Elizabeth G Loboa

Summary

Affiliation: North Carolina State University
Country: USA

Publications

  1. ncbi request reprint Mechanical strain affects dura mater biological processes: implications for immature calvarial healing
    Kenton D Fong
    Department of Surgery, School of Medicine, Stanford University, CA 94305, USA
    Plast Reconstr Surg 112:1312-27. 2003
  2. pmc Characterization of electrospun nanocomposite scaffolds and biocompatibility with adipose-derived human mesenchymal stem cells
    Seth D McCullen
    Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC 27695, USA
    Int J Nanomedicine 2:253-63. 2007
  3. pmc Primary cilia: the chemical antenna regulating human adipose-derived stem cell osteogenesis
    Josephine C Bodle
    Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, North Carolina, United States of America
    PLoS ONE 8:e62554. 2013
  4. ncbi request reprint Mechanobiology of mandibular distraction osteogenesis: experimental analyses with a rat model
    Elizabeth G Loboa
    Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305 5148, USA
    Bone 34:336-43. 2004
  5. ncbi request reprint Mechanobiology of mandibular distraction osteogenesis: finite element analyses with a rat model
    Elizabeth G Loboa
    Biomechanical Engineering Division, Mechanical Engineering Department, Stanford University, CA 94305, USA
    J Orthop Res 23:663-70. 2005
  6. doi request reprint Release profiles of tricalcium phosphate nanoparticles from poly(L-lactic acid) electrospun scaffolds with single component, core-sheath, or porous fiber morphologies: effects on hASC viability and osteogenic differentiation
    Mahsa Mohiti Asli
    College of Textiles, North Carolina State University, Raleigh, NC 27695, USA
    Macromol Biosci 12:893-900. 2012
  7. doi request reprint Collagen-PCL sheath-core bicomponent electrospun scaffolds increase osteogenic differentiation and calcium accretion of human adipose-derived stem cells
    Carla Maria Haslauer
    Joint Department of Biomedical Engineering, North Carolina State University, Raleigh, NC 27695, USA
    J Biomater Sci Polym Ed 22:1695-712. 2011
  8. doi request reprint Osteogenic effects of rest inserted and continuous cyclic tensile strain on hASC lines with disparate osteodifferentiation capabilities
    Ariel D Hanson
    Joint Department of Biomedical Engineering, North Carolina State University and UNC Chapel Hill, 2142 Burlington Laboratories, Campus Box 7115, Raleigh, NC 27695 7115, USA
    Ann Biomed Eng 37:955-65. 2009
  9. pmc Finite element modeling of 3D human mesenchymal stem cell-seeded collagen matrices exposed to tensile strain
    T Wayne Pfeiler
    2142 Burlington Laboratories, Joint Department of Biomedical Engineering at NC State University and UNC Chapel Hill, Campus Box 7115, Raleigh, NC 27695 7115, USA
    J Biomech 41:2289-96. 2008
  10. ncbi request reprint Equibiaxial tensile strain affects calvarial osteoblast biology
    Kenton D Fong
    Department of Surgery, Stanford University School of Medicine, 257 Campus Drive, Stanford, CA 94305 5148, USA
    J Craniofac Surg 14:348-55. 2003

Collaborators

  • Dennis R Carter
  • Nancy A Monteiro-Riviere
  • David S Lalush
  • James H Henderson
  • Lindsey S Alexander
  • Jane L Lubischer
  • James P McClung
  • Chad H Stahl
  • Ola L A Harrysson
  • Roger J Narayan
  • Denis J Marcellin-Little
  • Derek P Lindsey
  • Dong Yan
  • Jie Qi
  • Seth D McCullen
  • Susan H Bernacki
  • Michelle E Wall
  • Ruwan D Sumanasinghe
  • Josephine C Bodle
  • Ariel D Hanson
  • Pattie S Mathieu
  • Adisri Charoenpanich
  • Behnam Pourdeyhimi
  • Carla Maria Haslauer
  • T Wayne Pfeiler
  • Kenton D Fong
  • Carla M Haslauer
  • Stephen M Warren
  • Mahsa Mohiti-Asli
  • Jennifer Puetzer
  • Charles J Tucker
  • Danica M K Andrews
  • Mahsa Mohiti Asli
  • Avanika Mahajan
  • Albert J Banes
  • Jason A Osborne
  • Jennifer L Puetzer
  • Benjamin Moody
  • Michael T Longaker
  • Catherine M Cowan
  • Laura I Clarke
  • Russell E Gorga
  • Jillian G Rouse
  • Allison R Finger
  • Tony D Fang
  • Douglas R Dirschl
  • Michelle E Phillips
  • Candace D Rubenstein
  • Susan Bernacki
  • Allison Gillies
  • John Williams
  • Ajit K Moghe
  • Jack Odle
  • Daniel E Catrambone
  • Brynn S Seabolt
  • Bhupender S Gupta
  • Shaun D Gittard
  • Elizabeth Kirk
  • Jessica Collins Springer
  • Arthi Kannan
  • Philip R Miller
  • John P McQuilling
  • Robert M Grossfeld
  • Gregory S McCarty
  • Maureen L Onorato
  • John N Petitte
  • Jackie Zhan
  • Skylar W Marvel
  • John Van Aalst
  • Derrick R Stevens
  • Wesley A Roberts
  • Andrew Rachlin
  • Katherine O Dulaney
  • Carol A Otey
  • Carolyn Y Sargent
  • HanJoon M Song
  • H Peter Lorenz
  • Randall P Nacamuli
  • Constance M Chen

Detail Information

Publications36

  1. ncbi request reprint Mechanical strain affects dura mater biological processes: implications for immature calvarial healing
    Kenton D Fong
    Department of Surgery, School of Medicine, Stanford University, CA 94305, USA
    Plast Reconstr Surg 112:1312-27. 2003
    ..These findings suggest that mechanical strain can induce changes in dura mater biological processes and gene expression that may play important roles in coordinating the growth and healing of the neonatal calvaria...
  2. pmc Characterization of electrospun nanocomposite scaffolds and biocompatibility with adipose-derived human mesenchymal stem cells
    Seth D McCullen
    Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC 27695, USA
    Int J Nanomedicine 2:253-63. 2007
    ..SEM images of hMSCs at 14 days showed morphological differences, with hMSCs on PLA well spread and hMSCs on PLA with 1% MWNT closely packed and longitudinally aligned...
  3. pmc Primary cilia: the chemical antenna regulating human adipose-derived stem cell osteogenesis
    Josephine C Bodle
    Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, North Carolina, United States of America
    PLoS ONE 8:e62554. 2013
    ..Elucidating the dynamic role of the primary cilium and its associated proteins will help advance the application of hASC in generating autologous tissue engineered therapies in critical defect bone injuries...
  4. ncbi request reprint Mechanobiology of mandibular distraction osteogenesis: experimental analyses with a rat model
    Elizabeth G Loboa
    Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305 5148, USA
    Bone 34:336-43. 2004
    ..Taken together, our interpretation of these data is that daily distractions cause daily tissue damage which triggers new mesenchymal tissue formation...
  5. ncbi request reprint Mechanobiology of mandibular distraction osteogenesis: finite element analyses with a rat model
    Elizabeth G Loboa
    Biomechanical Engineering Division, Mechanical Engineering Department, Stanford University, CA 94305, USA
    J Orthop Res 23:663-70. 2005
    ....
  6. doi request reprint Release profiles of tricalcium phosphate nanoparticles from poly(L-lactic acid) electrospun scaffolds with single component, core-sheath, or porous fiber morphologies: effects on hASC viability and osteogenic differentiation
    Mahsa Mohiti Asli
    College of Textiles, North Carolina State University, Raleigh, NC 27695, USA
    Macromol Biosci 12:893-900. 2012
    ..Osteogenic differentiation of hASC and cell-mediated calcium accretion are largest on porous fibers...
  7. doi request reprint Collagen-PCL sheath-core bicomponent electrospun scaffolds increase osteogenic differentiation and calcium accretion of human adipose-derived stem cells
    Carla Maria Haslauer
    Joint Department of Biomedical Engineering, North Carolina State University, Raleigh, NC 27695, USA
    J Biomater Sci Polym Ed 22:1695-712. 2011
    ..The sheath-core composite fibers significantly increased calcium accretion of hASCs, indicating that collagen-PCL sheath-core bicomponent structures have potential for bone tissue engineering applications using hASCs...
  8. doi request reprint Osteogenic effects of rest inserted and continuous cyclic tensile strain on hASC lines with disparate osteodifferentiation capabilities
    Ariel D Hanson
    Joint Department of Biomedical Engineering, North Carolina State University and UNC Chapel Hill, 2142 Burlington Laboratories, Campus Box 7115, Raleigh, NC 27695 7115, USA
    Ann Biomed Eng 37:955-65. 2009
    ....
  9. pmc Finite element modeling of 3D human mesenchymal stem cell-seeded collagen matrices exposed to tensile strain
    T Wayne Pfeiler
    2142 Burlington Laboratories, Joint Department of Biomedical Engineering at NC State University and UNC Chapel Hill, Campus Box 7115, Raleigh, NC 27695 7115, USA
    J Biomech 41:2289-96. 2008
    ..3% and 21.8%, respectively. Model results were also compared to experimental studies in an attempt to explain observed differences between hMSC response to 10% and 12% cyclic tensile strain...
  10. ncbi request reprint Equibiaxial tensile strain affects calvarial osteoblast biology
    Kenton D Fong
    Department of Surgery, Stanford University School of Medicine, 257 Campus Drive, Stanford, CA 94305 5148, USA
    J Craniofac Surg 14:348-55. 2003
    ....
  11. pmc Application of low-frequency alternating current electric fields via interdigitated electrodes: effects on cellular viability, cytoplasmic calcium, and osteogenic differentiation of human adipose-derived stem cells
    Seth D McCullen
    Joint Department of Biomedical Engineering at The University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, North Carolina, USA
    Tissue Eng Part C Methods 16:1377-86. 2010
    ....
  12. ncbi request reprint Human adipose-derived adult stem cells upregulate palladin during osteogenesis and in response to cyclic tensile strain
    Michelle E Wall
    Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, North Carolina 27695 7115, USA
    Am J Physiol Cell Physiol 293:C1532-8. 2007
    ..Silencing the palladin gene, however, did not affect hADAS cells' commitment down the osteogenic lineage...
  13. doi request reprint Expression of proinflammatory cytokines by human mesenchymal stem cells in response to cyclic tensile strain
    Ruwan D Sumanasinghe
    Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, North Carolina 27695 7115, USA
    J Cell Physiol 219:77-83. 2009
    ..IL-6 and IL-8 expressions by hMSCs were induced by cyclic tensile strain and osteogenic differentiating media, indicating that IL-6 and IL-8 may be functioning as autocrine signals during osteogenic differentiation of hMSCs...
  14. ncbi request reprint Effect of varied ionic calcium on human adipose-derived stem cell mineralization
    Seth D McCullen
    Joint Department of Biomedical Engineering at The University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, North Carolina 27695 7115, USA
    Tissue Eng Part A 16:1971-81. 2010
    ..Ionic calcium should be considered a potent regulator in hASC mineralization and could serve as a potential treatment for inducing prompt ossification of hASC-seeded scaffolds for bone tissue engineering prior to implantation...
  15. doi request reprint Mesenchymal stem cell-seeded collagen matrices for bone repair: effects of cyclic tensile strain, cell density, and media conditions on matrix contraction in vitro
    Ruwan D Sumanasinghe
    Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, North Carolina
    J Biomed Mater Res A 88:778-86. 2009
    ..It is vital to understand the effects of culture conditions on collagen matrix contraction by hMSCs in order to consider hMSC-seeded collagen constructs for functional bone tissue engineering in vitro...
  16. doi request reprint In vitro biocompatibility of titanium alloy discs made using direct metal fabrication
    Carla Maria Haslauer
    Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC 27695, USA
    Med Eng Phys 32:645-52. 2010
    ..EBM FFF may be considered as an option for the fabrication of custom orthopedic implants...
  17. ncbi request reprint Differential effects on messenger ribonucleic acid expression by bone marrow-derived human mesenchymal stem cells seeded in agarose constructs due to ramped and steady applications of cyclic hydrostatic pressure
    Allison R Finger
    Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, North Carolina 27695, USA
    Tissue Eng 13:1151-8. 2007
    ....
  18. doi request reprint Musculoskeletal mechanobiology: interpretation by external force and engineered substratum
    Seth D McCullen
    Joint Department of Biomedical Engineering at University of North Carolina at Chapel Hill and North Carolina State University, 2142 Burlington Laboratories, Campus Box 7115, Raleigh, NC 27695 7115, USA
    J Biomech 43:119-27. 2010
    ....
  19. pmc Microarray analysis of human adipose-derived stem cells in three-dimensional collagen culture: osteogenesis inhibits bone morphogenic protein and Wnt signaling pathways, and cyclic tensile strain causes upregulation of proinflammatory cytokine regulators
    Adisri Charoenpanich
    Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, North Carolina 27695 7115, USA
    Tissue Eng Part A 17:2615-27. 2011
    ....
  20. doi request reprint Isolation of human mesenchymal stem cells from bone and adipose tissue
    Susan H Bernacki
    Joint Department of Biomedical Engineering at NC State University and UNC Chapel Hill, Burlington Laboratories Raleigh, NC 27695, USA
    Methods Cell Biol 86:257-78. 2008
  21. pmc The effects of cyclic hydrostatic pressure on chondrogenesis and viability of human adipose- and bone marrow-derived mesenchymal stem cells in three-dimensional agarose constructs
    Jennifer Puetzer
    Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, North Carolina, USA
    Tissue Eng Part A 19:299-306. 2013
    ....
  22. ncbi request reprint Effects of serial passaging on the adipogenic and osteogenic differentiation potential of adipose-derived human mesenchymal stem cells
    Michelle E Wall
    Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, North Carolina 27695, USA
    Tissue Eng 13:1291-8. 2007
    ....
  23. ncbi request reprint Osteogenic differentiation of human mesenchymal stem cells in collagen matrices: effect of uniaxial cyclic tensile strain on bone morphogenetic protein (BMP-2) mRNA expression
    Ruwan D Sumanasinghe
    Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, North Carolina 27695 7115, USA
    Tissue Eng 12:3459-65. 2006
    ..Induction of bone differentiation in 3D culture is a critical step in the creation of bioengineered bone constructs...
  24. ncbi request reprint Comparative review of growth factors for induction of three-dimensional in vitro chondrogenesis in human mesenchymal stem cells isolated from bone marrow and adipose tissue
    Jennifer L Puetzer
    Joint Department of Biomedical Engineering at UNC Chapel Hill and North Carolina State University, Raleigh, North Carolina 27695, USA
    Tissue Eng Part B Rev 16:435-44. 2010
    ..Continued research must be performed to examine the expression cascades of the TFGbeta superfamily to further determine the effects of each growth factor alone and in combination on these stem cell lines...
  25. doi request reprint In situ collagen polymerization of layered cell-seeded electrospun scaffolds for bone tissue engineering applications
    Seth D McCullen
    Joint Department of Biomedical Engineering at the University of North Carolina at Chapel Hill, North Carolina State University, Raleigh, North Carolina 27695 7115, USA
    Tissue Eng Part C Methods 16:1095-105. 2010
    ....
  26. pmc Adipose-derived stem cells in functional bone tissue engineering: lessons from bone mechanobiology
    Josephine C Bodle
    Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, North Carolina 27695 7115, USA
    Tissue Eng Part B Rev 17:195-211. 2011
    ..Specific emphasis is placed on the use of human ASC for this application...
  27. doi request reprint Dietary calcium restriction affects mesenchymal stem cell activity and bone development in neonatal pigs
    Avanika Mahajan
    Laboratory of Developmental Nutrition, Department of Animal Science, North Carolina State University, Raleigh, NC 27695, USA
    J Nutr 141:373-9. 2011
    ..The results indicate that neonatal Ca nutrition is crucial for bone integrity and suggest that early-life Ca restriction may have long-term effects on bone integrity via programming of MSC...
  28. pmc Cyclic tensile strain enhances osteogenesis and angiogenesis in mesenchymal stem cells from osteoporotic donors
    Adisri Charoenpanich
    1 Joint Department of Biomedical Engineering at University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, and North Carolina State University, Raleigh, North Carolina
    Tissue Eng Part A 20:67-78. 2014
    ....
  29. pmc Cytoskeletal and focal adhesion influences on mesenchymal stem cell shape, mechanical properties, and differentiation down osteogenic, adipogenic, and chondrogenic pathways
    Pattie S Mathieu
    Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC, USA
    Tissue Eng Part B Rev 18:436-44. 2012
    ..Different mechanical stimuli can be implemented to alter these cytoskeletal patterns and encourage MSC differentiation to the desired lineage...
  30. ncbi request reprint Tools and techniques for craniofacial tissue engineering
    Stephen M Warren
    Department of Surgery, Stanford University School of Medicine, Stanford, California 94305 5148, USA
    Tissue Eng 9:187-200. 2003
    ..In this review, we highlight the major gene- and cell-based preclinical tools and techniques that are currently being developed to solve common craniofacial problems...
  31. ncbi request reprint Effects of oxygen plasma treatment on adipose-derived human mesenchymal stem cell adherence to poly(L-lactic acid) scaffolds
    Ariel D Hanson
    Joint Department of Biomedical Engineering, 2142 Burlington Nuclear Engineering Laboratories, Campus Box 7115, North Carolina State University, Raleigh, NC 27695, USA
    J Biomater Sci Polym Ed 18:1387-400. 2007
    ..This early induction of cell spreading and the uniform distribution of cells, in turn, may increase future proliferation and differentiation of hMSCs under conditions that simulate the microenvironment in vivo...
  32. doi request reprint In situ monitoring of adipogenesis with human-adipose-derived stem cells using surface-enhanced Raman spectroscopy
    Benjamin Moody
    University of North Carolina, Chapel Hill and North Carolina State University, Joint Department of Biomedical Engineering, Raleigh, North Carolina 27695, USA
    Appl Spectrosc 64:1227-33. 2010
    ..After 22 days of differentiation, the cells show visible and spectroscopic indications of completed adipogenesis yet still share spectral features common to the progenitor stem cells...
  33. ncbi request reprint Cyclic tensile strain increases interactions between human epidermal keratinocytes and quantum dot nanoparticles
    Jillian G Rouse
    Center for Chemical Toxicology Research and Pharmacokinetics, Department of Clinical Sciences, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA
    Toxicol In Vitro 22:491-7. 2008
    ..Application of physiological load conditions can increase cell membrane permeability, thereby increasing the concentration of QD nanoparticles in cells...
  34. pmc Primary cilium mechanotransduction of tensile strain in 3D culture: Finite element analyses of strain amplification caused by tensile strain applied to a primary cilium embedded in a collagen matrix
    Pattie S Mathieu
    Joint Department of Biomedical Engineering at North Carolina State University and University of North Carolina Chapel Hill, Engineering Building III EB3 4208B, Box 7115, NCSU Campus, Raleigh, NC 27695, USA
    J Biomech 47:2211-7. 2014
    ....
  35. pmc Novel, silver-ion-releasing nanofibrous scaffolds exhibit excellent antibacterial efficacy without the use of silver nanoparticles
    Mahsa Mohiti-Asli
    Joint Department of Biomedical Engineering at University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC 27695, USA
    Acta Biomater 10:2096-104. 2014
    ..5╬╝gml(-1) within the coating solution. This is the first study to show that silver ions can be effectively delivered with nanofibrous scaffolds without the use of silver nanoparticles. ..
  36. pmc Genetic background influences fluoride's effects on osteoclastogenesis
    Dong Yan
    Dental Research, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Bone 41:1036-44. 2007
    ..The expected anabolic effects were observed in B6 and novel actions hallmarked by enhanced osteoclastogenesis shifts in hematopoietic cell differentiation in the C3H strain...