Research Topics
| Yilong MaSummaryAffiliation: North Shore University Hospital Country: USA Publications
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Detail Information
Publications
Abnormal metabolic brain networks in a nonhuman primate model of parkinsonismYilong Ma
Center for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, New York 11030, USA
J Cereb Blood Flow Metab 32:633-42. 2012..Network quantification may provide a useful biomarker for the evaluation of new therapeutic agents in preclinical models of PD...
Abnormal metabolic network activity in Parkinson's disease: test-retest reproducibilityYilong Ma
Center for Neurosciences, Feinstein Institute for Medical Research, North Shore Long Island Jewish Health System, Manhasset, NY 11030, USA
J Cereb Blood Flow Metab 27:597-605. 2007..The quantification of PDRP expression in PD patients can serve as a potential biomarker in PET intervention studies for this disorder...- Functional imaging of cerebral blood flow and glucose metabolism in Parkinson's disease and Huntington's diseaseYilong Ma
Center for Neurosciences, Feinstein Institute for Medical Research, North Shore Long Island Jewish Health System, New York University School of Medicine, Manhasset, NY, USA
Mol Imaging Biol 9:223-33. 2007..In particular, we present data to validate the reproducibility and reliability of unique spatial covariance patterns related with PD and HD... - Parametric mapping of [18F]FPCIT binding in early stage Parkinson's disease: a PET studyY Ma
Center for Neurosciences, North Shore Long Island Jewish Research Institute, Functional Brain Imaging Laboratory, North Shore University Hospital, New York University School of Medicine, Manhasset, New York 11030, USA
Synapse 45:125-33. 2002..This method provides a useful tool to track the onset and progression of PD at its earliest stages... - Dopamine cell implantation in Parkinson's disease: long-term clinical and (18)F-FDOPA PET outcomesYilong Ma
Center for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, New York 11030, USA
J Nucl Med 51:7-15. 2010..Nonetheless, clinical improvement was significant only in younger (age < or = 60 y) transplant recipients, as indicated by a reduction in Unified Parkinson's Disease Rating Scale (UPDRS) motor scores... - Dopamine cell transplantation in Parkinson's disease: challenge and perspectiveYilong Ma
Center for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, NY 11030, USA
Br Med Bull 100:173-89. 2011..Functional imaging provides a valuable adjunct to clinical evaluation for assessing the efficacy of cell-based restorative therapies in Parkinson's disease (PD)... - Caudate nucleus: influence of dopaminergic input on sequence learning and brain activation in ParkinsonismMaren Carbon
Center for Neurosciences, North Shore-Long Island Jewish Research Institute, New York, NY 11030, USA
Neuroimage 21:1497-507. 2004..Despite minimal reductions in nigro-caudate input, PD patients demonstrate a loss of this coupling early in the disease... - Network modulation in the treatment of Parkinson's diseaseKotaro Asanuma
Center for Neurosciences, Feinstein Institute for Medical Research, North Shore-Long Island Jewish Health System, Manhasset, NY 11030, USA
Brain 129:2667-78. 2006..The modulation of pathological brain networks is a critical feature of the treatment response in parkinsonism... - Network modulation by the subthalamic nucleus in the treatment of Parkinson's diseaseMaja Trost
Center for Neurosciences, Institute for Medical Research, North Shore-Long Island Jewish Health System, Manhasset, NY 11030, USA
Neuroimage 31:301-7. 2006..These findings indicate that suppression of abnormal network activity is a feature of both STN stimulation and lesioning. Nonetheless, these two interventions may differ metabolically at a regional level... - Dyskinesia after fetal cell transplantation for parkinsonism: a PET studyYilong Ma
Center for Neurosciences, North Shore Long Island Jewish Research Institute and Department of Neurology, North Shore University Hospital, 350 Community Drive, Manhasset, NY 11030, USA
Ann Neurol 52:628-34. 2002..These findings suggest that unbalanced increases in dopaminergic function can complicate the outcome of neuronal transplantation for parkinsonism... - Changes in network activity with the progression of Parkinson's diseaseChaorui Huang
Center for Neurosciences, Feinstein Institute for Medical Research, North Shore Long Island Jewish Health System, 350 Community Drive, Manhasset, NY 11030, USA
Brain 130:1834-46. 2007..Potential disease-modifying therapies may alter the time course of one or both of these abnormal networks... 
Differential diagnosis of parkinsonian syndromes using PCA-based functional imaging featuresPhoebe G Spetsieris
Center for Neurosciences, The Feinstein Institute for Medical Research, North Shore LIJ Health System, 350 Community Drive, Manhasset, NY 11030, USA
Neuroimage 45:1241-52. 2009..Results illustrate that highly accurate diagnosis can often be achieved by simple comparison of scores utilizing optimized patterns...- Dissociation of metabolic and neurovascular responses to levodopa in the treatment of Parkinson's diseaseShigeki Hirano
The Feinstein Institute for Medical Research, Manhasset, New York 11030, USA
J Neurosci 28:4201-9. 2008..These findings suggest that flow-metabolism dissociation is a distinctive feature of LD treatment. This phenomenon may be especially pronounced in patients with LD-induced dyskinesia... - The metabolic pathology of dopa-responsive dystoniaKotaro Asanuma
Center for Neurosciences, Institute for Medical Research, North Shore-Long Island Jewish Health System, Manhasset, New York, NY, USA
Ann Neurol 57:596-600. 2005..This pattern was not expressed in mutation carriers for primary torsion dystonia. Dopa-responsive dystonia has a unique metabolic architecture that differs from other inherited forms of dystonia... - Dosimetry of the dopamine transporter radioligand 18F-FPCIT in human subjectsWilliam Robeson
Center for Neurosciences, North Shore University Hospital, Manhasset, New York, USA
J Nucl Med 44:961-6. 2003..The goal was to determine a limiting dose consistent with accepted guidelines for use in clinical studies and to compare the radiation burden with other agents such as (123)I-FPCIT, (18)F-fluorodopa, and (18)F-FDG... - Thalamic stimulation for parkinsonian tremor: correlation between regional cerebral blood flow and physiological tremor characteristicsMasafumi Fukuda
Center for Neurosciences, North Shore-Long Island Jewish Research Institute, Manhasset, NY 11030, USA
Neuroimage 21:608-15. 2004..05, uncorrected). Our results suggest that Vim DBS for PD tremor modulates the activity of cerebello-thalamo-cortical pathways. Specific tremor characteristics relate to activity in different nodes of this system... - Parkinson's disease tremor-related metabolic network: characterization, progression, and treatment effectsHideo Mure
The Feinstein Institute for Medical Research, Manhasset, NY 11030, USA
Neuroimage 54:1244-53. 2011..Quantification of treatment-mediated changes in both PDTP and PDRP scores can provide an objective means of evaluating the differential effects of novel antiparkinsonian interventions on the different motor features of the disorder... - Selective serotonin reuptake inhibitor (SSRI) modulation of striatal dopamine measured with [11C]-raclopride and positron emission tomographyGwenn S Smith
Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, New York 11004, USA
Synapse 63:1-6. 2009.... - Preclinical Huntington's disease: compensatory brain responses during learningAndrew Feigin
Center for Neurosciences, Institute for Medical Research, North Shore-Long Island Jewish Health System, 350 Community Drive, Manhasset, NY 11030, USA
Ann Neurol 59:53-9. 2006..Nonetheless, this mechanism may not be sufficient to sustain a normal level of task performance, even during the presymptomatic stage of the disease... - Abnormal regional brain function in Parkinson's disease: truth or fiction?Yilong Ma
Center for Neurosciences, The Feinstein Institute for Medical Research, North Shore Long Island Jewish Health System, Manhasset, NY 11030, USA
Neuroimage 45:260-6. 2009..Moreover, stability of the normalized measurements, particularly at the network level, makes these metabolic indices suitable as imaging biomarkers of PD progression and the treatment response... - Cerebral glucose metabolism and D2/D3 receptor availability in young adults with cannabis dependence measured with positron emission tomographySerge Sevy
The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, NY 11004, USA
Psychopharmacology (Berl) 197:549-56. 2008.... - Parkinson's disease spatial covariance pattern: noninvasive quantification with perfusion MRIYilong Ma
Center for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, New York 11030, USA
J Cereb Blood Flow Metab 30:505-9. 2010..01) in patients scanned with either modality, and the two values were highly intercorrelated (P<0.0001). Perfusion MRI methods can be used for accurate quantification of disease-related covariance patterns... - New strategies for automated differential diagnosis of degenerative brain disordersPhoebe G Spetsieris
Center for Neurosciences, Feinstein Institute for Medical Research, North Shore LIJ Health System, Manhasset, NY 11030, USA
Conf Proc IEEE Eng Med Biol Soc 2007:3421-5. 2007..It is shown that the extraction of exclusive sub-networks that stem from contrasting image features between conditions can be an effective tool for optimization that does not require expert knowledge... - The metabolic topography of posthypoxic myoclonusSteven J Frucht
Department of Neurology, Columbia Presbyterian Medical Center, New York, NY, USA
Neurology 62:1879-81. 2004..Interventions such as deep brain stimulation that interrupt networks that involve these structures may be useful in patients with severe PHM... - Comparative analysis of striatal FDOPA uptake in Parkinson's disease: ratio method versus graphical approachVijay Dhawan
Center for Neuroscience, North Shore Long Island Jewish Research Institute, Manhasset, New York 11030, USA
J Nucl Med 43:1324-30. 2002..CONCLUSION: These results suggest that SOR determined from a single 10-min scan at 95 min is as accurate as K(i)(occ) in separating PD patients from healthy subjects and in predicting clinical measures of disease severity... - Evolving metabolic changes during the first postoperative year after subthalamotomyMaja Trost
Center for Neurosciences, North Shore-Long Island Jewish Research Institute, Manhasset, USA
J Neurosurg 99:872-8. 2003..In contrast, the recurrence of tremor may relate to changes in the function of an STN-GPe oscillatory network... - Correlation of laparoscopic experience with differential functional brain activation: a positron emission tomography study with oxygen 15-labeled waterBrian Duty
Smith Institute for Urology, North Shore Long Island Jewish Health System, New Hyde Park, NY 11042, USA
Arch Surg 147:627-32. 2012..Regions of functional brain activation differ between novice and expert laparoscopists... - Cerebral glucose metabolic response to combined total sleep deprivation and antidepressant treatment in geriatric depression: a randomized, placebo-controlled studyGwenn S Smith
Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY, USA
Psychiatry Res 171:1-9. 2009.... - Abnormal network topographies and changes in global activity: Absence of a causal relationshipVijay Dhawan
Center for Neurosciences, The Feinstein Institute for Medical Research, 350 Community Drive, Manhasset, NY 11030, USA Electronic address
Neuroimage 63:1827-32. 2012..In aggregate, the data demonstrate that abnormal PDRP expression is not induced by reductions in global activity. Moreover, significant declines in GMR are not associated with the appearance of PDRP-like spatial topographies... - Primary dystonia: is abnormal functional brain architecture linked to genotype?Maja Trost
Center for Neurosciences, North Shore Long Island Jewish Research Institute, 350 Community Drive, Manhasset, NY 11030, USA
Ann Neurol 52:853-6. 2002..The findings suggest that the DYT1 metabolic topography is not genotype specific and may be present in carriers of other dystonia mutations... - Pallidal stimulation for parkinsonism: improved brain activation during sequence learningMasafumi Fukuda
Center for Neurosciences, North Shore-Long Island Jewish Research Institute, Manhasset, NY 11030, USA
Ann Neurol 52:144-52. 2002..Improved sequence learning with stimulation may be directly related to these functional changes... - Networks mediating the clinical effects of pallidal brain stimulation for Parkinson's disease: a PET study of resting-state glucose metabolismM Fukuda
Center for Neurosciences, North Shore-Long Island Jewish Research Institute, Manhasset, New York 11030, USA
Brain 124:1601-9. 2001.... - Blinded positron emission tomography study of dopamine cell implantation for Parkinson's diseaseT Nakamura
Functional Brain Imaging Laboratory, North Shore-Long Island Jewish Research Institute, Manhasset, NY 11030, USA
Ann Neurol 50:181-7. 2001..However, host age may influence the time course of the downstream functional changes that are needed for clinical benefit to occur... - Thalamic metabolism and symptom onset in preclinical Huntington's diseaseA Feigin
Center for Neurosciences, The Feinstein Institute for Medical Research, North Shore Long Island Jewish Health System, Manhasset, NY 11030, USA
Brain 130:2858-67. 2007..Increases in network expression and thalamic glucose metabolism may be compensatory for early neuronal losses in p-HD. Declines in these measures may herald the onset of symptoms in gene carriers... - Decreased striatal D2 receptor binding in non-manifesting carriers of the DYT1 dystonia mutationK Asanuma
Center for Neurosciences, North Shore-Long Island Jewish Research Institute, Manhasset, NY 11030, USA
Neurology 64:347-9. 2005..D2 receptor binding was reduced by approximately 15% in caudate and putamen (p < 0.005). These results suggest that striatal D2 binding reductions are a trait feature of the DYT1 genotype... - Abnormal striatal and thalamic dopamine neurotransmission: Genotype-related features of dystoniaM Carbon
Center for Neurosciences, The Feinstein Institute for Medical Research, North Shore Long Island Jewish Health System, Manhasset, NY 11030, USA
Neurology 72:2097-103. 2009..To determine whether changes in D(2) receptor availability are present in carriers of genetic mutations for primary dystonia... - Effects of serotonin transporter promoter polymorphisms on serotonin functionGwenn S Smith
Department of Psychiatry, The Zucker Hillside Hospital, Glen Oaks, NY 11004, USA
Neuropsychopharmacology 29:2226-34. 2004.... - Serotonin modulation of cerebral glucose metabolism in normal agingSara Goldberg
Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore-Long Island Jewish Health System, 75-59 263rd Street, Glen Oaks, NY 11004, USA
Neurobiol Aging 25:167-74. 2004..These results suggest different compensatory processes in anterior compared to posterior brain regions secondary to the age-related loss of serotonin innervation... - Subthalamic glutamic acid decarboxylase gene therapy: changes in motor function and cortical metabolismMarina E Emborg
Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI, USA
J Cereb Blood Flow Metab 27:501-9. 2007..The changes in motor cortical glucose utilization observed after gene therapy are consistent with the modulation of metabolic brain networks associated with this disorder... - Glucose metabolic response to total sleep deprivation, recovery sleep, and acute antidepressant treatment as functional neuroanatomic correlates of treatment outcome in geriatric depressionGwenn S Smith
Department of Psychiatry Research, Hillside Hospital of the North Shore Long Island Jewish Health System, 75 59 263rd Street, Glen Oaks, NY 11004, USA
Am J Geriatr Psychiatry 10:561-7. 2002.... - Acute and chronic effects of citalopram on cerebral glucose metabolism in geriatric depressionGwenn S Smith
Department of Psychiatry Research, Hillside Hospital and the Neuroscience Institute of the North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
Am J Geriatr Psychiatry 10:715-23. 2002.... - Serotonin modulation of cerebral glucose metabolism measured with positron emission tomography (PET) in human subjectsGwenn S Smith
Department of Psychiatry Research, Hillside Hospital, Neuroscience Institute of the North Shore Long Island Jewish Health System, Glen Oaks, New York 11004, USA
Synapse 45:105-12. 2002..Future studies will evaluate how the acute metabolic response to citalopram relates to the metabolic response after chronic treatment in patients with geriatric depression... - Abnormal metabolic networks in atypical parkinsonismThomas Eckert
Department of Neurology II, University of Magdeburg, Germany
Mov Disord 23:727-33. 2008..These disease-related networks can potentially be used in conjunction with functional brain imaging as quantifiable biomarkers for the assessment of these pathological conditions...