanoparticles, the recovery of Ag in the venous effluent was 90 ± 5.0% and 87 ± 22% of the infused Ag for Ag-citrate and Ag-silica, respectively...
  50. ncbi Mapping the surface adsorption forces of nanomaterials in biological systems
    Xin R Xia
    Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, Raleigh, North Carolina 27607, USA
    ACS Nano 5:9074-81. 2011
    ....
  51. ncbi Differential relationship between the carbon chain length of jet fuel aliphatic hydrocarbons and their ability to induce cytotoxicity vs. interleukin-8 release in human epidermal keratinocytes
    Chi-Chung Chou
    Center for Chemical Toxicology Research and Pharmacokinetics (CCTRP, North Carolina State University, 4700 Hillsborough Street, Raleigh, North Carolina 27606, USA
    Toxicol Sci 69:226-33. 2002
    ....
  52. ncbi Cellular uptake mechanisms and toxicity of quantum dots in dendritic cells
    Leshuai W Zhang
    Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, Raleigh, NC 27606, USA
    Nanomedicine (Lond) 6:777-91. 2011
    ..Conclusion: These findings shed light on the mechanism of QD655-COOH uptake in DCs and that cellular uptake pathways are dependent on cell type and cell differentiation...
  53. ncbi Lectins modulate multi-walled carbon nanotubes cellular uptake in human epidermal keratinocytes
    Leshuai W Zhang
    Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, Raleigh, NC 27606, United States
    Toxicol In Vitro 24:546-51. 2010
    ..F-actin, a cytoskeleton protein, was used to visualize how the MWCNT interacted with the cytoskeleton in the cells. MWCNT traversed through the cells' cytoskeleton and the plasma membrane into adjacent keratinocytes...
  54. ncbi Microfabricated curtains for controlled cell seeding in high throughput microfluidic systems
    Adrian T O'Neill
    Joint Department of Biomedical Engineering at The University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC 27695 7115, USA
    Lab Chip 9:1756-62. 2009
    ..Curtain use permitted high initial cell seeding densities and increased the amount of time cells can be cultured compared to multi-well plates...
  55. ncbi Comparison of quantum dot biodistribution with a blood-flow-limited physiologically based pharmacokinetic model
    Hyun A Lee
    College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27606, USA
    Nano Lett 9:794-9. 2009
    ..The model predicted the experimentally observed persistence of QDs in tissues but not early time profiles or different QD biodistribution. Therefore, more complex models will be needed to better predict QD biodistribution in vivo...
  56. ncbi An index for characterization of nanomaterials in biological systems
    Xin Rui Xia
    Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, Raleigh, North Carolina, USA
    Nat Nanotechnol 5:671-5. 2010
    ..The biological surface adsorption index nanodescriptors can be used to develop pharmacokinetic and safety assessment models for nanomaterials...
  57. ncbi A serial dilution microfluidic device for cytotoxicity assays
    Adrian T O'Neill
    Dept of Biomed Eng, North Carolina Univ, Chapel Hill, NC, USA
    Conf Proc IEEE Eng Med Biol Soc 1:2836-9. 2006
    ..9993. The device functions equivalently over a wide range of flow rates. The standard deviation of dilution values averages 0.76% over six flow rates spanning 0.5 to 16 microl min(-1)...
  58. ncbi A novel in-vitro technique for studying percutaneous permeation with a membrane-coated fiber and gas chromatography/mass spectrometry: part I. Performances of the technique and determination of the permeation rates and partition coefficients of chemical m
    Xin-Rui Xia
    Center for Chemical Toxicology Research and Pharmacokinetics (CCTRP, College of Veterinary Medicine, Campus Box 8401, 4700 Hillsborough Street, North Carolina State University, Raleigh, North Carolina 27606, USA
    Pharm Res 20:275-82. 2003
    ..The initial permeation rate and equilibrium time can be obtained for each compound, which could serve as characteristic parameters regarding the skin permeability of the compound...
  59. ncbi Rapid prototyping of scaphoid and lunate bones
    Shaun D Gittard
    Joint Department of Biomedical Engineering, University of North Carolina North Carolina State University, Raleigh, NC 27599 7575, USA
    Biotechnol J 4:129-34. 2009
    ..The results of this study indicate that small bone prostheses fabricated by stereolithography using eShell 200 polymer may have suitable geometry, mechanical properties, and cytocompatibility properties for in vivo use...
  60. ncbi Penetration of intact skin by quantum dots with diverse physicochemical properties
    Jessica P Ryman-Rasmussen
    Center for Chemical Toxicology Research and Pharmacokinetics, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27606, USA
    Toxicol Sci 91:159-65. 2006
    ....
  61. ncbi Predicting skin permeability from complex vehicles
    Daniela Karadzovska
    Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, Raleigh, NC 27607, USA
    Adv Drug Deliv Rev 65:265-77. 2013
    ..These models have been compiled and statistically validated using the data generated from in vitro or ex vivo experimental techniques. This review highlights the progress made in predicting skin permeability from complex vehicles...
  62. ncbi Pathogenesis of acute ulceration response (AUR) in hybrid striped bass
    Pareeya Udomkusonsri
    Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, North Carolina 27607, USA
    Dis Aquat Organ 61:199-213. 2004
    ..Our study indicates that acute confinement can rapidly cause significant damage to epidermal and ocular epithelium. AUR might be a primary cause of morbidity in acutely stressed fish...
  63. ncbi Topical isoflavones provide effective photoprotection to skin
    Jing Yi Lin
    Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taipei, Taiwan
    Photodermatol Photoimmunol Photomed 24:61-6. 2008
    ..The aim of this study is to obtain a more comprehensive understanding of the isoflavone-mediated photoprotection with the pig skin model, a more human-resembling model...
  64. ncbi Multi-walled carbon nanotube exposure alters protein expression in human keratinocytes
    Frank A Witzmann
    Department of Cellular and Integrative Physiology, Biotechnology Research and Training Center, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Nanomedicine 2:158-68. 2006
    ..These data clearly show that MWCNTs are capable of altering protein expression in a target epithelial cell that constitutes a primary route of occupational exposure for manufactured nanotubes...
  65. ncbi Expression profiling of human epidermal keratinocyte response following 1-minute JP-8 exposure
    Chi Chung Chou
    Department of Veterinary Medicine and Veterinary Medicine Teaching Hospital, National Chung Hsing University, Taichung, Taiwan, ROC
    Cutan Ocul Toxicol 25:141-53. 2006
    ..These results indicated that human keratinocyte responds to a single dose of JP-8 insult and revealed several cellular processes previously not associated with jet fuel exposure...
  66. ncbi Toxicity of jet fuel aliphatic and aromatic hydrocarbon mixtures on human epidermal keratinocytes: evaluation based on in vitro cytotoxicity and interleukin-8 release
    Jen-Hung Yang
    Department of Dermatology, Chung-Shan Medical University Hospital, Taichung, Taiwan, R.O.C
    Arch Toxicol 80:508-23. 2006
    ..The mixture effects must be considered when evaluating jet fuel toxicity to HEK...
  67. ncbi Ubiquinone, idebenone, and kinetin provide ineffective photoprotection to skin when compared to a topical antioxidant combination of vitamins C and E with ferulic acid
    Joshua A Tournas
    J Invest Dermatol 126:1185-7. 2006
  68. ncbi UV photoprotection by combination topical antioxidants vitamin C and vitamin E
    Jing-Yi Lin
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    J Am Acad Dermatol 48:866-74. 2003
    ..CONCLUSION: Appreciable photoprotection can be obtained from the combination of topical vitamins C and E. We suggest that these natural products may protect against skin cancer and photoaging...
  69. ncbi Alpha-lipoic acid is ineffective as a topical antioxidant for photoprotection of skin
    Jing-Yi Lin
    J Invest Dermatol 123:996-8. 2004
  70. ncbi Research strategies for safety evaluation of nanomaterials, part II: toxicological and safety evaluation of nanomaterials, current challenges and data needs
    Michael P Holsapple
    ILSI Health and Environmental Sciences Institute, One Thomas Circle, NW, 9th Floor, Washington, District of Columbia 20005, USA
    Toxicol Sci 88:12-7. 2005
    ....
  71. ncbi Ferulic acid stabilizes a solution of vitamins C and E and doubles its photoprotection of skin
    Fu-Hsiung Lin
    Duke University Medical Center, Durham, North Carolina 27710, USA
    J Invest Dermatol 125:826-32. 2005
    ..This combination of pure natural low molecular weight antioxidants provides meaningful synergistic protection against oxidative stress in skin and should be useful for protection against photoaging and skin cancer...

Research Grants2

  1. Comparative In Vivo Biodistribution of Characterized Manufactured Nanomaterials
    Nancy A Monteiro Riviere; Fiscal Year: 2010
    ..These coordinated studies will provide data to link physical chemical characterizations to in vivo MNM disposition. ..