Yilong Ma

Summary

Affiliation: North Shore University Hospital
Country: USA

Publications

  1. pmc Abnormal metabolic brain networks in a nonhuman primate model of parkinsonism
    Yilong Ma
    Center for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, New York 11030, USA
    J Cereb Blood Flow Metab 32:633-42. 2012
  2. pmc Dopamine cell transplantation in Parkinson's disease: challenge and perspective
    Yilong Ma
    Center for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, NY 11030, USA
    Br Med Bull 100:173-89. 2011
  3. ncbi request reprint Functional imaging of cerebral blood flow and glucose metabolism in Parkinson's disease and Huntington's disease
    Yilong Ma
    Center for Neurosciences, Feinstein Institute for Medical Research, North Shore Long Island Jewish Health System, New York University School of Medicine, Manhasset, NY, USA
    Mol Imaging Biol 9:223-33. 2007
  4. ncbi request reprint Parametric mapping of [18F]FPCIT binding in early stage Parkinson's disease: a PET study
    Y Ma
    Center for Neurosciences, North Shore Long Island Jewish Research Institute, Functional Brain Imaging Laboratory, North Shore University Hospital, New York University School of Medicine, Manhasset, New York 11030, USA
    Synapse 45:125-33. 2002
  5. pmc Dopamine cell implantation in Parkinson's disease: long-term clinical and (18)F-FDOPA PET outcomes
    Yilong Ma
    Center for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, New York 11030, USA
    J Nucl Med 51:7-15. 2010
  6. ncbi request reprint Abnormal metabolic network activity in Parkinson's disease: test-retest reproducibility
    Yilong Ma
    Center for Neurosciences, Feinstein Institute for Medical Research, North Shore Long Island Jewish Health System, Manhasset, NY 11030, USA
    J Cereb Blood Flow Metab 27:597-605. 2007
  7. ncbi request reprint Network modulation by the subthalamic nucleus in the treatment of Parkinson's disease
    Maja Trost
    Center for Neurosciences, Institute for Medical Research, North Shore Long Island Jewish Health System, Manhasset, NY 11030, USA
    Neuroimage 31:301-7. 2006
  8. ncbi request reprint Caudate nucleus: influence of dopaminergic input on sequence learning and brain activation in Parkinsonism
    Maren Carbon
    Center for Neurosciences, North Shore Long Island Jewish Research Institute, New York, NY 11030, USA
    Neuroimage 21:1497-507. 2004
  9. ncbi request reprint Network modulation in the treatment of Parkinson's disease
    Kotaro Asanuma
    Center for Neurosciences, Feinstein Institute for Medical Research, North Shore Long Island Jewish Health System, Manhasset, NY 11030, USA
    Brain 129:2667-78. 2006
  10. pmc Parkinson's disease: increased motor network activity in the absence of movement
    Ji Hyun Ko
    Center for Neurosciences, Feinstein Institute for Medical Research, Manhasset, New York 11030, USA
    J Neurosci 33:4540-9. 2013

Detail Information

Publications46

  1. pmc Abnormal metabolic brain networks in a nonhuman primate model of parkinsonism
    Yilong Ma
    Center for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, New York 11030, USA
    J Cereb Blood Flow Metab 32:633-42. 2012
    ..Network quantification may provide a useful biomarker for the evaluation of new therapeutic agents in preclinical models of PD...
  2. pmc Dopamine cell transplantation in Parkinson's disease: challenge and perspective
    Yilong Ma
    Center for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, NY 11030, USA
    Br Med Bull 100:173-89. 2011
    ..Functional imaging provides a valuable adjunct to clinical evaluation for assessing the efficacy of cell-based restorative therapies in Parkinson's disease (PD)...
  3. ncbi request reprint Functional imaging of cerebral blood flow and glucose metabolism in Parkinson's disease and Huntington's disease
    Yilong Ma
    Center for Neurosciences, Feinstein Institute for Medical Research, North Shore Long Island Jewish Health System, New York University School of Medicine, Manhasset, NY, USA
    Mol Imaging Biol 9:223-33. 2007
    ..In particular, we present data to validate the reproducibility and reliability of unique spatial covariance patterns related with PD and HD...
  4. ncbi request reprint Parametric mapping of [18F]FPCIT binding in early stage Parkinson's disease: a PET study
    Y Ma
    Center for Neurosciences, North Shore Long Island Jewish Research Institute, Functional Brain Imaging Laboratory, North Shore University Hospital, New York University School of Medicine, Manhasset, New York 11030, USA
    Synapse 45:125-33. 2002
    ..This method provides a useful tool to track the onset and progression of PD at its earliest stages...
  5. pmc Dopamine cell implantation in Parkinson's disease: long-term clinical and (18)F-FDOPA PET outcomes
    Yilong Ma
    Center for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, New York 11030, USA
    J Nucl Med 51:7-15. 2010
    ..Nonetheless, clinical improvement was significant only in younger (age < or = 60 y) transplant recipients, as indicated by a reduction in Unified Parkinson's Disease Rating Scale (UPDRS) motor scores...
  6. ncbi request reprint Abnormal metabolic network activity in Parkinson's disease: test-retest reproducibility
    Yilong Ma
    Center for Neurosciences, Feinstein Institute for Medical Research, North Shore Long Island Jewish Health System, Manhasset, NY 11030, USA
    J Cereb Blood Flow Metab 27:597-605. 2007
    ..The quantification of PDRP expression in PD patients can serve as a potential biomarker in PET intervention studies for this disorder...
  7. ncbi request reprint Network modulation by the subthalamic nucleus in the treatment of Parkinson's disease
    Maja Trost
    Center for Neurosciences, Institute for Medical Research, North Shore Long Island Jewish Health System, Manhasset, NY 11030, USA
    Neuroimage 31:301-7. 2006
    ..These findings indicate that suppression of abnormal network activity is a feature of both STN stimulation and lesioning. Nonetheless, these two interventions may differ metabolically at a regional level...
  8. ncbi request reprint Caudate nucleus: influence of dopaminergic input on sequence learning and brain activation in Parkinsonism
    Maren Carbon
    Center for Neurosciences, North Shore Long Island Jewish Research Institute, New York, NY 11030, USA
    Neuroimage 21:1497-507. 2004
    ..Despite minimal reductions in nigro-caudate input, PD patients demonstrate a loss of this coupling early in the disease...
  9. ncbi request reprint Network modulation in the treatment of Parkinson's disease
    Kotaro Asanuma
    Center for Neurosciences, Feinstein Institute for Medical Research, North Shore Long Island Jewish Health System, Manhasset, NY 11030, USA
    Brain 129:2667-78. 2006
    ..The modulation of pathological brain networks is a critical feature of the treatment response in parkinsonism...
  10. pmc Parkinson's disease: increased motor network activity in the absence of movement
    Ji Hyun Ko
    Center for Neurosciences, Feinstein Institute for Medical Research, Manhasset, New York 11030, USA
    J Neurosci 33:4540-9. 2013
    ..22). Thus, the resting state in PD is characterized by changes in the activity of normal as well as pathological brain networks...
  11. pmc Abnormal network topographies and changes in global activity: absence of a causal relationship
    Vijay Dhawan
    Center for Neurosciences, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY 11030, USA
    Neuroimage 63:1827-32. 2012
    ..In aggregate, the data demonstrate that abnormal PDRP expression is not induced by reductions in global activity. Moreover, significant declines in GMR are not associated with the appearance of PDRP-like spatial topographies...
  12. ncbi request reprint Dyskinesia after fetal cell transplantation for parkinsonism: a PET study
    Yilong Ma
    Center for Neurosciences, North Shore Long Island Jewish Research Institute and Department of Neurology, North Shore University Hospital, 350 Community Drive, Manhasset, NY 11030, USA
    Ann Neurol 52:628-34. 2002
    ..These findings suggest that unbalanced increases in dopaminergic function can complicate the outcome of neuronal transplantation for parkinsonism...
  13. ncbi request reprint Changes in network activity with the progression of Parkinson's disease
    Chaorui Huang
    Center for Neurosciences, Feinstein Institute for Medical Research, North Shore Long Island Jewish Health System, 350 Community Drive, Manhasset, NY 11030, USA
    Brain 130:1834-46. 2007
    ..Potential disease-modifying therapies may alter the time course of one or both of these abnormal networks...
  14. pmc Dissociation of metabolic and neurovascular responses to levodopa in the treatment of Parkinson's disease
    Shigeki Hirano
    The Feinstein Institute for Medical Research, Manhasset, New York 11030, USA
    J Neurosci 28:4201-9. 2008
    ..These findings suggest that flow-metabolism dissociation is a distinctive feature of LD treatment. This phenomenon may be especially pronounced in patients with LD-induced dyskinesia...
  15. doi request reprint Differential diagnosis of parkinsonian syndromes using PCA-based functional imaging features
    Phoebe G Spetsieris
    Center for Neurosciences, The Feinstein Institute for Medical Research, North Shore LIJ Health System, 350 Community Drive, Manhasset, NY 11030, USA
    Neuroimage 45:1241-52. 2009
    ..Results illustrate that highly accurate diagnosis can often be achieved by simple comparison of scores utilizing optimized patterns...
  16. doi request reprint Selective serotonin reuptake inhibitor (SSRI) modulation of striatal dopamine measured with [11C]-raclopride and positron emission tomography
    Gwenn S Smith
    Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, New York 11004, USA
    Synapse 63:1-6. 2009
    ....
  17. ncbi request reprint The metabolic pathology of dopa-responsive dystonia
    Kotaro Asanuma
    Center for Neurosciences, Institute for Medical Research, North Shore Long Island Jewish Health System, Manhasset, New York, NY, USA
    Ann Neurol 57:596-600. 2005
    ..This pattern was not expressed in mutation carriers for primary torsion dystonia. Dopa-responsive dystonia has a unique metabolic architecture that differs from other inherited forms of dystonia...
  18. ncbi request reprint Dosimetry of the dopamine transporter radioligand 18F-FPCIT in human subjects
    William Robeson
    Center for Neurosciences, North Shore University Hospital, Manhasset, New York, USA
    J Nucl Med 44:961-6. 2003
    ..The goal was to determine a limiting dose consistent with accepted guidelines for use in clinical studies and to compare the radiation burden with other agents such as (123)I-FPCIT, (18)F-fluorodopa, and (18)F-FDG...
  19. pmc Parkinson's disease cognitive network correlates with caudate dopamine
    Martin Niethammer
    Center for Neurosciences, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY 11030, USA
    Neuroimage 78:204-9. 2013
    ..These baseline measures likely function in concert to determine the cognitive effects of dopaminergic therapy in PD...
  20. pmc Preclinical Huntington's disease: compensatory brain responses during learning
    Andrew Feigin
    Center for Neurosciences, Institute for Medical Research, North Shore Long Island Jewish Health System, 350 Community Drive, Manhasset, NY 11030, USA
    Ann Neurol 59:53-9. 2006
    ..Nonetheless, this mechanism may not be sufficient to sustain a normal level of task performance, even during the presymptomatic stage of the disease...
  21. pmc Metabolic network as a progression biomarker of premanifest Huntington's disease
    Chris C Tang
    Center for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, New York 11030, USA
    J Clin Invest 123:4076-88. 2013
    ..Here we used a computational approach to identify a functional brain network associated with the progression of preclinical Huntington's disease (HD)...
  22. doi request reprint Cerebral glucose metabolism and D2/D3 receptor availability in young adults with cannabis dependence measured with positron emission tomography
    Serge Sevy
    The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, NY 11004, USA
    Psychopharmacology (Berl) 197:549-56. 2008
    ....
  23. pmc Parkinson's disease tremor-related metabolic network: characterization, progression, and treatment effects
    Hideo Mure
    The Feinstein Institute for Medical Research, Manhasset, NY 11030, USA
    Neuroimage 54:1244-53. 2011
    ..Quantification of treatment-mediated changes in both PDTP and PDRP scores can provide an objective means of evaluating the differential effects of novel antiparkinsonian interventions on the different motor features of the disorder...
  24. pmc Abnormal regional brain function in Parkinson's disease: truth or fiction?
    Yilong Ma
    Center for Neurosciences, The Feinstein Institute for Medical Research, North Shore Long Island Jewish Health System, Manhasset, NY 11030, USA
    Neuroimage 45:260-6. 2009
    ..Moreover, stability of the normalized measurements, particularly at the network level, makes these metabolic indices suitable as imaging biomarkers of PD progression and the treatment response...
  25. ncbi request reprint Thalamic stimulation for parkinsonian tremor: correlation between regional cerebral blood flow and physiological tremor characteristics
    Masafumi Fukuda
    Center for Neurosciences, North Shore Long Island Jewish Research Institute, Manhasset, NY 11030, USA
    Neuroimage 21:608-15. 2004
    ..05, uncorrected). Our results suggest that Vim DBS for PD tremor modulates the activity of cerebello-thalamo-cortical pathways. Specific tremor characteristics relate to activity in different nodes of this system...
  26. pmc Parkinson's disease spatial covariance pattern: noninvasive quantification with perfusion MRI
    Yilong Ma
    Center for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, New York 11030, USA
    J Cereb Blood Flow Metab 30:505-9. 2010
    ..01) in patients scanned with either modality, and the two values were highly intercorrelated (P<0.0001). Perfusion MRI methods can be used for accurate quantification of disease-related covariance patterns...
  27. pmc Cerebral glucose metabolic response to combined total sleep deprivation and antidepressant treatment in geriatric depression: a randomized, placebo-controlled study
    Gwenn S Smith
    Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY, USA
    Psychiatry Res 171:1-9. 2009
    ....
  28. ncbi request reprint Comparative analysis of striatal FDOPA uptake in Parkinson's disease: ratio method versus graphical approach
    Vijay Dhawan
    Center for Neuroscience, North Shore Long Island Jewish Research Institute, Manhasset, New York 11030, USA
    J Nucl Med 43:1324-30. 2002
    ..CONCLUSION: These results suggest that SOR determined from a single 10-min scan at 95 min is as accurate as K(i)(occ) in separating PD patients from healthy subjects and in predicting clinical measures of disease severity...
  29. ncbi request reprint Evolving metabolic changes during the first postoperative year after subthalamotomy
    Maja Trost
    Center for Neurosciences, North Shore Long Island Jewish Research Institute, Manhasset, USA
    J Neurosurg 99:872-8. 2003
    ..In this study positron emission tomography (PET) scanning was used to assess these changes and their relation to long-term benefits of subthalamotomy...
  30. ncbi request reprint The metabolic topography of posthypoxic myoclonus
    Steven J Frucht
    Department of Neurology, Columbia Presbyterian Medical Center, New York, NY, USA
    Neurology 62:1879-81. 2004
    ..Interventions such as deep brain stimulation that interrupt networks that involve these structures may be useful in patients with severe PHM...
  31. ncbi request reprint New strategies for automated differential diagnosis of degenerative brain disorders
    Phoebe G Spetsieris
    Center for Neurosciences, Feinstein Institute for Medical Research, North Shore LIJ Health System, Manhasset, NY 11030, USA
    Conf Proc IEEE Eng Med Biol Soc 2007:3421-5. 2007
    ..It is shown that the extraction of exclusive sub-networks that stem from contrasting image features between conditions can be an effective tool for optimization that does not require expert knowledge...
  32. ncbi request reprint Serotonin modulation of cerebral glucose metabolism in normal aging
    Sara Goldberg
    Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, 75 59 263rd Street, Glen Oaks, NY 11004, USA
    Neurobiol Aging 25:167-74. 2004
    ..These results suggest different compensatory processes in anterior compared to posterior brain regions secondary to the age-related loss of serotonin innervation...
  33. doi request reprint Correlation of laparoscopic experience with differential functional brain activation: a positron emission tomography study with oxygen 15-labeled water
    Brian Duty
    Smith Institute for Urology, North Shore Long Island Jewish Health System, New Hyde Park, NY 11042, USA
    Arch Surg 147:627-32. 2012
    ..Regions of functional brain activation differ between novice and expert laparoscopists...
  34. ncbi request reprint Primary dystonia: is abnormal functional brain architecture linked to genotype?
    Maja Trost
    Center for Neurosciences, North Shore Long Island Jewish Research Institute, 350 Community Drive, Manhasset, NY 11030, USA
    Ann Neurol 52:853-6. 2002
    ..The findings suggest that the DYT1 metabolic topography is not genotype specific and may be present in carriers of other dystonia mutations...
  35. ncbi request reprint Pallidal stimulation for parkinsonism: improved brain activation during sequence learning
    Masafumi Fukuda
    Center for Neurosciences, North Shore Long Island Jewish Research Institute, Manhasset, NY 11030, USA
    Ann Neurol 52:144-52. 2002
    ..Improved sequence learning with stimulation may be directly related to these functional changes...
  36. ncbi request reprint Networks mediating the clinical effects of pallidal brain stimulation for Parkinson's disease: a PET study of resting-state glucose metabolism
    M Fukuda
    Center for Neurosciences, North Shore-Long Island Jewish Research Institute, Manhasset, New York 11030, USA
    Brain 124:1601-9. 2001
    ....
  37. ncbi request reprint Blinded positron emission tomography study of dopamine cell implantation for Parkinson's disease
    T Nakamura
    Functional Brain Imaging Laboratory, North Shore-Long Island Jewish Research Institute, Manhasset, NY 11030, USA
    Ann Neurol 50:181-7. 2001
    ..However, host age may influence the time course of the downstream functional changes that are needed for clinical benefit to occur...
  38. ncbi request reprint Decreased striatal D2 receptor binding in non-manifesting carriers of the DYT1 dystonia mutation
    K Asanuma
    Center for Neurosciences, North Shore Long Island Jewish Research Institute, Manhasset, NY 11030, USA
    Neurology 64:347-9. 2005
    ..D2 receptor binding was reduced by approximately 15% in caudate and putamen (p < 0.005). These results suggest that striatal D2 binding reductions are a trait feature of the DYT1 genotype...
  39. ncbi request reprint Thalamic metabolism and symptom onset in preclinical Huntington's disease
    A Feigin
    Center for Neurosciences, The Feinstein Institute for Medical Research, North Shore Long Island Jewish Health System, Manhasset, NY 11030, USA
    Brain 130:2858-67. 2007
    ..Increases in network expression and thalamic glucose metabolism may be compensatory for early neuronal losses in p-HD. Declines in these measures may herald the onset of symptoms in gene carriers...
  40. pmc Abnormal striatal and thalamic dopamine neurotransmission: Genotype-related features of dystonia
    M Carbon
    Center for Neurosciences, The Feinstein Institute for Medical Research, North Shore Long Island Jewish Health System, Manhasset, NY 11030, USA
    Neurology 72:2097-103. 2009
    ..To determine whether changes in D(2) receptor availability are present in carriers of genetic mutations for primary dystonia...
  41. ncbi request reprint Effects of serotonin transporter promoter polymorphisms on serotonin function
    Gwenn S Smith
    Department of Psychiatry, The Zucker Hillside Hospital, Glen Oaks, NY 11004, USA
    Neuropsychopharmacology 29:2226-34. 2004
    ....
  42. ncbi request reprint Acute and chronic effects of citalopram on cerebral glucose metabolism in geriatric depression
    Gwenn S Smith
    Department of Psychiatry Research, Hillside Hospital and the Neuroscience Institute of the North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
    Am J Geriatr Psychiatry 10:715-23. 2002
    ....
  43. ncbi request reprint Glucose metabolic response to total sleep deprivation, recovery sleep, and acute antidepressant treatment as functional neuroanatomic correlates of treatment outcome in geriatric depression
    Gwenn S Smith
    Department of Psychiatry Research, Hillside Hospital of the North Shore Long Island Jewish Health System, 75 59 263rd Street, Glen Oaks, NY 11004, USA
    Am J Geriatr Psychiatry 10:561-7. 2002
    ....
  44. doi request reprint Abnormal metabolic networks in atypical parkinsonism
    Thomas Eckert
    Department of Neurology II, University of Magdeburg, Germany
    Mov Disord 23:727-33. 2008
    ..These disease-related networks can potentially be used in conjunction with functional brain imaging as quantifiable biomarkers for the assessment of these pathological conditions...
  45. ncbi request reprint Serotonin modulation of cerebral glucose metabolism measured with positron emission tomography (PET) in human subjects
    Gwenn S Smith
    Department of Psychiatry Research, Hillside Hospital, Neuroscience Institute of the North Shore Long Island Jewish Health System, Glen Oaks, New York 11004, USA
    Synapse 45:105-12. 2002
    ..Future studies will evaluate how the acute metabolic response to citalopram relates to the metabolic response after chronic treatment in patients with geriatric depression...
  46. ncbi request reprint Subthalamic glutamic acid decarboxylase gene therapy: changes in motor function and cortical metabolism
    Marina E Emborg
    Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI, USA
    J Cereb Blood Flow Metab 27:501-9. 2007
    ..The changes in motor cortical glucose utilization observed after gene therapy are consistent with the modulation of metabolic brain networks associated with this disorder...