Trudy F Mackay

Summary

Affiliation: North Carolina State University
Country: USA

Publications

  1. pmc The Drosophila melanogaster Genetic Reference Panel
    Trudy F C Mackay
    Department of Genetics, North Carolina State University, Raleigh, North Carolina 27695, USA
    Nature 482:173-8. 2012
  2. pmc Quantitative and molecular genetic analyses of mutations increasing Drosophila life span
    Michael M Magwire
    Department of Genetics and W M Keck Center for Behavioral Biology, North Carolina State University, Raleigh, North Carolina, United States of America
    PLoS Genet 6:e1001037. 2010
  3. pmc The genetic basis of alcoholism: multiple phenotypes, many genes, complex networks
    Tatiana V Morozova
    Department of Biology, Box 7617, North Carolina State University, Raleigh, NC 27695, USA
    Genome Biol 13:239. 2012
  4. pmc Genome-wide association study of sleep in Drosophila melanogaster
    Susan T Harbison
    Department of Genetics, North Carolina State University, Raleigh, North Carolina 27695, USA
    BMC Genomics 14:281. 2013
  5. pmc Nuclear genomic control of naturally occurring variation in mitochondrial function in Drosophila melanogaster
    Patricia Jumbo-Lucioni
    Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    BMC Genomics 13:659. 2012
  6. pmc Quantitative genomics of starvation stress resistance in Drosophila
    Susan T Harbison
    Department of Genetics, North Carolina State University, Raleigh, NC 27695, USA
    Genome Biol 6:R36. 2005
  7. pmc A transcriptional network associated with natural variation in Drosophila aggressive behavior
    Alexis C Edwards
    Department of Genetics, North Carolina State University, Raleigh, North Carolina 27695, USA
    Genome Biol 10:R76. 2009
  8. pmc Transcriptional response to alcohol exposure in Drosophila melanogaster
    Tatiana V Morozova
    WM Keck Center for Behavioral Biology, North Carolina State University, Raleigh, NC 27695, USA
    Genome Biol 7:R95. 2006
  9. pmc Quantitative genomics of locomotor behavior in Drosophila melanogaster
    Katherine W Jordan
    Department of Genetics and WM Keck Center for Behavioral Biology, North Carolina State University, Raleigh, NC 27695 7614, USA
    Genome Biol 8:R172. 2007
  10. pmc Phenotypic and transcriptional response to selection for alcohol sensitivity in Drosophila melanogaster
    Tatiana V Morozova
    Department of Zoology, North Carolina State University, Raleigh, NC 27695, USA
    Genome Biol 8:R231. 2007

Research Grants

  1. QUANTITATIVE TRAIT LOCI IN DROSOPHILA
    Trudy Mackay; Fiscal Year: 2006
  2. Genetics of Alcohol Sensitivity in Drosophila
    Trudy Mackay; Fiscal Year: 2007
  3. Genetics of Aggression in Drosophila
    Trudy Mackay; Fiscal Year: 2007
  4. THE GENETIC ARCHITECTURE OF QUANTITATIVE TRAITS
    Trudy Mackay; Fiscal Year: 2007
  5. Genetics of Alcohol Sensitivity in Drosophila
    Trudy Mackay; Fiscal Year: 2008
  6. Initiative for Maximizing Student Diversity in Biomedical and Behavioral Sciences
    Trudy Mackay; Fiscal Year: 2008
  7. Genetics of Aggression in Drosophila
    Trudy Mackay; Fiscal Year: 2008
  8. THE GENETIC ARCHITECTURE OF QUANTITATIVE TRAITS
    Trudy Mackay; Fiscal Year: 2008
  9. Genetics of Alcohol Sensitivity in Drosophila
    Trudy Mackay; Fiscal Year: 2009
  10. Genetics of Aggression in Drosophila
    Trudy Mackay; Fiscal Year: 2009

Collaborators

Detail Information

Publications80

  1. pmc The Drosophila melanogaster Genetic Reference Panel
    Trudy F C Mackay
    Department of Genetics, North Carolina State University, Raleigh, North Carolina 27695, USA
    Nature 482:173-8. 2012
    ..Many variants in novel genes, most at low frequency, are associated with quantitative traits and explain a large fraction of the phenotypic variance. The DGRP facilitates genotype-phenotype mapping using the power of Drosophila genetics...
  2. pmc Quantitative and molecular genetic analyses of mutations increasing Drosophila life span
    Michael M Magwire
    Department of Genetics and W M Keck Center for Behavioral Biology, North Carolina State University, Raleigh, North Carolina, United States of America
    PLoS Genet 6:e1001037. 2010
    ..Comparison of transcript profiles of long-lived mutations and the control line reveals a transcriptional signature of increased life span...
  3. pmc The genetic basis of alcoholism: multiple phenotypes, many genes, complex networks
    Tatiana V Morozova
    Department of Biology, Box 7617, North Carolina State University, Raleigh, NC 27695, USA
    Genome Biol 13:239. 2012
    ..Alcoholism is a significant public health problem. A picture of the genetic architecture underlying alcohol-related phenotypes is emerging from genome-wide association studies and work on genetically tractable model organisms...
  4. pmc Genome-wide association study of sleep in Drosophila melanogaster
    Susan T Harbison
    Department of Genetics, North Carolina State University, Raleigh, North Carolina 27695, USA
    BMC Genomics 14:281. 2013
    ..Sleep is a highly conserved behavior, yet its duration and pattern vary extensively among species and between individuals within species. The genetic basis of natural variation in sleep remains unknown...
  5. pmc Nuclear genomic control of naturally occurring variation in mitochondrial function in Drosophila melanogaster
    Patricia Jumbo-Lucioni
    Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    BMC Genomics 13:659. 2012
    ..Here, we used Drosophila melanogaster as our model organism to address this question...
  6. pmc Quantitative genomics of starvation stress resistance in Drosophila
    Susan T Harbison
    Department of Genetics, North Carolina State University, Raleigh, NC 27695, USA
    Genome Biol 6:R36. 2005
    ..Here, we tested the efficacy of whole-genome transcriptional profiling for identifying genes affecting starvation stress resistance...
  7. pmc A transcriptional network associated with natural variation in Drosophila aggressive behavior
    Alexis C Edwards
    Department of Genetics, North Carolina State University, Raleigh, North Carolina 27695, USA
    Genome Biol 10:R76. 2009
    ..Populations of Drosophila melanogaster harbor quantitative genetic variation in aggressive behavior, providing an excellent model system for dissecting the genetic basis of naturally occurring variation in aggression...
  8. pmc Transcriptional response to alcohol exposure in Drosophila melanogaster
    Tatiana V Morozova
    WM Keck Center for Behavioral Biology, North Carolina State University, Raleigh, NC 27695, USA
    Genome Biol 7:R95. 2006
    ....
  9. pmc Quantitative genomics of locomotor behavior in Drosophila melanogaster
    Katherine W Jordan
    Department of Genetics and WM Keck Center for Behavioral Biology, North Carolina State University, Raleigh, NC 27695 7614, USA
    Genome Biol 8:R172. 2007
    ..However, the genetic basis of this complex behavior is largely uncharacterized...
  10. pmc Phenotypic and transcriptional response to selection for alcohol sensitivity in Drosophila melanogaster
    Tatiana V Morozova
    Department of Zoology, North Carolina State University, Raleigh, NC 27695, USA
    Genome Biol 8:R231. 2007
    ..Furthermore, flies exposed to ethanol undergo physiological and behavioral changes that resemble human alcohol intoxication, including loss of postural control, sedation, and development of tolerance...
  11. pmc Systems genetics analysis of body weight and energy metabolism traits in Drosophila melanogaster
    Patricia Jumbo-Lucioni
    Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL 35294 3360, USA
    BMC Genomics 11:297. 2010
    ....
  12. pmc Mutations in many genes affect aggressive behavior in Drosophila melanogaster
    Alexis C Edwards
    Department of Genetics, North Carolina State University, Raleigh, NC, USA
    BMC Biol 7:29. 2009
    ..Here, we present the results of a screen of 170 Drosophila P-element insertional mutations for quantitative differences in aggressive behavior from their co-isogenic control line...
  13. ncbi request reprint The genetic architecture of quantitative traits: lessons from Drosophila
    Trudy F C Mackay
    Department of Genetics, Campus Box 7614, North Carolina State University, Raleigh, North Carolina 27695 7614, USA
    Curr Opin Genet Dev 14:253-7. 2004
    ..These observations offer valuable lessons for understanding the genetic basis of variation for complex traits in other organisms, including humans...
  14. ncbi request reprint Of flies and man: Drosophila as a model for human complex traits
    Trudy F C Mackay
    Department of Genetics, North Carolina State University, Raleigh, North Carolina, 27695, USA
    Annu Rev Genomics Hum Genet 7:339-67. 2006
    ....
  15. ncbi request reprint Ain't misbehavin' ? Genotype-environment interactions and the genetics of behavior
    Trudy F C Mackay
    Department of Genetics, North Carolina State University, Raleigh, NC 27695, USA
    Trends Genet 23:311-4. 2007
    ..This report, together with studies from Drosophila, stresses the importance of understanding genotype-environment interactions...
  16. ncbi request reprint Methods for genetic dissection of complex traits
    Trudy F C Mackay
    Department of Genetics, North Carolina State University, Raleigh, NC 27695, USA
    Sci Aging Knowledge Environ 2004:pe17. 2004
    ..In this Perspective, the author responds to a recent SAGE KE Perspective. An alternative view of the benefits of quantitative trait loci mapping as a way to understand the molecular mechanisms of life-span determination is presented...
  17. pmc Genetics and genomics of Drosophila mating behavior
    Trudy F C Mackay
    Department of Genetics, North Carolina State University, Raleigh, 27695, USA
    Proc Natl Acad Sci U S A 102:6622-9. 2005
    ..Future functional studies are necessary to test the extent to which transcript profiling of divergent selection lines accurately predicts genes that directly affect the selected trait...
  18. pmc Polygenic mutation in Drosophila melanogaster: Mapping spontaneous mutations affecting sensory bristle number
    Trudy F C Mackay
    Department of Genetics, North Carolina State University, Raleigh, North Carolina 27695, USA
    Genetics 170:1723-35. 2005
    ....
  19. pmc Drosophila bristles and the nature of quantitative genetic variation
    Trudy F Mackay
    Department of Genetics, North Carolina State University, Campus Box 7614, Raleigh, NC 27612, USA
    Philos Trans R Soc Lond B Biol Sci 360:1513-27. 2005
    ..We found that molecular polymorphisms at Ddc are indeed associated with variation in environmental plasticity of abdominal bristle number...
  20. pmc Polygenic mutation in Drosophila melanogaster: genetic interactions between selection lines and candidate quantitative trait loci
    T F Mackay
    Department of Genetics, North Carolina State University, Raleigh 27695, USA
    Genetics 144:671-88. 1996
    ..It is possible that much of the response to selection was from new mutations at candidate bristle number quantitative trait loci, and that for some of these loci, mutation rates were high...
  21. pmc Quantitative genetic variation of odor-guided behavior in a natural population of Drosophila melanogaster
    T F Mackay
    Department of Genetics, North Carolina State University, Raleigh 27695, USA
    Genetics 144:727-35. 1996
    ..This unusual genetic architecture implies that divergent evolutionary trajectories for olfactory behavior may occur in males and females...
  22. ncbi request reprint The genetic architecture of quantitative traits
    T F Mackay
    Department of Genetics, North Carolina State University, Raleigh, Box 7614, North Carolina 27695, USA
    Annu Rev Genet 35:303-39. 2001
    ....
  23. ncbi request reprint The nature of quantitative genetic variation for Drosophila longevity
    Trudy F C Mackay
    Department of Genetics, Box 7614, North Carolina State University, Raleigh, NC 27695 7614, USA
    Mech Ageing Dev 123:95-104. 2002
    ..In the future, linkage disequilibrium mapping can be used to determine which candidate genes in a QTL region correspond to the genetic loci affecting variation in life span, and define the QTL alleles at the molecular level...
  24. doi request reprint The genetics of quantitative traits: challenges and prospects
    Trudy F C Mackay
    Department of Genetics, North Carolina State University, Raleigh, North Carolina 27695, USA
    Nat Rev Genet 10:565-77. 2009
    ..This systems genetics approach enables us to understand the biology inside the 'black box' that lies between genotype and phenotype in terms of causal networks of interacting genes...
  25. pmc Mutations and quantitative genetic variation: lessons from Drosophila
    Trudy F C Mackay
    Department of Genetics, W M Keck Center for Behavioral Biology, North Carolina State University, Campus Box 7614, Raleigh, NC 27697, USA
    Philos Trans R Soc Lond B Biol Sci 365:1229-39. 2010
    ..Future genome wide association analyses of many quantitative traits on a common panel of fully sequenced Drosophila strains will provide much needed empirical data on the molecular genetic basis of quantitative traits...
  26. doi request reprint The genetic architecture of complex behaviors: lessons from Drosophila
    Trudy F C Mackay
    Department of Genetics and The Keck Center for Behavioral Biology, North Carolina State University, Campus Box 7614, Raleigh, NC 27695, USA
    Genetica 136:295-302. 2009
    ..These observations offer valuable lessons for understanding the genetic basis of variation for complex behaviors in other organisms, including humans...
  27. pmc Phenotypic plasticity and genotype by environment interaction for olfactory behavior in Drosophila melanogaster
    Deepa Sambandan
    W M Keck Center for Behavioral Biology, North Carolina State University, Raleigh, North Carolina 27695, USA
    Genetics 179:1079-88. 2008
    ....
  28. ncbi request reprint Phenotypic variation and natural selection at catsup, a pleiotropic quantitative trait gene in Drosophila
    Mary Anna Carbone
    Department of Genetics, North Carolina State University, Raleigh, North Carolina 27695, USA
    Curr Biol 16:912-9. 2006
    ..Molecular population genetic analyses of Catsup sequences are consistent with balancing selection maintaining multiple functional polymorphisms...
  29. ncbi request reprint Dopa decarboxylase (Ddc) affects variation in Drosophila longevity
    Maria De Luca
    Department of Genetics, Box 7614, North Carolina State University, Raleigh, North Carolina 27695, USA
    Nat Genet 34:429-33. 2003
    ..DDC catalyzes the final step in the synthesis of the neurotransmitters, dopamine and serotonin. Thus, these data implicate variation in the synthesis of bioamines as a factor contributing to natural variation in individual life span...
  30. pmc Scribble is essential for olfactory behavior in Drosophila melanogaster
    Indrani Ganguly
    The W M Keck Center for Behavioral Biology, North Carolina State University, Raleigh, NC 27695, USA
    Genetics 164:1447-57. 2003
    ..Expression of Scrib is widespread in olfactory organs and the central nervous system. Finally, alternative splicing of scrib generates transcripts that differ in the number of leucine-rich repeats and PDZ domains...
  31. pmc The genetic basis of postzygotic reproductive isolation between Drosophila santomea and D. yakuba due to hybrid male sterility
    Amanda J Moehring
    Department of Genetics, North Carolina State University, Raleigh 27695, USA
    Genetics 173:225-33. 2006
    ..yakuba and D. santomea. These results provide the basis for future high-resolution mapping and ultimately, molecular cloning, of the interacting genes that contribute to hybrid sterility...
  32. pmc Quantitative genomics of aggressive behavior in Drosophila melanogaster
    Alexis C Edwards
    Department of Genetics and W M Keck Center for Behavioral Biology, North Carolina State University, Raleigh, North Carolina, United States of America
    PLoS Genet 2:e154. 2006
    ..Expression profiling of genetically divergent lines is an effective strategy for identifying genes affecting complex traits...
  33. pmc Alcohol sensitivity in Drosophila: translational potential of systems genetics
    Tatiana V Morozova
    Department of Biology, W M Keck Center for Behavioral Biology, North Carolina State University, Raleigh, NC 27695, USA
    Genetics 183:733-45, 1SI-12SI. 2009
    ....
  34. pmc Vanaso is a candidate quantitative trait gene for Drosophila olfactory behavior
    Juan José Fanara
    W M Keck Center for Behavioral Biology, North Carolina State University, Raleigh 27695, USA
    Genetics 162:1321-8. 2002
    ....
  35. pmc Association of polymorphisms in odorant-binding protein genes with variation in olfactory response to benzaldehyde in Drosophila
    Ping Wang
    Department of Genetics, North Carolina State University, Raleigh, North Carolina 27695, USA
    Genetics 177:1655-65. 2007
    ..Model predictions of alternative pre-mRNA secondary structures associated with polymorphic sites suggest that alterations in Obp mRNA structure could contribute to phenotypic variation in olfactory behavior...
  36. pmc Dynamic genetic interactions determine odor-guided behavior in Drosophila melanogaster
    Deepa Sambandan
    Department of Genetics, The W M Keck Center for Behavioral Biology, North Carolina State University, Raleigh 27695 7617, USA
    Genetics 174:1349-63. 2006
    ..Our results show that the manifestation of epistatic networks dynamically changes with alterations in the environment...
  37. ncbi request reprint The complex genetic architecture of Drosophila life span
    Jeff Leips
    Department of Genetics, North Carolina State University, Raleigh, North Carolina, USA
    Exp Aging Res 28:361-90. 2002
    ..We summarize all of the QTL mapping data for Drosophila life span, and outline future prospects for disentangling the genetic and environmental influences on this trait...
  38. pmc Quantitative trait loci affecting starvation resistance in Drosophila melanogaster
    Susan T Harbison
    Department of Genetics and W M Keck Center for Behavioral Biology, North Carolina State University, Raleigh, North Carolina 27695, USA
    Genetics 166:1807-23. 2004
    ..However, we also found genes with cell fate specification and cell proliferation phenotypes, which implies that resource allocation during development and at the cellular level may also influence the phenotypic response to starvation...
  39. pmc Quantitative trait loci for aggressive behavior in Drosophila melanogaster
    Alexis C Edwards
    Department of Genetics and W M Keck Center for Behavioral Biology, North Carolina State University, Raleigh, North Carolina 27695, USA
    Genetics 182:889-97. 2009
    ..Extensive epistasis poses a serious challenge for understanding the genetic basis of complex traits...
  40. pmc Co-regulated transcriptional networks contribute to natural genetic variation in Drosophila sleep
    Susan T Harbison
    Department of Genetics, North Carolina State University, Raleigh, North Carolina 27695, USA
    Nat Genet 41:371-5. 2009
    ..We confirmed co-regulated gene expression using P-element mutants. Quantitative genetic analysis of natural phenotypic variation is an efficient method for revealing candidate genes and pathways...
  41. pmc The early developmental gene Semaphorin 5c contributes to olfactory behavior in adult Drosophila
    Stephanie M Rollmann
    Department of Zoology, North Carolina State University, Raleigh, North Carolina 27695, USA
    Genetics 176:947-56. 2007
    ..Our results demonstrate how hypomorphic mutation of an early developmental gene results in genomewide transcriptional consequences and alterations in brain structure accompanied by profound impairment of adult behavior...
  42. ncbi request reprint Pinocchio, a novel protein expressed in the antenna, contributes to olfactory behavior in Drosophila melanogaster
    Stephanie M Rollmann
    Department of Zoology, North Carolina State University, Raleigh, 27695 7617, USA
    J Neurobiol 63:146-58. 2005
    ..Furthermore, in situ hybridization reveals CG4710 expression in the third antennal segment. We have named this gene of previously unknown function and its product "Pinocchio (Pino)"...
  43. pmc Plasticity of the chemoreceptor repertoire in Drosophila melanogaster
    Shanshan Zhou
    Department of Biology, North Carolina State University, Raleigh, North Carolina, United States of America
    PLoS Genet 5:e1000681. 2009
    ..This finely pixilated modular organization of the chemosensory subgenome enables fine tuning of the expression of the chemoreceptor repertoire in response to ecologically relevant environmental and physiological conditions...
  44. pmc The genetic architecture of Drosophila sensory bristle number
    Christy L Dilda
    Department of Genetics, North Carolina State University, Raleigh, North Carolina 27695 7614, USA
    Genetics 162:1655-74. 2002
    ..These features are germane to evolutionary models for the maintenance of genetic variation for quantitative traits, but complicate efforts to understand the molecular genetic basis of variation for complex traits...
  45. ncbi request reprint The genetic architecture of odor-guided behavior in Drosophila: epistasis and the transcriptome
    Robert R H Anholt
    The Department of Zoology, North Carolina State University, Raleigh, North Carolina 27695, USA
    Nat Genet 35:180-4. 2003
    ....
  46. ncbi request reprint Enabling population and quantitative genomics
    Greg Gibson
    Department of Genetics, Gardner Hall, North Carolina State University, Raleigh, NC 27695 7614, USA
    Genet Res 80:1-6. 2002
    ..Here we discuss the set of community-wide genetic and molecular resources, including panels of specific types of inbred lines and high density resequencing and SNP detection, that will facilitate such studies...
  47. pmc Pleiotropic effects of Drosophila neuralized on complex behaviors and brain structure
    Stephanie M Rollmann
    Department of Zoology, North Carolina State University, Raleigh, North Carolina 27695 7617, USA
    Genetics 179:1327-36. 2008
    ....
  48. pmc Genotype-environment interactions at quantitative trait loci affecting inflorescence development in Arabidopsis thaliana
    Mark C Ungerer
    Department of Genetics, North Carolina State University, Raleigh, North Carolina 27695, USA
    Genetics 165:353-65. 2003
    ..High-resolution mapping will be necessary to distinguish between the alternative explanations of pleiotropy and tight linkage among multiple genes...
  49. ncbi request reprint Quantitative trait loci affecting natural variation in Drosophila longevity
    Gretchen L Geiger-Thornsberry
    Department of Genetics, Box 7614, North Carolina State University, Raleigh 27695, USA
    Mech Ageing Dev 125:179-89. 2004
    ..Quantitative complementation tests are therefore useful for identifying QTL contributing to segregating genetic variation in life span in nature...
  50. pmc Systems genetics of complex traits in Drosophila melanogaster
    Julien F Ayroles
    Department of Genetics, North Carolina State University, Raleigh, North Carolina 27695, USA
    Nat Genet 41:299-307. 2009
    ..Overlapping transcripts in modules associated with different traits provide insight into the molecular basis of pleiotropy between complex traits...
  51. pmc High-resolution mapping of quantitative trait loci affecting increased life span in Drosophila melanogaster
    Rhonda H Wilson
    Department of Genetics, North Carolina State University, Raleigh, North Carolina 27695, USA
    Genetics 173:1455-63. 2006
    ..The QTL were mapped with high resolution and contained from 12 to 170 positional candidate genes...
  52. pmc The quantitative genetic basis of male mating behavior in Drosophila melanogaster
    Amanda J Moehring
    Department of Genetics, North Carolina State University, Raleigh, North Carolina 27695 7614, USA
    Genetics 167:1249-63. 2004
    ..None of these genes have been previously implicated in mating behavior, demonstrating that quantitative analysis of subtle variants can reveal novel pleiotropic effects of key developmental loci on behavior...
  53. pmc Quantitative trait loci for locomotor behavior in Drosophila melanogaster
    Katherine W Jordan
    Department of Genetics and W M Keck Center for Behavioral Biology, North Carolina State University, Raleigh, North Carolina 27695 7614, USA
    Genetics 174:271-84. 2006
    ..These data implicate variation in the synthesis of bioamines as a factor contributing to natural variation in locomotor reactivity...
  54. ncbi request reprint Pleiotropic fitness effects of the Tre1-Gr5a region in Drosophila melanogaster
    Stephanie M Rollmann
    Department of Zoology, North Carolina State University, Raleigh, North Carolina 27695 7617, USA
    Nat Genet 38:824-9. 2006
    ..Transposon-induced sex-specific and sex-antagonistic effects further accentuate the complex influences that intergenic transposable elements can contribute to quantitative trait phenotypes...
  55. pmc The genetic basis of prezygotic reproductive isolation between Drosophila santomea and D. yakuba due to mating preference
    Amanda J Moehring
    Department of Genetics, North Carolina State University, Raleigh 27695, USA
    Genetics 173:215-23. 2006
    ..mauritiana and with QTL affecting differences in pigmentation between D. santomea and D. yakuba. Future high-resolution mapping and, ultimately, positional cloning, will reveal whether these traits do indeed have a common genetic basis...
  56. pmc Quantitative trait loci for sexual isolation between Drosophila simulans and D. mauritiana
    Amanda J Moehring
    Department of Genetics, North Carolina State University, Raleigh, North Carolina 27695, USA
    Genetics 167:1265-74. 2004
    ..The observation of a few QTL with moderate to large effects will facilitate positional cloning of genes underlying sexual isolation...
  57. pmc Quantitative trait loci affecting the difference in pigmentation between Drosophila yakuba and D. santomea
    Mary Anna Carbone
    Department of Genetics, North Carolina State University, Raleigh 27695, USA
    Genetics 171:211-25. 2005
    ..The regions delimited by the QTL included many positional candidate loci in the pigmentation pathway, including genes affecting catecholamine biosynthesis, melanization of the cuticle, and many additional pleiotropic effects...
  58. ncbi request reprint Quantitative genetic analyses of complex behaviours in Drosophila
    Robert R H Anholt
    Department of Zoology, W M Keck Center for Behavioral Biology, North Carolina State University, Raleigh, North Carolina 27695 7617, USA
    Nat Rev Genet 5:838-49. 2004
    ..Recent advances in quantitative genetic and functional genomic approaches now enable the extensive characterization of complex genetic networks that mediate behaviours in this important model organism...
  59. pmc Natural variation in odorant recognition among odorant-binding proteins in Drosophila melanogaster
    Ping Wang
    Department of Biology, North Carolina State University, Raleigh, North Carolina 27695, USA
    Genetics 184:759-67. 2010
    ..Thus, dual olfactory recognition where OBPs regulate odorant access to receptors may enhance olfactory discrimination...
  60. pmc Epistatic interactions attenuate mutations affecting startle behaviour in Drosophila melanogaster
    Akihiko Yamamoto
    Department of Biology, North Carolina State University, Raleigh, NC, USA
    Genet Res (Camb) 91:373-82. 2009
    ....
  61. ncbi request reprint Association of single-nucleotide polymorphisms at the Delta locus with genotype by environment interaction for sensory bristle number in drosophila Melanogaster
    Gretchen L Geiger-Thornsberry
    Department of Genetics, North Carolina State University, Raleigh 27695, USA
    Genet Res 79:211-8. 2002
    ..Therefore, this mechanism of GEI seems unlikely to be responsible for maintaining the common bristle number polymorphisms at Dl...
  62. pmc The DSC1 channel, encoded by the smi60E locus, contributes to odor-guided behavior in Drosophila melanogaster
    Nalini H Kulkarni
    The W M Keck Center for Behavioral Biology, North Carolina State University, Raleigh, North Carolina 27695, USA
    Genetics 161:1507-16. 2002
    ..These results indicate that the DSC1 channel contributes to processing of olfactory information during the olfactory avoidance response...
  63. pmc Quantitative trait loci for inflorescence development in Arabidopsis thaliana
    Mark C Ungerer
    Department of Genetics, North Carolina State University, Raleigh, North Carolina 27695, USA
    Genetics 160:1133-51. 2002
    ..Previously identified flowering time, inflorescence architecture, floral meristem identity, and hormone signaling genes represent some of the many candidate genes in these regions...
  64. pmc Neurogenetic networks for startle-induced locomotion in Drosophila melanogaster
    Akihiko Yamamoto
    Department of Zoology, North Carolina State University, Raleigh, NC 27695, USA
    Proc Natl Acad Sci U S A 105:12393-8. 2008
    ..We find that behavioral and neuroanatomical phenotypes are determined by a common set of genes that are organized as partially overlapping genetic networks...
  65. ncbi request reprint Microclinal variation for ovariole number and body size in Drosophila melanogaster in 'Evolution Canyon'
    Marta L Wayne
    Departament of Genetics, Campus Box 7614, North Carolina State University, Raleigh, NC 27695 7614, USA
    Genetica 123:263-70. 2005
    ..Genetic variation between sites within easy dispersal range is consistent with the action of strong natural selection, although neither the selective agent(s) nor the direct targets of selection are known...
  66. ncbi request reprint Variation in Drosophila sensory bristle number at 'Evolution Canyon'
    Richard F Lyman
    Department of Genetics, Box 7614, North Carolina State University, Raleigh, NC 27695, USA
    Genet Res 80:215-23. 2002
    ....
  67. doi request reprint Understanding the neurogenetics of sleep: progress from Drosophila
    Susan T Harbison
    Department of Genetics, North Carolina State University, Raleigh, NC 27695, USA
    Trends Genet 25:262-9. 2009
    ..Advances in systems genetics coupled with the ability to target specific brain regions enable the characterization of transcriptional networks and neural circuits contributing to phenotypic variation in sleep...
  68. pmc Overexpression of myocilin in the Drosophila eye activates the unfolded protein response: implications for glaucoma
    Mary Anna Carbone
    Department of Genetics, North Carolina State University, Raleigh, North Carolina, USA
    PLoS ONE 4:e4216. 2009
    ..Among several hypotheses, activation of the unfolded protein response (UPR) has emerged as a possible disease mechanism...
  69. pmc The 2004 Genetics Society of America Medal
    Bruce S Weir
    Genetics 166:647-8. 2004
  70. pmc No evidence for an association between common nonsynonymous polymorphisms in delta and bristle number variation in natural and laboratory populations of Drosophila melanogaster
    Anne Genissel
    Department of Ecology and Evolutionary Biology, University of California, Irvine, California 92697 2525, USA
    Genetics 166:291-306. 2004
    ..Unidentified regulatory variants more parsimoniously explain previous observations...
  71. ncbi request reprint Candidate genes affecting Drosophila life span identified by integrating microarray gene expression analysis and QTL mapping
    Chao Qiang Lai
    JM USDA Human Nutrition Research Center on Aging, Nutrition and Genomics, Tufts University, Boston, MA 02111, United States
    Mech Ageing Dev 128:237-49. 2007
    ....
  72. pmc hairy: A quantitative trait locus for drosophila sensory bristle number
    Charles Robin
    Centre for Environmental Stress and Adaptation Research, Department of Genetics, University of Melbourne, Victoria, 3010, Australia
    Genetics 162:155-64. 2002
    ..This polymorphism, present in 17.5% of the h alleles, was associated with an increase of 0.5 bristle and accounted for 31% of the genetic variance in bristle number in the NIL...
  73. ncbi request reprint Genetic and behavioral analysis of natural variation in Drosophila melanogaster pupation position
    Craig A L Riedl
    Biology Department, University of Toronto at Mississauga, Mississauga, Ontario, Canada
    Fly (Austin) 1:23-32. 2007
    ....
  74. ncbi request reprint Shuttle craft: a candidate quantitative trait gene for Drosophila lifespan
    Elena G Pasyukova
    Institute of Molecular Genetics, Russian Academy of Sciences, Moscow 123182, Russia
    Aging Cell 3:297-307. 2004
    ..Quantitative genetic analysis of naturally occurring variants with subtle effects on lifespan can identify novel candidate genes and pathways important in the regulation of longevity...
  75. pmc Heterogeneous selection at specific loci in natural environments in Arabidopsis thaliana
    Cynthia Weinig
    Department of Ecology and Evolutionary Biology, Brown University, Providence, Rhode Island 02912, USA
    Genetics 165:321-9. 2003
    ..Thus, both environmental heterogeneity and epistatic selection may maintain genetic variation for fitness in wild plant species...
  76. ncbi request reprint Speed-mapping quantitative trait loci using microarrays
    Chao Qiang Lai
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Nutrition and Genomics, Tufts University, 711 Washington Street, Boston, Massachusetts 02111, USA
    Nat Methods 4:839-41. 2007
    ..We used changes of gene frequency of 2,326 single-feature polymorphisms (SFPs) to map previously identified and additional QTLs affecting lifespan...
  77. pmc Novel loci control variation in reproductive timing in Arabidopsis thaliana in natural environments
    Cynthia Weinig
    Department of Ecology and Evolutionary Biology, Brown University, Providence, Rhode Island 02912, USA
    Genetics 162:1875-84. 2002
    ..These novel loci suggest the involvement of additional genes in the transition to flowering under ecologically relevant conditions...
  78. ncbi request reprint Complementing complexity
    Trudy F C Mackay
    Nat Genet 36:1145-7. 2004
  79. pmc Transcription profiling in Drosophila eyes that overexpress the human glaucoma-associated trabecular meshwork-inducible glucocorticoid response protein/myocilin (TIGR/MYOC)
    TERESA BORRAS
    Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Genetics 163:637-45. 2003
    ..Our observations establish the Drosophila eye as an advantageous system for the discovery of genes that are associated with glaucoma...

Research Grants30

  1. QUANTITATIVE TRAIT LOCI IN DROSOPHILA
    Trudy Mackay; Fiscal Year: 2006
    ..Identification of new genes affecting Drosophila behaviors will enrich our understanding of the network of genetic interactions required to produce these complex traits. ..
  2. Genetics of Alcohol Sensitivity in Drosophila
    Trudy Mackay; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  3. Genetics of Aggression in Drosophila
    Trudy Mackay; Fiscal Year: 2007
    ..Given the evolutionary conservation of function for fundamental traits, such as aggression, genes and pathways discovered in model organisms can be incorporated as candidate genes in human linkage and association studies. ..
  4. THE GENETIC ARCHITECTURE OF QUANTITATIVE TRAITS
    Trudy Mackay; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  5. Genetics of Alcohol Sensitivity in Drosophila
    Trudy Mackay; Fiscal Year: 2008
    ..abstract_text> ..
  6. Initiative for Maximizing Student Diversity in Biomedical and Behavioral Sciences
    Trudy Mackay; Fiscal Year: 2008
    ..Realizing this goal of workforce diversity in the United States continues to be a challenge, one which this IMSD proposal will address. ..
  7. Genetics of Aggression in Drosophila
    Trudy Mackay; Fiscal Year: 2008
    ..Given the evolutionary conservation of function for fundamental traits, such as aggression, genes and pathways discovered in model organisms can be incorporated as candidate genes in human linkage and association studies. ..
  8. THE GENETIC ARCHITECTURE OF QUANTITATIVE TRAITS
    Trudy Mackay; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  9. Genetics of Alcohol Sensitivity in Drosophila
    Trudy Mackay; Fiscal Year: 2009
    ..abstract_text> ..
  10. Genetics of Aggression in Drosophila
    Trudy Mackay; Fiscal Year: 2009
    ..Given the evolutionary conservation of function for fundamental traits, such as aggression, genes and pathways discovered in model organisms can be incorporated as candidate genes in human linkage and association studies. ..
  11. QTLs in Drosophila
    Trudy Mackay; Fiscal Year: 2009
    ..The insight into general principles of genotype-phenotype relationships will be applicable to human disease. ..
  12. Genetics of Alcohol Sensitivity in Drosophila
    Trudy F Mackay; Fiscal Year: 2010
    ..abstract_text> ..
  13. QTLs in Drosophila
    Eric A Stone; Fiscal Year: 2010
    ..The insight into general principles of genotype-phenotype relationships will be applicable to human disease. ..
  14. Genetics of Aggression in Drosophila
    Trudy Mackay; Fiscal Year: 2006
    ..Given the evolutionary conservation of function for fundamental traits, such as aggression, genes and pathways discovered in model organisms can be incorporated as candidate genes in human linkage and association studies. ..
  15. Genetics of Alcohol Sensitivity in Drosophila
    Trudy Mackay; Fiscal Year: 2006
    ....
  16. QUANTITATIVE TRAIT LOCI IN DROSOPHILA
    Trudy Mackay; Fiscal Year: 1999
    ..Finally, they shall fine-map QTLs causing response to selection from segregating variation and from new mutations, using a set of overlapping deficiencies covering 70 percent of the Drosophila genome. ..
  17. QUANTITATIVE TRAIT LOCI IN DROSOPHILA
    Trudy Mackay; Fiscal Year: 1992
    ..Restriction map variation will be determined for the nine loci, and associations between molecular polymorphisms and phenotypic effects will be examined...
  18. QUANTITATIVE TRAIT LOCI IN DROSOPHILA
    Trudy Mackay; Fiscal Year: 1993
    ..Restriction map variation will be determined for the nine loci, and associations between molecular polymorphisms and phenotypic effects will be examined...
  19. QUANTITATIVE TRAIT LOCI IN DROSOPHILA
    Trudy Mackay; Fiscal Year: 2000
    ..Associations between phenotypic variation and molecular polymorphisms will be assessed. ..
  20. QUANTITATIVE TRAIT LOCI IN DROSOPHILA
    Trudy Mackay; Fiscal Year: 2001
    ..Associations between phenotypic variation and molecular polymorphisms will be assessed. ..
  21. QUANTITATIVE TRAIT LOCI IN DROSOPHILA
    Trudy Mackay; Fiscal Year: 2002
    ..Associations between phenotypic variation and molecular polymorphisms will be assessed. ..
  22. QUANTITATIVE TRAIT LOCI IN DROSOPHILA
    Trudy Mackay; Fiscal Year: 2003
    ..Identification of new genes affecting Drosophila behaviors will enrich our understanding of the network of genetic interactions required to produce these complex traits. ..
  23. QUANTITATIVE TRAIT LOCI IN DROSOPHILA
    Trudy Mackay; Fiscal Year: 2004
    ..Identification of new genes affecting Drosophila behaviors will enrich our understanding of the network of genetic interactions required to produce these complex traits. ..
  24. QUANTITATIVE TRAIT LOCI IN DROSOPHILA
    Trudy Mackay; Fiscal Year: 2005
    ..Identification of new genes affecting Drosophila behaviors will enrich our understanding of the network of genetic interactions required to produce these complex traits. ..
  25. QTLs in Drosophila
    Trudy Mackay; Fiscal Year: 2009
    ..The insight into general principles of genotype-phenotype relationships will be applicable to human disease. ..