Nicholas S Luke

Summary

Affiliation: North Carolina A and T State University
Country: USA

Publications

  1. doi Development of a quantitative model of pregnane X receptor (PXR) mediated xenobiotic metabolizing enzyme induction
    Nicholas S Luke
    Department of Mathematics, North Carolina Agricultural and Technical State University, Greensboro, NC 27411, USA
    Bull Math Biol 72:1799-819. 2010
  2. pmc Employing a Mechanistic Model for the MAPK Pathway to Examine the Impact of Cellular all or None Behavior on Overall Tissue Response
    Nicholas S Luke
    Department of Mathematics, North Carolina Agricultural and Technical State University, Greensboro, NC 27411
    Dose Response 8:347-67. 2009
  3. doi Development of a quantitative model incorporating key events in a hepatotoxic mode of action to predict tumor incidence
    Nicholas S Luke
    Department of Mathematics, North Carolina Agricultural and Technical State University, Greensboro, North Carolina 27411, USA
    Toxicol Sci 115:253-66. 2010

Detail Information

Publications3

  1. doi Development of a quantitative model of pregnane X receptor (PXR) mediated xenobiotic metabolizing enzyme induction
    Nicholas S Luke
    Department of Mathematics, North Carolina Agricultural and Technical State University, Greensboro, NC 27411, USA
    Bull Math Biol 72:1799-819. 2010
    ..A sensitivity analysis is performed to evaluate the model structure and identify future data needs which would be critical to revising the model...
  2. pmc Employing a Mechanistic Model for the MAPK Pathway to Examine the Impact of Cellular all or None Behavior on Overall Tissue Response
    Nicholas S Luke
    Department of Mathematics, North Carolina Agricultural and Technical State University, Greensboro, NC 27411
    Dose Response 8:347-67. 2009
    ..These mechanistic models enable us to identify key biological events which quantitatively impact the shape of the dose response curve, especially at low environmentally relevant doses...
  3. doi Development of a quantitative model incorporating key events in a hepatotoxic mode of action to predict tumor incidence
    Nicholas S Luke
    Department of Mathematics, North Carolina Agricultural and Technical State University, Greensboro, North Carolina 27411, USA
    Toxicol Sci 115:253-66. 2010
    ..This implies that additional steps beyond cytotoxicity leading to induced cellular proliferation can be quantitatively different among chemicals that share cytotoxicity as a hypothesized carcinogenic MOA...